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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: FURIN (spascer ID:5045)

Gene summary for FURIN

Gene summary

Gene information
	Species	Human
	Gene symbol	FURIN
	Gene ID	5045
	Gene name	furin, paired basic amino acid cleaving enzyme
	Synonyms	FUR\|PACE\|PCSK3\|SPC1
	Cytomap	15q26.1
	Type of gene	protein-coding
	Description	furinFES upstream regiondibasic processing enzymefurin, membrane associated receptor proteinpaired basic amino acid residue-cleaving enzymeproprotein convertase subtilisin/kexin 3proprotein convertase subtilisin/kexin type 3subtilisin-like proprote
	Modification date	20220513
	UniProtAcc	P09958

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
FURIN	GO:0004252	serine-type endopeptidase activity	21873635	Function
FURIN	GO:0005802	trans-Golgi network	21873635	Component
FURIN	GO:0016020	membrane	21873635	Component
FURIN	GO:0016485	protein processing	21873635	Process
FURIN	GO:0016486	peptide hormone processing	21873635	Process
FURIN	GO:0030173	integral component of Golgi membrane	21873635	Component

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Spatial pattern events for FURIN

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
FURIN	Human	Intestine	rep_colon1	34417225	1.95e-15
FURIN	Human	Intestine	rep_colon2	34417225	8.30e-12
FURIN	Human	Intestine	rep_colon4	34417225	8.42e-08
FURIN	Human	Liver	rep_liver1	34417225	3.57e-15
FURIN	Human	Liver	rep_liver2	34417225	6.98e-16
FURIN	Human	Liver	rep_liver3	34417225	6.13e-15
FURIN	Human	Liver	rep_liver4	34417225	9.89e-11
FURIN	Human	Intestine	A4	33406409	6.31e-09
FURIN	Human	Intestine	A6	33406409	5.29e-06
FURIN	Human	Uterus	rep_2	34857954	7.12e-13
FURIN	Human	Breast	1160920F	34493872	1.48e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Intestine_A4_H&E
Intestine_A6_H&E
Uterus_rep_2_H&E
Breast_1160920F_H&E

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Spatial pattern pathway has FURIN envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
FURIN	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Brain	rep_1	2.3e-68
FURIN	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Brain	rep_1	7.4e-34
FURIN	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
FURIN	GOBP_Negative_Regulation_Of_Proteolysis	Human	Brain	rep_1	2.8e-23
FURIN	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Brain	rep_1	4.4e-07
FURIN	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Brain	rep_1	4.6e-05
FURIN	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
FURIN	GOBP_Positive_Regulation_Of_Proteolysis	Human	Brain	rep_1	1.2e-161
FURIN	GOBP_Protein_Maturation	Human	Brain	rep_1	1.3e-161
FURIN	GOBP_Protein_Processing	Human	Brain	rep_1	1.3e-161
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Brain	rep_1	4.4e-07
FURIN	GOBP_Regulation_Of_Transport	Human	Brain	rep_1	3.1e-16
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
FURIN	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Brain	rep_4	4.1e-17
FURIN	GOBP_Cytokine_Production	Human	Brain	rep_4	4.1e-17
FURIN	GOBP_Positive_Regulation_Of_Cytokine_Production	Human	Brain	rep_4	4.1e-17
FURIN	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Brain	rep_4	4.1e-17
FURIN	GOBP_Response_To_Endogenous_Stimulus	Human	Brain	rep_10	2.8e-23
FURIN	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Bladder	rep_2	1.3e-05
FURIN	GOBP_External_Encapsulating_Structure_Organization	Human	Bladder	rep_2	8.7e-05
FURIN	GOBP_Negative_Regulation_Of_Transforming_Growth_Factor_Beta_Production	Human	Bladder	rep_2	4.8e-07
