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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: SERPINA5 (spascer ID:5104)

Gene summary for SERPINA5

Gene summary

Gene information
	Species	Human
	Gene symbol	SERPINA5
	Gene ID	5104
	Gene name	serpin family A member 5
	Synonyms	PAI-3\|PAI3\|PCI\|PCI-B\|PLANH3\|PROCI
	Cytomap	14q32.13
	Type of gene	protein-coding
	Description	plasma serine protease inhibitoracrosomal serine protease inhibitorplasminogen activator inhibitor IIIplasminogen activator inhibitor-3protein C inhibitorserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member
	Modification date	20220515
	UniProtAcc	P05154

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
SERPINA5	GO:0004867	serine-type endopeptidase inhibitor activity	21873635	Function
SERPINA5	GO:0005615	extracellular space	21873635	Component
SERPINA5	GO:0010951	negative regulation of endopeptidase activity	21873635	Process

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Spatial pattern events for SERPINA5

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
SERPINA5	Human	Liver	rep_liver1	34417225	3.57e-15
SERPINA5	Human	Liver	rep_liver2	34417225	6.98e-16
SERPINA5	Human	Liver	rep_liver3	34417225	3.51e-15
SERPINA5	Human	Liver	rep_liver4	34417225	7.71e-16
SERPINA5	Human	Pancreas	PDAC-A-st1	31932730	1.11e-14
SERPINA5	Human	Pancreas	PDAC-D-st1	31932730	2.90e-09
SERPINA5	Human	Uterus	rep_1	34857954	5.13e-15
SERPINA5	Human	Uterus	rep_3	34857954	1.66e-15
SERPINA5	Human	Breast	CID4535	34493872	1.11e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Uterus_rep_1_H&E
Uterus_rep_3_H&E
Breast_CID4535_H&E

