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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: FASTKD2 (spascer ID:22868)

Gene summary for FASTKD2

Gene summary

Gene information
	Species	Human
	Gene symbol	FASTKD2
	Gene ID	22868
	Gene name	FAST kinase domains 2
	Synonyms	COXPD44\|KIAA0971
	Cytomap	2q33.3
	Type of gene	protein-coding
	Description	FAST kinase domain-containing protein 2, mitochondrial
	Modification date	20220513
	UniProtAcc	Q9NYY8

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
FASTKD2	GO:0000963	mitochondrial RNA processing	21873635	Process
FASTKD2	GO:0003723	RNA binding	21873635	Function
FASTKD2	GO:0005759	mitochondrial matrix	21873635	Component
FASTKD2	GO:0035770	ribonucleoprotein granule	21873635	Component
FASTKD2	GO:0044528	regulation of mitochondrial mRNA stability	21873635	Process

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Spatial pattern events for FASTKD2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
FASTKD2	Human	Intestine	rep_colon1	34417225	4.54e-10
FASTKD2	Human	Liver	rep_liver1	34417225	2.76e-09
FASTKD2	Human	Liver	rep_liver2	34417225	6.98e-16

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E

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Spatial pattern pathway has FASTKD2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
FASTKD2	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Brain	rep_1	4.4e-07
FASTKD2	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
FASTKD2	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Liver	rep_1	3.7e-85
FASTKD2	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
FASTKD2	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Intestine	rep_colon4	6.4e-48
FASTKD2	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
FASTKD2	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
FASTKD2	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
FASTKD2	GOBP_Positive_Regulation_Of_Translation	Human	Intestine	A1	7.9e-07
FASTKD2	GOBP_Ribosomal_Large_Subunit_Assembly	Human	Intestine	A1	2.8e-14
FASTKD2	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Intestine	A1	4.4e-09
FASTKD2	GOBP_Ribosome_Assembly	Human	Intestine	A1	2.8e-16
FASTKD2	GOBP_Ribosome_Biogenesis	Human	Intestine	A1	6.5e-08
FASTKD2	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
FASTKD2	GOBP_Mitochondrial_Ribosome_Assembly	Human	Intestine	A3	1.6e-09
FASTKD2	GOBP_Mrna_Metabolic_Process	Human	Intestine	A3	7.7e-20
FASTKD2	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
FASTKD2	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
FASTKD2	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Intestine	A3	3.7e-11
FASTKD2	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
FASTKD2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
FASTKD2	GOBP_Regulation_Of_Catabolic_Process	Human	Intestine	A3	3.5e-16
FASTKD2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
FASTKD2	GOBP_Regulation_Of_Mrna_Catabolic_Process	Human	Intestine	A3	5.8e-13
FASTKD2	GOBP_Regulation_Of_Mrna_Metabolic_Process	Human	Intestine	A3	1.6e-13
FASTKD2	GOBP_Ribonucleoprotein_Complex_Subunit_Organization	Human	Intestine	A3	1.6e-07
FASTKD2	GOBP_Rna_Catabolic_Process	Human	Intestine	A3	5.9e-24
FASTKD2	GOBP_Mitochondrial_Gene_Expression	Human	Intestine	A8	1.4e-08
FASTKD2	GOBP_Mitochondrial_Translation	Human	Intestine	A8	1.7e-08
FASTKD2	GOBP_Positive_Regulation_Of_Mitochondrial_Translation	Human	Intestine	A8	7.5e-07
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Gene_Expression	Human	Intestine	A8	1.3e-15
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Mrna_Stability	Human	Intestine	A8	2.2e-30
FASTKD2	GOBP_Mitochondrial_Translation	Human	Pancreas	PDAC-B-st1	5.1e-05
FASTKD2	GOBP_Mrna_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
FASTKD2	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Pancreas	PDAC-B-st1	5.3e-05
FASTKD2	GOBP_Rna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	8.0e-05
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Gene_Expression	Human	Pancreas	PDAC-A-st2	6.0e-05
