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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GLS (spascer ID:2744)

Gene summary for GLS

Gene summary

Gene information
	Species	Human
	Gene symbol	GLS
	Gene ID	2744
	Gene name	glutaminase
	Synonyms	AAD20\|CASGID\|DEE71\|EIEE71\|GAC\|GAM\|GDPAG\|GLS1\|KGA
	Cytomap	2q32.2
	Type of gene	protein-coding
	Description	glutaminase kidney isoform, mitochondrialK-glutaminaseL-glutamine amidohydrolaseglutaminase Cglutaminase, phosphate-activated
	Modification date	20220513
	UniProtAcc	O94925

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GLS	GO:0004359	glutaminase activity	21873635	Function
GLS	GO:0006537	glutamate biosynthetic process	21873635	Process
GLS	GO:0006543	glutamine catabolic process	21873635	Process

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Spatial pattern events for GLS

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GLS	Human	Brain	rep_5	33558695	6.82e-07
GLS	Human	Brain	rep_6	33558695	1.81e-06
GLS	Human	Brain	rep_7	33558695	7.92e-07
GLS	Human	Brain	rep_9	33558695	3.01e-15
GLS	Human	Brain	rep_10	33558695	3.23e-15
GLS	Human	Brain	rep_11	33558695	3.73e-11
GLS	Human	Brain	rep_12	33558695	3.65e-15
GLS	Human	Intestine	rep_colon1	34417225	1.95e-15
GLS	Human	Intestine	rep_colon2	34417225	5.82e-09
GLS	Human	Intestine	rep_colon4	34417225	1.14e-15
GLS	Human	Liver	rep_liver1	34417225	1.08e-15
GLS	Human	Liver	rep_liver2	34417225	6.98e-16
GLS	Human	Liver	rep_liver4	34417225	7.71e-16
GLS	Human	Intestine	A6	33406409	1.52e-12
GLS	Human	Uterus	rep_3	34857954	3.02e-15
GLS	Human	Breast	G1	34650042	1.92e-08
GLS	Human	Breast	1142243F	34493872	2.30e-15
GLS	Human	Breast	CID44971	34493872	1.32e-06
GLS	Human	Breast	CID4535	34493872	1.92e-07
GLS	Human	Skin	P2_rep1	32946785	2.19e-13
GLS	Human	Skin	P2_rep3	32946785	5.09e-11
GLS	Human	Lung	rep_1	35355018	4.48e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_5_H&E
Brain_rep_6_H&E
Brain_rep_7_H&E
Brain_rep_9_H&E
Brain_rep_10_H&E
Brain_rep_11_H&E
Brain_rep_12_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Intestine_A6_H&E
Uterus_rep_3_H&E
Breast_G1_H&E
Breast_1142243F_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Skin_P2_rep3_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has GLS envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GLS	GOBP_Glutamate_Biosynthetic_Process	Human	Bladder	rep_2	1.2e-08
GLS	GOBP_Glutamate_Homeostasis	Human	Bladder	rep_2	6.2e-04
GLS	GOBP_Amino_Acid_Transport	Human	Intestine	A3	1.3e-07
GLS	GOBP_Behavior	Human	Intestine	A3	1.8e-11
GLS	GOBP_Cell_Cell_Signaling	Human	Intestine	A3	6.4e-08
GLS	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
GLS	GOBP_Nervous_System_Process	Human	Intestine	A3	9.7e-07
GLS	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
GLS	GOBP_Secretion	Human	Intestine	A3	1.8e-13
GLS	GOBP_Suckling_Behavior	Human	Intestine	A3	4.5e-09
GLS	GOBP_Synaptic_Signaling	Human	Intestine	A3	5.0e-10
