Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PCCB (spascer ID:5096)

Gene summary for PCCB

Gene summary

Gene information
	Species	Human
	Gene symbol	PCCB
	Gene ID	5096
	Gene name	propionyl-CoA carboxylase subunit beta
	Synonyms	-
	Cytomap	3q22.3
	Type of gene	protein-coding
	Description	propionyl-CoA carboxylase beta chain, mitochondrialPCCase subunit betapropanoyl-CoA:carbon dioxide ligase subunit betapropionyl CoA carboxylase, beta polypeptidepropionyl Coenzyme A carboxylase, beta polypeptidepropionyl-CoA carboxylase beta subunit
	Modification date	20220513
	UniProtAcc	P05166

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PCCB	GO:0004658	propionyl-CoA carboxylase activity	21873635	Function
PCCB	GO:0005739	mitochondrion	21873635	Component

Top

Spatial pattern events for PCCB

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PCCB	Human	Intestine	rep_colon4	34417225	1.14e-15
PCCB	Human	Liver	rep_liver2	34417225	6.98e-16
PCCB	Human	Uterus	rep_1	34857954	5.13e-15
PCCB	Human	Uterus	rep_3	34857954	1.66e-15
PCCB	Human	Breast	1142243F	34493872	1.94e-07
PCCB	Human	Breast	CID4465	34493872	6.42e-09
PCCB	Human	Breast	CID44971	34493872	1.76e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon4_H&E
Liver_rep_liver2_H&E
Uterus_rep_1_H&E
Uterus_rep_3_H&E
Breast_1142243F_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E

Top

Spatial pattern pathway has PCCB envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PCCB	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
PCCB	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
PCCB	GOBP_Cellular_Lipid_Metabolic_Process	Human	Intestine	A8	3.8e-13
PCCB	GOBP_Fatty_Acid_Catabolic_Process	Human	Intestine	A8	2.2e-14
PCCB	GOBP_Fatty_Acid_Metabolic_Process	Human	Intestine	A8	7.3e-13
PCCB	GOBP_Lipid_Catabolic_Process	Human	Intestine	A8	3.2e-08
PCCB	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
PCCB	GOBP_Monocarboxylic_Acid_Catabolic_Process	Human	Intestine	A8	1.5e-10
PCCB	GOBP_Monocarboxylic_Acid_Metabolic_Process	Human	Intestine	A8	7.3e-16
PCCB	GOBP_Organic_Acid_Catabolic_Process	Human	Intestine	A8	1.6e-12
PCCB	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
PCCB	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Human	Intestine	A8	1.8e-09
PCCB	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Human	Intestine	A8	1.6e-09
PCCB	GOBP_Small_Molecule_Catabolic_Process	Human	Intestine	A8	2.2e-13
PCCB	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
PCCB	GOBP_Sulfur_Compound_Metabolic_Process	Human	Intestine	A8	2.5e-14
PCCB	GOBP_Vitamin_Metabolic_Process	Human	Intestine	A8	1.8e-09
PCCB	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Human	Intestine	A8	5.2e-09
PCCB	GOBP_Vitamin_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.8e-07
PCCB	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Human	Uterus	rep_25	1.9e-13
PCCB	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Human	Uterus	rep_25	5.0e-12
PCCB	GOBP_Cellular_Lipid_Catabolic_Process	Human	Uterus	rep_26	4.6e-06
PCCB	GOBP_Fatty_Acid_Metabolic_Process	Human	Uterus	rep_26	1.3e-06
PCCB	GOBP_Monocarboxylic_Acid_Catabolic_Process	Human	Uterus	rep_26	1.3e-10
PCCB	GOBP_Organic_Acid_Catabolic_Process	Human	Uterus	rep_26	6.9e-09
PCCB	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
PCCB	GOBP_Small_Molecule_Catabolic_Process	Human	Uterus	rep_26	9.1e-13
PCCB	GOBP_Sulfur_Compound_Metabolic_Process	Human	Uterus	rep_26	8.8e-08
PCCB	GOBP_Vitamin_Metabolic_Process	Human	Uterus	rep_26	3.9e-06
PCCB	GOBP_Monocarboxylic_Acid_Catabolic_Process	Human	Breast	rep_1	5.8e-04
PCCB	GOBP_Vitamin_Metabolic_Process	Human	Breast	rep_1	3.1e-13
PCCB	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Human	Breast	rep_1	2.6e-13
PCCB	GOBP_Cellular_Lipid_Metabolic_Process	Human	Breast	rep_5	2.6e-07
PCCB	GOBP_Fatty_Acid_Metabolic_Process	Human	Breast	rep_5	1.2e-06
PCCB	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
PCCB	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
PCCB	GOBP_Cellular_Lipid_Catabolic_Process	Human	Breast	rep_6	3.6e-11
PCCB	GOBP_Fatty_Acid_Catabolic_Process	Human	Breast	rep_6	8.9e-13
PCCB	GOBP_Lipid_Catabolic_Process	Human	Breast	rep_6	2.9e-05
PCCB	GOBP_Monocarboxylic_Acid_Metabolic_Process	Human	Breast	rep_6	6.1e-07
PCCB	GOBP_Organic_Acid_Catabolic_Process	Human	Breast	rep_6	1.5e-11
PCCB	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
PCCB	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Human	Breast	rep_6	1.2e-06
PCCB	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Human	Breast	rep_6	9.6e-05
PCCB	GOBP_Small_Molecule_Catabolic_Process	Human	Breast	rep_6	4.7e-07
PCCB	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
PCCB	GOBP_Sulfur_Compound_Metabolic_Process	Human	Breast	rep_6	3.0e-10
PCCB	GOBP_Lipid_Catabolic_Process	Human	Lung	rep_2	1.4e-09

Top

PCCB function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

PCCB function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for PCCB envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for PCCB

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
PCCB	P05166	DB00121	Biotin	Propionyl-CoA carboxylase beta chain, mitochondrial	SmallMoleculeDrug	approved\|investigational\|nutraceutical
PCCB	P05166	DB00161	Valine	Propionyl-CoA carboxylase beta chain, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

Top

Related Diseases for PCCB

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PCCB	C0268579	Propionic acidemia	11	CTD_human;GENOMICS_ENGLAND;UNIPROT
PCCB	C1449563	Cardiomyopathy, Familial Idiopathic	1	GENOMICS_ENGLAND
PCCB	C2717876	Propionicaciduria	1	CTD_human;GENOMICS_ENGLAND