FURIN	GOBP_Positive_Regulation_Of_Transforming_Growth_Factor_Beta_Production	Human	Bladder	rep_2	5.6e-08
FURIN	GOBP_Response_To_Growth_Factor	Human	Bladder	rep_2	1.2e-08
FURIN	GOBP_Response_To_Transforming_Growth_Factor_Beta	Human	Bladder	rep_2	1.5e-11
FURIN	GOBP_Skin_Development	Human	Bladder	rep_2	4.8e-19
FURIN	GOBP_Transforming_Growth_Factor_Beta_Production	Human	Bladder	rep_2	3.2e-09
FURIN	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Human	Bladder	rep_2	2.2e-29
FURIN	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Human	Bladder	rep_2	2.5e-23
FURIN	GOBP_Zymogen_Activation	Human	Bladder	rep_2	8.2e-04
FURIN	GOBP_Cornification	Human	Bladder	rep_4	3.3e-14
FURIN	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Liver	rep_1	6.0e-76
FURIN	GOBP_Cytokine_Production	Human	Liver	rep_1	1.0e-70
FURIN	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Liver	rep_1	8.8e-90
FURIN	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Liver	rep_1	1.5e-73
FURIN	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Human	Liver	rep_1	2.8e-53
FURIN	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
FURIN	GOBP_Negative_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.0e-70
FURIN	GOBP_Positive_Regulation_Of_Cytokine_Production	Human	Liver	rep_1	6.0e-76
FURIN	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Liver	rep_1	3.7e-85
FURIN	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Liver	rep_1	1.1e-67
FURIN	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
FURIN	GOBP_Positive_Regulation_Of_Proteolysis	Human	Liver	rep_1	2.0e-70
FURIN	GOBP_Protein_Maturation	Human	Liver	rep_1	4.6e-81
FURIN	GOBP_Protein_Processing	Human	Liver	rep_1	6.7e-84
FURIN	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Liver	rep_1	6.0e-76
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.1e-67
FURIN	GOBP_Regulation_Of_Transport	Human	Liver	rep_1	9.4e-68
FURIN	GOBP_Response_To_Endogenous_Stimulus	Human	Liver	rep_1	3.0e-55
FURIN	GOBP_Zymogen_Activation	Human	Liver	rep_1	7.7e-79
FURIN	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Intestine	rep_colon2	5.0e-29
FURIN	GOBP_Positive_Regulation_Of_Proteolysis	Human	Intestine	rep_colon2	1.6e-21
FURIN	GOBP_Protein_Maturation	Human	Intestine	rep_colon2	7.9e-42
FURIN	GOBP_Protein_Processing	Human	Intestine	rep_colon2	1.2e-19
FURIN	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
FURIN	GOBP_Cytokine_Production	Human	Intestine	rep_colon4	9.0e-12
FURIN	GOBP_Positive_Regulation_Of_Cytokine_Production	Human	Intestine	rep_colon4	1.9e-09
FURIN	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Intestine	rep_colon4	6.4e-48
FURIN	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	rep_colon4	2.2e-52
FURIN	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
FURIN	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	rep_colon4	1.9e-09
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Intestine	rep_colon4	1.2e-51
FURIN	GOBP_Regulation_Of_Transport	Human	Intestine	rep_colon4	1.0e-26
FURIN	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	rep_liver2	3.7e-39
FURIN	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
FURIN	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
FURIN	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Intestine	A3	3.5e-14
FURIN	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
FURIN	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
FURIN	GOBP_Collagen_Catabolic_Process	Human	Intestine	A3	2.5e-08
FURIN	GOBP_Cytokine_Production	Human	Intestine	A3	8.9e-12
FURIN	GOBP_Embryo_Development	Human	Intestine	A3	2.4e-07