GLS	GOBP_Acidic_Amino_Acid_Transport	Human	Intestine	A8	6.2e-22
GLS	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Intestine	A8	7.0e-13
GLS	GOBP_Amino_Acid_Homeostasis	Human	Intestine	A8	1.0e-07
GLS	GOBP_Anion_Homeostasis	Human	Intestine	A8	4.2e-11
GLS	GOBP_Carboxylic_Acid_Transport	Human	Intestine	A8	4.8e-16
GLS	GOBP_Cellular_Amino_Acid_Biosynthetic_Process	Human	Intestine	A8	3.7e-12
GLS	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Intestine	A8	2.5e-14
GLS	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Intestine	A8	5.3e-13
GLS	GOBP_Chemical_Homeostasis	Human	Intestine	A8	1.3e-12
GLS	GOBP_Dicarboxylic_Acid_Metabolic_Process	Human	Intestine	A8	2.6e-15
GLS	GOBP_Dicarboxylic_Acid_Transport	Human	Intestine	A8	1.1e-15
GLS	GOBP_Fatty_Acid_Transport	Human	Intestine	A8	3.0e-08
GLS	GOBP_Feeding_Behavior	Human	Intestine	A8	3.2e-15
GLS	GOBP_Glutamate_Biosynthetic_Process	Human	Intestine	A8	1.2e-20
GLS	GOBP_Glutamate_Homeostasis	Human	Intestine	A8	1.0e-08
GLS	GOBP_Glutamate_Secretion	Human	Intestine	A8	7.7e-11
GLS	GOBP_Glutamine_Family_Amino_Acid_Metabolic_Process	Human	Intestine	A8	4.2e-08
GLS	GOBP_Glutamine_Metabolic_Process	Human	Intestine	A8	6.1e-09
GLS	GOBP_Ion_Homeostasis	Human	Intestine	A8	6.1e-15
GLS	GOBP_Lipid_Localization	Human	Intestine	A8	2.5e-15
GLS	GOBP_Monocarboxylic_Acid_Transport	Human	Intestine	A8	7.2e-16
GLS	GOBP_Organic_Acid_Biosynthetic_Process	Human	Intestine	A8	2.1e-08
GLS	GOBP_Organic_Acid_Catabolic_Process	Human	Intestine	A8	1.6e-12
GLS	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
GLS	GOBP_Organic_Acid_Transport	Human	Intestine	A8	1.5e-15
GLS	GOBP_Organic_Anion_Transport	Human	Intestine	A8	3.5e-15
GLS	GOBP_Protein_Homotetramerization	Human	Intestine	A8	2.6e-12
GLS	GOBP_Protein_Tetramerization	Human	Intestine	A8	2.0e-12
GLS	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
GLS	GOBP_Small_Molecule_Catabolic_Process	Human	Intestine	A8	2.2e-13
GLS	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
GLS	GOBP_Acidic_Amino_Acid_Transport	Human	Pancreas	PDAC-B-st1	2.9e-05
GLS	GOBP_Amino_Acid_Transport	Human	Pancreas	PDAC-B-st1	3.8e-07
GLS	GOBP_Dicarboxylic_Acid_Transport	Human	Pancreas	PDAC-B-st1	4.8e-08
GLS	GOBP_Protein_Complex_Oligomerization	Human	Pancreas	PDAC-B-st1	8.7e-05
GLS	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Pancreas	PDAC-A-st2	9.6e-05
GLS	GOBP_Protein_Homotetramerization	Human	Uterus	rep_1	5.6e-07
GLS	GOBP_Acidic_Amino_Acid_Transport	Human	Uterus	rep_25	3.9e-07
GLS	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	1.2e-11
GLS	GOBP_Amino_Acid_Transport	Human	Uterus	rep_25	3.6e-06
GLS	GOBP_Dicarboxylic_Acid_Biosynthetic_Process	Human	Uterus	rep_25	8.4e-15
GLS	GOBP_Dicarboxylic_Acid_Transport	Human	Uterus	rep_25	1.3e-06
GLS	GOBP_Glutamate_Biosynthetic_Process	Human	Uterus	rep_25	6.0e-09
GLS	GOBP_Glutamate_Metabolic_Process	Human	Uterus	rep_25	3.2e-08
GLS	GOBP_Glutamine_Family_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	1.8e-06
