|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
|
Spatial pattern gene: KLF3 (spascer ID:51274) |
Gene summary for KLF3 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | KLF3 | Gene ID | 51274 |
| Gene name | Kruppel like factor 3 |
| Synonyms | BKLF |
| Cytomap | 4p14 |
| Type of gene | protein-coding |
| Description | Krueppel-like factor 3CACCC-box-binding protein BKLFKruppel-like factor 3 (basic)TEF-2basic Kruppel-like factorbasic krueppel-like factorbasic kruppel like factortranscript ch138 |
| Modification date | 20220513 |
| UniProtAcc | P57682 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| KLF3 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 21873635 | Function |
| KLF3 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 21873635 | Function |
| KLF3 | GO:0006357 | regulation of transcription by RNA polymerase II | 21873635 | Process |
Top |
Spatial pattern events for KLF3 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| KLF3 | Human | Intestine | rep_colon1 | 34417225 | 3.42e-15 |
| KLF3 | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| KLF3 | Human | Intestine | rep_colon4 | 34417225 | 1.19e-08 |
| KLF3 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| KLF3 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| KLF3 | Human | Liver | rep_liver4 | 34417225 | 2.32e-06 |
| KLF3 | Human | Intestine | A1 | 33406409 | 2.09e-15 |
| KLF3 | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| KLF3 | Human | Uterus | rep_1 | 34857954 | 1.39e-07 |
| KLF3 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| KLF3 | Human | Uterus | rep_4 | 34857954 | 2.81e-09 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_3_H&E  |  |
Uterus_rep_4_H&E  |  |
Top |
Spatial pattern pathway has KLF3 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| KLF3 | GOBP_Response_To_Endogenous_Stimulus | Human | Brain | rep_10 | 2.8e-23 |
| KLF3 | GOBP_Response_To_Oxygen_Containing_Compound | Human | Brain | rep_10 | 5.3e-26 |
| KLF3 | GOBP_Response_To_Peptide | Human | Bladder | rep_2 | 2.3e-11 |
| KLF3 | GOBP_Response_To_Endogenous_Stimulus | Human | Liver | rep_1 | 3.0e-55 |
| KLF3 | GOBP_Response_To_Oxygen_Containing_Compound | Human | Liver | rep_1 | 1.5e-74 |
| KLF3 | GOBP_Response_To_Endogenous_Stimulus | Human | Intestine | rep_liver2 | 3.7e-39 |
| KLF3 | GOBP_Response_To_Oxygen_Containing_Compound | Human | Intestine | rep_liver2 | 3.3e-10 |
| KLF3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Human | Intestine | A3 | 5.9e-17 |
| KLF3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Intestine | A3 | 7.7e-14 |
| KLF3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Intestine | A3 | 1.9e-15 |
| KLF3 | GOBP_Response_To_Endogenous_Stimulus | Human | Intestine | A3 | 5.2e-09 |
| KLF3 | GOBP_Response_To_Oxygen_Containing_Compound | Human | Intestine | A3 | 8.2e-08 |
| KLF3 | GOBP_Cellular_Response_To_Oxygen_Containing_Compound | Human | Intestine | A8 | 1.4e-09 |
| KLF3 | GOBP_Cellular_Response_To_Peptide | Human | Intestine | A8 | 2.9e-08 |
| KLF3 | GOBP_Response_To_Nitrogen_Compound | Human | Intestine | A8 | 1.3e-12 |
| KLF3 | GOBP_Response_To_Peptide | Human | Intestine | A8 | 2.0e-09 |
| KLF3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Uterus | rep_26 | 2.1e-06 |
| KLF3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Uterus | rep_26 | 6.2e-13 |
| KLF3 | GOBP_Cellular_Response_To_Nitrogen_Compound | Human | Breast | rep_5 | 4.4e-13 |
| KLF3 | GOBP_Cellular_Response_To_Oxygen_Containing_Compound | Human | Breast | rep_5 | 4.9e-11 |
| KLF3 | GOBP_Response_To_Endogenous_Stimulus | Human | Breast | rep_5 | 3.6e-09 |
| KLF3 | GOBP_Response_To_Nitrogen_Compound | Human | Breast | rep_5 | 1.1e-11 |
| KLF3 | GOBP_Response_To_Oxygen_Containing_Compound | Human | Breast | rep_5 | 4.2e-13 |
| KLF3 | GOBP_Response_To_Peptide | Human | Breast | rep_5 | 1.2e-15 |
| KLF3 | GOBP_Cellular_Response_To_Peptide | Human | Breast | rep_6 | 8.4e-11 |
| KLF3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Human | Breast | rep_6 | 2.6e-08 |
| KLF3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Breast | rep_6 | 3.5e-08 |
| KLF3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Breast | rep_6 | 8.2e-08 |
| KLF3 | GOBP_Response_To_Oxygen_Containing_Compound | Human | Lung | rep_1 | 7.8e-08 |
Top |
KLF3 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
Top |
KLF3 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication | ||
Top |
Transcription factor for KLF3 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Klf3 | Kidney | LPS | PT_S3_OS | Gas7,Nsd3,Camk2n1, etc. | 0.284 |
| Klf3 | Kidney | LPS | TAL | Gas7,Nsd3,Camk2n1, etc. | 0.332 |
| Klf3 | Kidney | LPS | CNT | Gas7,Nsd3,Camk2n1, etc. | 0.265 |
| Klf3 | Kidney | LPS | PT_S2 | Gas7,Nsd3,Camk2n1, etc. | 0.27 |
| Klf3 | Kidney | LPS | PT_S3_C | Gas7,Nsd3,Camk2n1, etc. | 0.319 |
| KLF3 | Uterus | early | Glandular | ITGA2,LPIN1,GADD45A, etc. | 0.34 |
| KLF3 | Uterus | early | Glandular_secretory | ITGA2,LPIN1,GADD45A, etc. | 0.259 |
| KLF3 | Uterus | early | SOX9_LGR5 | ITGA2,LPIN1,GADD45A, etc. | 0.357 |
| KLF3 | Uterus | early | SOX9 | ITGA2,LPIN1,GADD45A, etc. | 0.472 |
| KLF3 | Uterus | early_mid | Glandular | NUP50,SLC30A1,DDX58, etc. | 0.39 |
| KLF3 | Uterus | early_mid | Lumenal 1 | NUP50,SLC30A1,DDX58, etc. | 0.493 |
| KLF3 | Uterus | early_mid | Glandular_secretory | NUP50,SLC30A1,DDX58, etc. | 0.267 |
| KLF3 | Uterus | mid | Glandular_secretory | DUSP14,IL6R,RBM12, etc. | 0.672 |
| KLF3 | Uterus | late | Glandular_secretory | SYNCRIP,C16orf72,SSFA2, etc. | 0.686 |
| KLF3 | Intestine | development | Epithelium | OTUD1,FOXP1,LIMA1, etc. | 0.461 |
| KLF3 | Intestine | development | Fibroblasts | OTUD1,FOXP1,LIMA1, etc. | 0.41 |
| KLF3 | Intestine | development | MyoFibroblasts | OTUD1,FOXP1,LIMA1, etc. | 0.272 |
| Klf3 | Kidney | IRI | PT_S1 | Jade2,Nav1,Eif5a, etc. | 0.289 |
| Klf3 | Kidney | IRI | PT_S3_C | Jade2,Nav1,Eif5a, etc. | 0.27 |
| Klf3 | Kidney | IRI | PT_Fibrinogen | Jade2,Nav1,Eif5a, etc. | 0.259 |
| Klf3 | Kidney | IRI | CD_IC | Jade2,Nav1,Eif5a, etc. | 0.284 |
| Klf3 | Kidney | IRI | TAL | Jade2,Nav1,Eif5a, etc. | 0.304 |
| Klf3 | Kidney | IRI | CD_PC | Jade2,Nav1,Eif5a, etc. | 0.285 |
| KLF3 | Uterus | proliferative | SOX9 | RDH13,CREBRF,FAM20A, etc. | 0.543 |
| KLF3 | Uterus | proliferative | SOX9_LGR5 | RDH13,CREBRF,FAM20A, etc. | 0.358 |
| KLF3 | Uterus | proliferative | SOX9_prolif | RDH13,CREBRF,FAM20A, etc. | 0.315 |
| Motif information. |
 | |
 | |
 | |
 | |
 | |
Top |
Related Drugs for KLF3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for KLF3 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
