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Spatial pattern gene: RNASEH1 (spascer ID:246243) |
Gene summary for RNASEH1 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | RNASEH1 | Gene ID | 246243 |
| Gene name | ribonuclease H1 |
| Synonyms | H1RNA|PEOB2|RNH1 |
| Cytomap | 2p25.3 |
| Type of gene | protein-coding |
| Description | ribonuclease H1ribonuclease H type II |
| Modification date | 20220513 |
| UniProtAcc | O60930 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| RNASEH1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity | 21873635 | Function |
| RNASEH1 | GO:0043137 | DNA replication, removal of RNA primer | 21873635 | Process |
| RNASEH1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 21873635 | Process |
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Spatial pattern events for RNASEH1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| RNASEH1 | Human | Intestine | rep_colon1 | 34417225 | 6.48e-15 |
| RNASEH1 | Human | Liver | rep_liver1 | 34417225 | 1.52e-08 |
| RNASEH1 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| RNASEH1 | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Breast_CID44971_H&E  |  |
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Spatial pattern pathway has RNASEH1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| RNASEH1 | GOBP_Dna_Metabolic_Process | Human | Intestine | A3 | 1.2e-09 |
| RNASEH1 | GOBP_Macromolecule_Catabolic_Process | Human | Intestine | A3 | 2.2e-16 |
| RNASEH1 | GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis | Human | Intestine | A3 | 1.9e-08 |
| RNASEH1 | GOBP_Organic_Cyclic_Compound_Catabolic_Process | Human | Intestine | A3 | 5.9e-24 |
| RNASEH1 | GOBP_Rna_Catabolic_Process | Human | Intestine | A3 | 5.9e-24 |
| RNASEH1 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Intestine | A3 | 2.3e-07 |
| RNASEH1 | GOBP_Rna_Catabolic_Process | Human | Pancreas | PDAC-B-st1 | 8.0e-05 |
| RNASEH1 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Pancreas | PDAC-B-st1 | 3.3e-05 |
| RNASEH1 | GOBP_Macromolecule_Catabolic_Process | Human | Uterus | rep_26 | 5.0e-08 |
| RNASEH1 | GOBP_Organic_Cyclic_Compound_Catabolic_Process | Human | Uterus | rep_26 | 2.6e-06 |
| RNASEH1 | GOBP_Rna_Catabolic_Process | Human | Uterus | rep_26 | 2.7e-07 |
| RNASEH1 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Endonucleolytic | Human | Uterus | rep_26 | 3.6e-07 |
| RNASEH1 | GOBP_Dna_Metabolic_Process | Human | Breast | rep_6 | 1.4e-10 |
| RNASEH1 | GOBP_Macromolecule_Catabolic_Process | Human | Breast | rep_6 | 1.3e-05 |
| RNASEH1 | GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis | Human | Breast | rep_6 | 2.6e-05 |
| RNASEH1 | GOBP_Organic_Cyclic_Compound_Catabolic_Process | Human | Breast | rep_6 | 7.7e-08 |
| RNASEH1 | GOBP_Rna_Catabolic_Process | Human | Breast | rep_6 | 3.9e-06 |
| RNASEH1 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Breast | rep_6 | 2.8e-06 |
| RNASEH1 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Endonucleolytic | Human | Breast | rep_6 | 3.0e-08 |
| RNASEH1 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Lung | rep_1 | 8.8e-08 |
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RNASEH1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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RNASEH1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for RNASEH1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for RNASEH1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RNASEH1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| RNASEH1 | C4225312 | PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE 2 | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| RNASEH1 | C4511138 | Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy | 1 | ORPHANET |
