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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GM2A (spascer ID:2760)

Gene summary for GM2A

Gene summary

Gene information
	Species	Human
	Gene symbol	GM2A
	Gene ID	2760
	Gene name	ganglioside GM2 activator
	Synonyms	GM2-AP\|GM2AP\|SAP-3
	Cytomap	5q33.1
	Type of gene	protein-coding
	Description	ganglioside GM2 activatorGM2 ganglioside activatorGM2-activator proteincerebroside sulfate activator proteinshingolipid activator protein 3sphingolipid activator protein 3
	Modification date	20220513
	UniProtAcc	P17900

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GM2A	GO:0005319	lipid transporter activity	21873635	Function
GM2A	GO:0006689	ganglioside catabolic process	21873635	Process
GM2A	GO:0006869	lipid transport	21873635	Process
GM2A	GO:0009898	cytoplasmic side of plasma membrane	21873635	Component

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Spatial pattern events for GM2A

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GM2A	Human	Brain	rep_9	33558695	5.33e-15
GM2A	Human	Brain	rep_10	33558695	1.91e-11
GM2A	Human	Brain	rep_12	33558695	9.68e-12
GM2A	Human	Bladder	rep_2	34385456	6.29e-15
GM2A	Human	Intestine	rep_colon1	34417225	5.99e-10
GM2A	Human	Intestine	rep_colon2	34417225	8.12e-16
GM2A	Human	Intestine	rep_colon3	34417225	1.01e-15
GM2A	Human	Intestine	rep_colon4	34417225	1.14e-15
GM2A	Human	Liver	rep_liver1	34417225	1.10e-11
GM2A	Human	Liver	rep_liver2	34417225	6.11e-11
GM2A	Human	Liver	rep_liver4	34417225	7.71e-16
GM2A	Human	Intestine	A2	33406409	3.85e-15
GM2A	Human	Breast	1142243F	34493872	2.30e-15
GM2A	Human	Breast	1160920F	34493872	1.48e-15
GM2A	Human	Breast	CID4290	34493872	2.47e-06
GM2A	Human	Breast	CID44971	34493872	1.76e-15
GM2A	Human	Breast	CID4535	34493872	1.22e-09
GM2A	Human	Skin	P2_rep1	32946785	6.57e-11
GM2A	Human	Skin	P2_rep3	32946785	1.33e-09
GM2A	Human	Lung	rep_1	35355018	1.46e-11

