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Spatial pattern gene: GLO1 (spascer ID:2739) |
Gene summary for GLO1 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | GLO1 | Gene ID | 2739 |
| Gene name | glyoxalase I |
| Synonyms | GLOD1|GLYI|HEL-S-74 |
| Cytomap | 6p21.2 |
| Type of gene | protein-coding |
| Description | lactoylglutathione lyaseS-D-lactoylglutathione methylglyoxal lyasealdoketomutaseepididymis secretory protein Li 74glx Iglyoxalase domain containing 1ketone-aldehyde mutaselactoyl glutathione lyasemethylglyoxalase |
| Modification date | 20220513 |
| UniProtAcc | Q04760 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
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Spatial pattern events for GLO1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| GLO1 | Human | Bladder | rep_2 | 34385456 | 5.16e-10 |
| GLO1 | Human | Intestine | rep_colon2 | 34417225 | 7.08e-11 |
| GLO1 | Human | Intestine | rep_colon4 | 34417225 | 2.06e-15 |
| GLO1 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| GLO1 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| GLO1 | Human | Liver | rep_liver4 | 34417225 | 3.21e-08 |
| GLO1 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| GLO1 | Human | Breast | 1142243F | 34493872 | 4.15e-15 |
| GLO1 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| GLO1 | Human | Breast | CID4535 | 34493872 | 8.03e-14 |
| GLO1 | Human | Skin | P2_rep3 | 32946785 | 5.99e-09 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_2_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID4535_H&E  |  |
Skin_P2_rep3_H&E  |  |
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Spatial pattern pathway has GLO1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| GLO1 | GOBP_Carbohydrate_Metabolic_Process | Human | Intestine | A3 | 4.1e-08 |
| GLO1 | GOBP_Immune_System_Development | Human | Intestine | A3 | 4.3e-10 |
| GLO1 | GOBP_Leukocyte_Differentiation | Human | Intestine | A3 | 2.0e-07 |
| GLO1 | GOBP_Negative_Regulation_Of_Cell_Death | Human | Intestine | A3 | 5.8e-14 |
| GLO1 | GOBP_Regulation_Of_Cell_Death | Human | Intestine | A3 | 7.1e-10 |
| GLO1 | GOBP_Cellular_Aldehyde_Metabolic_Process | Human | Intestine | A8 | 5.5e-08 |
| GLO1 | GOBP_Cellular_Ketone_Metabolic_Process | Human | Intestine | A8 | 1.2e-11 |
| GLO1 | GOBP_Cellular_Modified_Amino_Acid_Metabolic_Process | Human | Intestine | A8 | 5.4e-11 |
| GLO1 | GOBP_Glutathione_Metabolic_Process | Human | Intestine | A8 | 1.5e-09 |
| GLO1 | GOBP_Methylglyoxal_Metabolic_Process | Human | Intestine | A8 | 2.4e-11 |
| GLO1 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Human | Intestine | A8 | 7.3e-16 |
| GLO1 | GOBP_Myeloid_Cell_Differentiation | Human | Intestine | A8 | 1.2e-21 |
| GLO1 | GOBP_Myeloid_Leukocyte_Differentiation | Human | Intestine | A8 | 2.2e-14 |
| GLO1 | GOBP_Organic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.5e-18 |
| GLO1 | GOBP_Osteoclast_Differentiation | Human | Intestine | A8 | 7.2e-43 |
| GLO1 | GOBP_Pyruvate_Metabolic_Process | Human | Intestine | A8 | 1.4e-20 |
| GLO1 | GOBP_Small_Molecule_Metabolic_Process | Human | Intestine | A8 | 2.1e-15 |
| GLO1 | GOBP_Sulfur_Compound_Metabolic_Process | Human | Intestine | A8 | 2.5e-14 |
| GLO1 | GOBP_Glutathione_Metabolic_Process | Human | Uterus | rep_25 | 1.3e-13 |
| GLO1 | GOBP_Cellular_Aldehyde_Metabolic_Process | Human | Uterus | rep_26 | 1.2e-06 |
| GLO1 | GOBP_Cellular_Ketone_Metabolic_Process | Human | Uterus | rep_26 | 3.2e-13 |
| GLO1 | GOBP_Cellular_Modified_Amino_Acid_Metabolic_Process | Human | Uterus | rep_26 | 8.7e-10 |
| GLO1 | GOBP_Immune_System_Development | Human | Uterus | rep_26 | 1.0e-06 |
| GLO1 | GOBP_Leukocyte_Differentiation | Human | Uterus | rep_26 | 1.4e-08 |
| GLO1 | GOBP_Organic_Acid_Metabolic_Process | Human | Uterus | rep_26 | 4.9e-06 |
