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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GJB2 (spascer ID:2706)

Gene summary for GJB2

Gene summary

Gene information
	Species	Human
	Gene symbol	GJB2
	Gene ID	2706
	Gene name	gap junction protein beta 2
	Synonyms	BAPS\|CX26\|DFNA3\|DFNA3A\|DFNB1\|DFNB1A\|HID\|KID\|NSRD1\|PPK
	Cytomap	13q12.11
	Type of gene	protein-coding
	Description	gap junction beta-2 proteinconnexin 26gap junction beta 2 proteincgap junction protein, beta 2, 26kDamutant gap junction beta 2 proteinmutant gap junction protein beta 2
	Modification date	20220515
	UniProtAcc	P29033

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GJB2	GO:0005243	gap junction channel activity	21873635	Function
GJB2	GO:0005922	connexin complex	21873635	Component
GJB2	GO:0007267	cell-cell signaling	21873635	Process

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Spatial pattern events for GJB2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GJB2	Human	Bladder	rep_1	34385456	8.93e-15
GJB2	Human	Intestine	rep_colon1	34417225	1.19e-13
GJB2	Human	Liver	rep_liver1	34417225	1.08e-15
GJB2	Human	Liver	rep_liver2	34417225	4.16e-08
GJB2	Human	Breast	CID4290	34493872	1.59e-07
GJB2	Human	Breast	CID4465	34493872	2.76e-06
GJB2	Human	Skin	P2_rep1	32946785	5.41e-15
GJB2	Human	Skin	P2_rep2	32946785	5.48e-15
GJB2	Human	Skin	P2_rep3	32946785	5.90e-15
GJB2	Human	Skin	P5_rep1	32946785	1.32e-14
GJB2	Human	Skin	P5_rep2	32946785	9.66e-15
GJB2	Human	Skin	P5_rep3	32946785	7.99e-15
GJB2	Human	Skin	P9_rep1	32946785	1.20e-14
GJB2	Human	Skin	P9_rep2	32946785	5.77e-15
GJB2	Human	Skin	P9_rep3	32946785	3.66e-09
GJB2	Human	Skin	P10_rep1	32946785	4.80e-15
GJB2	Human	Skin	P10_rep2	32946785	5.10e-15
GJB2	Human	Skin	P10_rep3	32946785	9.21e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_1_H&E
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Breast_CID4290_H&E
Breast_CID4465_H&E
Skin_P2_rep3_H&E
Skin_P5_rep1_H&E
Skin_P5_rep2_H&E
Skin_P5_rep3_H&E
Skin_P9_rep1_H&E
Skin_P9_rep2_H&E
Skin_P9_rep3_H&E
Skin_P10_rep1_H&E
Skin_P10_rep2_H&E
Skin_P10_rep3_H&E

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Spatial pattern pathway has GJB2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GJB2	GOBP_Response_To_Bacterium	Human	Brain	rep_1	3.1e-16
GJB2	GOBP_Transmembrane_Transport	Human	Brain	rep_1	2.8e-23
GJB2	GOBP_Tube_Development	Human	Brain	rep_4	4.1e-17
GJB2	GOBP_Response_To_Endogenous_Stimulus	Human	Brain	rep_10	2.8e-23
GJB2	GOBP_Response_To_Hormone	Human	Brain	rep_10	2.8e-23
GJB2	GOBP_Response_To_Lipid	Human	Brain	rep_10	2.8e-23
GJB2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
GJB2	GOBP_Response_To_Ketone	Human	Brain	rep_11	2.5e-12
