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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: TBC1D7 (spascer ID:51256)

Gene summary for TBC1D7

Gene summary

Gene information
	Species	Human
	Gene symbol	TBC1D7
	Gene ID	51256
	Gene name	TBC1 domain family member 7
	Synonyms	MGCPH\|PIG51\|TBC7
	Cytomap	6p24.1
	Type of gene	protein-coding
	Description	TBC1 domain family member 7TS complex subunit 3cell migration-inducing protein 23
	Modification date	20220513
	UniProtAcc	Q9P0N9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
TBC1D7	GO:0005096	GTPase activator activity	21873635	Function
TBC1D7	GO:0032007	negative regulation of TOR signaling	21873635	Process
TBC1D7	GO:0090630	activation of GTPase activity	21873635	Process

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Spatial pattern events for TBC1D7

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
TBC1D7	Human	Liver	rep_liver1	34417225	1.08e-15
TBC1D7	Human	Liver	rep_liver2	34417225	6.98e-16
TBC1D7	Human	Breast	1160920F	34493872	2.68e-15
TBC1D7	Human	Breast	CID44971	34493872	6.44e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Breast_1160920F_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has TBC1D7 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
TBC1D7	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
TBC1D7	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_1	8.7e-71
TBC1D7	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Brain	rep_1	2.8e-23
TBC1D7	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
TBC1D7	GOBP_Regulation_Of_Protein_Modification_Process	Human	Brain	rep_1	7.4e-34
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
TBC1D7	GOBP_Response_To_Growth_Factor	Human	Bladder	rep_2	1.2e-08
TBC1D7	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Liver	rep_1	2.8e-53
TBC1D7	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
TBC1D7	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	4.9e-46
TBC1D7	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Liver	rep_1	1.0e-70
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
TBC1D7	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
TBC1D7	GOBP_Regulation_Of_Protein_Modification_Process	Human	Liver	rep_1	1.0e-70
TBC1D7	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
TBC1D7	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon2	4.1e-22
TBC1D7	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
TBC1D7	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
TBC1D7	GOBP_Cell_Projection_Assembly	Human	Intestine	A3	4.9e-09
TBC1D7	GOBP_Cell_Projection_Organization	Human	Intestine	A3	1.1e-09
TBC1D7	GOBP_Cilium_Organization	Human	Intestine	A3	7.4e-11
TBC1D7	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	9.1e-10
TBC1D7	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-18
TBC1D7	GOBP_Negative_Regulation_Of_Organelle_Organization	Human	Intestine	A3	3.5e-11
TBC1D7	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Intestine	A3	6.0e-11
TBC1D7	GOBP_Negative_Regulation_Of_Signaling	Human	Intestine	A3	4.9e-15
TBC1D7	GOBP_Negative_Regulation_Of_Tor_Signaling	Human	Intestine	A3	1.4e-13
TBC1D7	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
TBC1D7	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.8e-12
TBC1D7	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	2.8e-16
TBC1D7	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	4.9e-09
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	9.1e-12
TBC1D7	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
TBC1D7	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
TBC1D7	GOBP_Regulation_Of_Cell_Projection_Assembly	Human	Intestine	A3	4.1e-07
TBC1D7	GOBP_Regulation_Of_Cell_Projection_Organization	Human	Intestine	A3	7.0e-08
TBC1D7	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	8.8e-12
TBC1D7	GOBP_Regulation_Of_Cilium_Assembly	Human	Intestine	A3	3.3e-09
TBC1D7	GOBP_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.0e-12
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
TBC1D7	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
TBC1D7	GOBP_Regulation_Of_Organelle_Assembly	Human	Intestine	A3	9.7e-21
TBC1D7	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
TBC1D7	GOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	3.0e-12
TBC1D7	GOBP_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	1.1e-14
TBC1D7	GOBP_Regulation_Of_Tor_Signaling	Human	Intestine	A3	1.7e-12
TBC1D7	GOBP_Tor_Signaling	Human	Intestine	A3	5.1e-07
TBC1D7	GOBP_Activation_Of_Gtpase_Activity	Human	Intestine	A8	1.0e-11
TBC1D7	GOBP_Negative_Regulation_Of_Cilium_Assembly	Human	Intestine	A8	8.1e-08
TBC1D7	GOBP_Negative_Regulation_Of_Organelle_Organization	Human	Pancreas	PDAC-B-st1	6.2e-05
TBC1D7	GOBP_Negative_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Human	Pancreas	PDAC-B-st1	8.3e-05
TBC1D7	GOBP_Negative_Regulation_Of_Signaling	Human	Pancreas	PDAC-B-st1	1.7e-05
