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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PCBD1 (spascer ID:5092)

Gene summary for PCBD1

Gene summary

Gene information
	Species	Human
	Gene symbol	PCBD1
	Gene ID	5092
	Gene name	pterin-4 alpha-carbinolamine dehydratase 1
	Synonyms	DCOH\|PCBD\|PCD\|PHS
	Cytomap	10q22.1
	Type of gene	protein-coding
	Description	pterin-4-alpha-carbinolamine dehydratase4-alpha-hydroxy-tetrahydropterin dehydratase6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)dimerizing cofactor for HNF1phenylalanine hydroxylase-stimulating
	Modification date	20220513
	UniProtAcc	P61457

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PCBD1	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	21873635	Function

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Spatial pattern events for PCBD1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PCBD1	Human	Bladder	rep_2	34385456	2.57e-08
PCBD1	Human	Intestine	rep_colon1	34417225	1.95e-15
PCBD1	Human	Intestine	rep_colon2	34417225	8.12e-16
PCBD1	Human	Intestine	rep_colon3	34417225	3.51e-15
PCBD1	Human	Intestine	rep_colon4	34417225	1.73e-12
PCBD1	Human	Liver	rep_liver1	34417225	1.08e-15
PCBD1	Human	Liver	rep_liver2	34417225	6.98e-16
PCBD1	Human	Liver	rep_liver3	34417225	3.66e-08
PCBD1	Human	Intestine	A1	33406409	1.79e-12
PCBD1	Human	Intestine	A2	33406409	2.75e-14
PCBD1	Human	Intestine	A8	33406409	3.20e-06
PCBD1	Human	Uterus	rep_3	34857954	1.66e-15
PCBD1	Human	Breast	1160920F	34493872	1.48e-15
PCBD1	Human	Breast	CID4465	34493872	7.83e-15
PCBD1	Human	Breast	CID44971	34493872	3.80e-12
PCBD1	Human	Lung	rep_1	35355018	3.37e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Intestine_A8_H&E
Uterus_rep_3_H&E
Breast_1160920F_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has PCBD1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PCBD1	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
PCBD1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
PCBD1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	5.1e-13
PCBD1	GOBP_Regulation_Of_Binding	Human	Intestine	A3	4.9e-11
PCBD1	GOBP_Regulation_Of_Protein_Binding	Human	Intestine	A3	4.4e-10
PCBD1	GOBP_Alcohol_Biosynthetic_Process	Human	Intestine	A8	5.3e-09
PCBD1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Intestine	A8	7.0e-13
PCBD1	GOBP_Aromatic_Amino_Acid_Family_Catabolic_Process	Human	Intestine	A8	3.7e-11
PCBD1	GOBP_Aromatic_Amino_Acid_Family_Metabolic_Process	Human	Intestine	A8	6.9e-12
PCBD1	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Intestine	A8	2.5e-14
PCBD1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Intestine	A8	5.3e-13
PCBD1	GOBP_Diol_Biosynthetic_Process	Human	Intestine	A8	5.7e-13
PCBD1	GOBP_Diol_Metabolic_Process	Human	Intestine	A8	6.5e-11
PCBD1	GOBP_L_Phenylalanine_Metabolic_Process	Human	Intestine	A8	5.5e-34
PCBD1	GOBP_Organic_Acid_Catabolic_Process	Human	Intestine	A8	1.6e-12
PCBD1	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
PCBD1	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Intestine	A8	1.2e-10
PCBD1	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Intestine	A8	6.4e-10
PCBD1	GOBP_Polyol_Biosynthetic_Process	Human	Intestine	A8	1.3e-18
PCBD1	GOBP_Polyol_Metabolic_Process	Human	Intestine	A8	6.2e-14
PCBD1	GOBP_Pteridine_Containing_Compound_Metabolic_Process	Human	Intestine	A8	6.3e-16
PCBD1	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
PCBD1	GOBP_Small_Molecule_Catabolic_Process	Human	Intestine	A8	2.2e-13
PCBD1	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
PCBD1	GOBP_Tetrahydrobiopterin_Metabolic_Process	Human	Intestine	A8	6.0e-14
PCBD1	GOBP_Alcohol_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
PCBD1	GOBP_Polyol_Metabolic_Process	Human	Pancreas	PDAC-B-st1	9.8e-06
PCBD1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Pancreas	PDAC-A-st2	9.6e-05
PCBD1	GOBP_Tetrahydrobiopterin_Metabolic_Process	Human	Pancreas	PDAC-A-st2	5.1e-05