FURIN	GOBP_Epidermis_Development	Human	Intestine	A3	2.4e-10
FURIN	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
FURIN	GOBP_Membrane_Protein_Proteolysis	Human	Intestine	A3	2.9e-08
FURIN	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Intestine	A3	5.0e-10
FURIN	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	3.0e-12
FURIN	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Intestine	A3	9.0e-12
FURIN	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
FURIN	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	A3	6.2e-10
FURIN	GOBP_Negative_Regulation_Of_Protein_Catabolic_Process	Human	Intestine	A3	3.2e-07
FURIN	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
FURIN	GOBP_Organic_Hydroxy_Compound_Transport	Human	Intestine	A3	7.3e-09
FURIN	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
FURIN	GOBP_Positive_Regulation_Of_Catabolic_Process	Human	Intestine	A3	2.8e-16
FURIN	GOBP_Positive_Regulation_Of_Cytokine_Production	Human	Intestine	A3	8.0e-16
FURIN	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Intestine	A3	3.7e-11
FURIN	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	A3	8.6e-17
FURIN	GOBP_Positive_Regulation_Of_Protein_Catabolic_Process	Human	Intestine	A3	7.7e-21
FURIN	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
FURIN	GOBP_Positive_Regulation_Of_Proteolysis	Human	Intestine	A3	5.2e-21
FURIN	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
FURIN	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
FURIN	GOBP_Receptor_Metabolic_Process	Human	Intestine	A3	1.2e-10
FURIN	GOBP_Regulation_Of_Catabolic_Process	Human	Intestine	A3	3.5e-16
FURIN	GOBP_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	7.2e-15
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	A3	9.8e-13
FURIN	GOBP_Regulation_Of_Protein_Catabolic_Process	Human	Intestine	A3	1.2e-14
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Intestine	A3	9.5e-13
FURIN	GOBP_Regulation_Of_Transport	Human	Intestine	A3	4.4e-11
FURIN	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	A3	5.2e-09
FURIN	GOBP_Secretion	Human	Intestine	A3	1.8e-13
FURIN	GOBP_Viral_Life_Cycle	Human	Intestine	A3	1.1e-12
FURIN	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	A8	3.3e-08
FURIN	GOBP_Blastocyst_Development	Human	Intestine	A8	6.6e-17
FURIN	GOBP_Blastocyst_Formation	Human	Intestine	A8	9.4e-26
FURIN	GOBP_Cornification	Human	Intestine	A8	4.7e-37
FURIN	GOBP_Epidermal_Cell_Differentiation	Human	Intestine	A8	2.8e-14
FURIN	GOBP_Epithelial_Cell_Differentiation	Human	Intestine	A8	6.8e-07
FURIN	GOBP_Extracellular_Matrix_Disassembly	Human	Intestine	A8	6.1e-14
FURIN	GOBP_Keratinization	Human	Intestine	A8	4.3e-11
FURIN	GOBP_Keratinocyte_Differentiation	Human	Intestine	A8	6.0e-13
FURIN	GOBP_Lipid_Localization	Human	Intestine	A8	2.5e-15
FURIN	GOBP_Membrane_Protein_Ectodomain_Proteolysis	Human	Intestine	A8	5.9e-08
FURIN	GOBP_Negative_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Intestine	A8	1.5e-10
FURIN	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Intestine	A8	6.2e-16
FURIN	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Intestine	A8	2.1e-14
FURIN	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Intestine	A8	4.6e-12
FURIN	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Intestine	A8	1.7e-19
FURIN	GOBP_Negative_Regulation_Of_Proteolysis	Human	Intestine	A8	8.9e-12
FURIN	GOBP_Negative_Regulation_Of_Transforming_Growth_Factor_Beta1_Production	Human	Intestine	A8	1.8e-36
FURIN	GOBP_Protein_Maturation	Human	Intestine	A8	1.1e-12
FURIN	GOBP_Protein_Processing	Human	Intestine	A8	4.1e-18