GJB2	GOBP_Cellular_Response_To_Glucagon_Stimulus	Human	Bladder	rep_2	2.7e-07
GJB2	GOBP_Response_To_Corticosteroid	Human	Bladder	rep_2	3.3e-18
GJB2	GOBP_Response_To_Estradiol	Human	Bladder	rep_2	1.6e-18
GJB2	GOBP_Response_To_Peptide	Human	Bladder	rep_2	2.3e-11
GJB2	GOBP_Response_To_Peptide_Hormone	Human	Bladder	rep_2	2.9e-13
GJB2	GOBP_Response_To_Retinoic_Acid	Human	Bladder	rep_2	1.8e-08
GJB2	GOBP_Sensory_Perception_Of_Mechanical_Stimulus	Human	Bladder	rep_2	1.4e-23
GJB2	GOBP_Response_To_Bacterium	Human	Liver	rep_1	9.4e-68
GJB2	GOBP_Response_To_Endogenous_Stimulus	Human	Liver	rep_1	3.0e-55
GJB2	GOBP_Response_To_Hormone	Human	Liver	rep_1	3.0e-55
GJB2	GOBP_Response_To_Ketone	Human	Liver	rep_1	1.7e-73
GJB2	GOBP_Response_To_Lipid	Human	Liver	rep_1	3.0e-55
GJB2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
GJB2	GOBP_Transmembrane_Transport	Human	Liver	rep_1	1.0e-70
GJB2	GOBP_Tube_Development	Human	Liver	rep_1	6.0e-76
GJB2	GOBP_Response_To_Bacterium	Human	Intestine	rep_colon4	1.0e-26
GJB2	GOBP_Tube_Development	Human	Intestine	rep_colon4	1.9e-09
GJB2	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	rep_liver2	3.7e-39
GJB2	GOBP_Response_To_Hormone	Human	Intestine	rep_liver2	3.7e-39
GJB2	GOBP_Response_To_Ketone	Human	Intestine	rep_liver2	8.9e-16
GJB2	GOBP_Response_To_Lipid	Human	Intestine	rep_liver2	3.7e-39
GJB2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
GJB2	GOBP_Aging	Human	Intestine	A3	9.0e-18
GJB2	GOBP_Cell_Cell_Junction_Assembly	Human	Intestine	A3	7.8e-08
GJB2	GOBP_Cell_Cell_Signaling	Human	Intestine	A3	6.4e-08
GJB2	GOBP_Cell_Junction_Assembly	Human	Intestine	A3	6.2e-12
GJB2	GOBP_Cell_Junction_Organization	Human	Intestine	A3	1.1e-08
GJB2	GOBP_Cellular_Response_To_Chemical_Stress	Human	Intestine	A3	1.1e-11
GJB2	GOBP_Cellular_Response_To_Hormone_Stimulus	Human	Intestine	A3	8.7e-19
GJB2	GOBP_Cellular_Response_To_Lipid	Human	Intestine	A3	7.7e-08
GJB2	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	2.5e-14
GJB2	GOBP_Cellular_Response_To_Peptide_Hormone_Stimulus	Human	Intestine	A3	4.0e-16
GJB2	GOBP_Cellular_Response_To_Steroid_Hormone_Stimulus	Human	Intestine	A3	5.6e-26
GJB2	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Intestine	A3	2.7e-15
GJB2	GOBP_Ear_Development	Human	Intestine	A3	2.7e-14
GJB2	GOBP_Multi_Multicellular_Organism_Process	Human	Intestine	A3	5.6e-10
GJB2	GOBP_Multicellular_Organism_Reproduction	Human	Intestine	A3	4.1e-15
GJB2	GOBP_Nervous_System_Process	Human	Intestine	A3	9.7e-07
GJB2	GOBP_Placenta_Development	Human	Intestine	A3	2.1e-07
GJB2	GOBP_Reproduction	Human	Intestine	A3	4.6e-19
GJB2	GOBP_Reproductive_System_Development	Human	Intestine	A3	2.9e-14
GJB2	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	A3	5.2e-09
GJB2	GOBP_Response_To_Lipid	Human	Intestine	A3	1.7e-09
