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Spatial pattern gene: GJB1 (spascer ID:2705) |
Gene summary for GJB1 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | GJB1 | Gene ID | 2705 |
| Gene name | gap junction protein beta 1 |
| Synonyms | CMTX|CMTX1|CX32 |
| Cytomap | Xq13.1 |
| Type of gene | protein-coding |
| Description | gap junction beta-1 proteinGAP junction 28 kDa liver proteinconnexin-32gap junction protein, beta 1, 32kDa |
| Modification date | 20220513 |
| UniProtAcc | P08034 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| GJB1 | GO:0005243 | gap junction channel activity | 21873635 | Function |
| GJB1 | GO:0005922 | connexin complex | 21873635 | Component |
| GJB1 | GO:0007267 | cell-cell signaling | 21873635 | Process |
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Spatial pattern events for GJB1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| GJB1 | Human | Brain | rep_9 | 33558695 | 3.01e-15 |
| GJB1 | Human | Brain | rep_10 | 33558695 | 3.23e-15 |
| GJB1 | Human | Intestine | rep_colon4 | 34417225 | 3.06e-08 |
| GJB1 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| GJB1 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| GJB1 | Human | Liver | rep_liver4 | 34417225 | 1.21e-10 |
| GJB1 | Human | Intestine | A2 | 33406409 | 7.00e-15 |
| GJB1 | Human | Intestine | A4 | 33406409 | 9.63e-15 |
| GJB1 | Human | Intestine | A8 | 33406409 | 7.53e-07 |
| GJB1 | Human | Intestine | A9 | 33406409 | 6.82e-11 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A2_H&E  |  |
Intestine_A4_H&E  |  |
Intestine_A8_H&E  |  |
Intestine_A9_H&E  |  |
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Spatial pattern pathway has GJB1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| GJB1 | GOBP_Transmembrane_Transport | Human | Brain | rep_1 | 2.8e-23 |
| GJB1 | GOBP_Transmembrane_Transport | Human | Liver | rep_1 | 1.0e-70 |
| GJB1 | GOBP_Cell_Cell_Junction_Assembly | Human | Intestine | A3 | 7.8e-08 |
| GJB1 | GOBP_Cell_Cell_Signaling | Human | Intestine | A3 | 6.4e-08 |
| GJB1 | GOBP_Cell_Junction_Assembly | Human | Intestine | A3 | 6.2e-12 |
| GJB1 | GOBP_Cell_Junction_Organization | Human | Intestine | A3 | 1.1e-08 |
| GJB1 | GOBP_Transmembrane_Transport | Human | Intestine | A3 | 1.4e-10 |
| GJB1 | GOBP_Gap_Junction_Assembly | Human | Intestine | A8 | 2.2e-18 |
| GJB1 | GOBP_Gap_Junction_Assembly | Human | Uterus | rep_25 | 4.4e-13 |
| GJB1 | GOBP_Cell_Cell_Junction_Assembly | Human | Breast | rep_1 | 9.9e-144 |
| GJB1 | GOBP_Cell_Cell_Junction_Organization | Human | Breast | rep_1 | 8.1e-146 |
| GJB1 | GOBP_Cell_Junction_Assembly | Human | Breast | rep_1 | 4.4e-63 |
| GJB1 | GOBP_Cell_Junction_Organization | Human | Breast | rep_1 | 3.0e-10 |
| GJB1 | GOBP_Transmembrane_Transport | Human | Breast | rep_1 | 3.2e-56 |
| GJB1 | GOBP_Cell_Cell_Signaling | Human | Breast | rep_6 | 5.0e-05 |
| GJB1 | GOBP_Gap_Junction_Assembly | Human | Breast | rep_6 | 5.6e-05 |
| GJB1 | GOBP_Cell_Cell_Junction_Organization | Human | Skin | P2_rep1 | 3.4e-11 |
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GJB1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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GJB1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for GJB1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for GJB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GJB1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
