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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CASC3 (spascer ID:22794)

Gene summary for CASC3

Gene summary

Gene information
	Species	Human
	Gene symbol	CASC3
	Gene ID	22794
	Gene name	CASC3 exon junction complex subunit
	Synonyms	BTZ\|MLN51
	Cytomap	17q21.1
	Type of gene	protein-coding
	Description	protein CASC3MLN 51barentszcancer susceptibility 3cancer susceptibility candidate 3cancer susceptibility candidate gene 3 proteinmetastatic lymph node 51metastatic lymph node gene 51 proteinprotein barentsz
	Modification date	20220513
	UniProtAcc	O15234

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CASC3	GO:0035145	exon-exon junction complex	21873635	Component

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Spatial pattern events for CASC3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CASC3	Human	Brain	rep_10	33558695	4.67e-07
CASC3	Human	Liver	rep_liver1	34417225	1.08e-15
CASC3	Human	Liver	rep_liver2	34417225	6.98e-16
CASC3	Human	Breast	D1	34650042	4.36e-10
CASC3	Human	Breast	D2	34650042	9.10e-12
CASC3	Human	Breast	D3	34650042	1.84e-09
CASC3	Human	Breast	D5	34650042	3.19e-09
CASC3	Human	Breast	E1	34650042	6.22e-13
CASC3	Human	Breast	E2	34650042	1.57e-07
CASC3	Human	Breast	E3	34650042	2.00e-13

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_10_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Breast_D1_H&E
Breast_D2_H&E
Breast_D3_H&E
Breast_D5_H&E
Breast_E1_H&E
Breast_E2_H&E
Breast_E3_H&E

