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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: SPCS1 (spascer ID:28972)

Gene summary for SPCS1

Gene summary

Gene information
	Species	Human
	Gene symbol	SPCS1
	Gene ID	28972
	Gene name	signal peptidase complex subunit 1
	Synonyms	HSPC033\|SPC1\|SPC12\|YJR010C-A
	Cytomap	3p21.1
	Type of gene	protein-coding
	Description	signal peptidase complex subunit 1SPase 12 kDa subunitmicrosomal signal peptidase 12 kDa subunitsignal peptidase 12kDasignal peptidase complex 12 kDa subunitsignal peptidase complex subunit 1 homolog
	Modification date	20220513
	UniProtAcc	Q9Y6A9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
SPCS1	GO:0005787	signal peptidase complex	21873635	Component
SPCS1	GO:0006465	signal peptide processing	21873635	Process
SPCS1	GO:0030176	integral component of endoplasmic reticulum membrane	21873635	Component
SPCS1	GO:0045047	protein targeting to ER	21873635	Process

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Spatial pattern events for SPCS1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
SPCS1	Human	Bladder	rep_2	34385456	2.41e-11
SPCS1	Human	Intestine	rep_colon1	34417225	1.95e-15
SPCS1	Human	Intestine	rep_colon2	34417225	2.28e-13
SPCS1	Human	Intestine	rep_colon4	34417225	1.14e-15
SPCS1	Human	Liver	rep_liver1	34417225	1.08e-15
SPCS1	Human	Liver	rep_liver2	34417225	6.98e-16
SPCS1	Human	Liver	rep_liver4	34417225	7.71e-16
SPCS1	Human	Uterus	rep_1	34857954	8.93e-15
SPCS1	Human	Uterus	rep_3	34857954	1.66e-15
SPCS1	Human	Breast	1142243F	34493872	8.31e-10
SPCS1	Human	Breast	1160920F	34493872	5.08e-15
SPCS1	Human	Breast	CID4290	34493872	1.35e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Uterus_rep_1_H&E
Uterus_rep_3_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E

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Spatial pattern pathway has SPCS1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
SPCS1	GOBP_Protein_Maturation	Human	Brain	rep_1	1.3e-161
SPCS1	GOBP_Protein_Processing	Human	Brain	rep_1	1.3e-161
SPCS1	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
SPCS1	GOBP_Protein_Maturation	Human	Liver	rep_1	4.6e-81
SPCS1	GOBP_Protein_Processing	Human	Liver	rep_1	6.7e-84
SPCS1	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
SPCS1	GOBP_Protein_Maturation	Human	Intestine	rep_colon2	7.9e-42
SPCS1	GOBP_Protein_Processing	Human	Intestine	rep_colon2	1.2e-19
SPCS1	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
SPCS1	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Intestine	A3	3.5e-14
SPCS1	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
SPCS1	GOBP_Establishment_Of_Protein_Localization	Human	Intestine	A3	5.0e-10
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Intestine	A3	1.0e-07
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Human	Intestine	A3	3.8e-08
SPCS1	GOBP_Intracellular_Protein_Transport	Human	Intestine	A3	4.8e-12
SPCS1	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
SPCS1	GOBP_Protein_Localization_To_Organelle	Human	Intestine	A3	1.5e-12
SPCS1	GOBP_Protein_Targeting	Human	Intestine	A3	6.5e-09
SPCS1	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
SPCS1	GOBP_Viral_Life_Cycle	Human	Intestine	A3	1.1e-12
SPCS1	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Intestine	A8	1.0e-11
SPCS1	GOBP_Protein_Maturation	Human	Intestine	A8	1.1e-12
SPCS1	GOBP_Protein_Processing	Human	Intestine	A8	4.1e-18
SPCS1	GOBP_Viral_Gene_Expression	Human	Intestine	A8	1.8e-23
SPCS1	GOBP_Virion_Assembly	Human	Intestine	A8	3.6e-09
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Pancreas	PDAC-B-st1	9.1e-06
SPCS1	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Pancreas	PDAC-B-st1	9.9e-06
SPCS1	GOBP_Protein_Targeting	Human	Pancreas	PDAC-B-st1	9.4e-05
SPCS1	GOBP_Signal_Peptide_Processing	Human	Pancreas	PDAC-A-st2	5.5e-05
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Uterus	rep_1	4.6e-06
SPCS1	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Uterus	rep_1	1.2e-09
SPCS1	GOBP_Signal_Peptide_Processing	Human	Uterus	rep_2	3.1e-06
SPCS1	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Uterus	rep_26	5.9e-08
SPCS1	GOBP_Viral_Life_Cycle	Human	Uterus	rep_26	2.1e-06
SPCS1	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Breast	rep_1	5.4e-30
SPCS1	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
SPCS1	GOBP_Establishment_Of_Protein_Localization	Human	Breast	rep_1	7.2e-05
SPCS1	GOBP_Protein_Maturation	Human	Breast	rep_1	4.1e-23
SPCS1	GOBP_Protein_Processing	Human	Breast	rep_1	4.4e-37
SPCS1	GOBP_Viral_Life_Cycle	Human	Breast	rep_1	1.2e-08
SPCS1	GOBP_Virion_Assembly	Human	Breast	rep_1	4.8e-09
SPCS1	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
SPCS1	GOBP_Signal_Peptide_Processing	Human	Breast	rep_5	4.2e-06
SPCS1	GOBP_Viral_Gene_Expression	Human	Breast	rep_5	4.2e-10
SPCS1	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Breast	rep_6	1.7e-07
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Human	Breast	rep_6	8.5e-11
SPCS1	GOBP_Intracellular_Protein_Transport	Human	Breast	rep_6	6.4e-12
SPCS1	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
SPCS1	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
SPCS1	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Breast	rep_6	2.0e-07
SPCS1	GOBP_Protein_Localization_To_Organelle	Human	Breast	rep_6	1.1e-07
SPCS1	GOBP_Protein_Targeting	Human	Breast	rep_6	5.5e-10
SPCS1	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Skin	P5_rep1	9.0e-10
SPCS1	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Skin	P5_rep1	1.5e-10
SPCS1	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Skin	P9_rep2	4.7e-10
SPCS1	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Lung	rep_1	2.4e-10
SPCS1	GOBP_Viral_Life_Cycle	Human	Lung	rep_1	2.0e-16

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SPCS1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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SPCS1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for SPCS1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for SPCS1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SPCS1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source