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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: DIS3 (spascer ID:22894)

Gene summary for DIS3

Gene summary

Gene information
	Species	Human
	Gene symbol	DIS3
	Gene ID	22894
	Gene name	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
	Synonyms	2810028N01Rik\|EXOSC11\|KIAA1008\|RRP44\|dis3p
	Cytomap	13q21.33
	Type of gene	protein-coding
	Description	exosome complex exonuclease RRP44DIS3 exosome endoribonuclease and 3'-5' exoribonucleaseDIS3 mitotic control homologexosome component 11mitotic control protein dis3 homologribosomal RNA-processing protein 44
	Modification date	20220513
	UniProtAcc	Q9Y2L1

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
DIS3	GO:0000175	3'-5'-exoribonuclease activity	21873635	Function
DIS3	GO:0000176	nuclear exosome (RNase complex)	21873635	Component
DIS3	GO:0000177	cytoplasmic exosome (RNase complex)	21873635	Component
DIS3	GO:0000178	exosome (RNase complex)	21873635	Component
DIS3	GO:0004519	endonuclease activity	21873635	Function
DIS3	GO:0016075	rRNA catabolic process	21873635	Process

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Spatial pattern events for DIS3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
DIS3	Human	Intestine	rep_colon4	34417225	2.25e-13
DIS3	Human	Liver	rep_liver2	34417225	6.98e-16

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon4_H&E
Liver_rep_liver2_H&E

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Spatial pattern pathway has DIS3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
DIS3	GOBP_Ribosome_Biogenesis	Human	Intestine	A1	6.5e-08
DIS3	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
DIS3	GOBP_Mrna_Metabolic_Process	Human	Intestine	A3	7.7e-20
DIS3	GOBP_Ncrna_Catabolic_Process	Human	Intestine	A3	4.1e-12
DIS3	GOBP_Ncrna_Metabolic_Process	Human	Intestine	A3	8.6e-07
DIS3	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Intestine	A3	2.8e-10
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Intestine	A3	1.5e-09
DIS3	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	1.9e-08
DIS3	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
DIS3	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
DIS3	GOBP_Regulation_Of_Catabolic_Process	Human	Intestine	A3	3.5e-16
DIS3	GOBP_Regulation_Of_Mrna_Catabolic_Process	Human	Intestine	A3	5.8e-13
DIS3	GOBP_Regulation_Of_Mrna_Metabolic_Process	Human	Intestine	A3	1.6e-13
DIS3	GOBP_Rna_Catabolic_Process	Human	Intestine	A3	5.9e-24
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	2.3e-07
DIS3	GOBP_Rna_Processing	Human	Intestine	A3	3.9e-09
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Intestine	A8	1.9e-13
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Intestine	A8	6.5e-10
DIS3	GOBP_Mrna_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	9.4e-06
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Pancreas	PDAC-B-st1	5.2e-05
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Pancreas	PDAC-B-st1	5.0e-05
DIS3	GOBP_Rna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	8.0e-05
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Pancreas	PDAC-B-st1	3.3e-05
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Pancreas	PDAC-A-st2	1.4e-05
DIS3	GOBP_Ncrna_Processing	Human	Uterus	rep_1	4.5e-06
DIS3	GOBP_Ribosome_Biogenesis	Human	Uterus	rep_1	9.5e-06
DIS3	GOBP_Rrna_Metabolic_Process	Human	Uterus	rep_1	2.4e-07
DIS3	GOBP_Rrna_Catabolic_Process	Human	Uterus	rep_25	2.5e-09
DIS3	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Uterus	rep_26	8.1e-10
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Uterus	rep_26	2.2e-12
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Uterus	rep_26	1.2e-11
DIS3	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
DIS3	GOBP_Rna_Catabolic_Process	Human	Uterus	rep_26	2.7e-07
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Uterus	rep_26	9.7e-09
DIS3	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
DIS3	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
DIS3	GOBP_Mrna_Metabolic_Process	Human	Breast	rep_6	3.0e-08
DIS3	GOBP_Ncrna_Catabolic_Process	Human	Breast	rep_6	3.6e-04
DIS3	GOBP_Ncrna_Metabolic_Process	Human	Breast	rep_6	1.9e-04
DIS3	GOBP_Ncrna_Processing	Human	Breast	rep_6	1.3e-05
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Breast	rep_6	8.1e-07
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Breast	rep_6	1.7e-04
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Breast	rep_6	3.7e-07
DIS3	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.6e-05
DIS3	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
DIS3	GOBP_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	3.3e-04
DIS3	GOBP_Regulation_Of_Mrna_Catabolic_Process	Human	Breast	rep_6	6.1e-05
DIS3	GOBP_Regulation_Of_Mrna_Metabolic_Process	Human	Breast	rep_6	9.5e-05
DIS3	GOBP_Ribonucleoprotein_Complex_Biogenesis	Human	Breast	rep_6	1.3e-07
DIS3	GOBP_Ribosome_Biogenesis	Human	Breast	rep_6	2.0e-06
DIS3	GOBP_Rna_Catabolic_Process	Human	Breast	rep_6	3.9e-06
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.8e-06
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Breast	rep_6	3.0e-08
DIS3	GOBP_Rna_Processing	Human	Breast	rep_6	3.5e-06
DIS3	GOBP_Rrna_Catabolic_Process	Human	Breast	rep_6	1.2e-04
DIS3	GOBP_Rrna_Metabolic_Process	Human	Breast	rep_6	4.0e-06
DIS3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Skin	P5_rep1	4.0e-09
DIS3	GOBP_Mrna_Metabolic_Process	Human	Skin	P5_rep3	1.8e-08
DIS3	GOBP_Regulation_Of_Mrna_Metabolic_Process	Human	Skin	P5_rep3	4.0e-08
DIS3	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Lung	rep_1	8.8e-08

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DIS3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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DIS3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for DIS3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for DIS3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DIS3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source