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Spatial pattern pathway has CASC3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CASC3	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
CASC3	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
CASC3	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
CASC3	GOBP_Establishment_Of_Protein_Localization	Human	Intestine	A3	5.0e-10
CASC3	GOBP_Establishment_Of_Rna_Localization	Human	Intestine	A3	9.7e-11
CASC3	GOBP_Intracellular_Protein_Transport	Human	Intestine	A3	4.8e-12
CASC3	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
CASC3	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
CASC3	GOBP_Mrna_3_End_Processing	Human	Intestine	A3	4.9e-12
CASC3	GOBP_Mrna_Export_From_Nucleus	Human	Intestine	A3	9.9e-15
CASC3	GOBP_Mrna_Metabolic_Process	Human	Intestine	A3	7.7e-20
CASC3	GOBP_Mrna_Processing	Human	Intestine	A3	4.9e-17
CASC3	GOBP_Mrna_Transport	Human	Intestine	A3	6.6e-09
CASC3	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
CASC3	GOBP_Nuclear_Export	Human	Intestine	A3	3.6e-07
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Intestine	A3	2.8e-10
CASC3	GOBP_Nuclear_Transport	Human	Intestine	A3	5.6e-10
CASC3	GOBP_Nucleobase_Containing_Compound_Transport	Human	Intestine	A3	2.5e-11
CASC3	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
CASC3	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
CASC3	GOBP_Protein_Containing_Complex_Localization	Human	Intestine	A3	6.4e-12
CASC3	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
CASC3	GOBP_Rna_3_End_Processing	Human	Intestine	A3	9.2e-07
CASC3	GOBP_Rna_Catabolic_Process	Human	Intestine	A3	5.9e-24
CASC3	GOBP_Rna_Export_From_Nucleus	Human	Intestine	A3	3.3e-10
CASC3	GOBP_Rna_Localization	Human	Intestine	A3	1.4e-08
CASC3	GOBP_Rna_Processing	Human	Intestine	A3	3.9e-09
CASC3	GOBP_Rna_Splicing	Human	Intestine	A3	3.3e-19
CASC3	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Human	Intestine	A3	2.2e-12
CASC3	GOBP_Intracellular_Mrna_Localization	Human	Intestine	A8	8.5e-12
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Intestine	A8	4.7e-09
CASC3	GOBP_Intracellular_Mrna_Localization	Human	Pancreas	PDAC-B-st1	2.2e-05
CASC3	GOBP_Mrna_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	9.4e-06
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Pancreas	PDAC-B-st1	6.1e-05
CASC3	GOBP_Rna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	8.0e-05
CASC3	GOBP_Rna_Export_From_Nucleus	Human	Pancreas	PDAC-B-st1	6.7e-05
CASC3	GOBP_Rna_Splicing	Human	Pancreas	PDAC-B-st1	1.9e-05
CASC3	GOBP_Mrna_Export_From_Nucleus	Human	Pancreas	PDAC-A-st2	3.9e-08
CASC3	GOBP_Nuclear_Export	Human	Uterus	rep_25	7.4e-11
CASC3	GOBP_Nuclear_Transport	Human	Uterus	rep_25	2.3e-13
CASC3	GOBP_Establishment_Of_Rna_Localization	Human	Uterus	rep_26	8.7e-07
CASC3	GOBP_Intracellular_Mrna_Localization	Human	Uterus	rep_26	1.2e-09
CASC3	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
CASC3	GOBP_Mrna_Export_From_Nucleus	Human	Uterus	rep_26	3.9e-08
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Uterus	rep_26	8.1e-10
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Uterus	rep_26	3.0e-08
CASC3	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
CASC3	GOBP_Rna_Catabolic_Process	Human	Uterus	rep_26	2.7e-07
CASC3	GOBP_Rna_Export_From_Nucleus	Human	Uterus	rep_26	3.8e-10
CASC3	GOBP_Rna_Localization	Human	Uterus	rep_26	1.2e-09
CASC3	GOBP_Rna_Splicing	Human	Uterus	rep_26	1.0e-05
CASC3	GOBP_Mrna_3_End_Processing	Human	Uterus	rep_27	5.1e-08
CASC3	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
CASC3	GOBP_Establishment_Of_Protein_Localization	Human	Breast	rep_1	7.2e-05
CASC3	GOBP_Intracellular_Mrna_Localization	Human	Breast	rep_1	3.8e-53
CASC3	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
CASC3	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
CASC3	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
CASC3	GOBP_Intracellular_Protein_Transport	Human	Breast	rep_6	6.4e-12
CASC3	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
CASC3	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
CASC3	GOBP_Mrna_3_End_Processing	Human	Breast	rep_6	6.6e-04
CASC3	GOBP_Mrna_Export_From_Nucleus	Human	Breast	rep_6	1.1e-04
CASC3	GOBP_Mrna_Metabolic_Process	Human	Breast	rep_6	3.0e-08
CASC3	GOBP_Mrna_Processing	Human	Breast	rep_6	1.5e-06
CASC3	GOBP_Mrna_Transport	Human	Breast	rep_6	1.9e-10
CASC3	GOBP_Nuclear_Export	Human	Breast	rep_6	1.4e-05
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Breast	rep_6	8.1e-07
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Breast	rep_6	4.8e-06
CASC3	GOBP_Nuclear_Transport	Human	Breast	rep_6	3.1e-08
CASC3	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
CASC3	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
CASC3	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
CASC3	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
CASC3	GOBP_Protein_Containing_Complex_Localization	Human	Breast	rep_6	1.3e-06
CASC3	GOBP_Rna_3_End_Processing	Human	Breast	rep_6	1.8e-05
CASC3	GOBP_Rna_Catabolic_Process	Human	Breast	rep_6	3.9e-06
CASC3	GOBP_Rna_Export_From_Nucleus	Human	Breast	rep_6	9.6e-09
CASC3	GOBP_Rna_Localization	Human	Breast	rep_6	7.7e-05
CASC3	GOBP_Rna_Processing	Human	Breast	rep_6	3.5e-06
CASC3	GOBP_Rna_Splicing	Human	Breast	rep_6	1.1e-09
CASC3	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Human	Breast	rep_6	5.4e-08
CASC3	GOBP_Intracellular_Mrna_Localization	Human	Skin	P5_rep1	4.8e-08
CASC3	GOBP_Nuclear_Transport	Human	Skin	P5_rep1	5.0e-19
CASC3	GOBP_Mrna_Metabolic_Process	Human	Skin	P5_rep3	1.8e-08
CASC3	GOBP_Mrna_Processing	Human	Skin	P5_rep3	9.7e-09
CASC3	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Skin	P5_rep3	1.2e-10

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CASC3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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CASC3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for CASC3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for CASC3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CASC3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source