Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PCOLCE (spascer ID:5118)

Gene summary for PCOLCE

Gene summary

Gene information
	Species	Human
	Gene symbol	PCOLCE
	Gene ID	5118
	Gene name	procollagen C-endopeptidase enhancer
	Synonyms	PCPE\|PCPE-1\|PCPE1
	Cytomap	7q22.1
	Type of gene	protein-coding
	Description	procollagen C-endopeptidase enhancer 1procollagen C-proteinase enhancer 1procollagen COOH-terminal proteinase enhancer 1procollagen, type 1, COOH-terminal proteinase enhancertype 1 procollagen C-proteinase enhancer proteintype I procollagen COOH-term
	Modification date	20220513
	UniProtAcc	Q15113

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PCOLCE	GO:0005518	collagen binding	21873635	Function
PCOLCE	GO:0006508	proteolysis	21873635	Process
PCOLCE	GO:0016504	peptidase activator activity	21873635	Function

Top

Spatial pattern events for PCOLCE

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PCOLCE	Human	Prostate	rep_7	29925878	1.06e-14
PCOLCE	Human	Bladder	rep_1	34385456	1.09e-07
PCOLCE	Human	Bladder	rep_2	34385456	6.29e-15
PCOLCE	Human	Intestine	rep_colon1	34417225	1.95e-15
PCOLCE	Human	Intestine	rep_colon2	34417225	8.12e-16
PCOLCE	Human	Intestine	rep_colon3	34417225	1.01e-15
PCOLCE	Human	Liver	rep_liver1	34417225	1.08e-15
PCOLCE	Human	Liver	rep_liver2	34417225	6.98e-16
PCOLCE	Human	Liver	rep_liver3	34417225	3.51e-15
PCOLCE	Human	Liver	rep_liver4	34417225	1.39e-15
PCOLCE	Human	Intestine	A2	33406409	2.47e-15
PCOLCE	Human	Intestine	A3	33406409	7.05e-06
PCOLCE	Human	Intestine	A4	33406409	1.70e-12
PCOLCE	Human	Intestine	A6	33406409	2.20e-08
PCOLCE	Human	Intestine	A8	33406409	3.35e-09
PCOLCE	Human	Intestine	A9	33406409	5.42e-14
PCOLCE	Human	Pancreas	PDAC-A-st1	31932730	1.27e-06
PCOLCE	Human	Uterus	rep_1	34857954	5.13e-15
PCOLCE	Human	Uterus	rep_2	34857954	2.55e-15
PCOLCE	Human	Uterus	rep_3	34857954	5.81e-15
PCOLCE	Human	Uterus	rep_4	34857954	1.82e-15
PCOLCE	Human	Breast	B3	34650042	9.10e-06
PCOLCE	Human	Breast	B5	34650042	5.58e-06
PCOLCE	Human	Breast	D4	34650042	1.85e-12
PCOLCE	Human	Breast	D5	34650042	3.25e-07
PCOLCE	Human	Breast	D6	34650042	1.36e-07
PCOLCE	Human	Breast	G1	34650042	6.63e-12
PCOLCE	Human	Breast	1142243F	34493872	2.30e-15
PCOLCE	Human	Breast	1160920F	34493872	1.48e-15
PCOLCE	Human	Breast	CID4290	34493872	4.68e-15
PCOLCE	Human	Breast	CID4465	34493872	4.85e-15
PCOLCE	Human	Breast	CID44971	34493872	1.76e-15
PCOLCE	Human	Breast	CID4535	34493872	6.37e-15
PCOLCE	Human	Heart	w6_s1	31835037	1.37e-03
PCOLCE	Human	Heart	w6_s3	31835037	1.35e-13
PCOLCE	Human	Heart	w6_s4	31835037	7.00e-14
PCOLCE	Human	Heart	w6_s5	31835037	2.01e-06
PCOLCE	Human	Heart	w6_s6	31835037	7.85e-04
PCOLCE	Human	Heart	w6_s8	31835037	6.70e-03
PCOLCE	Human	Heart	w9_s1	31835037	6.97e-14
PCOLCE	Human	Heart	w9_s2	31835037	1.71e-12
PCOLCE	Human	Heart	w9_s3	31835037	1.40e-04
PCOLCE	Human	Heart	w9_s4	31835037	5.67e-03
PCOLCE	Human	Heart	w9_s5	31835037	2.40e-14
PCOLCE	Human	Heart	w9_s6	31835037	2.66e-14
PCOLCE	Human	Skin	P2_rep1	32946785	5.41e-15
PCOLCE	Human	Skin	P2_rep2	32946785	5.48e-15
PCOLCE	Human	Skin	P2_rep3	32946785	5.90e-15
PCOLCE	Human	Lung	rep_1	35355018	4.99e-15
PCOLCE	Human	Lung	rep_2	35355018	1.37e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_1_H&E
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Intestine_A2_H&E
Intestine_A3_H&E
Intestine_A4_H&E
Intestine_A6_H&E
Intestine_A8_H&E
Intestine_A9_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Breast_B3_H&E
Breast_B5_H&E
Breast_D4_H&E
Breast_D5_H&E
Breast_D6_H&E
Breast_G1_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Skin_P2_rep3_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E