FASTKD2	GOBP_Ribosome_Biogenesis	Human	Uterus	rep_1	9.5e-06
FASTKD2	GOBP_Mitochondrial_Ribosome_Assembly	Human	Uterus	rep_25	1.4e-09
FASTKD2	GOBP_Mitochondrial_Translation	Human	Uterus	rep_25	3.6e-06
FASTKD2	GOBP_Positive_Regulation_Of_Mitochondrial_Translation	Human	Uterus	rep_25	1.8e-11
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Gene_Expression	Human	Uterus	rep_25	1.8e-10
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Mrna_Stability	Human	Uterus	rep_25	3.0e-15
FASTKD2	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
FASTKD2	GOBP_Mitochondrial_Gene_Expression	Human	Uterus	rep_26	1.3e-15
FASTKD2	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
FASTKD2	GOBP_Ribonucleoprotein_Complex_Subunit_Organization	Human	Uterus	rep_26	4.6e-06
FASTKD2	GOBP_Ribosomal_Large_Subunit_Assembly	Human	Uterus	rep_26	6.8e-17
FASTKD2	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Uterus	rep_26	1.5e-07
FASTKD2	GOBP_Ribosome_Assembly	Human	Uterus	rep_26	6.3e-19
FASTKD2	GOBP_Rna_Catabolic_Process	Human	Uterus	rep_26	2.7e-07
FASTKD2	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Breast	rep_1	7.3e-07
FASTKD2	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
FASTKD2	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
FASTKD2	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
FASTKD2	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
FASTKD2	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
FASTKD2	GOBP_Mitochondrial_Gene_Expression	Human	Breast	rep_6	9.9e-07
FASTKD2	GOBP_Mitochondrial_Ribosome_Assembly	Human	Breast	rep_6	1.6e-09
FASTKD2	GOBP_Mitochondrial_Translation	Human	Breast	rep_6	1.3e-06
FASTKD2	GOBP_Mrna_Metabolic_Process	Human	Breast	rep_6	3.0e-08
FASTKD2	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
FASTKD2	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
FASTKD2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
FASTKD2	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
FASTKD2	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
FASTKD2	GOBP_Positive_Regulation_Of_Translation	Human	Breast	rep_6	3.8e-04
FASTKD2	GOBP_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	3.3e-04
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Gene_Expression	Human	Breast	rep_6	1.0e-05
FASTKD2	GOBP_Regulation_Of_Mrna_Catabolic_Process	Human	Breast	rep_6	6.1e-05
FASTKD2	GOBP_Regulation_Of_Mrna_Metabolic_Process	Human	Breast	rep_6	9.5e-05
FASTKD2	GOBP_Ribonucleoprotein_Complex_Biogenesis	Human	Breast	rep_6	1.3e-07
FASTKD2	GOBP_Ribonucleoprotein_Complex_Subunit_Organization	Human	Breast	rep_6	1.4e-08
FASTKD2	GOBP_Ribosomal_Large_Subunit_Assembly	Human	Breast	rep_6	7.7e-09
FASTKD2	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Breast	rep_6	2.7e-06
FASTKD2	GOBP_Ribosome_Assembly	Human	Breast	rep_6	7.2e-08
FASTKD2	GOBP_Ribosome_Biogenesis	Human	Breast	rep_6	2.0e-06
FASTKD2	GOBP_Rna_Catabolic_Process	Human	Breast	rep_6	3.9e-06
FASTKD2	GOBP_Mrna_Metabolic_Process	Human	Skin	P5_rep3	1.8e-08
FASTKD2	GOBP_Regulation_Of_Mrna_Metabolic_Process	Human	Skin	P5_rep3	4.0e-08
FASTKD2	GOBP_Mitochondrial_Ribosome_Assembly	Human	Skin	P10_rep1	2.0e-10
FASTKD2	GOBP_Ribosomal_Large_Subunit_Assembly	Human	Skin	P10_rep1	8.2e-09
FASTKD2	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Skin	P10_rep1	1.5e-10
FASTKD2	GOBP_Regulation_Of_Mitochondrial_Gene_Expression	Human	Skin	P10_rep2	7.9e-11
FASTKD2	GOBP_Ribosomal_Large_Subunit_Assembly	Human	Lung	rep_1	1.6e-07

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FASTKD2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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FASTKD2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for FASTKD2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for FASTKD2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FASTKD2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
FASTKD2	C0268237	Cytochrome-c Oxidase Deficiency	2	CTD_human;GENOMICS_ENGLAND
FASTKD2	C0751651	Mitochondrial Diseases	1	GENOMICS_ENGLAND
FASTKD2	C4755278	FASTKD2-related infantile mitochondrial encephalomyopathy	1	ORPHANET