FURIN	GOBP_Receptor_Catabolic_Process	Human	Intestine	A8	7.5e-14
FURIN	GOBP_Regulation_Of_Anion_Transport	Human	Intestine	A8	2.7e-14
FURIN	GOBP_Regulation_Of_Hormone_Levels	Human	Intestine	A8	3.0e-13
FURIN	GOBP_Regulation_Of_Ion_Transport	Human	Intestine	A8	2.0e-13
FURIN	GOBP_Regulation_Of_Membrane_Protein_Ectodomain_Proteolysis	Human	Intestine	A8	1.6e-08
FURIN	GOBP_Regulation_Of_Transforming_Growth_Factor_Beta_Activation	Human	Intestine	A8	1.0e-12
FURIN	GOBP_Response_To_Transforming_Growth_Factor_Beta	Human	Intestine	A8	1.1e-10
FURIN	GOBP_Transforming_Growth_Factor_Beta_Activation	Human	Intestine	A8	9.4e-11
FURIN	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Human	Intestine	A8	5.8e-13
FURIN	GOBP_Viral_Gene_Expression	Human	Intestine	A8	1.8e-23
FURIN	GOBP_Zymogen_Activation	Human	Intestine	A8	4.1e-11
FURIN	GOBP_Extracellular_Matrix_Disassembly	Human	Pancreas	PDAC-B-st1	6.6e-05
FURIN	GOBP_Positive_Regulation_Of_Protein_Catabolic_Process	Human	Pancreas	PDAC-B-st1	6.7e-05
FURIN	GOBP_Positive_Regulation_Of_Transforming_Growth_Factor_Beta_Production	Human	Pancreas	PDAC-B-st1	1.3e-05
FURIN	GOBP_Receptor_Metabolic_Process	Human	Pancreas	PDAC-B-st1	6.8e-05
FURIN	GOBP_Regulation_Of_Anion_Transport	Human	Pancreas	PDAC-B-st1	4.7e-06
FURIN	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Human	Pancreas	PDAC-B-st1	1.5e-05
FURIN	GOBP_Signal_Peptide_Processing	Human	Pancreas	PDAC-A-st2	5.5e-05
FURIN	GOBP_Regulation_Of_Transforming_Growth_Factor_Beta_Activation	Human	Pancreas	PDAC-A-st3	3.4e-05
FURIN	GOBP_Collagen_Catabolic_Process	Human	Uterus	rep_1	2.8e-07
FURIN	GOBP_Collagen_Metabolic_Process	Human	Uterus	rep_1	6.8e-06
FURIN	GOBP_Extracellular_Matrix_Disassembly	Human	Uterus	rep_1	2.1e-07
FURIN	GOBP_Sterol_Transport	Human	Uterus	rep_1	2.9e-06
FURIN	GOBP_Signal_Peptide_Processing	Human	Uterus	rep_2	3.1e-06
FURIN	GOBP_Positive_Regulation_Of_Membrane_Protein_Ectodomain_Proteolysis	Human	Uterus	rep_4	9.0e-07
FURIN	GOBP_Keratinization	Human	Uterus	rep_25	6.1e-07
FURIN	GOBP_Regulation_Of_Anion_Transport	Human	Uterus	rep_25	1.5e-11
FURIN	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Uterus	rep_26	5.9e-08
FURIN	GOBP_Blastocyst_Development	Human	Uterus	rep_26	5.7e-10
FURIN	GOBP_Blastocyst_Formation	Human	Uterus	rep_26	1.9e-09
FURIN	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
FURIN	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
FURIN	GOBP_Lipid_Localization	Human	Uterus	rep_26	3.7e-10
FURIN	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
FURIN	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Uterus	rep_26	4.0e-09
FURIN	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Uterus	rep_26	4.4e-10
FURIN	GOBP_Negative_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	9.6e-19
FURIN	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Uterus	rep_26	6.8e-07
FURIN	GOBP_Negative_Regulation_Of_Protein_Catabolic_Process	Human	Uterus	rep_26	1.3e-06
FURIN	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
FURIN	GOBP_Positive_Regulation_Of_Protein_Catabolic_Process	Human	Uterus	rep_26	2.4e-09
FURIN	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
FURIN	GOBP_Receptor_Metabolic_Process	Human	Uterus	rep_26	3.6e-08
FURIN	GOBP_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	2.7e-10
FURIN	GOBP_Regulation_Of_Protein_Catabolic_Process	Human	Uterus	rep_26	7.3e-06
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Uterus	rep_26	2.1e-07
FURIN	GOBP_Transforming_Growth_Factor_Beta1_Production	Human	Uterus	rep_26	3.9e-09
FURIN	GOBP_Viral_Life_Cycle	Human	Uterus	rep_26	2.1e-06