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Spatial pattern pathway has SERPINA5 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
SERPINA5	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Brain	rep_1	7.4e-34
SERPINA5	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
SERPINA5	GOBP_Negative_Regulation_Of_Proteolysis	Human	Brain	rep_1	2.8e-23
SERPINA5	GOBP_Regulation_Of_Body_Fluid_Levels	Human	Brain	rep_1	6.9e-125
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Brain	rep_1	4.4e-07
SERPINA5	GOBP_Response_To_Wounding	Human	Brain	rep_1	6.9e-125
SERPINA5	GOBP_Wound_Healing	Human	Brain	rep_1	6.9e-125
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
SERPINA5	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Brain	rep_4	4.1e-17
SERPINA5	GOBP_Wound_Healing	Human	Bladder	rep_2	4.6e-05
SERPINA5	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Liver	rep_1	1.5e-73
SERPINA5	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SERPINA5	GOBP_Negative_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.0e-70
SERPINA5	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
SERPINA5	GOBP_Regulation_Of_Body_Fluid_Levels	Human	Liver	rep_1	3.1e-62
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Liver	rep_1	6.0e-76
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.1e-67
SERPINA5	GOBP_Response_To_Wounding	Human	Liver	rep_1	3.1e-62
SERPINA5	GOBP_Wound_Healing	Human	Liver	rep_1	3.1e-62
SERPINA5	GOBP_Regulation_Of_Body_Fluid_Levels	Human	Intestine	rep_colon2	3.9e-21
SERPINA5	GOBP_Response_To_Wounding	Human	Intestine	rep_colon2	3.9e-21
SERPINA5	GOBP_Wound_Healing	Human	Intestine	rep_colon2	3.9e-21
SERPINA5	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	rep_colon4	1.9e-09
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Intestine	rep_colon4	1.2e-51
SERPINA5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Human	Intestine	A3	2.5e-12
SERPINA5	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Intestine	A3	2.7e-15
SERPINA5	GOBP_Fertilization	Human	Intestine	A3	1.8e-11
SERPINA5	GOBP_Gamete_Generation	Human	Intestine	A3	4.2e-13
SERPINA5	GOBP_Gland_Development	Human	Intestine	A3	2.3e-14
SERPINA5	GOBP_Male_Gamete_Generation	Human	Intestine	A3	4.8e-15
SERPINA5	GOBP_Membrane_Fusion	Human	Intestine	A3	3.2e-07
SERPINA5	GOBP_Membrane_Organization	Human	Intestine	A3	2.7e-18
SERPINA5	GOBP_Multicellular_Organism_Reproduction	Human	Intestine	A3	4.1e-15
SERPINA5	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	3.0e-12
SERPINA5	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
SERPINA5	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
SERPINA5	GOBP_Regulation_Of_Body_Fluid_Levels	Human	Intestine	A3	2.9e-09
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	A3	9.8e-13
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Intestine	A3	9.5e-13
SERPINA5	GOBP_Reproduction	Human	Intestine	A3	4.6e-19
SERPINA5	GOBP_Reproductive_System_Development	Human	Intestine	A3	2.9e-14
SERPINA5	GOBP_Single_Fertilization	Human	Intestine	A3	2.8e-12
SERPINA5	GOBP_Lipid_Localization	Human	Intestine	A8	2.5e-15
SERPINA5	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Intestine	A8	2.1e-14
SERPINA5	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Intestine	A8	4.6e-12
SERPINA5	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Intestine	A8	1.7e-19
SERPINA5	GOBP_Negative_Regulation_Of_Proteolysis	Human	Intestine	A8	8.9e-12
SERPINA5	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Uterus	rep_1	1.6e-06
SERPINA5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Human	Uterus	rep_26	6.1e-12
SERPINA5	GOBP_Fertilization	Human	Uterus	rep_26	8.7e-10
SERPINA5	GOBP_Gamete_Generation	Human	Uterus	rep_26	3.8e-10
SERPINA5	GOBP_Gland_Development	Human	Uterus	rep_26	1.6e-07
SERPINA5	GOBP_Lipid_Localization	Human	Uterus	rep_26	3.7e-10
SERPINA5	GOBP_Male_Gamete_Generation	Human	Uterus	rep_26	7.4e-14
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Uterus	rep_26	2.1e-07
SERPINA5	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Uterus	rep_29	4.3e-12
SERPINA5	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	2.9e-08
SERPINA5	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Uterus	rep_29	1.6e-12
SERPINA5	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	2.0e-13
SERPINA5	GOBP_Regulation_Of_Body_Fluid_Levels	Human	Uterus	rep_29	1.7e-06
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	1.4e-10
SERPINA5	GOBP_Gland_Development	Human	Breast	rep_1	2.0e-26
SERPINA5	GOBP_Membrane_Fusion	Human	Breast	rep_1	9.3e-62
SERPINA5	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Breast	rep_1	7.1e-11
SERPINA5	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	7.8e-05
SERPINA5	GOBP_Regulation_Of_Body_Fluid_Levels	Human	Breast	rep_1	3.7e-127
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	2.2e-33
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Breast	rep_1	6.4e-05
SERPINA5	GOBP_Response_To_Wounding	Human	Breast	rep_1	4.7e-165
SERPINA5	GOBP_Wound_Healing	Human	Breast	rep_1	5.3e-150
SERPINA5	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Breast	rep_5	1.5e-12
SERPINA5	GOBP_Fusion_Of_Sperm_To_Egg_Plasma_Membrane_Involved_In_Single_Fertilization	Human	Breast	rep_5	1.3e-17
SERPINA5	GOBP_Lipid_Localization	Human	Breast	rep_5	1.4e-06
SERPINA5	GOBP_Multicellular_Organism_Reproduction	Human	Breast	rep_5	8.1e-07
SERPINA5	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	3.6e-05
SERPINA5	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
SERPINA5	GOBP_Negative_Regulation_Of_Proteolysis	Human	Breast	rep_5	2.0e-06
SERPINA5	GOBP_Plasma_Membrane_Fusion	Human	Breast	rep_5	4.0e-13
SERPINA5	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
SERPINA5	GOBP_Reproduction	Human	Breast	rep_5	8.1e-06
SERPINA5	GOBP_Reproductive_System_Development	Human	Breast	rep_5	3.6e-15
SERPINA5	GOBP_Single_Fertilization	Human	Breast	rep_5	1.0e-04
SERPINA5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Human	Breast	rep_6	4.4e-11
SERPINA5	GOBP_Fertilization	Human	Breast	rep_6	1.9e-11
SERPINA5	GOBP_Gamete_Generation	Human	Breast	rep_6	7.3e-08
SERPINA5	GOBP_Male_Gamete_Generation	Human	Breast	rep_6	4.3e-06
SERPINA5	GOBP_Membrane_Fusion	Human	Skin	P5_rep1	3.5e-12
SERPINA5	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Lung	rep_1	1.4e-08
SERPINA5	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	5.7e-10
SERPINA5	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-10
SERPINA5	GOBP_Negative_Regulation_Of_Proteolysis	Human	Lung	rep_1	5.7e-10
SERPINA5	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
SERPINA5	GOBP_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-11
SERPINA5	GOBP_Regulation_Of_Proteolysis	Human	Lung	rep_1	3.2e-08

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SERPINA5 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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SERPINA5 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for SERPINA5 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for SERPINA5

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
SERPINA5	P05154	DB00013	Urokinase	Plasma serine protease inhibitor	BiotechDrug	approved\|investigational\|withdrawn
SERPINA5	P05154	DB00055	Drotrecogin alfa	Plasma serine protease inhibitor	BiotechDrug	approved\|investigational\|withdrawn

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Related Diseases for SERPINA5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
SERPINA5	C0008370	Cholestasis	1	CTD_human
SERPINA5	C0236733	Amphetamine-Related Disorders	1	CTD_human
SERPINA5	C0236804	Amphetamine Addiction	1	CTD_human
SERPINA5	C0236807	Amphetamine Abuse	1	CTD_human