GJB2	GOBP_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	3.2e-15
GJB2	GOBP_Response_To_Oxidative_Stress	Human	Intestine	A3	5.4e-18
GJB2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
GJB2	GOBP_Response_To_Steroid_Hormone	Human	Intestine	A3	2.1e-13
GJB2	GOBP_Sensory_Organ_Development	Human	Intestine	A3	1.3e-12
GJB2	GOBP_Sensory_Perception_Of_Mechanical_Stimulus	Human	Intestine	A3	1.6e-07
GJB2	GOBP_Transmembrane_Transport	Human	Intestine	A3	1.4e-10
GJB2	GOBP_Tube_Development	Human	Intestine	A3	7.6e-08
GJB2	GOBP_Cell_Communication_By_Electrical_Coupling	Human	Intestine	A8	8.1e-08
GJB2	GOBP_Cellular_Response_To_Corticosteroid_Stimulus	Human	Intestine	A8	1.6e-19
GJB2	GOBP_Cellular_Response_To_Dexamethasone_Stimulus	Human	Intestine	A8	2.1e-09
GJB2	GOBP_Cellular_Response_To_Glucagon_Stimulus	Human	Intestine	A8	8.9e-09
GJB2	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Intestine	A8	1.4e-09
GJB2	GOBP_Cellular_Response_To_Peptide	Human	Intestine	A8	2.9e-08
GJB2	GOBP_Decidualization	Human	Intestine	A8	2.1e-17
GJB2	GOBP_Gap_Junction_Assembly	Human	Intestine	A8	2.2e-18
GJB2	GOBP_Maternal_Placenta_Development	Human	Intestine	A8	8.4e-20
GJB2	GOBP_Maternal_Process_Involved_In_Female_Pregnancy	Human	Intestine	A8	2.3e-21
GJB2	GOBP_Response_To_Antibiotic	Human	Intestine	A8	4.0e-10
GJB2	GOBP_Response_To_Bacterium	Human	Intestine	A8	3.3e-17
GJB2	GOBP_Response_To_Corticosteroid	Human	Intestine	A8	4.4e-19
GJB2	GOBP_Response_To_Dexamethasone	Human	Intestine	A8	1.4e-12
GJB2	GOBP_Response_To_Glucagon	Human	Intestine	A8	5.7e-10
GJB2	GOBP_Response_To_Hormone	Human	Intestine	A8	2.3e-13
GJB2	GOBP_Response_To_Ischemia	Human	Intestine	A8	1.5e-30
GJB2	GOBP_Response_To_Ketone	Human	Intestine	A8	1.1e-27
GJB2	GOBP_Response_To_Molecule_Of_Bacterial_Origin	Human	Intestine	A8	1.0e-14
GJB2	GOBP_Response_To_Nitrogen_Compound	Human	Intestine	A8	1.3e-12
GJB2	GOBP_Response_To_Peptide	Human	Intestine	A8	2.0e-09
GJB2	GOBP_Response_To_Peptide_Hormone	Human	Intestine	A8	3.4e-09
GJB2	GOBP_Response_To_Retinoic_Acid	Human	Intestine	A8	2.7e-08
GJB2	GOBP_Sensory_Perception	Human	Intestine	A8	2.1e-09
GJB2	GOBP_Cellular_Response_To_Corticosteroid_Stimulus	Human	Pancreas	PDAC-B-st1	3.7e-05
GJB2	GOBP_Response_To_Antibiotic	Human	Pancreas	PDAC-B-st1	1.1e-05
GJB2	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Uterus	rep_1	1.6e-06
GJB2	GOBP_Gap_Junction_Assembly	Human	Uterus	rep_25	4.4e-13
GJB2	GOBP_Response_To_Antibiotic	Human	Uterus	rep_25	3.1e-09
GJB2	GOBP_Response_To_Gonadotropin	Human	Uterus	rep_25	6.4e-10
GJB2	GOBP_Cellular_Response_To_Corticosteroid_Stimulus	Human	Uterus	rep_26	5.2e-07
GJB2	GOBP_Cellular_Response_To_Steroid_Hormone_Stimulus	Human	Uterus	rep_26	9.7e-06
