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Spatial pattern gene: SKA2 (spascer ID:348235) |
Gene summary for SKA2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | SKA2 | Gene ID | 348235 |
| Gene name | spindle and kinetochore associated complex subunit 2 |
| Synonyms | FAM33A |
| Cytomap | 17q22 |
| Type of gene | protein-coding |
| Description | spindle and kinetochore-associated protein 2family with sequence similarity 33, member Aspindle and KT (kinetochore) associated 2 |
| Modification date | 20220513 |
| UniProtAcc | Q8WVK7 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| SKA2 | GO:0000278 | mitotic cell cycle | 21873635 | Process |
| SKA2 | GO:0000940 | outer kinetochore | 21873635 | Component |
| SKA2 | GO:0005876 | spindle microtubule | 21873635 | Component |
| SKA2 | GO:0007059 | chromosome segregation | 21873635 | Process |
| SKA2 | GO:0008017 | microtubule binding | 21873635 | Function |
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Spatial pattern events for SKA2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| SKA2 | Human | Intestine | rep_colon1 | 34417225 | 1.92e-14 |
| SKA2 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| SKA2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| SKA2 | Human | Intestine | A2 | 33406409 | 3.71e-09 |
| SKA2 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| SKA2 | Human | Breast | 1142243F | 34493872 | 8.33e-11 |
| SKA2 | Human | Breast | CID44971 | 34493872 | 2.80e-07 |
| SKA2 | Human | Skin | P2_rep1 | 32946785 | 1.56e-08 |
| SKA2 | Human | Skin | P2_rep3 | 32946785 | 7.72e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_CID44971_H&E  |  |
Skin_P2_rep3_H&E  |  |
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Spatial pattern pathway has SKA2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| SKA2 | GOBP_Cell_Cycle | Human | Intestine | A3 | 2.7e-11 |
| SKA2 | GOBP_Cell_Division | Human | Intestine | A3 | 2.7e-10 |
| SKA2 | GOBP_Chromosome_Segregation | Human | Intestine | A3 | 4.7e-12 |
| SKA2 | GOBP_Microtubule_Based_Process | Human | Intestine | A3 | 3.4e-11 |
| SKA2 | GOBP_Microtubule_Cytoskeleton_Organization | Human | Intestine | A3 | 4.8e-11 |
| SKA2 | GOBP_Microtubule_Polymerization_Or_Depolymerization | Human | Intestine | A3 | 8.8e-18 |
| SKA2 | GOBP_Mitotic_Cell_Cycle | Human | Intestine | A3 | 1.8e-12 |
| SKA2 | GOBP_Regulation_Of_Cytoskeleton_Organization | Human | Intestine | A3 | 6.4e-13 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Based_Process | Human | Intestine | A3 | 1.2e-12 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Cytoskeleton_Organization | Human | Intestine | A3 | 2.3e-15 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Polymerization_Or_Depolymerization | Human | Intestine | A3 | 3.7e-16 |
| SKA2 | GOBP_Regulation_Of_Organelle_Organization | Human | Intestine | A3 | 1.1e-11 |
| SKA2 | GOBP_Cell_Division | Human | Pancreas | PDAC-B-st1 | 5.8e-05 |
| SKA2 | GOBP_Chromosome_Segregation | Human | Pancreas | PDAC-B-st1 | 3.3e-05 |
| SKA2 | GOBP_Chromosome_Segregation | Human | Uterus | rep_26 | 5.6e-19 |
| SKA2 | GOBP_Microtubule_Polymerization_Or_Depolymerization | Human | Uterus | rep_26 | 8.0e-10 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Cytoskeleton_Organization | Human | Uterus | rep_26 | 1.4e-06 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Polymerization_Or_Depolymerization | Human | Uterus | rep_26 | 3.6e-08 |
| SKA2 | GOBP_Cytoskeleton_Organization | Human | Breast | rep_1 | 1.3e-22 |
| SKA2 | GOBP_Regulation_Of_Cytoskeleton_Organization | Human | Breast | rep_1 | 7.8e-76 |
| SKA2 | GOBP_Regulation_Of_Organelle_Organization | Human | Breast | rep_1 | 8.7e-11 |
| SKA2 | GOBP_Cell_Cycle | Human | Breast | rep_6 | 3.4e-09 |
| SKA2 | GOBP_Cell_Division | Human | Breast | rep_6 | 8.2e-07 |
| SKA2 | GOBP_Chromosome_Segregation | Human | Breast | rep_6 | 1.9e-05 |
| SKA2 | GOBP_Microtubule_Based_Process | Human | Breast | rep_6 | 1.8e-04 |
| SKA2 | GOBP_Microtubule_Cytoskeleton_Organization | Human | Breast | rep_6 | 1.9e-04 |
| SKA2 | GOBP_Microtubule_Polymerization_Or_Depolymerization | Human | Breast | rep_6 | 6.1e-05 |
| SKA2 | GOBP_Mitotic_Cell_Cycle | Human | Breast | rep_6 | 3.2e-09 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Based_Process | Human | Breast | rep_6 | 2.1e-05 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Cytoskeleton_Organization | Human | Breast | rep_6 | 1.8e-05 |
| SKA2 | GOBP_Regulation_Of_Microtubule_Polymerization_Or_Depolymerization | Human | Breast | rep_6 | 2.0e-05 |
| SKA2 | GOBP_Cytoskeleton_Organization | Human | Skin | P9_rep3 | 3.1e-12 |
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SKA2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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SKA2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for SKA2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for SKA2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SKA2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
