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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GRB7 (spascer ID:2886)

Gene summary for GRB7

Gene summary

Gene information
	Species	Human
	Gene symbol	GRB7
	Gene ID	2886
	Gene name	growth factor receptor bound protein 7
	Synonyms	-
	Cytomap	17q12
	Type of gene	protein-coding
	Description	growth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7
	Modification date	20220513
	UniProtAcc	Q14451

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GRB7	GO:0008286	insulin receptor signaling pathway	21873635	Process
GRB7	GO:0046627	negative regulation of insulin receptor signaling pathway	21873635	Process

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Spatial pattern events for GRB7

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GRB7	Human	Intestine	rep_colon4	34417225	2.24e-07
GRB7	Human	Liver	rep_liver1	34417225	1.08e-15
GRB7	Human	Liver	rep_liver2	34417225	6.98e-16
GRB7	Human	Intestine	A4	33406409	5.70e-06
GRB7	Human	Uterus	rep_2	34857954	2.55e-15
GRB7	Human	Breast	A3	34650042	1.83e-09
GRB7	Human	Breast	A4	34650042	1.33e-06
GRB7	Human	Breast	A6	34650042	1.08e-06
GRB7	Human	Breast	B5	34650042	2.33e-06
GRB7	Human	Breast	D2	34650042	6.63e-08
GRB7	Human	Breast	E1	34650042	1.81e-14
GRB7	Human	Breast	E2	34650042	2.12e-14
GRB7	Human	Breast	E3	34650042	1.82e-14
GRB7	Human	Breast	F3	34650042	4.35e-06
GRB7	Human	Breast	G2	34650042	5.02e-07
GRB7	Human	Breast	G3	34650042	1.34e-06
GRB7	Human	Breast	1160920F	34493872	1.48e-15
GRB7	Human	Breast	CID44971	34493872	1.76e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Intestine_A4_H&E
Uterus_rep_2_H&E
Breast_A3_H&E
Breast_A4_H&E
Breast_A6_H&E
Breast_B5_H&E
Breast_D2_H&E
Breast_E1_H&E
Breast_E2_H&E
Breast_E3_H&E
Breast_F3_H&E
Breast_G2_H&E
Breast_G3_H&E
Breast_1160920F_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has GRB7 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GRB7	GOBP_Cell_Migration	Human	Brain	rep_1	3.1e-68
GRB7	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Brain	rep_1	2.3e-68
GRB7	GOBP_Locomotion	Human	Brain	rep_1	3.1e-68
GRB7	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
GRB7	GOBP_Neurogenesis	Human	Brain	rep_1	7.4e-34
GRB7	GOBP_Neuron_Development	Human	Brain	rep_1	7.4e-34
GRB7	GOBP_Neuron_Differentiation	Human	Brain	rep_1	7.4e-34
GRB7	GOBP_Positive_Regulation_Of_Locomotion	Human	Brain	rep_1	3.1e-68
GRB7	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Brain	rep_1	3.1e-68
GRB7	GOBP_Taxis	Human	Brain	rep_1	2.3e-68
GRB7	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Brain	rep_1	2.3e-68
GRB7	GOBP_Cell_Morphogenesis	Human	Brain	rep_4	1.0e-14
GRB7	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Bladder	rep_2	1.3e-05
GRB7	GOBP_Cell_Migration	Human	Liver	rep_1	1.9e-71
GRB7	GOBP_Cell_Morphogenesis	Human	Liver	rep_1	2.1e-52
GRB7	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Liver	rep_1	8.8e-90
GRB7	GOBP_Locomotion	Human	Liver	rep_1	1.9e-71
GRB7	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
GRB7	GOBP_Neurogenesis	Human	Liver	rep_1	1.0e-70
GRB7	GOBP_Neuron_Development	Human	Liver	rep_1	1.5e-73
GRB7	GOBP_Neuron_Differentiation	Human	Liver	rep_1	1.5e-73
GRB7	GOBP_Positive_Regulation_Of_Locomotion	Human	Liver	rep_1	1.9e-71
GRB7	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Liver	rep_1	1.9e-71
GRB7	GOBP_Taxis	Human	Liver	rep_1	8.8e-90
GRB7	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Liver	rep_1	8.8e-90
GRB7	GOBP_Cell_Morphogenesis	Human	Intestine	rep_colon2	1.5e-57
GRB7	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Intestine	rep_colon2	5.0e-29
GRB7	GOBP_Taxis	Human	Intestine	rep_colon2	5.0e-29
GRB7	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Intestine	rep_colon2	5.0e-29
GRB7	GOBP_Cell_Migration	Human	Intestine	rep_liver2	1.0e-64
GRB7	GOBP_Locomotion	Human	Intestine	rep_liver2	1.0e-64
GRB7	GOBP_Positive_Regulation_Of_Locomotion	Human	Intestine	rep_liver2	1.0e-64
GRB7	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Intestine	rep_liver2	1.0e-64
GRB7	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
GRB7	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
GRB7	GOBP_Cell_Migration	Human	Intestine	A3	1.6e-10
GRB7	GOBP_Cell_Morphogenesis	Human	Intestine	A3	9.7e-08
GRB7	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Human	Intestine	A3	3.7e-07
GRB7	GOBP_Cell_Part_Morphogenesis	Human	Intestine	A3	8.9e-08
GRB7	GOBP_Cell_Projection_Organization	Human	Intestine	A3	1.1e-09
GRB7	GOBP_Erbb_Signaling_Pathway	Human	Intestine	A3	7.9e-08
GRB7	GOBP_Leukocyte_Migration	Human	Intestine	A3	1.5e-08
GRB7	GOBP_Locomotion	Human	Intestine	A3	1.9e-08
GRB7	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Intestine	A3	5.9e-17
GRB7	GOBP_Negative_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	1.1e-11