FURIN	GOBP_Negative_Regulation_Of_Transforming_Growth_Factor_Beta1_Production	Human	Uterus	rep_27	2.0e-07
FURIN	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Uterus	rep_29	4.3e-12
FURIN	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	2.9e-08
FURIN	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Uterus	rep_29	1.6e-12
FURIN	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	2.0e-13
FURIN	GOBP_Organic_Hydroxy_Compound_Transport	Human	Uterus	rep_29	3.2e-06
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
FURIN	GOBP_Regulation_Of_Lipase_Activity	Human	Uterus	rep_29	1.2e-07
FURIN	GOBP_Regulation_Of_Lipoprotein_Lipase_Activity	Human	Uterus	rep_29	3.0e-10
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	1.4e-10
FURIN	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Human	Uterus	rep_29	6.4e-06
FURIN	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Breast	rep_1	1.9e-98
FURIN	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Breast	rep_1	5.4e-30
FURIN	GOBP_Blastocyst_Formation	Human	Breast	rep_1	1.1e-06
FURIN	GOBP_Collagen_Catabolic_Process	Human	Breast	rep_1	3.3e-18
FURIN	GOBP_Collagen_Metabolic_Process	Human	Breast	rep_1	1.8e-27
FURIN	GOBP_Cornification	Human	Breast	rep_1	1.3e-86
FURIN	GOBP_Cytokine_Production	Human	Breast	rep_1	6.5e-12
FURIN	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Human	Breast	rep_1	7.7e-07
FURIN	GOBP_Epidermal_Cell_Differentiation	Human	Breast	rep_1	6.0e-94
FURIN	GOBP_Epidermis_Development	Human	Breast	rep_1	1.4e-136
FURIN	GOBP_Epithelial_Cell_Differentiation	Human	Breast	rep_1	4.5e-30
FURIN	GOBP_Epithelium_Development	Human	Breast	rep_1	2.0e-22
FURIN	GOBP_External_Encapsulating_Structure_Organization	Human	Breast	rep_1	2.8e-108
FURIN	GOBP_Extracellular_Matrix_Disassembly	Human	Breast	rep_1	4.6e-83
FURIN	GOBP_Hormone_Metabolic_Process	Human	Breast	rep_1	2.8e-38
FURIN	GOBP_In_Utero_Embryonic_Development	Human	Breast	rep_1	1.5e-18
FURIN	GOBP_Keratinocyte_Differentiation	Human	Breast	rep_1	6.5e-159
FURIN	GOBP_Low_Density_Lipoprotein_Receptor_Particle_Metabolic_Process	Human	Breast	rep_1	1.4e-79
FURIN	GOBP_Membrane_Protein_Ectodomain_Proteolysis	Human	Breast	rep_1	2.6e-145
FURIN	GOBP_Membrane_Protein_Proteolysis	Human	Breast	rep_1	6.2e-110
FURIN	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Breast	rep_1	1.3e-70
FURIN	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Breast	rep_1	7.1e-11
FURIN	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Human	Breast	rep_1	8.3e-12
FURIN	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	7.8e-05
FURIN	GOBP_Negative_Regulation_Of_Transforming_Growth_Factor_Beta_Production	Human	Breast	rep_1	0.0e+00
FURIN	GOBP_Negative_Regulation_Of_Transforming_Growth_Factor_Beta1_Production	Human	Breast	rep_1	2.5e-19
FURIN	GOBP_Organic_Hydroxy_Compound_Transport	Human	Breast	rep_1	9.0e-228
FURIN	GOBP_Positive_Regulation_Of_Cytokine_Production	Human	Breast	rep_1	6.5e-10
FURIN	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Breast	rep_1	7.3e-07
FURIN	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Breast	rep_1	5.8e-20
FURIN	GOBP_Positive_Regulation_Of_Protein_Catabolic_Process	Human	Breast	rep_1	2.2e-13
FURIN	GOBP_Positive_Regulation_Of_Proteolysis	Human	Breast	rep_1	1.7e-07
FURIN	GOBP_Positive_Regulation_Of_Transforming_Growth_Factor_Beta_Production	Human	Breast	rep_1	2.3e-15
FURIN	GOBP_Positive_Regulation_Of_Transforming_Growth_Factor_Beta1_Production	Human	Breast	rep_1	5.7e-24
FURIN	GOBP_Protein_Maturation	Human	Breast	rep_1	4.1e-23
