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Spatial pattern gene: PUF60 (spascer ID:22827) |
Gene summary for PUF60 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | PUF60 | Gene ID | 22827 |
| Gene name | poly(U) binding splicing factor 60 |
| Synonyms | FIR|RoBPI|SIAHBP1|VRJS |
| Cytomap | 8q24.3 |
| Type of gene | protein-coding |
| Description | poly(U)-binding-splicing factor PUF60FBP interacting repressorFUSE-binding protein-interacting repressorRo ribonucleoprotein-binding protein 1Siah binding protein 1poly(U) binding splicing factor 60KDapyrimidine tract binding splicing factor |
| Modification date | 20220513 |
| UniProtAcc | Q9UHX1 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| PUF60 | GO:0000380 | alternative mRNA splicing, via spliceosome | 21873635 | Process |
| PUF60 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21873635 | Process |
| PUF60 | GO:0006376 | mRNA splice site selection | 21873635 | Process |
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Spatial pattern events for PUF60 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| PUF60 | Human | Brain | rep_10 | 33558695 | 8.22e-07 |
| PUF60 | Human | Bladder | rep_1 | 34385456 | 2.66e-09 |
| PUF60 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| PUF60 | Human | Intestine | rep_colon2 | 34417225 | 1.83e-14 |
| PUF60 | Human | Intestine | rep_colon3 | 34417225 | 2.31e-09 |
| PUF60 | Human | Intestine | rep_colon4 | 34417225 | 2.06e-15 |
| PUF60 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| PUF60 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| PUF60 | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| PUF60 | Human | Uterus | rep_2 | 34857954 | 4.63e-15 |
| PUF60 | Human | Uterus | rep_3 | 34857954 | 5.81e-15 |
| PUF60 | Human | Breast | 1142243F | 34493872 | 1.67e-11 |
| PUF60 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| PUF60 | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_10_H&E  |  |
Bladder_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID44971_H&E  |  |
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Spatial pattern pathway has PUF60 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| PUF60 | GOBP_Alternative_Mrna_Splicing_Via_Spliceosome | Human | Intestine | A3 | 1.1e-09 |
| PUF60 | GOBP_Mrna_Metabolic_Process | Human | Intestine | A3 | 7.7e-20 |
| PUF60 | GOBP_Mrna_Processing | Human | Intestine | A3 | 4.9e-17 |
| PUF60 | GOBP_Mrna_Splice_Site_Selection | Human | Intestine | A3 | 6.7e-13 |
| PUF60 | GOBP_Regulation_Of_Alternative_Mrna_Splicing_Via_Spliceosome | Human | Intestine | A3 | 2.3e-08 |
| PUF60 | GOBP_Regulation_Of_Mrna_Metabolic_Process | Human | Intestine | A3 | 1.6e-13 |
| PUF60 | GOBP_Regulation_Of_Mrna_Processing | Human | Intestine | A3 | 1.2e-11 |
| PUF60 | GOBP_Regulation_Of_Rna_Splicing | Human | Intestine | A3 | 5.6e-22 |
| PUF60 | GOBP_Ribonucleoprotein_Complex_Subunit_Organization | Human | Intestine | A3 | 1.6e-07 |
| PUF60 | GOBP_Rna_Processing | Human | Intestine | A3 | 3.9e-09 |
| PUF60 | GOBP_Rna_Splicing | Human | Intestine | A3 | 3.3e-19 |
| PUF60 | GOBP_Rna_Splicing_Via_Transesterification_Reactions | Human | Intestine | A3 | 2.2e-12 |
| PUF60 | GOBP_Spliceosomal_Complex_Assembly | Human | Intestine | A3 | 8.7e-10 |
| PUF60 | GOBP_Alternative_Mrna_Splicing_Via_Spliceosome | Human | Pancreas | PDAC-B-st1 | 4.0e-05 |
| PUF60 | GOBP_Mrna_Metabolic_Process | Human | Pancreas | PDAC-B-st1 | 2.6e-05 |
| PUF60 | GOBP_Regulation_Of_Rna_Splicing | Human | Pancreas | PDAC-B-st1 | 3.5e-05 |
| PUF60 | GOBP_Rna_Splicing | Human | Pancreas | PDAC-B-st1 | 1.9e-05 |
| PUF60 | GOBP_Ribonucleoprotein_Complex_Subunit_Organization | Human | Uterus | rep_26 | 4.6e-06 |
| PUF60 | GOBP_Rna_Splicing | Human | Uterus | rep_26 | 1.0e-05 |
| PUF60 | GOBP_Spliceosomal_Complex_Assembly | Human | Uterus | rep_26 | 5.6e-09 |
| PUF60 | GOBP_Alternative_Mrna_Splicing_Via_Spliceosome | Human | Breast | rep_6 | 2.3e-06 |
| PUF60 | GOBP_Mrna_Metabolic_Process | Human | Breast | rep_6 | 3.0e-08 |
| PUF60 | GOBP_Mrna_Processing | Human | Breast | rep_6 | 1.5e-06 |
| PUF60 | GOBP_Mrna_Splice_Site_Selection | Human | Breast | rep_6 | 7.1e-06 |
| PUF60 | GOBP_Regulation_Of_Alternative_Mrna_Splicing_Via_Spliceosome | Human | Breast | rep_6 | 2.4e-06 |
| PUF60 | GOBP_Regulation_Of_Mrna_Metabolic_Process | Human | Breast | rep_6 | 9.5e-05 |
| PUF60 | GOBP_Regulation_Of_Mrna_Processing | Human | Breast | rep_6 | 2.4e-04 |
| PUF60 | GOBP_Regulation_Of_Mrna_Splicing_Via_Spliceosome | Human | Breast | rep_6 | 3.0e-05 |
| PUF60 | GOBP_Regulation_Of_Rna_Splicing | Human | Breast | rep_6 | 5.8e-06 |
| PUF60 | GOBP_Ribonucleoprotein_Complex_Biogenesis | Human | Breast | rep_6 | 1.3e-07 |
| PUF60 | GOBP_Ribonucleoprotein_Complex_Subunit_Organization | Human | Breast | rep_6 | 1.4e-08 |
| PUF60 | GOBP_Rna_Processing | Human | Breast | rep_6 | 3.5e-06 |
| PUF60 | GOBP_Rna_Splicing | Human | Breast | rep_6 | 1.1e-09 |
| PUF60 | GOBP_Rna_Splicing_Via_Transesterification_Reactions | Human | Breast | rep_6 | 5.4e-08 |
| PUF60 | GOBP_Spliceosomal_Complex_Assembly | Human | Breast | rep_6 | 2.2e-12 |
| PUF60 | GOBP_Mrna_Metabolic_Process | Human | Skin | P5_rep3 | 1.8e-08 |
| PUF60 | GOBP_Mrna_Processing | Human | Skin | P5_rep3 | 9.7e-09 |
| PUF60 | GOBP_Regulation_Of_Mrna_Metabolic_Process | Human | Skin | P5_rep3 | 4.0e-08 |
| PUF60 | GOBP_Mrna_Splice_Site_Selection | Human | Skin | P10_rep2 | 2.9e-12 |
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PUF60 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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PUF60 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for PUF60 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for PUF60 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PUF60 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| PUF60 | C3810023 | VERHEIJ SYNDROME | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| PUF60 | C0025500 | Mesothelioma | 1 | CTD_human |
| PUF60 | C0027540 | Necrosis | 1 | CTD_human |
| PUF60 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| PUF60 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
