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Spatial pattern gene: GPX2 (spascer ID:2877) |
Gene summary for GPX2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | GPX2 | Gene ID | 2877 |
| Gene name | glutathione peroxidase 2 |
| Synonyms | GI-GPx|GPRP|GPRP-2|GPx-2|GPx-GI|GSHPX-GI|GSHPx-2 |
| Cytomap | 14q23.3 |
| Type of gene | protein-coding |
| Description | glutathione peroxidase 2gastrointestinal glutathione peroxidaseglutathione peroxidase 2 (gastrointestinal)glutathione peroxidase-related protein 2selenoprotein GPX2 |
| Modification date | 20220513 |
| UniProtAcc | P18283 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| GPX2 | GO:0004601 | peroxidase activity | 21873635 | Function |
| GPX2 | GO:0004602 | glutathione peroxidase activity | 21873635 | Function |
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Spatial pattern events for GPX2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| GPX2 | Human | Bladder | rep_1 | 34385456 | 1.49e-14 |
| GPX2 | Human | Bladder | rep_3 | 34385456 | 4.69e-14 |
| GPX2 | Human | Liver | rep_1 | 34792289 | 5.19e-11 |
| GPX2 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| GPX2 | Human | Intestine | rep_colon2 | 34417225 | 1.48e-15 |
| GPX2 | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| GPX2 | Human | Liver | rep_liver1 | 34417225 | 1.89e-15 |
| GPX2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| GPX2 | Human | Liver | rep_liver3 | 34417225 | 3.51e-15 |
| GPX2 | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| GPX2 | Human | Intestine | A1 | 33406409 | 2.09e-15 |
| GPX2 | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| GPX2 | Human | Intestine | A9 | 33406409 | 6.56e-13 |
| GPX2 | Human | Pancreas | PDAC-A-st1 | 31932730 | 1.93e-14 |
| GPX2 | Human | Pancreas | PDAC-B-st1 | 31932730 | 2.21e-13 |
| GPX2 | Human | Pancreas | PDAC-D-st1 | 31932730 | 6.89e-14 |
| GPX2 | Human | Lung | rep_1 | 35355018 | 4.99e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_1_H&E  |  |
Bladder_rep_3_H&E  |  |
Liver_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver3_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Intestine_A9_H&E  |  |
Lung_rep_1_H&E  |  |
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Spatial pattern pathway has GPX2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| GPX2 | GOBP_Electron_Transport_Chain | Human | Bladder | rep_4 | 1.0e-20 |
| GPX2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Bladder | rep_4 | 3.4e-12 |
| GPX2 | GOBP_Cellular_Response_To_Chemical_Stress | Human | Intestine | A3 | 1.1e-11 |
| GPX2 | GOBP_Electron_Transport_Chain | Human | Intestine | A3 | 1.4e-19 |
| GPX2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Intestine | A3 | 4.3e-14 |
| GPX2 | GOBP_Response_To_Oxidative_Stress | Human | Intestine | A3 | 5.4e-18 |
| GPX2 | GOBP_Detoxification | Human | Intestine | A8 | 8.7e-17 |
| GPX2 | GOBP_Response_To_Toxic_Substance | Human | Intestine | A8 | 8.6e-21 |
| GPX2 | GOBP_Electron_Transport_Chain | Human | Uterus | rep_26 | 1.9e-08 |
| GPX2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Uterus | rep_26 | 1.8e-06 |
| GPX2 | GOBP_Response_To_Toxic_Substance | Human | Uterus | rep_26 | 4.2e-06 |
| GPX2 | GOBP_Detoxification | Human | Breast | rep_5 | 5.6e-07 |
| GPX2 | GOBP_Electron_Transport_Chain | Human | Breast | rep_5 | 6.2e-04 |
| GPX2 | GOBP_Response_To_Oxidative_Stress | Human | Breast | rep_5 | 1.0e-04 |
| GPX2 | GOBP_Response_To_Toxic_Substance | Human | Breast | rep_5 | 1.2e-07 |
| GPX2 | GOBP_Cellular_Oxidant_Detoxification | Human | Breast | rep_6 | 4.9e-06 |
| GPX2 | GOBP_Cellular_Response_To_Chemical_Stress | Human | Breast | rep_6 | 3.6e-05 |
| GPX2 | GOBP_Cellular_Response_To_Toxic_Substance | Human | Breast | rep_6 | 9.0e-06 |
| GPX2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Breast | rep_6 | 7.1e-09 |
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GPX2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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GPX2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for GPX2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for GPX2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GPX2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
