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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GLE1 (spascer ID:2733)

Gene summary for GLE1

Gene summary

Gene information
	Species	Human
	Gene symbol	GLE1
	Gene ID	2733
	Gene name	GLE1 RNA export mediator
	Synonyms	CAAHC\|CAAHD\|GLE1L\|LCCS\|LCCS1\|hGLE1
	Cytomap	9q34.11
	Type of gene	protein-coding
	Description	mRNA export factor GLE1GLE1 RNA export mediator homologGLE1-like proteinGLE1-like, RNA export mediatornucleoporin GLE1
	Modification date	20220513
	UniProtAcc	Q53GS7

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GLE1	GO:0000822	inositol hexakisphosphate binding	21873635	Function
GLE1	GO:0005543	phospholipid binding	21873635	Function
GLE1	GO:0005737	cytoplasm	21873635	Component
GLE1	GO:0006406	mRNA export from nucleus	21873635	Process
GLE1	GO:0006446	regulation of translational initiation	21873635	Process
GLE1	GO:0006449	regulation of translational termination	21873635	Process
GLE1	GO:0031369	translation initiation factor binding	21873635	Function
GLE1	GO:0044614	nuclear pore cytoplasmic filaments	21873635	Component

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Spatial pattern events for GLE1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GLE1	Human	Liver	rep_liver1	34417225	1.08e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E

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Spatial pattern pathway has GLE1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GLE1	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
GLE1	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
GLE1	GOBP_Regulation_Of_Translational_Termination	Human	Intestine	A1	2.8e-11
GLE1	GOBP_Translational_Termination	Human	Intestine	A1	3.9e-07
GLE1	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
GLE1	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
GLE1	GOBP_Establishment_Of_Protein_Localization	Human	Intestine	A3	5.0e-10
GLE1	GOBP_Establishment_Of_Rna_Localization	Human	Intestine	A3	9.7e-11
GLE1	GOBP_Intracellular_Protein_Transport	Human	Intestine	A3	4.8e-12
GLE1	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
GLE1	GOBP_Mrna_Export_From_Nucleus	Human	Intestine	A3	9.9e-15
GLE1	GOBP_Mrna_Transport	Human	Intestine	A3	6.6e-09
GLE1	GOBP_Nuclear_Export	Human	Intestine	A3	3.6e-07
GLE1	GOBP_Nuclear_Transport	Human	Intestine	A3	5.6e-10
GLE1	GOBP_Nucleobase_Containing_Compound_Transport	Human	Intestine	A3	2.5e-11
GLE1	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
GLE1	GOBP_Protein_Containing_Complex_Localization	Human	Intestine	A3	6.4e-12
GLE1	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
GLE1	GOBP_Regulation_Of_Translational_Initiation	Human	Intestine	A3	9.4e-12
GLE1	GOBP_Rna_Export_From_Nucleus	Human	Intestine	A3	3.3e-10
GLE1	GOBP_Rna_Localization	Human	Intestine	A3	1.4e-08
GLE1	GOBP_Translational_Initiation	Human	Intestine	A3	5.0e-09
GLE1	GOBP_Rna_Export_From_Nucleus	Human	Pancreas	PDAC-B-st1	6.7e-05
GLE1	GOBP_Mrna_Export_From_Nucleus	Human	Pancreas	PDAC-A-st2	3.9e-08
GLE1	GOBP_Regulation_Of_Translational_Termination	Human	Uterus	rep_1	6.5e-09
GLE1	GOBP_Translational_Termination	Human	Uterus	rep_1	5.2e-09
GLE1	GOBP_Nuclear_Export	Human	Uterus	rep_25	7.4e-11
GLE1	GOBP_Nuclear_Transport	Human	Uterus	rep_25	2.3e-13
GLE1	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
GLE1	GOBP_Establishment_Of_Rna_Localization	Human	Uterus	rep_26	8.7e-07
GLE1	GOBP_Mrna_Export_From_Nucleus	Human	Uterus	rep_26	3.9e-08
GLE1	GOBP_Poly_A_Plus_Mrna_Export_From_Nucleus	Human	Uterus	rep_26	4.0e-07
GLE1	GOBP_Rna_Export_From_Nucleus	Human	Uterus	rep_26	3.8e-10
GLE1	GOBP_Rna_Localization	Human	Uterus	rep_26	1.2e-09
GLE1	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
GLE1	GOBP_Establishment_Of_Protein_Localization	Human	Breast	rep_1	7.2e-05
GLE1	GOBP_Regulation_Of_Protein_Containing_Complex_Disassembly	Human	Breast	rep_1	1.1e-29
GLE1	GOBP_Regulation_Of_Translational_Termination	Human	Breast	rep_1	2.9e-14
GLE1	GOBP_Translational_Termination	Human	Breast	rep_1	7.0e-06
GLE1	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
GLE1	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
GLE1	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
GLE1	GOBP_Intracellular_Protein_Transport	Human	Breast	rep_6	6.4e-12
GLE1	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
GLE1	GOBP_Mrna_Export_From_Nucleus	Human	Breast	rep_6	1.1e-04
GLE1	GOBP_Mrna_Transport	Human	Breast	rep_6	1.9e-10
GLE1	GOBP_Nuclear_Export	Human	Breast	rep_6	1.4e-05
GLE1	GOBP_Nuclear_Transport	Human	Breast	rep_6	3.1e-08
GLE1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
GLE1	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
GLE1	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
GLE1	GOBP_Protein_Containing_Complex_Disassembly	Human	Breast	rep_6	1.0e-13
GLE1	GOBP_Protein_Containing_Complex_Localization	Human	Breast	rep_6	1.3e-06
GLE1	GOBP_Regulation_Of_Translational_Initiation	Human	Breast	rep_6	6.5e-06
GLE1	GOBP_Rna_Export_From_Nucleus	Human	Breast	rep_6	9.6e-09
GLE1	GOBP_Rna_Localization	Human	Breast	rep_6	7.7e-05
GLE1	GOBP_Translational_Initiation	Human	Breast	rep_6	2.2e-09
GLE1	GOBP_Nuclear_Transport	Human	Skin	P5_rep1	5.0e-19
GLE1	GOBP_Regulation_Of_Translational_Termination	Human	Skin	P10_rep1	2.1e-12
GLE1	GOBP_Translational_Termination	Human	Skin	P10_rep1	6.7e-10
GLE1	GOBP_Poly_A_Plus_Mrna_Export_From_Nucleus	Human	Skin	P10_rep2	1.4e-12
GLE1	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07

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GLE1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GLE1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GLE1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GLE1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GLE1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
GLE1	C1854664	LETHAL CONGENITAL CONTRACTURE SYNDROME 1	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
GLE1	C2678471	Lethal Arthrogryposis With Anterior Horn Cell Disease	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
GLE1	C0002736	Amyotrophic Lateral Sclerosis	1	ORPHANET