GJB2	GOBP_Nervous_System_Process	Human	Uterus	rep_26	2.3e-07
GJB2	GOBP_Response_To_Dexamethasone	Human	Uterus	rep_26	6.8e-07
GJB2	GOBP_Response_To_Ischemia	Human	Uterus	rep_26	9.9e-09
GJB2	GOBP_Response_To_Retinoic_Acid	Human	Uterus	rep_26	3.0e-14
GJB2	GOBP_Sensory_Perception_Of_Mechanical_Stimulus	Human	Uterus	rep_26	1.1e-09
GJB2	GOBP_Decidualization	Human	Uterus	rep_28	1.8e-06
GJB2	GOBP_Maternal_Placenta_Development	Human	Uterus	rep_28	3.1e-08
GJB2	GOBP_Maternal_Process_Involved_In_Female_Pregnancy	Human	Uterus	rep_28	1.9e-07
GJB2	GOBP_Response_To_Bacterium	Human	Uterus	rep_28	3.0e-06
GJB2	GOBP_Cellular_Response_To_Glucagon_Stimulus	Human	Uterus	rep_29	9.5e-06
GJB2	GOBP_Multi_Multicellular_Organism_Process	Human	Uterus	rep_29	2.8e-06
GJB2	GOBP_Response_To_Corticosteroid	Human	Uterus	rep_29	4.7e-06
GJB2	GOBP_Aging	Human	Breast	rep_1	1.7e-60
GJB2	GOBP_Cell_Cell_Junction_Assembly	Human	Breast	rep_1	9.9e-144
GJB2	GOBP_Cell_Cell_Junction_Organization	Human	Breast	rep_1	8.1e-146
GJB2	GOBP_Cell_Junction_Assembly	Human	Breast	rep_1	4.4e-63
GJB2	GOBP_Cell_Junction_Organization	Human	Breast	rep_1	3.0e-10
GJB2	GOBP_Cellular_Response_To_Corticosteroid_Stimulus	Human	Breast	rep_1	5.0e-06
GJB2	GOBP_Cellular_Response_To_Glucagon_Stimulus	Human	Breast	rep_1	4.6e-06
GJB2	GOBP_Cellular_Response_To_Ketone	Human	Breast	rep_1	8.9e-05
GJB2	GOBP_Decidualization	Human	Breast	rep_1	1.9e-43
GJB2	GOBP_Maternal_Placenta_Development	Human	Breast	rep_1	1.1e-120
GJB2	GOBP_Maternal_Process_Involved_In_Female_Pregnancy	Human	Breast	rep_1	6.5e-130
GJB2	GOBP_Multi_Multicellular_Organism_Process	Human	Breast	rep_1	1.7e-22
GJB2	GOBP_Nervous_System_Process	Human	Breast	rep_1	1.2e-04
GJB2	GOBP_Response_To_Corticosteroid	Human	Breast	rep_1	1.5e-56
GJB2	GOBP_Response_To_Glucagon	Human	Breast	rep_1	8.2e-23
GJB2	GOBP_Response_To_Gonadotropin	Human	Breast	rep_1	2.2e-57
GJB2	GOBP_Response_To_Molecule_Of_Bacterial_Origin	Human	Breast	rep_1	1.2e-20
GJB2	GOBP_Response_To_Peptide_Hormone	Human	Breast	rep_1	2.0e-36
GJB2	GOBP_Transmembrane_Transport	Human	Breast	rep_1	3.2e-56
GJB2	GOBP_Tube_Development	Human	Breast	rep_1	3.8e-32
GJB2	GOBP_Cellular_Response_To_Hormone_Stimulus	Human	Breast	rep_5	9.6e-12
GJB2	GOBP_Cellular_Response_To_Lipid	Human	Breast	rep_5	3.3e-11
GJB2	GOBP_Cellular_Response_To_Nitrogen_Compound	Human	Breast	rep_5	4.4e-13
GJB2	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	5.1e-18
GJB2	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.9e-11
GJB2	GOBP_Cellular_Response_To_Peptide_Hormone_Stimulus	Human	Breast	rep_5	6.3e-04
GJB2	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Breast	rep_5	1.5e-12
GJB2	GOBP_Multicellular_Organism_Reproduction	Human	Breast	rep_5	8.1e-07
GJB2	GOBP_Placenta_Development	Human	Breast	rep_5	1.6e-05