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_9_H&E
Brain_rep_10_H&E
Brain_rep_12_H&E
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Intestine_A2_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Skin_P2_rep3_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has GM2A envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GM2A	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
GM2A	GOBP_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
GM2A	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
GM2A	GOBP_Maintenance_Of_Location	Human	Brain	rep_1	2.8e-23
GM2A	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	2.8e-23
GM2A	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
GM2A	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_1	8.7e-71
GM2A	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
GM2A	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
GM2A	GOBP_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	9.0e-62
GM2A	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
GM2A	GOBP_Maintenance_Of_Location	Human	Liver	rep_1	1.0e-70
GM2A	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	1.0e-70
GM2A	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
GM2A	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	4.9e-46
GM2A	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
GM2A	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
GM2A	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon2	4.1e-22
GM2A	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
GM2A	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
GM2A	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	rep_colon4	1.3e-27
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
GM2A	GOBP_Behavior	Human	Intestine	A3	1.8e-11
GM2A	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
GM2A	GOBP_Carbohydrate_Metabolic_Process	Human	Intestine	A3	4.1e-08
GM2A	GOBP_Cell_Activation	Human	Intestine	A3	6.2e-08
GM2A	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Intestine	A3	4.0e-14
GM2A	GOBP_Cognition	Human	Intestine	A3	5.7e-09
GM2A	GOBP_Exocytosis	Human	Intestine	A3	4.7e-10
GM2A	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
GM2A	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	A3	8.2e-10
GM2A	GOBP_Maintenance_Of_Location	Human	Intestine	A3	7.1e-07
GM2A	GOBP_Nervous_System_Process	Human	Intestine	A3	9.7e-07
GM2A	GOBP_Neuromuscular_Process	Human	Intestine	A3	1.3e-09
GM2A	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
GM2A	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
GM2A	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	2.8e-16
GM2A	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
GM2A	GOBP_Secretion	Human	Intestine	A3	1.8e-13
GM2A	GOBP_Carbohydrate_Catabolic_Process	Human	Intestine	A8	2.0e-14
GM2A	GOBP_Carbohydrate_Derivative_Catabolic_Process	Human	Intestine	A8	3.2e-10
GM2A	GOBP_Cellular_Lipid_Metabolic_Process	Human	Intestine	A8	3.8e-13
GM2A	GOBP_Ceramide_Metabolic_Process	Human	Intestine	A8	8.7e-10
GM2A	GOBP_Lipid_Catabolic_Process	Human	Intestine	A8	3.2e-08
GM2A	GOBP_Lipid_Localization	Human	Intestine	A8	2.5e-15
GM2A	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
GM2A	GOBP_Membrane_Lipid_Metabolic_Process	Human	Intestine	A8	1.9e-14
GM2A	GOBP_Myeloid_Leukocyte_Activation	Human	Intestine	A8	3.8e-18
GM2A	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Intestine	A8	8.5e-11
GM2A	GOBP_Sphingolipid_Metabolic_Process	Human	Intestine	A8	1.1e-13
GM2A	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Pancreas	PDAC-B-st1	1.2e-05
GM2A	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
GM2A	GOBP_Leukocyte_Mediated_Immunity	Human	Uterus	rep_4	2.0e-31
GM2A	GOBP_Ganglioside_Catabolic_Process	Human	Uterus	rep_2	1.8e-07
GM2A	GOBP_Ceramide_Catabolic_Process	Human	Uterus	rep_25	9.1e-07
GM2A	GOBP_Ganglioside_Metabolic_Process	Human	Uterus	rep_25	9.1e-13
GM2A	GOBP_Glycolipid_Catabolic_Process	Human	Uterus	rep_25	2.3e-07
GM2A	GOBP_Glycosphingolipid_Metabolic_Process	Human	Uterus	rep_25	3.8e-09
GM2A	GOBP_Membrane_Lipid_Catabolic_Process	Human	Uterus	rep_25	3.5e-07
GM2A	GOBP_Oligosaccharide_Catabolic_Process	Human	Uterus	rep_25	3.5e-06
GM2A	GOBP_Carbohydrate_Derivative_Catabolic_Process	Human	Uterus	rep_26	5.1e-11