GLS	GOBP_Glutamine_Metabolic_Process	Human	Uterus	rep_25	4.4e-06
GLS	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	1.6e-06
GLS	GOBP_Carboxylic_Acid_Transport	Human	Uterus	rep_26	9.1e-08
GLS	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Uterus	rep_26	3.2e-12
GLS	GOBP_Glutamine_Family_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	5.2e-08
GLS	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
GLS	GOBP_Lipid_Export_From_Cell	Human	Uterus	rep_26	5.7e-10
GLS	GOBP_Lipid_Localization	Human	Uterus	rep_26	3.7e-10
GLS	GOBP_Nervous_System_Process	Human	Uterus	rep_26	2.3e-07
GLS	GOBP_Organic_Acid_Biosynthetic_Process	Human	Uterus	rep_26	2.3e-06
GLS	GOBP_Organic_Acid_Catabolic_Process	Human	Uterus	rep_26	6.9e-09
GLS	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
GLS	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
GLS	GOBP_Regulation_Of_Respiratory_Gaseous_Exchange	Human	Uterus	rep_26	3.9e-06
GLS	GOBP_Regulation_Of_Respiratory_System_Process	Human	Uterus	rep_26	6.0e-08
GLS	GOBP_Regulation_Of_System_Process	Human	Uterus	rep_26	6.6e-10
GLS	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
GLS	GOBP_Small_Molecule_Catabolic_Process	Human	Uterus	rep_26	9.1e-13
GLS	GOBP_Synaptic_Signaling	Human	Uterus	rep_26	3.3e-08
GLS	GOBP_Protein_Tetramerization	Human	Uterus	rep_29	4.3e-07
GLS	GOBP_Chemical_Homeostasis	Human	Breast	rep_1	4.8e-18
GLS	GOBP_Glutamate_Secretion	Human	Breast	rep_1	4.8e-12
GLS	GOBP_Glutamine_Family_Amino_Acid_Catabolic_Process	Human	Breast	rep_1	5.6e-18
GLS	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
GLS	GOBP_Ion_Homeostasis	Human	Breast	rep_1	1.4e-53
GLS	GOBP_Nervous_System_Process	Human	Breast	rep_1	1.2e-04
GLS	GOBP_Protein_Complex_Oligomerization	Human	Breast	rep_1	1.7e-04
GLS	GOBP_Protein_Homotetramerization	Human	Breast	rep_1	5.2e-07
GLS	GOBP_Regulation_Of_System_Process	Human	Breast	rep_1	1.0e-09
GLS	GOBP_Respiratory_Gaseous_Exchange_By_Respiratory_System	Human	Breast	rep_1	2.3e-22
GLS	GOBP_Respiratory_System_Process	Human	Breast	rep_1	9.0e-55
GLS	GOBP_Secretion	Human	Breast	rep_1	9.7e-57
GLS	GOBP_Synaptic_Signaling	Human	Breast	rep_1	3.5e-04
GLS	GOBP_Anion_Homeostasis	Human	Breast	rep_4	3.6e-07
GLS	GOBP_Acidic_Amino_Acid_Transport	Human	Breast	rep_5	2.0e-13
GLS	GOBP_Amino_Acid_Transport	Human	Breast	rep_5	1.8e-19
GLS	GOBP_Behavior	Human	Breast	rep_5	3.9e-08
GLS	GOBP_Carboxylic_Acid_Transport	Human	Breast	rep_5	5.4e-12
GLS	GOBP_Dicarboxylic_Acid_Transport	Human	Breast	rep_5	2.9e-10
GLS	GOBP_Feeding_Behavior	Human	Breast	rep_5	9.3e-09
GLS	GOBP_Glutamate_Biosynthetic_Process	Human	Breast	rep_5	2.7e-05
GLS	GOBP_Glutamate_Homeostasis	Human	Breast	rep_5	3.0e-04
GLS	GOBP_Glutamate_Metabolic_Process	Human	Breast	rep_5	3.1e-12
GLS	GOBP_Glutamine_Family_Amino_Acid_Biosynthetic_Process	Human	Breast	rep_5	4.2e-14
GLS	GOBP_Lipid_Localization	Human	Breast	rep_5	1.4e-06
GLS	GOBP_Organic_Acid_Biosynthetic_Process	Human	Breast	rep_5	3.5e-09
