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Spatial pattern gene: HIBCH (spascer ID:26275) |
Gene summary for HIBCH |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | HIBCH | Gene ID | 26275 |
| Gene name | 3-hydroxyisobutyryl-CoA hydrolase |
| Synonyms | HIBYLCOAH |
| Cytomap | 2q32.2 |
| Type of gene | protein-coding |
| Description | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial3-hydroxyisobutyryl-Coenzyme A hydrolaseHIB-CoA hydrolaseHIBYL-CoA-Htesticular tissue protein Li 86 |
| Modification date | 20220513 |
| UniProtAcc | Q6NVY1 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| HIBCH | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity | 21873635 | Function |
| HIBCH | GO:0005739 | mitochondrion | 21873635 | Component |
| HIBCH | GO:0006574 | valine catabolic process | 21873635 | Process |
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Spatial pattern events for HIBCH |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| HIBCH | Human | Liver | rep_liver1 | 34417225 | 8.83e-14 |
| HIBCH | Human | Liver | rep_liver2 | 34417225 | 2.49e-15 |
| HIBCH | Human | Breast | D5 | 34650042 | 8.23e-07 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Breast_D5_H&E  |  |
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Spatial pattern pathway has HIBCH envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| HIBCH | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Intestine | A3 | 4.5e-13 |
| HIBCH | GOBP_Branched_Chain_Amino_Acid_Metabolic_Process | Human | Intestine | A8 | 2.1e-15 |
| HIBCH | GOBP_Cellular_Amino_Acid_Catabolic_Process | Human | Intestine | A8 | 2.5e-14 |
| HIBCH | GOBP_Cellular_Amino_Acid_Metabolic_Process | Human | Intestine | A8 | 5.3e-13 |
| HIBCH | GOBP_Organic_Acid_Catabolic_Process | Human | Intestine | A8 | 1.6e-12 |
| HIBCH | GOBP_Organic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.5e-18 |
| HIBCH | GOBP_Small_Molecule_Catabolic_Process | Human | Intestine | A8 | 2.2e-13 |
| HIBCH | GOBP_Small_Molecule_Metabolic_Process | Human | Intestine | A8 | 2.1e-15 |
| HIBCH | GOBP_Valine_Metabolic_Process | Human | Intestine | A8 | 2.7e-08 |
| HIBCH | GOBP_Cellular_Amino_Acid_Metabolic_Process | Human | Pancreas | PDAC-A-st2 | 9.6e-05 |
| HIBCH | GOBP_Valine_Metabolic_Process | Human | Uterus | rep_25 | 4.6e-07 |
| HIBCH | GOBP_Branched_Chain_Amino_Acid_Metabolic_Process | Human | Uterus | rep_26 | 1.0e-15 |
| HIBCH | GOBP_Cellular_Amino_Acid_Catabolic_Process | Human | Uterus | rep_26 | 3.2e-12 |
| HIBCH | GOBP_Organic_Acid_Catabolic_Process | Human | Uterus | rep_26 | 6.9e-09 |
| HIBCH | GOBP_Organic_Acid_Metabolic_Process | Human | Uterus | rep_26 | 4.9e-06 |
| HIBCH | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Uterus | rep_26 | 1.0e-08 |
| HIBCH | GOBP_Small_Molecule_Catabolic_Process | Human | Uterus | rep_26 | 9.1e-13 |
| HIBCH | GOBP_Branched_Chain_Amino_Acid_Metabolic_Process | Human | Breast | rep_5 | 3.3e-05 |
| HIBCH | GOBP_Cellular_Amino_Acid_Catabolic_Process | Human | Breast | rep_6 | 1.6e-05 |
| HIBCH | GOBP_Cellular_Amino_Acid_Metabolic_Process | Human | Breast | rep_6 | 1.0e-10 |
| HIBCH | GOBP_Organic_Acid_Catabolic_Process | Human | Breast | rep_6 | 1.5e-11 |
| HIBCH | GOBP_Organic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.7e-05 |
| HIBCH | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Breast | rep_6 | 9.5e-06 |
| HIBCH | GOBP_Small_Molecule_Catabolic_Process | Human | Breast | rep_6 | 4.7e-07 |
| HIBCH | GOBP_Small_Molecule_Metabolic_Process | Human | Breast | rep_6 | 5.5e-09 |
| HIBCH | GOBP_Valine_Metabolic_Process | Human | Breast | rep_6 | 9.0e-10 |
| HIBCH | GOBP_Valine_Metabolic_Process | Human | Skin | P10_rep2 | 5.2e-15 |
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HIBCH function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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HIBCH function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for HIBCH envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for HIBCH |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HIBCH |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| HIBCH | C0342738 | Beta-Hydroxyisobutyryl CoA Deacylase Deficiency | 9 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| HIBCH | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| HIBCH | C0086743 | Osteoarthrosis Deformans | 1 | CTD_human |