FURIN	GOBP_Protein_Processing	Human	Breast	rep_1	4.4e-37
FURIN	GOBP_Receptor_Catabolic_Process	Human	Breast	rep_1	3.1e-21
FURIN	GOBP_Receptor_Metabolic_Process	Human	Breast	rep_1	8.0e-42
FURIN	GOBP_Regulation_Of_Hormone_Levels	Human	Breast	rep_1	1.1e-80
FURIN	GOBP_Regulation_Of_Ion_Transport	Human	Breast	rep_1	1.7e-09
FURIN	GOBP_Regulation_Of_Membrane_Protein_Ectodomain_Proteolysis	Human	Breast	rep_1	9.9e-35
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	2.2e-33
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Breast	rep_1	6.4e-05
FURIN	GOBP_Regulation_Of_Receptor_Catabolic_Process	Human	Breast	rep_1	8.9e-59
FURIN	GOBP_Regulation_Of_Sterol_Transport	Human	Breast	rep_1	1.1e-07
FURIN	GOBP_Regulation_Of_Transport	Human	Breast	rep_1	3.7e-17
FURIN	GOBP_Response_To_Growth_Factor	Human	Breast	rep_1	1.2e-13
FURIN	GOBP_Response_To_Transforming_Growth_Factor_Beta	Human	Breast	rep_1	2.4e-65
FURIN	GOBP_Secretion	Human	Breast	rep_1	9.7e-57
FURIN	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Human	Breast	rep_1	5.2e-05
FURIN	GOBP_Skin_Development	Human	Breast	rep_1	2.0e-70
FURIN	GOBP_Sterol_Transport	Human	Breast	rep_1	5.3e-15
FURIN	GOBP_Transforming_Growth_Factor_Beta_Activation	Human	Breast	rep_1	4.1e-14
FURIN	GOBP_Transforming_Growth_Factor_Beta_Production	Human	Breast	rep_1	2.2e-176
FURIN	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Human	Breast	rep_1	4.6e-27
FURIN	GOBP_Viral_Life_Cycle	Human	Breast	rep_1	1.2e-08
FURIN	GOBP_Zymogen_Activation	Human	Breast	rep_1	1.6e-17
FURIN	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
FURIN	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
FURIN	GOBP_Embryo_Development	Human	Breast	rep_5	5.5e-08
FURIN	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Breast	rep_5	4.6e-14
FURIN	GOBP_Lipid_Localization	Human	Breast	rep_5	1.4e-06
FURIN	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	3.6e-05
FURIN	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
FURIN	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
FURIN	GOBP_Negative_Regulation_Of_Proteolysis	Human	Breast	rep_5	2.0e-06
FURIN	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
FURIN	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
FURIN	GOBP_Regulation_Of_Anion_Transport	Human	Breast	rep_5	1.6e-05
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
FURIN	GOBP_Regulation_Of_Lipase_Activity	Human	Breast	rep_5	1.9e-06
FURIN	GOBP_Regulation_Of_Lipid_Localization	Human	Breast	rep_5	1.1e-05
FURIN	GOBP_Regulation_Of_Lipid_Transport	Human	Breast	rep_5	2.0e-04
FURIN	GOBP_Response_To_Endogenous_Stimulus	Human	Breast	rep_5	3.6e-09
FURIN	GOBP_Signal_Peptide_Processing	Human	Breast	rep_5	4.2e-06
FURIN	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Human	Breast	rep_5	4.5e-06
FURIN	GOBP_Viral_Gene_Expression	Human	Breast	rep_5	4.2e-10
FURIN	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
FURIN	GOBP_Blastocyst_Development	Human	Breast	rep_6	1.7e-08
FURIN	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
FURIN	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
FURIN	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	2.0e-06
FURIN	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Breast	rep_6	1.0e-06
FURIN	GOBP_Negative_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Breast	rep_6	4.8e-10
FURIN	GOBP_Negative_Regulation_Of_Protein_Catabolic_Process	Human	Breast	rep_6	1.3e-04
FURIN	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
FURIN	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
FURIN	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
