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Spatial pattern gene: ORC5 (spascer ID:5001) |
Gene summary for ORC5 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | ORC5 | Gene ID | 5001 |
| Gene name | origin recognition complex subunit 5 |
| Synonyms | ORC5L|ORC5P|ORC5T|PPP1R117 |
| Cytomap | 7q22.1-q22.2 |
| Type of gene | protein-coding |
| Description | origin recognition complex subunit 5protein phosphatase 1, regulatory subunit 117 |
| Modification date | 20220513 |
| UniProtAcc | O43913 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| ORC5 | GO:0003688 | DNA replication origin binding | 21873635 | Function |
| ORC5 | GO:0005664 | nuclear origin of replication recognition complex | 21873635 | Component |
| ORC5 | GO:0006270 | DNA replication initiation | 21873635 | Process |
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Spatial pattern events for ORC5 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| ORC5 | Human | Liver | rep_liver1 | 34417225 | 2.56e-07 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
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Spatial pattern pathway has ORC5 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| ORC5 | GOBP_Dna_Dependent_Dna_Replication | Human | Bladder | rep_4 | 5.7e-05 |
| ORC5 | GOBP_Cell_Cycle | Human | Intestine | A3 | 2.7e-11 |
| ORC5 | GOBP_Cell_Cycle_Phase_Transition | Human | Intestine | A3 | 3.5e-07 |
| ORC5 | GOBP_Cell_Cycle_Process | Human | Intestine | A3 | 2.7e-14 |
| ORC5 | GOBP_Dna_Dependent_Dna_Replication | Human | Intestine | A3 | 2.2e-07 |
| ORC5 | GOBP_Dna_Metabolic_Process | Human | Intestine | A3 | 1.2e-09 |
| ORC5 | GOBP_Dna_Replication | Human | Intestine | A3 | 2.5e-08 |
| ORC5 | GOBP_Mitotic_Cell_Cycle | Human | Intestine | A3 | 1.8e-12 |
| ORC5 | GOBP_Regulation_Of_Dna_Replication | Human | Intestine | A3 | 2.9e-12 |
| ORC5 | GOBP_Cell_Cycle_G1_S_Phase_Transition | Human | Intestine | A8 | 8.5e-07 |
| ORC5 | GOBP_Dna_Replication_Initiation | Human | Uterus | rep_25 | 3.5e-10 |
| ORC5 | GOBP_Cell_Cycle_Phase_Transition | Human | Uterus | rep_26 | 1.9e-06 |
| ORC5 | GOBP_Dna_Dependent_Dna_Replication | Human | Uterus | rep_26 | 2.7e-14 |
| ORC5 | GOBP_Dna_Replication | Human | Uterus | rep_26 | 1.5e-09 |
| ORC5 | GOBP_Regulation_Of_Dna_Replication | Human | Uterus | rep_26 | 1.5e-08 |
| ORC5 | GOBP_Cell_Cycle | Human | Breast | rep_6 | 3.4e-09 |
| ORC5 | GOBP_Cell_Cycle_G1_S_Phase_Transition | Human | Breast | rep_6 | 3.5e-11 |
| ORC5 | GOBP_Cell_Cycle_Phase_Transition | Human | Breast | rep_6 | 4.9e-09 |
| ORC5 | GOBP_Cell_Cycle_Process | Human | Breast | rep_6 | 6.7e-09 |
| ORC5 | GOBP_Dna_Dependent_Dna_Replication | Human | Breast | rep_6 | 5.7e-04 |
| ORC5 | GOBP_Dna_Metabolic_Process | Human | Breast | rep_6 | 1.4e-10 |
| ORC5 | GOBP_Dna_Replication | Human | Breast | rep_6 | 3.5e-07 |
| ORC5 | GOBP_Dna_Replication_Initiation | Human | Breast | rep_6 | 3.9e-07 |
| ORC5 | GOBP_Mitotic_Cell_Cycle | Human | Breast | rep_6 | 3.2e-09 |
| ORC5 | GOBP_Regulation_Of_Dna_Replication | Human | Breast | rep_6 | 1.8e-08 |
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ORC5 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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ORC5 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for ORC5 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for ORC5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ORC5 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
