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Spatial pattern gene: SLC22A18 (spascer ID:5002) |
Gene summary for SLC22A18 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | SLC22A18 | Gene ID | 5002 |
| Gene name | solute carrier family 22 member 18 |
| Synonyms | BWR1A|BWSCR1A|HET|IMPT1|ITM|ORCTL2|SLC22A1L|TSSC5|p45-BWR1A |
| Cytomap | 11p15.4 |
| Type of gene | protein-coding |
| Description | solute carrier family 22 member 18beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A proteinefflux transporter-like proteinimprinted multi-membrane-spanning polyspecific transporter-related protein 1organic cation transporter-like prote |
| Modification date | 20220513 |
| UniProtAcc | Q96BI1 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| SLC22A18 | GO:0022857 | transmembrane transporter activity | 21873635 | Function |
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Spatial pattern events for SLC22A18 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| SLC22A18 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| SLC22A18 | Human | Intestine | rep_colon4 | 34417225 | 2.06e-15 |
| SLC22A18 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| SLC22A18 | Human | Liver | rep_liver2 | 34417225 | 6.95e-06 |
| SLC22A18 | Human | Intestine | A1 | 33406409 | 5.19e-08 |
| SLC22A18 | Human | Intestine | A2 | 33406409 | 3.85e-15 |
| SLC22A18 | Human | Intestine | A4 | 33406409 | 1.73e-06 |
| SLC22A18 | Human | Intestine | A8 | 33406409 | 6.20e-08 |
| SLC22A18 | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Intestine_A4_H&E  |  |
Intestine_A8_H&E  |  |
Breast_CID44971_H&E  |  |
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Spatial pattern pathway has SLC22A18 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| SLC22A18 | GOBP_Transmembrane_Transport | Human | Brain | rep_1 | 2.8e-23 |
| SLC22A18 | GOBP_Export_Across_Plasma_Membrane | Human | Bladder | rep_4 | 5.9e-07 |
| SLC22A18 | GOBP_Transmembrane_Transport | Human | Liver | rep_1 | 1.0e-70 |
| SLC22A18 | GOBP_Cation_Transport | Human | Intestine | A3 | 1.3e-09 |
| SLC22A18 | GOBP_Excretion | Human | Intestine | A3 | 4.5e-11 |
| SLC22A18 | GOBP_Transmembrane_Transport | Human | Intestine | A3 | 1.4e-10 |
| SLC22A18 | GOBP_Detoxification | Human | Intestine | A8 | 8.7e-17 |
| SLC22A18 | GOBP_Export_Across_Plasma_Membrane | Human | Intestine | A8 | 5.9e-18 |
| SLC22A18 | GOBP_Organic_Cation_Transport | Human | Intestine | A8 | 1.6e-08 |
| SLC22A18 | GOBP_Response_To_Toxic_Substance | Human | Intestine | A8 | 8.6e-21 |
| SLC22A18 | GOBP_Xenobiotic_Transport | Human | Intestine | A8 | 9.4e-18 |
| SLC22A18 | GOBP_Organic_Cation_Transport | Human | Uterus | rep_2 | 6.9e-06 |
| SLC22A18 | GOBP_Excretion | Human | Uterus | rep_26 | 4.1e-12 |
| SLC22A18 | GOBP_Response_To_Toxic_Substance | Human | Uterus | rep_26 | 4.2e-06 |
| SLC22A18 | GOBP_Xenobiotic_Transport | Human | Uterus | rep_26 | 1.6e-06 |
| SLC22A18 | GOBP_Cation_Transport | Human | Breast | rep_1 | 8.4e-53 |
| SLC22A18 | GOBP_Transmembrane_Transport | Human | Breast | rep_1 | 3.2e-56 |
| SLC22A18 | GOBP_Detoxification | Human | Breast | rep_5 | 5.6e-07 |
| SLC22A18 | GOBP_Organic_Cation_Transport | Human | Breast | rep_5 | 1.6e-07 |
| SLC22A18 | GOBP_Response_To_Toxic_Substance | Human | Breast | rep_5 | 1.2e-07 |
| SLC22A18 | GOBP_Xenobiotic_Transport | Human | Breast | rep_5 | 3.0e-14 |
| SLC22A18 | GOBP_Excretion | Human | Breast | rep_6 | 5.0e-16 |
| SLC22A18 | GOBP_Export_Across_Plasma_Membrane | Human | Breast | rep_6 | 3.2e-06 |
| SLC22A18 | GOBP_Organic_Cation_Transport | Human | Skin | P5_rep3 | 6.2e-13 |
| SLC22A18 | GOBP_Excretion | Human | Skin | P10_rep1 | 1.7e-09 |
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SLC22A18 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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SLC22A18 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for SLC22A18 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for SLC22A18 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SLC22A18 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| SLC22A18 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| SLC22A18 | C0206656 | Embryonal Rhabdomyosarcoma | 1 | ORPHANET |
| SLC22A18 | C0684249 | Carcinoma of lung | 1 | CGI;UNIPROT |