GM2A	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Uterus	rep_26	1.5e-11
GM2A	GOBP_Cellular_Lipid_Catabolic_Process	Human	Uterus	rep_26	4.6e-06
GM2A	GOBP_Cognition	Human	Uterus	rep_26	3.8e-07
GM2A	GOBP_Exocytosis	Human	Uterus	rep_26	5.1e-10
GM2A	GOBP_Lipid_Localization	Human	Uterus	rep_26	3.7e-10
GM2A	GOBP_Liposaccharide_Metabolic_Process	Human	Uterus	rep_26	7.7e-10
GM2A	GOBP_Myeloid_Leukocyte_Activation	Human	Uterus	rep_26	1.4e-11
GM2A	GOBP_Nervous_System_Process	Human	Uterus	rep_26	2.3e-07
GM2A	GOBP_Neuromuscular_Process	Human	Uterus	rep_26	3.9e-09
GM2A	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
GM2A	GOBP_Cell_Activation	Human	Uterus	rep_28	2.5e-06
GM2A	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Uterus	rep_28	8.7e-06
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
GM2A	GOBP_Ceramide_Metabolic_Process	Human	Breast	rep_1	7.4e-07
GM2A	GOBP_Exocytosis	Human	Breast	rep_1	2.8e-29
GM2A	GOBP_Lipid_Storage	Human	Breast	rep_1	1.1e-11
GM2A	GOBP_Maintenance_Of_Location	Human	Breast	rep_1	3.8e-39
GM2A	GOBP_Myeloid_Leukocyte_Activation	Human	Breast	rep_1	2.2e-37
GM2A	GOBP_Nervous_System_Process	Human	Breast	rep_1	1.2e-04
GM2A	GOBP_Neuromuscular_Process	Human	Breast	rep_1	4.3e-06
GM2A	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_1	7.8e-04
GM2A	GOBP_Secretion	Human	Breast	rep_1	9.7e-57
GM2A	GOBP_Behavior	Human	Breast	rep_5	3.9e-08
GM2A	GOBP_Carbohydrate_Derivative_Catabolic_Process	Human	Breast	rep_5	1.1e-09
GM2A	GOBP_Carbohydrate_Metabolic_Process	Human	Breast	rep_5	3.5e-10
GM2A	GOBP_Cellular_Lipid_Metabolic_Process	Human	Breast	rep_5	2.6e-07
GM2A	GOBP_Ceramide_Catabolic_Process	Human	Breast	rep_5	6.1e-05
GM2A	GOBP_Ganglioside_Catabolic_Process	Human	Breast	rep_5	9.9e-17
GM2A	GOBP_Ganglioside_Metabolic_Process	Human	Breast	rep_5	2.8e-07
GM2A	GOBP_Glycolipid_Catabolic_Process	Human	Breast	rep_5	3.1e-05
GM2A	GOBP_Glycosphingolipid_Metabolic_Process	Human	Breast	rep_5	4.6e-15
GM2A	GOBP_Lipid_Localization	Human	Breast	rep_5	1.4e-06
GM2A	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
GM2A	GOBP_Liposaccharide_Metabolic_Process	Human	Breast	rep_5	1.8e-11
GM2A	GOBP_Membrane_Lipid_Catabolic_Process	Human	Breast	rep_5	4.9e-09
GM2A	GOBP_Membrane_Lipid_Metabolic_Process	Human	Breast	rep_5	1.9e-17
GM2A	GOBP_Neuromuscular_Process_Controlling_Balance	Human	Breast	rep_5	1.5e-10
GM2A	GOBP_Oligosaccharide_Catabolic_Process	Human	Breast	rep_5	3.9e-10
GM2A	GOBP_Oligosaccharide_Metabolic_Process	Human	Breast	rep_5	5.3e-07
GM2A	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
GM2A	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
GM2A	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
GM2A	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
GM2A	GOBP_Cellular_Lipid_Catabolic_Process	Human	Breast	rep_6	3.6e-11
GM2A	GOBP_Lipid_Catabolic_Process	Human	Breast	rep_6	2.9e-05
GM2A	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
GM2A	GOBP_Sphingolipid_Metabolic_Process	Human	Breast	rep_6	3.0e-06
GM2A	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Skin	P10_rep2	1.1e-22
GM2A	GOBP_Cell_Activation	Human	Lung	rep_1	2.1e-08
GM2A	GOBP_Ganglioside_Metabolic_Process	Human	Lung	rep_1	8.3e-07
GM2A	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
GM2A	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Lung	rep_2	8.0e-10
GM2A	GOBP_Lipid_Catabolic_Process	Human	Lung	rep_2	1.4e-09
GM2A	GOBP_Lipid_Storage	Human	Lung	rep_2	1.4e-07
GM2A	GOBP_Maintenance_Of_Location	Human	Lung	rep_2	1.1e-08
GM2A	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_2	7.9e-07

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GM2A function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GM2A function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GM2A envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GM2A

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GM2A	P17900	DB03017	Lauric acid	Ganglioside GM2 activator	SmallMoleculeDrug	approved\|experimental

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Related Diseases for GM2A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
GM2A	C0268275	Tay-Sachs Disease, AB Variant	6	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
GM2A	C0036572	Seizures	1	GENOMICS_ENGLAND
GM2A	C0039373	Tay-Sachs Disease	1	GENOMICS_ENGLAND