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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PAIP2 (spascer ID:51247)

Gene summary for PAIP2

Gene summary

Gene information
	Species	Human
	Gene symbol	PAIP2
	Gene ID	51247
	Gene name	poly(A) binding protein interacting protein 2
	Synonyms	PAIP-2\|PAIP2A
	Cytomap	5q31.2
	Type of gene	protein-coding
	Description	polyadenylate-binding protein-interacting protein 2PABC1-interacting protein 2PABP-interacting protein 2polyA-binding protein-interacting protein 2
	Modification date	20220513
	UniProtAcc	Q9BPZ3

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PAIP2	GO:0005737	cytoplasm	21873635	Component
PAIP2	GO:0017148	negative regulation of translation	21873635	Process
PAIP2	GO:0030371	translation repressor activity	21873635	Function

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Spatial pattern events for PAIP2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PAIP2	Human	Intestine	rep_colon1	34417225	3.08e-13
PAIP2	Human	Intestine	rep_colon2	34417225	8.12e-16
PAIP2	Human	Intestine	rep_colon4	34417225	1.30e-09
PAIP2	Human	Liver	rep_liver1	34417225	1.08e-15
PAIP2	Human	Intestine	A4	33406409	1.06e-07
PAIP2	Human	Intestine	A6	33406409	7.71e-07
PAIP2	Human	Breast	1142243F	34493872	4.09e-13
PAIP2	Human	Breast	CID44971	34493872	2.14e-07
PAIP2	Human	Heart	w6_s4	31835037	3.81e-03

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Intestine_A4_H&E
Intestine_A6_H&E
Breast_1142243F_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has PAIP2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PAIP2	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
PAIP2	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
PAIP2	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
PAIP2	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
PAIP2	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
PAIP2	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
PAIP2	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
PAIP2	GOBP_Behavior	Human	Intestine	A3	1.8e-11
PAIP2	GOBP_Cell_Cell_Signaling	Human	Intestine	A3	6.4e-08
PAIP2	GOBP_Cognition	Human	Intestine	A3	5.7e-09
PAIP2	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Intestine	A3	2.7e-15
PAIP2	GOBP_Gamete_Generation	Human	Intestine	A3	4.2e-13
PAIP2	GOBP_Male_Gamete_Generation	Human	Intestine	A3	4.8e-15
PAIP2	GOBP_Multicellular_Organism_Reproduction	Human	Intestine	A3	4.1e-15
PAIP2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Intestine	A3	5.9e-17
PAIP2	GOBP_Negative_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	1.1e-11
PAIP2	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
PAIP2	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
PAIP2	GOBP_Nervous_System_Process	Human	Intestine	A3	9.7e-07
PAIP2	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
PAIP2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
PAIP2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
PAIP2	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Intestine	A3	4.7e-08
PAIP2	GOBP_Regulation_Of_Translational_Initiation	Human	Intestine	A3	9.4e-12
PAIP2	GOBP_Reproduction	Human	Intestine	A3	4.6e-19
PAIP2	GOBP_Synaptic_Signaling	Human	Intestine	A3	5.0e-10
PAIP2	GOBP_Translational_Initiation	Human	Intestine	A3	5.0e-09
PAIP2	GOBP_Long_Term_Synaptic_Potentiation	Human	Intestine	A8	3.2e-09
PAIP2	GOBP_Memory	Human	Intestine	A8	1.2e-07
PAIP2	GOBP_Negative_Regulation_Of_Translational_Initiation	Human	Intestine	A8	1.5e-08
PAIP2	GOBP_Positive_Regulation_Of_Synaptic_Transmission	Human	Intestine	A8	1.7e-08
PAIP2	GOBP_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Intestine	A8	6.4e-08
PAIP2	GOBP_Regulation_Of_Synaptic_Plasticity	Human	Intestine	A8	3.7e-08
PAIP2	GOBP_Regulation_Of_Synaptic_Plasticity	Human	Pancreas	PDAC-B-st1	6.0e-05
PAIP2	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Pancreas	PDAC-B-st1	5.9e-05
PAIP2	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Uterus	rep_1	1.6e-06
PAIP2	GOBP_Negative_Regulation_Of_Translational_Initiation	Human	Uterus	rep_25	6.9e-09
PAIP2	GOBP_Cognition	Human	Uterus	rep_26	3.8e-07
PAIP2	GOBP_Gamete_Generation	Human	Uterus	rep_26	3.8e-10
PAIP2	GOBP_Male_Gamete_Generation	Human	Uterus	rep_26	7.4e-14
PAIP2	GOBP_Nervous_System_Process	Human	Uterus	rep_26	2.3e-07
PAIP2	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Uterus	rep_26	1.2e-08
PAIP2	GOBP_Synaptic_Signaling	Human	Uterus	rep_26	3.3e-08
PAIP2	GOBP_Nervous_System_Process	Human	Breast	rep_1	1.2e-04
PAIP2	GOBP_Synaptic_Signaling	Human	Breast	rep_1	3.5e-04
PAIP2	GOBP_Behavior	Human	Breast	rep_5	3.9e-08
PAIP2	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Breast	rep_5	1.5e-12
PAIP2	GOBP_Long_Term_Synaptic_Potentiation	Human	Breast	rep_5	1.2e-07
PAIP2	GOBP_Multicellular_Organism_Reproduction	Human	Breast	rep_5	8.1e-07
PAIP2	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
PAIP2	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
PAIP2	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
PAIP2	GOBP_Positive_Regulation_Of_Synaptic_Transmission	Human	Breast	rep_5	2.7e-12
PAIP2	GOBP_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Breast	rep_5	4.7e-05
PAIP2	GOBP_Regulation_Of_Synaptic_Plasticity	Human	Breast	rep_5	4.7e-13
PAIP2	GOBP_Reproduction	Human	Breast	rep_5	8.1e-06
PAIP2	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
PAIP2	GOBP_Cell_Cell_Signaling	Human	Breast	rep_6	5.0e-05
PAIP2	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
PAIP2	GOBP_Gamete_Generation	Human	Breast	rep_6	7.3e-08
PAIP2	GOBP_Male_Gamete_Generation	Human	Breast	rep_6	4.3e-06
PAIP2	GOBP_Memory	Human	Breast	rep_6	8.7e-06
PAIP2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Breast	rep_6	2.6e-08
PAIP2	GOBP_Negative_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	1.4e-05
PAIP2	GOBP_Negative_Regulation_Of_Translational_Initiation	Human	Breast	rep_6	2.2e-07
PAIP2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
PAIP2	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
PAIP2	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
PAIP2	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Breast	rep_6	1.3e-06
PAIP2	GOBP_Regulation_Of_Translational_Initiation	Human	Breast	rep_6	6.5e-06
PAIP2	GOBP_Translational_Initiation	Human	Breast	rep_6	2.2e-09
PAIP2	GOBP_Negative_Regulation_Of_Translational_Initiation	Human	Skin	P10_rep2	8.3e-16
PAIP2	GOBP_Long_Term_Synaptic_Potentiation	Human	Lung	rep_1	7.4e-07
PAIP2	GOBP_Memory	Human	Lung	rep_2	3.9e-09

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PAIP2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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PAIP2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for PAIP2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for PAIP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PAIP2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PAIP2	C0009402	Colorectal Carcinoma	1	CTD_human
PAIP2	C0009404	Colorectal Neoplasms	1	CTD_human