TBC1D7	GOBP_Regulation_Of_Gtpase_Activity	Human	Pancreas	PDAC-B-st1	9.7e-05
TBC1D7	GOBP_Activation_Of_Gtpase_Activity	Human	Pancreas	PDAC-A-st2	4.8e-06
TBC1D7	GOBP_Regulation_Of_Cilium_Assembly	Human	Pancreas	PDAC-A-st2	2.2e-06
TBC1D7	GOBP_Regulation_Of_Tor_Signaling	Human	Pancreas	PDAC-A-st2	2.1e-05
TBC1D7	GOBP_Negative_Regulation_Of_Organelle_Assembly	Human	Uterus	rep_1	6.8e-07
TBC1D7	GOBP_Negative_Regulation_Of_Cilium_Assembly	Human	Uterus	rep_25	1.1e-10
TBC1D7	GOBP_Activation_Of_Gtpase_Activity	Human	Uterus	rep_26	2.2e-07
TBC1D7	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_26	2.7e-06
TBC1D7	GOBP_Negative_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Human	Uterus	rep_26	2.9e-14
TBC1D7	GOBP_Negative_Regulation_Of_Tor_Signaling	Human	Uterus	rep_26	3.8e-06
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	2.2e-08
TBC1D7	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
TBC1D7	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
TBC1D7	GOBP_Regulation_Of_Cilium_Assembly	Human	Uterus	rep_26	3.5e-10
TBC1D7	GOBP_Regulation_Of_Organelle_Assembly	Human	Uterus	rep_26	2.0e-06
TBC1D7	GOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	2.9e-09
TBC1D7	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Uterus	rep_29	1.2e-06
TBC1D7	GOBP_Negative_Regulation_Of_Signaling	Human	Uterus	rep_29	5.3e-06
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
TBC1D7	GOBP_Activation_Of_Gtpase_Activity	Human	Breast	rep_1	5.7e-24
TBC1D7	GOBP_Cell_Projection_Assembly	Human	Breast	rep_1	1.9e-26
TBC1D7	GOBP_Cell_Projection_Organization	Human	Breast	rep_1	1.8e-20
TBC1D7	GOBP_Negative_Regulation_Of_Cell_Projection_Organization	Human	Breast	rep_1	1.2e-39
TBC1D7	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	7.3e-14
TBC1D7	GOBP_Negative_Regulation_Of_Cilium_Assembly	Human	Breast	rep_1	1.5e-44
TBC1D7	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_1	3.6e-04
TBC1D7	GOBP_Negative_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	2.9e-09
TBC1D7	GOBP_Negative_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Human	Breast	rep_1	6.5e-196
TBC1D7	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Breast	rep_1	2.4e-07
TBC1D7	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	1.4e-13
TBC1D7	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_1	7.8e-04
TBC1D7	GOBP_Regulation_Of_Cell_Projection_Assembly	Human	Breast	rep_1	6.5e-29
TBC1D7	GOBP_Regulation_Of_Cell_Projection_Organization	Human	Breast	rep_1	3.8e-16
TBC1D7	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	4.6e-05
TBC1D7	GOBP_Regulation_Of_Cilium_Assembly	Human	Breast	rep_1	8.0e-07
TBC1D7	GOBP_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	9.6e-08
TBC1D7	GOBP_Regulation_Of_Organelle_Assembly	Human	Breast	rep_1	1.0e-12
TBC1D7	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
TBC1D7	GOBP_Response_To_Growth_Factor	Human	Breast	rep_1	1.2e-13
TBC1D7	GOBP_Negative_Regulation_Of_Signaling	Human	Breast	rep_5	8.6e-14
TBC1D7	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
TBC1D7	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_5	3.0e-10
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
TBC1D7	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
TBC1D7	GOBP_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_5	9.1e-07
TBC1D7	GOBP_Cilium_Organization	Human	Breast	rep_6	3.8e-08
TBC1D7	GOBP_Negative_Regulation_Of_Organelle_Assembly	Human	Breast	rep_6	2.7e-13
TBC1D7	GOBP_Negative_Regulation_Of_Tor_Signaling	Human	Breast	rep_6	1.1e-04
TBC1D7	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
TBC1D7	GOBP_Positive_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	1.5e-06
TBC1D7	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
TBC1D7	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
TBC1D7	GOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	1.0e-10
TBC1D7	GOBP_Regulation_Of_Tor_Signaling	Human	Breast	rep_6	4.2e-09
TBC1D7	GOBP_Tor_Signaling	Human	Breast	rep_6	2.9e-08
TBC1D7	GOBP_Negative_Regulation_Of_Cilium_Assembly	Human	Skin	P5_rep3	7.8e-12
TBC1D7	GOBP_Negative_Regulation_Of_Organelle_Assembly	Human	Skin	P10_rep2	2.3e-09
TBC1D7	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
TBC1D7	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_2	7.9e-07

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TBC1D7 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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TBC1D7 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for TBC1D7 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for TBC1D7

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TBC1D7

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
TBC1D7	C0221355	Macrocephaly	2	GENOMICS_ENGLAND;ORPHANET
TBC1D7	C3806412	MACROCEPHALY/MEGALENCEPHALY SYNDROME, AUTOSOMAL RECESSIVE	2	GENOMICS_ENGLAND
TBC1D7	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND