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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: OTC (spascer ID:5009)

Gene summary for OTC

Gene summary

Gene information
	Species	Human
	Gene symbol	OTC
	Gene ID	5009
	Gene name	ornithine transcarbamylase
	Synonyms	OCTD\|OTCD
	Cytomap	Xp11.4
	Type of gene	protein-coding
	Description	ornithine transcarbamylase, mitochondrialOTCaseornithine carbamoyltransferase, mitochondrial
	Modification date	20220513
	UniProtAcc	P00480

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
OTC	GO:0004585	ornithine carbamoyltransferase activity	21873635	Function
OTC	GO:0005739	mitochondrion	21873635	Component
OTC	GO:0019240	citrulline biosynthetic process	21873635	Process
OTC	GO:0042450	arginine biosynthetic process via ornithine	21873635	Process
OTC	GO:0043231	intracellular membrane-bounded organelle	21873635	Component

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Spatial pattern events for OTC

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
OTC	Human	Liver	rep_liver1	34417225	1.08e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E

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Spatial pattern pathway has OTC envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
OTC	GOBP_Tube_Development	Human	Brain	rep_4	4.1e-17
OTC	GOBP_Response_To_Endogenous_Stimulus	Human	Brain	rep_10	2.8e-23
OTC	GOBP_Response_To_Hormone	Human	Brain	rep_10	2.8e-23
OTC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
OTC	GOBP_Response_To_Extracellular_Stimulus	Human	Brain	rep_11	2.5e-12
OTC	GOBP_Response_To_Nutrient	Human	Brain	rep_11	2.5e-12
OTC	GOBP_Response_To_Vitamin	Human	Brain	rep_11	2.5e-12
OTC	GOBP_Citrulline_Biosynthetic_Process	Human	Brain	st	1.7e-24
OTC	GOBP_Midgut_Development	Human	Bladder	rep_2	6.7e-04
OTC	GOBP_Response_To_Nutrient	Human	Bladder	rep_2	9.6e-14
OTC	GOBP_Response_To_Peptide	Human	Bladder	rep_2	2.3e-11
OTC	GOBP_Response_To_Peptide_Hormone	Human	Bladder	rep_2	2.9e-13
OTC	GOBP_Response_To_Vitamin	Human	Bladder	rep_2	3.3e-13
OTC	GOBP_Response_To_Zinc_Ion	Human	Bladder	rep_2	8.5e-05
OTC	GOBP_Urea_Cycle	Human	Bladder	rep_2	7.7e-05
OTC	GOBP_Urea_Metabolic_Process	Human	Bladder	rep_2	7.7e-05
OTC	GOBP_Response_To_Endogenous_Stimulus	Human	Liver	rep_1	3.0e-55
OTC	GOBP_Response_To_Extracellular_Stimulus	Human	Liver	rep_1	1.7e-73
OTC	GOBP_Response_To_Hormone	Human	Liver	rep_1	3.0e-55
OTC	GOBP_Response_To_Nutrient	Human	Liver	rep_1	1.7e-73
OTC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
OTC	GOBP_Response_To_Vitamin	Human	Liver	rep_1	1.7e-73
OTC	GOBP_Tube_Development	Human	Liver	rep_1	6.0e-76
OTC	GOBP_Tube_Development	Human	Intestine	rep_colon4	1.9e-09
OTC	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	rep_liver2	3.7e-39
OTC	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	rep_liver2	8.9e-16
OTC	GOBP_Response_To_Hormone	Human	Intestine	rep_liver2	3.7e-39
OTC	GOBP_Response_To_Nutrient	Human	Intestine	rep_liver2	8.9e-16
OTC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
OTC	GOBP_Response_To_Vitamin	Human	Intestine	rep_liver2	8.9e-16
OTC	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
OTC	GOBP_Gland_Development	Human	Intestine	A3	2.3e-14
OTC	GOBP_Hepaticobiliary_System_Development	Human	Intestine	A3	1.6e-07
OTC	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
OTC	GOBP_Monovalent_Inorganic_Cation_Homeostasis	Human	Intestine	A3	1.2e-16
OTC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
OTC	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	A3	5.2e-09
OTC	GOBP_Response_To_Inorganic_Substance	Human	Intestine	A3	6.8e-07
OTC	GOBP_Response_To_Insulin	Human	Intestine	A3	2.2e-15
OTC	GOBP_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	3.2e-15
OTC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
OTC	GOBP_Tube_Development	Human	Intestine	A3	7.6e-08
OTC	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Intestine	A8	7.0e-13
OTC	GOBP_Anion_Homeostasis	Human	Intestine	A8	4.2e-11
OTC	GOBP_Cellular_Amino_Acid_Biosynthetic_Process	Human	Intestine	A8	3.7e-12
OTC	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Intestine	A8	2.5e-14
OTC	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Intestine	A8	5.3e-13
OTC	GOBP_Chemical_Homeostasis	Human	Intestine	A8	1.3e-12
OTC	GOBP_Citrulline_Biosynthetic_Process	Human	Intestine	A8	6.0e-11
OTC	GOBP_Glutamine_Family_Amino_Acid_Metabolic_Process	Human	Intestine	A8	4.2e-08
OTC	GOBP_Ion_Homeostasis	Human	Intestine	A8	6.1e-15
OTC	GOBP_Midgut_Development	Human	Intestine	A8	2.3e-07
OTC	GOBP_Organic_Acid_Biosynthetic_Process	Human	Intestine	A8	2.1e-08
OTC	GOBP_Organic_Acid_Catabolic_Process	Human	Intestine	A8	1.6e-12
OTC	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
OTC	GOBP_Ornithine_Metabolic_Process	Human	Intestine	A8	6.1e-17
OTC	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	A8	2.1e-23
OTC	GOBP_Response_To_Hormone	Human	Intestine	A8	2.3e-13
OTC	GOBP_Response_To_Metal_Ion	Human	Intestine	A8	2.1e-21
OTC	GOBP_Response_To_Nitrogen_Compound	Human	Intestine	A8	1.3e-12
OTC	GOBP_Response_To_Peptide	Human	Intestine	A8	2.0e-09
OTC	GOBP_Response_To_Peptide_Hormone	Human	Intestine	A8	3.4e-09
OTC	GOBP_Response_To_Zinc_Ion	Human	Intestine	A8	5.0e-16
OTC	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
OTC	GOBP_Small_Molecule_Catabolic_Process	Human	Intestine	A8	2.2e-13
OTC	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
OTC	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Pancreas	PDAC-A-st2	9.6e-05
OTC	GOBP_Arginine_Metabolic_Process	Human	Uterus	rep_1	4.7e-09
OTC	GOBP_Urea_Cycle	Human	Uterus	rep_1	1.7e-06
OTC	GOBP_Urea_Metabolic_Process	Human	Uterus	rep_1	1.7e-06
OTC	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	1.2e-11
OTC	GOBP_Citrulline_Metabolic_Process	Human	Uterus	rep_25	1.1e-07
OTC	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	1.6e-06
OTC	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Uterus	rep_26	3.2e-12
OTC	GOBP_Citrulline_Biosynthetic_Process	Human	Uterus	rep_26	4.1e-06
OTC	GOBP_Gland_Development	Human	Uterus	rep_26	1.6e-07
OTC	GOBP_Glutamine_Family_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	5.2e-08
OTC	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
OTC	GOBP_Organic_Acid_Biosynthetic_Process	Human	Uterus	rep_26	2.3e-06
OTC	GOBP_Organic_Acid_Catabolic_Process	Human	Uterus	rep_26	6.9e-09
OTC	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
OTC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
OTC	GOBP_Ornithine_Metabolic_Process	Human	Uterus	rep_26	7.0e-06
OTC	GOBP_Response_To_Extracellular_Stimulus	Human	Uterus	rep_26	1.1e-14
OTC	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
OTC	GOBP_Small_Molecule_Catabolic_Process	Human	Uterus	rep_26	9.1e-13
OTC	GOBP_Arginine_Biosynthetic_Process	Human	Uterus	rep_29	1.1e-08
OTC	GOBP_Response_To_Nutrient	Human	Uterus	rep_31	3.9e-06
OTC	GOBP_Arginine_Metabolic_Process	Human	Breast	rep_1	1.4e-48
OTC	GOBP_Chemical_Homeostasis	Human	Breast	rep_1	4.8e-18
OTC	GOBP_Citrulline_Metabolic_Process	Human	Breast	rep_1	1.4e-38
OTC	GOBP_Gland_Development	Human	Breast	rep_1	2.0e-26
OTC	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
OTC	GOBP_Ion_Homeostasis	Human	Breast	rep_1	1.4e-53
OTC	GOBP_Midgut_Development	Human	Breast	rep_1	2.3e-06
OTC	GOBP_Ornithine_Metabolic_Process	Human	Breast	rep_1	5.0e-15
OTC	GOBP_Response_To_Insulin	Human	Breast	rep_1	5.1e-04
OTC	GOBP_Response_To_Metal_Ion	Human	Breast	rep_1	3.0e-20
OTC	GOBP_Response_To_Nutrient	Human	Breast	rep_1	1.4e-05
OTC	GOBP_Response_To_Peptide_Hormone	Human	Breast	rep_1	2.0e-36
OTC	GOBP_Response_To_Vitamin	Human	Breast	rep_1	4.5e-26
OTC	GOBP_Tube_Development	Human	Breast	rep_1	3.8e-32
OTC	GOBP_Anion_Homeostasis	Human	Breast	rep_4	3.6e-07
OTC	GOBP_Glutamine_Family_Amino_Acid_Biosynthetic_Process	Human	Breast	rep_5	4.2e-14
OTC	GOBP_Monovalent_Inorganic_Cation_Homeostasis	Human	Breast	rep_5	5.5e-11
OTC	GOBP_Organic_Acid_Biosynthetic_Process	Human	Breast	rep_5	3.5e-09
OTC	GOBP_Response_To_Endogenous_Stimulus	Human	Breast	rep_5	3.6e-09
OTC	GOBP_Response_To_Extracellular_Stimulus	Human	Breast	rep_5	2.9e-12
OTC	GOBP_Response_To_Hormone	Human	Breast	rep_5	2.9e-13
OTC	GOBP_Response_To_Inorganic_Substance	Human	Breast	rep_5	1.8e-10
OTC	GOBP_Response_To_Nitrogen_Compound	Human	Breast	rep_5	1.1e-11
OTC	GOBP_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	7.5e-14
OTC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
OTC	GOBP_Response_To_Peptide	Human	Breast	rep_5	1.2e-15
OTC	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	2.6e-05
OTC	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.7e-08
OTC	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
OTC	GOBP_Arginine_Biosynthetic_Process	Human	Breast	rep_6	1.2e-05
OTC	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
OTC	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	1.6e-05
OTC	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.0e-10
OTC	GOBP_Hepaticobiliary_System_Development	Human	Breast	rep_6	1.5e-07
OTC	GOBP_Organic_Acid_Catabolic_Process	Human	Breast	rep_6	1.5e-11
OTC	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
OTC	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
OTC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
OTC	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
OTC	GOBP_Small_Molecule_Catabolic_Process	Human	Breast	rep_6	4.7e-07
OTC	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
OTC	GOBP_Arginine_Biosynthetic_Process	Human	Skin	P5_rep1	2.3e-09
OTC	GOBP_Glutamine_Family_Amino_Acid_Biosynthetic_Process	Human	Skin	P10_rep2	1.3e-12
OTC	GOBP_Response_To_Vitamin	Human	Skin	P10_rep2	2.3e-21
OTC	GOBP_Urea_Cycle	Human	Skin	P10_rep2	2.8e-17
OTC	GOBP_Urea_Metabolic_Process	Human	Skin	P10_rep2	2.8e-17
OTC	GOBP_Ion_Homeostasis	Human	Lung	rep_1	6.1e-07
OTC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08

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OTC function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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OTC function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for OTC envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for OTC

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
OTC	P00480	DB00129	Ornithine	Ornithine carbamoyltransferase, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

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Related Diseases for OTC

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
OTC	C0268542	Ornithine carbamoyltransferase deficiency	42	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
OTC	C0220994	Hyperammonemia	10	CTD_human
OTC	C0006111	Brain Diseases	1	CTD_human
OTC	C0009241	Cognition Disorders	1	CTD_human
OTC	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
OTC	C0027746	Nerve Degeneration	1	CTD_human
OTC	C0085584	Encephalopathies	1	CTD_human
OTC	C0376618	Endotoxemia	1	CTD_human