GJB2	GOBP_Reproduction	Human	Breast	rep_5	8.1e-06
GJB2	GOBP_Reproductive_System_Development	Human	Breast	rep_5	3.6e-15
GJB2	GOBP_Response_To_Endogenous_Stimulus	Human	Breast	rep_5	3.6e-09
GJB2	GOBP_Response_To_Estradiol	Human	Breast	rep_5	6.9e-16
GJB2	GOBP_Response_To_Hormone	Human	Breast	rep_5	2.9e-13
GJB2	GOBP_Response_To_Ischemia	Human	Breast	rep_5	5.2e-10
GJB2	GOBP_Response_To_Ketone	Human	Breast	rep_5	3.5e-14
GJB2	GOBP_Response_To_Lipid	Human	Breast	rep_5	1.6e-10
GJB2	GOBP_Response_To_Nitrogen_Compound	Human	Breast	rep_5	1.1e-11
GJB2	GOBP_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	7.5e-14
GJB2	GOBP_Response_To_Oxidative_Stress	Human	Breast	rep_5	1.0e-04
GJB2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
GJB2	GOBP_Response_To_Peptide	Human	Breast	rep_5	1.2e-15
GJB2	GOBP_Response_To_Progesterone	Human	Breast	rep_5	4.6e-04
GJB2	GOBP_Response_To_Steroid_Hormone	Human	Breast	rep_5	4.5e-13
GJB2	GOBP_Sensory_Perception_Of_Mechanical_Stimulus	Human	Breast	rep_5	1.4e-10
GJB2	GOBP_Cell_Cell_Signaling	Human	Breast	rep_6	5.0e-05
GJB2	GOBP_Cell_Communication_By_Electrical_Coupling	Human	Breast	rep_6	5.3e-09
GJB2	GOBP_Cellular_Response_To_Chemical_Stress	Human	Breast	rep_6	3.6e-05
GJB2	GOBP_Cellular_Response_To_Peptide	Human	Breast	rep_6	8.4e-11
GJB2	GOBP_Ear_Development	Human	Breast	rep_6	9.9e-13
GJB2	GOBP_Gap_Junction_Assembly	Human	Breast	rep_6	5.6e-05
GJB2	GOBP_Intercellular_Transport	Human	Breast	rep_6	6.0e-04
GJB2	GOBP_Response_To_Antibiotic	Human	Breast	rep_6	4.1e-07
GJB2	GOBP_Sensory_Organ_Development	Human	Breast	rep_6	1.3e-09
GJB2	GOBP_Cell_Cell_Junction_Organization	Human	Skin	P2_rep1	3.4e-11
GJB2	GOBP_Cell_Communication_By_Electrical_Coupling	Human	Skin	P2_rep2	5.7e-14
GJB2	GOBP_Response_To_Glucagon	Human	Skin	P2_rep2	1.5e-08
GJB2	GOBP_Response_To_Progesterone	Human	Skin	P2_rep3	6.7e-09
GJB2	GOBP_Response_To_Antibiotic	Human	Skin	P9_rep2	1.4e-08
GJB2	GOBP_Response_To_Ischemia	Human	Skin	P9_rep2	2.3e-08
GJB2	GOBP_Cellular_Response_To_Corticosteroid_Stimulus	Human	Lung	rep_1	8.4e-08
GJB2	GOBP_Cellular_Response_To_Lipid	Human	Lung	rep_1	1.3e-10
GJB2	GOBP_Response_To_Bacterium	Human	Lung	rep_1	1.1e-09
GJB2	GOBP_Response_To_Lipid	Human	Lung	rep_1	1.8e-09
GJB2	GOBP_Response_To_Molecule_Of_Bacterial_Origin	Human	Lung	rep_1	1.7e-07
GJB2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08

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GJB2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GJB2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GJB2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GJB2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GJB2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source