Top

Spatial pattern pathway has PCOLCE envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PCOLCE	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
PCOLCE	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_1	8.7e-71
PCOLCE	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
PCOLCE	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
PCOLCE	GOBP_Positive_Regulation_Of_Proteolysis	Human	Brain	rep_1	1.2e-161
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Brain	rep_1	4.4e-07
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
PCOLCE	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Brain	rep_4	4.1e-17
PCOLCE	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
PCOLCE	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	4.9e-46
PCOLCE	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
PCOLCE	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
PCOLCE	GOBP_Positive_Regulation_Of_Proteolysis	Human	Liver	rep_1	2.0e-70
PCOLCE	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Liver	rep_1	6.0e-76
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.1e-67
PCOLCE	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
PCOLCE	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon2	4.1e-22
PCOLCE	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
PCOLCE	GOBP_Positive_Regulation_Of_Proteolysis	Human	Intestine	rep_colon2	1.6e-21
PCOLCE	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
PCOLCE	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	rep_colon4	1.9e-09
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Intestine	rep_colon4	1.2e-51
PCOLCE	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
PCOLCE	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	2.8e-16
PCOLCE	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
PCOLCE	GOBP_Positive_Regulation_Of_Peptidase_Activity	Human	Intestine	A3	2.8e-12
PCOLCE	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
PCOLCE	GOBP_Positive_Regulation_Of_Proteolysis	Human	Intestine	A3	5.2e-21
PCOLCE	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	A3	9.8e-13
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Intestine	A3	9.5e-13
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Uterus	rep_26	2.1e-07
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	1.4e-10
PCOLCE	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_1	7.8e-04
PCOLCE	GOBP_Positive_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	5.6e-24
PCOLCE	GOBP_Positive_Regulation_Of_Proteolysis	Human	Breast	rep_1	1.7e-07
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	2.2e-33
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Breast	rep_1	6.4e-05
PCOLCE	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
PCOLCE	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
PCOLCE	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
PCOLCE	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
PCOLCE	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
PCOLCE	GOBP_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-11
PCOLCE	GOBP_Regulation_Of_Proteolysis	Human	Lung	rep_1	3.2e-08
PCOLCE	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_2	7.9e-07

Top

PCOLCE function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

PCOLCE function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for PCOLCE envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for PCOLCE

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for PCOLCE

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PCOLCE	C0019193	Hepatitis, Toxic	1	CTD_human
PCOLCE	C0023890	Liver Cirrhosis	1	CTD_human
PCOLCE	C0239946	Fibrosis, Liver	1	CTD_human
PCOLCE	C0860207	Drug-Induced Liver Disease	1	CTD_human
PCOLCE	C1262760	Hepatitis, Drug-Induced	1	CTD_human
PCOLCE	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
PCOLCE	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
PCOLCE	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human