PCBD1	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	1.2e-11
PCBD1	GOBP_Aromatic_Amino_Acid_Family_Catabolic_Process	Human	Uterus	rep_25	1.6e-11
PCBD1	GOBP_Aromatic_Amino_Acid_Family_Metabolic_Process	Human	Uterus	rep_25	1.1e-07
PCBD1	GOBP_Pteridine_Containing_Compound_Biosynthetic_Process	Human	Uterus	rep_25	3.9e-12
PCBD1	GOBP_Alcohol_Biosynthetic_Process	Human	Uterus	rep_26	2.6e-06
PCBD1	GOBP_Alcohol_Metabolic_Process	Human	Uterus	rep_26	1.3e-06
PCBD1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	1.6e-06
PCBD1	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Uterus	rep_26	3.2e-12
PCBD1	GOBP_Organic_Acid_Catabolic_Process	Human	Uterus	rep_26	6.9e-09
PCBD1	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
PCBD1	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
PCBD1	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Uterus	rep_26	3.2e-10
PCBD1	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Uterus	rep_26	2.5e-08
PCBD1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
PCBD1	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
PCBD1	GOBP_Small_Molecule_Catabolic_Process	Human	Uterus	rep_26	9.1e-13
PCBD1	GOBP_Aromatic_Amino_Acid_Family_Catabolic_Process	Human	Breast	rep_1	4.5e-36
PCBD1	GOBP_L_Phenylalanine_Metabolic_Process	Human	Breast	rep_1	6.5e-22
PCBD1	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Breast	rep_1	7.3e-16
PCBD1	GOBP_Regulation_Of_Binding	Human	Breast	rep_1	6.1e-11
PCBD1	GOBP_Regulation_Of_Protein_Binding	Human	Breast	rep_1	1.6e-99
PCBD1	GOBP_Polyol_Biosynthetic_Process	Human	Breast	rep_5	2.7e-07
PCBD1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_5	8.0e-09
PCBD1	GOBP_Alcohol_Biosynthetic_Process	Human	Breast	rep_6	9.0e-04
PCBD1	GOBP_Alcohol_Metabolic_Process	Human	Breast	rep_6	1.3e-04
PCBD1	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	2.6e-05
PCBD1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.7e-08
PCBD1	GOBP_Aromatic_Amino_Acid_Family_Metabolic_Process	Human	Breast	rep_6	4.0e-10
PCBD1	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	1.6e-05
PCBD1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.0e-10
PCBD1	GOBP_Diol_Biosynthetic_Process	Human	Breast	rep_6	2.9e-05
PCBD1	GOBP_Organic_Acid_Catabolic_Process	Human	Breast	rep_6	1.5e-11
PCBD1	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
PCBD1	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
PCBD1	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Breast	rep_6	2.5e-06
PCBD1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
PCBD1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
PCBD1	GOBP_Polyol_Metabolic_Process	Human	Breast	rep_6	2.9e-05
PCBD1	GOBP_Pteridine_Containing_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.7e-09
PCBD1	GOBP_Pteridine_Containing_Compound_Metabolic_Process	Human	Breast	rep_6	1.9e-06
PCBD1	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
PCBD1	GOBP_Small_Molecule_Catabolic_Process	Human	Breast	rep_6	4.7e-07
PCBD1	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
PCBD1	GOBP_Tetrahydrobiopterin_Metabolic_Process	Human	Breast	rep_6	1.9e-08
PCBD1	GOBP_Tetrahydrobiopterin_Metabolic_Process	Human	Skin	P10_rep1	3.8e-14
PCBD1	GOBP_Diol_Biosynthetic_Process	Human	Skin	P10_rep2	3.3e-13
PCBD1	GOBP_Diol_Metabolic_Process	Human	Skin	P10_rep2	7.5e-16

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PCBD1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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PCBD1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for PCBD1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for PCBD1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PCBD1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PCBD1	C1849700	Hyperphenylalaninemia with primapterinuria	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
PCBD1	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human