FURIN	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
FURIN	GOBP_Positive_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	9.2e-08
FURIN	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
FURIN	GOBP_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	3.3e-04
FURIN	GOBP_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Breast	rep_6	6.2e-07
FURIN	GOBP_Regulation_Of_Protein_Catabolic_Process	Human	Breast	rep_6	4.3e-04
FURIN	GOBP_Regulation_Of_Transforming_Growth_Factor_Beta_Activation	Human	Breast	rep_6	8.4e-05
FURIN	GOBP_Blastocyst_Development	Human	Skin	P5_rep3	6.5e-09
FURIN	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Skin	P9_rep2	4.7e-10
FURIN	GOBP_Epidermis_Development	Human	Skin	P9_rep3	3.7e-09
FURIN	GOBP_Epithelium_Development	Human	Skin	P9_rep3	4.2e-08
FURIN	GOBP_Collagen_Metabolic_Process	Human	Skin	P10_rep1	6.6e-15
FURIN	GOBP_Collagen_Catabolic_Process	Human	Skin	P10_rep2	5.8e-09
FURIN	GOBP_Positive_Regulation_Of_Transforming_Growth_Factor_Beta_Production	Human	Skin	P10_rep2	5.2e-12
FURIN	GOBP_Regulation_Of_Lipoprotein_Lipase_Activity	Human	Skin	P10_rep2	9.1e-14
FURIN	GOBP_Transforming_Growth_Factor_Beta1_Production	Human	Skin	P10_rep2	4.0e-08
FURIN	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Lung	rep_1	2.4e-10
FURIN	GOBP_Collagen_Catabolic_Process	Human	Lung	rep_1	3.5e-07
FURIN	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Lung	rep_1	1.4e-08
FURIN	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Lung	rep_1	8.4e-07
FURIN	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	5.7e-10
FURIN	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-10
FURIN	GOBP_Negative_Regulation_Of_Proteolysis	Human	Lung	rep_1	5.7e-10
FURIN	GOBP_Negative_Regulation_Of_Transforming_Growth_Factor_Beta1_Production	Human	Lung	rep_1	5.5e-07
FURIN	GOBP_Positive_Regulation_Of_Membrane_Protein_Ectodomain_Proteolysis	Human	Lung	rep_1	5.5e-07
FURIN	GOBP_Positive_Regulation_Of_Transforming_Growth_Factor_Beta1_Production	Human	Lung	rep_1	8.1e-08
FURIN	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
FURIN	GOBP_Regulation_Of_Membrane_Protein_Ectodomain_Proteolysis	Human	Lung	rep_1	5.4e-08
FURIN	GOBP_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-11
FURIN	GOBP_Regulation_Of_Proteolysis	Human	Lung	rep_1	3.2e-08
FURIN	GOBP_Viral_Life_Cycle	Human	Lung	rep_1	2.0e-16
FURIN	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07
FURIN	GOBP_Low_Density_Lipoprotein_Receptor_Particle_Metabolic_Process	Human	Lung	rep_2	8.4e-11
FURIN	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Lung	rep_2	3.4e-07
FURIN	GOBP_Receptor_Catabolic_Process	Human	Lung	rep_2	2.6e-09
FURIN	GOBP_Receptor_Metabolic_Process	Human	Lung	rep_2	1.1e-09
FURIN	GOBP_Regulation_Of_Hormone_Levels	Human	Lung	rep_2	1.6e-07
FURIN	GOBP_Regulation_Of_Lipase_Activity	Human	Lung	rep_2	1.6e-07
FURIN	GOBP_Regulation_Of_Lipid_Transport	Human	Lung	rep_2	7.8e-07
FURIN	GOBP_Regulation_Of_Lipoprotein_Lipase_Activity	Human	Lung	rep_2	1.4e-09
FURIN	GOBP_Regulation_Of_Receptor_Catabolic_Process	Human	Lung	rep_2	1.4e-10
FURIN	GOBP_Regulation_Of_Sterol_Transport	Human	Lung	rep_2	8.4e-10

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FURIN function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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FURIN function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for FURIN envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for FURIN

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FURIN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source