| GLO1 | GOBP_Pyruvate_Metabolic_Process | Human | Uterus | rep_26 | 1.3e-06 |
| GLO1 | GOBP_Sulfur_Compound_Metabolic_Process | Human | Uterus | rep_26 | 8.8e-08 |
| GLO1 | GOBP_Myeloid_Cell_Differentiation | Human | Uterus | rep_29 | 2.6e-10 |
| GLO1 | GOBP_Myeloid_Leukocyte_Differentiation | Human | Uterus | rep_29 | 1.2e-06 |
| GLO1 | GOBP_Cellular_Ketone_Metabolic_Process | Human | Breast | rep_1 | 6.1e-19 |
| GLO1 | GOBP_Cellular_Modified_Amino_Acid_Metabolic_Process | Human | Breast | rep_1 | 2.3e-10 |
| GLO1 | GOBP_Glutathione_Metabolic_Process | Human | Breast | rep_1 | 2.1e-10 |
| GLO1 | GOBP_Immune_System_Development | Human | Breast | rep_1 | 1.0e-31 |
| GLO1 | GOBP_Myeloid_Cell_Differentiation | Human | Breast | rep_1 | 1.6e-14 |
| GLO1 | GOBP_Myeloid_Leukocyte_Differentiation | Human | Breast | rep_1 | 1.2e-77 |
| GLO1 | GOBP_Osteoclast_Differentiation | Human | Breast | rep_1 | 1.7e-80 |
| GLO1 | GOBP_Carbohydrate_Metabolic_Process | Human | Breast | rep_5 | 3.5e-10 |
| GLO1 | GOBP_Negative_Regulation_Of_Cell_Death | Human | Breast | rep_5 | 1.9e-07 |
| GLO1 | GOBP_Regulation_Of_Cell_Death | Human | Breast | rep_5 | 9.8e-08 |
| GLO1 | GOBP_Cellular_Aldehyde_Metabolic_Process | Human | Breast | rep_6 | 3.0e-09 |
| GLO1 | GOBP_Cellular_Amide_Metabolic_Process | Human | Breast | rep_6 | 5.6e-05 |
| GLO1 | GOBP_Methylglyoxal_Metabolic_Process | Human | Breast | rep_6 | 9.4e-07 |
| GLO1 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.1e-07 |
| GLO1 | GOBP_Organic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.7e-05 |
| GLO1 | GOBP_Peptide_Metabolic_Process | Human | Breast | rep_6 | 8.7e-05 |
| GLO1 | GOBP_Pyruvate_Metabolic_Process | Human | Breast | rep_6 | 1.0e-04 |
| GLO1 | GOBP_Small_Molecule_Metabolic_Process | Human | Breast | rep_6 | 5.5e-09 |
| GLO1 | GOBP_Sulfur_Compound_Metabolic_Process | Human | Breast | rep_6 | 3.0e-10 |
| GLO1 | GOBP_Leukocyte_Differentiation | Human | Lung | rep_1 | 9.7e-07 |
| GLO1 | GOBP_Myeloid_Cell_Differentiation | Human | Lung | rep_1 | 8.1e-08 |
| GLO1 | GOBP_Cellular_Ketone_Metabolic_Process | Human | Lung | rep_2 | 2.1e-09 |
| GLO1 | GOBP_Immune_System_Development | Human | Lung | rep_2 | 7.9e-07 |
| GLO1 | GOBP_Osteoclast_Differentiation | Human | Lung | rep_2 | 9.5e-08 |
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GLO1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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GLO1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for GLO1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for GLO1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| GLO1 | Q04760 | DB00328 | Indomethacin | Lactoylglutathione lyase | SmallMoleculeDrug | approved|investigational |
| GLO1 | Q04760 | DB00143 | Glutathione | Lactoylglutathione lyase | SmallMoleculeDrug | approved|investigational|nutraceutical |
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Related Diseases for GLO1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| GLO1 | C0011570 | Mental Depression | 2 | PSYGENET |
| GLO1 | C0011581 | Depressive disorder | 2 | CTD_human;PSYGENET |
| GLO1 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| GLO1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| GLO1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| GLO1 | C0011573 | Endogenous depression | 1 | CTD_human |
| GLO1 | C0025193 | Melancholia | 1 | CTD_human |
| GLO1 | C0025202 | melanoma | 1 | CTD_human |
| GLO1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| GLO1 | C0041696 | Unipolar Depression | 1 | CTD_human |
| GLO1 | C0086133 | Depressive Syndrome | 1 | CTD_human |
| GLO1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| GLO1 | C0282126 | Depression, Neurotic | 1 | CTD_human |
| GLO1 | C0376280 | Anxiety States, Neurotic | 1 | CTD_human |
| GLO1 | C1279420 | Anxiety neurosis (finding) | 1 | CTD_human |