GRB7	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
GRB7	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
GRB7	GOBP_Neurogenesis	Human	Intestine	A3	6.4e-14
GRB7	GOBP_Neuron_Development	Human	Intestine	A3	1.3e-12
GRB7	GOBP_Neuron_Differentiation	Human	Intestine	A3	1.4e-11
GRB7	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
GRB7	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
GRB7	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Intestine	A3	1.1e-09
GRB7	GOBP_Taxis	Human	Intestine	A3	5.0e-08
GRB7	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Intestine	A3	2.0e-11
GRB7	GOBP_Erbb2_Signaling_Pathway	Human	Intestine	A8	7.0e-13
GRB7	GOBP_Positive_Regulation_Of_Locomotion	Human	Intestine	A8	9.7e-07
GRB7	GOBP_Stress_Granule_Assembly	Human	Pancreas	PDAC-B-st1	4.6e-05
GRB7	GOBP_Stress_Granule_Assembly	Human	Uterus	rep_26	8.3e-08
GRB7	GOBP_Erbb_Signaling_Pathway	Human	Uterus	rep_29	2.5e-06
GRB7	GOBP_Leukocyte_Migration	Human	Uterus	rep_29	1.5e-07
GRB7	GOBP_Axon_Development	Human	Breast	rep_1	5.1e-70
GRB7	GOBP_Cell_Migration	Human	Breast	rep_1	1.5e-45
GRB7	GOBP_Cell_Morphogenesis	Human	Breast	rep_1	5.7e-26
GRB7	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Human	Breast	rep_1	1.6e-61
GRB7	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Human	Breast	rep_1	1.4e-48
GRB7	GOBP_Cell_Part_Morphogenesis	Human	Breast	rep_1	6.2e-28
GRB7	GOBP_Cell_Projection_Organization	Human	Breast	rep_1	1.8e-20
GRB7	GOBP_Cellular_Component_Morphogenesis	Human	Breast	rep_1	2.7e-58
GRB7	GOBP_Locomotion	Human	Breast	rep_1	4.5e-54
GRB7	GOBP_Neurogenesis	Human	Breast	rep_1	8.0e-11
GRB7	GOBP_Neuron_Development	Human	Breast	rep_1	2.5e-26
GRB7	GOBP_Neuron_Differentiation	Human	Breast	rep_1	1.1e-16
GRB7	GOBP_Positive_Regulation_Of_Locomotion	Human	Breast	rep_1	7.2e-115
GRB7	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Breast	rep_1	5.5e-21
GRB7	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Breast	rep_1	1.4e-14
GRB7	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Breast	rep_5	4.6e-14
GRB7	GOBP_Erbb_Signaling_Pathway	Human	Breast	rep_5	3.8e-06
GRB7	GOBP_Leukocyte_Migration	Human	Breast	rep_5	6.0e-14
GRB7	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
GRB7	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
GRB7	GOBP_Taxis	Human	Breast	rep_5	1.2e-12
GRB7	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
GRB7	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
GRB7	GOBP_Erbb2_Signaling_Pathway	Human	Breast	rep_6	5.1e-04
GRB7	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Breast	rep_6	2.6e-08
GRB7	GOBP_Negative_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	1.4e-05
GRB7	GOBP_Neuron_Projection_Guidance	Human	Breast	rep_6	2.8e-07
GRB7	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
GRB7	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
GRB7	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
GRB7	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
GRB7	GOBP_Stress_Granule_Assembly	Human	Breast	rep_6	4.3e-06
GRB7	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Human	Skin	P2_rep1	9.6e-08
GRB7	GOBP_Taxis	Human	Skin	P2_rep2	1.2e-08
GRB7	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Human	Skin	P5_rep1	1.1e-09
GRB7	GOBP_Stress_Granule_Assembly	Human	Skin	P10_rep1	1.2e-09
GRB7	GOBP_Taxis	Human	Lung	rep_2	4.0e-07

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GRB7 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GRB7 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GRB7 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GRB7

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRB7

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
GRB7	C0006142	Malignant neoplasm of breast	2	CTD_human
GRB7	C0678222	Breast Carcinoma	2	CTD_human
GRB7	C1257931	Mammary Neoplasms, Human	2	CTD_human
GRB7	C1458155	Mammary Neoplasms	2	CTD_human
GRB7	C4704874	Mammary Carcinoma, Human	2	CTD_human
GRB7	C0001418	Adenocarcinoma	1	CTD_human
GRB7	C0007134	Renal Cell Carcinoma	1	CTD_human
GRB7	C0024121	Lung Neoplasms	1	CTD_human
GRB7	C0033578	Prostatic Neoplasms	1	CTD_human
GRB7	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
GRB7	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
GRB7	C0205643	Carcinoma, Cribriform	1	CTD_human
GRB7	C0205644	Carcinoma, Granular Cell	1	CTD_human
GRB7	C0205645	Adenocarcinoma, Tubular	1	CTD_human
GRB7	C0242379	Malignant neoplasm of lung	1	CTD_human
GRB7	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
GRB7	C0376358	Malignant neoplasm of prostate	1	CTD_human
GRB7	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
GRB7	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
GRB7	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
GRB7	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human