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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GLDC (spascer ID:2731)

Gene summary for GLDC

Gene summary

Gene information
	Species	Human
	Gene symbol	GLDC
	Gene ID	2731
	Gene name	glycine decarboxylase
	Synonyms	GCE\|GCSP\|HYGN1
	Cytomap	9p24.1
	Type of gene	protein-coding
	Description	glycine dehydrogenase (decarboxylating), mitochondrialglycine cleavage system protein Pglycine decarboxylase P-proteinglycine dehydrogenase (aminomethyl-transferring)glycine dehydrogenase [decarboxylating], mitochondrialnonketotic hyperglycinemia
	Modification date	20220513
	UniProtAcc	P23378

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GLDC	GO:0004375	glycine dehydrogenase (decarboxylating) activity	21873635	Function
GLDC	GO:0005739	mitochondrion	21873635	Component
GLDC	GO:0005960	glycine cleavage complex	21873635	Component
GLDC	GO:0016594	glycine binding	21873635	Function
GLDC	GO:0019464	glycine decarboxylation via glycine cleavage system	21873635	Process
GLDC	GO:0030170	pyridoxal phosphate binding	21873635	Function

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Spatial pattern events for GLDC

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GLDC	Human	Liver	rep_liver1	34417225	1.08e-15
GLDC	Human	Liver	rep_liver3	34417225	8.17e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Liver_rep_liver3_H&E

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Spatial pattern pathway has GLDC envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GLDC	GOBP_Response_To_Lipid	Human	Brain	rep_10	2.8e-23
GLDC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
GLDC	GOBP_Electron_Transport_Chain	Human	Bladder	rep_4	1.0e-20
GLDC	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Bladder	rep_4	3.4e-12
GLDC	GOBP_Response_To_Lipid	Human	Liver	rep_1	3.0e-55
GLDC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
GLDC	GOBP_Response_To_Lipid	Human	Intestine	rep_liver2	3.7e-39
GLDC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
GLDC	GOBP_Electron_Transport_Chain	Human	Intestine	A3	1.4e-19
GLDC	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Intestine	A3	4.3e-14
GLDC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
GLDC	GOBP_Response_To_Amine	Human	Intestine	A3	1.7e-13
GLDC	GOBP_Response_To_Lipid	Human	Intestine	A3	1.7e-09
GLDC	GOBP_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	3.2e-15
GLDC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
GLDC	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Intestine	A8	7.0e-13
GLDC	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Intestine	A8	2.5e-14
GLDC	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Intestine	A8	5.3e-13
GLDC	GOBP_Glycine_Metabolic_Process	Human	Intestine	A8	8.7e-08
GLDC	GOBP_Organic_Acid_Catabolic_Process	Human	Intestine	A8	1.6e-12
GLDC	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
GLDC	GOBP_Response_To_Nitrogen_Compound	Human	Intestine	A8	1.3e-12
GLDC	GOBP_Serine_Family_Amino_Acid_Metabolic_Process	Human	Intestine	A8	2.7e-10
GLDC	GOBP_Small_Molecule_Catabolic_Process	Human	Intestine	A8	2.2e-13
GLDC	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
GLDC	GOBP_Response_To_Fatty_Acid	Human	Pancreas	PDAC-B-st1	7.6e-06
GLDC	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Pancreas	PDAC-A-st2	9.6e-05
GLDC	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	1.2e-11
GLDC	GOBP_Glycine_Metabolic_Process	Human	Uterus	rep_25	2.9e-20
GLDC	GOBP_Serine_Family_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	9.3e-07
GLDC	GOBP_Serine_Family_Amino_Acid_Metabolic_Process	Human	Uterus	rep_25	6.9e-10
GLDC	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	1.6e-06
GLDC	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Uterus	rep_26	3.2e-12
GLDC	GOBP_Electron_Transport_Chain	Human	Uterus	rep_26	1.9e-08
GLDC	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Uterus	rep_26	1.8e-06
GLDC	GOBP_Organic_Acid_Catabolic_Process	Human	Uterus	rep_26	6.9e-09
GLDC	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
GLDC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
GLDC	GOBP_Response_To_Fatty_Acid	Human	Uterus	rep_26	2.0e-13
GLDC	GOBP_Small_Molecule_Catabolic_Process	Human	Uterus	rep_26	9.1e-13
GLDC	GOBP_Response_To_Fatty_Acid	Human	Breast	rep_1	3.3e-11
GLDC	GOBP_Electron_Transport_Chain	Human	Breast	rep_5	6.2e-04
GLDC	GOBP_Response_To_Lipid	Human	Breast	rep_5	1.6e-10
GLDC	GOBP_Response_To_Nitrogen_Compound	Human	Breast	rep_5	1.1e-11
GLDC	GOBP_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	7.5e-14
GLDC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
GLDC	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	2.6e-05
GLDC	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.7e-08
GLDC	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	1.6e-05
GLDC	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.0e-10
GLDC	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Breast	rep_6	7.1e-09
GLDC	GOBP_Glycine_Metabolic_Process	Human	Breast	rep_6	6.1e-04
GLDC	GOBP_Organic_Acid_Catabolic_Process	Human	Breast	rep_6	1.5e-11
GLDC	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
GLDC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
GLDC	GOBP_Response_To_Amine	Human	Breast	rep_6	1.4e-04
GLDC	GOBP_Serine_Family_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	5.3e-09
GLDC	GOBP_Small_Molecule_Catabolic_Process	Human	Breast	rep_6	4.7e-07
GLDC	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
GLDC	GOBP_Response_To_Amine	Human	Skin	P10_rep1	1.7e-14
GLDC	GOBP_Response_To_Lipid	Human	Lung	rep_1	1.8e-09
GLDC	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08

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GLDC function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GLDC function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GLDC envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GLDC

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
GLDC	P23378	DB00114	Pyridoxal phosphate	Glycine dehydrogenase (decarboxylating), mitochondrial	SmallMoleculeDrug	approved\|investigational\|nutraceutical

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Related Diseases for GLDC

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
GLDC	C0751748	Nonketotic Hyperglycinemia	18	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
GLDC	C0268561	Hyperglycinemia, Nonketotic, Type I	3	CTD_human
GLDC	C0268562	Hyperglycinemia, Nonketotic, Type II	3	CTD_human
GLDC	C0751747	Hyperglycinemia, Nonketotic, Type III	3	CTD_human
GLDC	C0036572	Seizures	1	GENOMICS_ENGLAND