GLS	GOBP_Organic_Anion_Transport	Human	Breast	rep_5	9.5e-10
GLS	GOBP_Suckling_Behavior	Human	Breast	rep_5	7.9e-11
GLS	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	2.6e-05
GLS	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.7e-08
GLS	GOBP_Cell_Cell_Signaling	Human	Breast	rep_6	5.0e-05
GLS	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	1.6e-05
GLS	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.0e-10
GLS	GOBP_Fatty_Acid_Transport	Human	Breast	rep_6	3.1e-06
GLS	GOBP_Lipid_Export_From_Cell	Human	Breast	rep_6	1.9e-12
GLS	GOBP_Monocarboxylic_Acid_Transport	Human	Breast	rep_6	1.9e-12
GLS	GOBP_Organic_Acid_Catabolic_Process	Human	Breast	rep_6	1.5e-11
GLS	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
GLS	GOBP_Organic_Acid_Transport	Human	Breast	rep_6	9.3e-09
GLS	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
GLS	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
GLS	GOBP_Regulation_Of_Respiratory_Gaseous_Exchange	Human	Breast	rep_6	1.7e-04
GLS	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
GLS	GOBP_Small_Molecule_Catabolic_Process	Human	Breast	rep_6	4.7e-07
GLS	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
GLS	GOBP_Fatty_Acid_Transport	Human	Skin	P2_rep2	1.4e-08
GLS	GOBP_Glutamate_Biosynthetic_Process	Human	Skin	P2_rep2	8.1e-08
GLS	GOBP_Carboxylic_Acid_Transport	Human	Skin	P5_rep1	3.2e-08
GLS	GOBP_Respiratory_Gaseous_Exchange_By_Respiratory_System	Human	Skin	P5_rep1	1.9e-10
GLS	GOBP_Respiratory_System_Process	Human	Skin	P5_rep1	9.4e-12
GLS	GOBP_Glutamate_Homeostasis	Human	Skin	P5_rep2	4.9e-08
GLS	GOBP_Suckling_Behavior	Human	Skin	P5_rep3	1.7e-10
GLS	GOBP_Lipid_Export_From_Cell	Human	Skin	P10_rep1	1.4e-24
GLS	GOBP_Protein_Homooligomerization	Human	Skin	P10_rep1	9.8e-09
GLS	GOBP_Glutamate_Secretion	Human	Skin	P10_rep2	9.6e-17
GLS	GOBP_Glutamine_Family_Amino_Acid_Biosynthetic_Process	Human	Skin	P10_rep2	1.3e-12
GLS	GOBP_Regulation_Of_Respiratory_Gaseous_Exchange	Human	Skin	P10_rep2	8.4e-14
GLS	GOBP_Dicarboxylic_Acid_Transport	Human	Lung	rep_1	8.0e-07
GLS	GOBP_Ion_Homeostasis	Human	Lung	rep_1	6.1e-07

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GLS function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GLS function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GLS envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GLS

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GLS	O94925	DB00142	Glutamic acid	Glutaminase kidney isoform, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical

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Related Diseases for GLS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
GLS	C0000786	Spontaneous abortion	1	CTD_human
GLS	C0000822	Abortion, Tubal	1	CTD_human
GLS	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
GLS	C0029408	Degenerative polyarthritis	1	CTD_human
GLS	C0086743	Osteoarthrosis Deformans	1	CTD_human
GLS	C3830362	Early Pregnancy Loss	1	CTD_human
GLS	C4552766	Miscarriage	1	CTD_human