Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CYLD (spascer ID:1540)

Gene summary for CYLD

Gene summary

Gene information
	Species	Human
	Gene symbol	CYLD
	Gene ID	1540
	Gene name	CYLD lysine 63 deubiquitinase
	Synonyms	BRSS\|CDMT\|CYLD1\|CYLDI\|EAC\|FTDALS8\|MFT\|MFT1\|SBS\|TEM\|USPL2
	Cytomap	16q12.1
	Type of gene	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase CYLDcylindromatosis (turban tumor syndrome)deubiquitinating enzyme CYLDprobable ubiquitin carboxyl-terminal hydrolase CYLDubiquitin specific peptidase like 2ubiquitin thioesterase CYLDubiquitin thiolesterase CYL
	Modification date	20220515
	UniProtAcc	Q9NQC7

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CYLD	GO:0004843	cysteine-type deubiquitinase activity	21873635	Function
CYLD	GO:0005829	cytosol	21873635	Component
CYLD	GO:0007346	regulation of mitotic cell cycle	21873635	Process
CYLD	GO:0032088	negative regulation of NF-kappaB transcription factor activity	21873635	Process
CYLD	GO:0061578	Lys63-specific deubiquitinase activity	21873635	Function
CYLD	GO:0070266	necroptotic process	21873635	Process
CYLD	GO:0070536	protein K63-linked deubiquitination	21873635	Process
CYLD	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	21873635	Process
CYLD	GO:2001242	regulation of intrinsic apoptotic signaling pathway	21873635	Process

Top

Spatial pattern events for CYLD

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CYLD	Human	Liver	rep_liver1	34417225	5.14e-11
CYLD	Human	Breast	1160920F	34493872	2.68e-15
CYLD	Human	Breast	CID44971	34493872	5.90e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Breast_1160920F_H&E
Breast_CID44971_H&E

Top

Spatial pattern pathway has CYLD envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CYLD	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Brain	rep_1	7.4e-34
CYLD	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
CYLD	GOBP_Regulation_Of_Defense_Response	Human	Brain	rep_1	3.1e-41
CYLD	GOBP_Regulation_Of_Inflammatory_Response	Human	Brain	rep_1	3.1e-41
CYLD	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
CYLD	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Brain	rep_1	4.6e-05
CYLD	GOBP_Regulation_Of_Response_To_Stress	Human	Brain	rep_1	4.6e-05
CYLD	GOBP_Cytokine_Production	Human	Brain	rep_4	4.1e-17
CYLD	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
CYLD	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
CYLD	GOBP_Inflammatory_Response	Human	Brain	rep_4	5.6e-28
CYLD	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
CYLD	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
CYLD	GOBP_Necrotic_Cell_Death	Human	Bladder	rep_4	8.2e-15
CYLD	GOBP_Regulation_Of_Necrotic_Cell_Death	Human	Bladder	rep_4	6.8e-16
CYLD	GOBP_Cytokine_Production	Human	Liver	rep_1	1.0e-70
CYLD	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
CYLD	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
CYLD	GOBP_Inflammatory_Response	Human	Liver	rep_1	1.1e-67
CYLD	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
CYLD	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Liver	rep_1	1.5e-73
CYLD	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Human	Liver	rep_1	2.8e-53
CYLD	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Liver	rep_1	2.8e-53
CYLD	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
CYLD	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
CYLD	GOBP_Regulation_Of_Defense_Response	Human	Liver	rep_1	3.7e-85
CYLD	GOBP_Regulation_Of_Inflammatory_Response	Human	Liver	rep_1	3.7e-85
CYLD	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
CYLD	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Liver	rep_1	5.3e-67
CYLD	GOBP_Regulation_Of_Response_To_Stress	Human	Liver	rep_1	5.3e-67
CYLD	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
CYLD	GOBP_Cytokine_Production	Human	Intestine	rep_colon4	9.0e-12
CYLD	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
CYLD	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
CYLD	GOBP_Inflammatory_Response	Human	Intestine	rep_colon4	3.1e-51
CYLD	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
CYLD	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
CYLD	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
CYLD	GOBP_Regulation_Of_Defense_Response	Human	Intestine	rep_colon4	5.8e-33
CYLD	GOBP_Regulation_Of_Inflammatory_Response	Human	Intestine	rep_colon4	5.8e-33
CYLD	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Intestine	rep_colon4	2.2e-52
CYLD	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	rep_colon4	2.2e-52
CYLD	GOBP_Apoptotic_Signaling_Pathway	Human	Intestine	A3	7.0e-12
CYLD	GOBP_Cell_Cell_Signaling	Human	Intestine	A3	6.4e-08
CYLD	GOBP_Cell_Cell_Signaling_By_Wnt	Human	Intestine	A3	3.1e-07
CYLD	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
CYLD	GOBP_Cell_Projection_Assembly	Human	Intestine	A3	4.9e-09
CYLD	GOBP_Cell_Projection_Organization	Human	Intestine	A3	1.1e-09
CYLD	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Human	Intestine	A3	7.0e-07
CYLD	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
CYLD	GOBP_Cilium_Organization	Human	Intestine	A3	7.4e-11
CYLD	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Intestine	A3	2.6e-09
CYLD	GOBP_Cytokine_Production	Human	Intestine	A3	8.9e-12
CYLD	GOBP_Cytoplasmic_Pattern_Recognition_Receptor_Signaling_Pathway	Human	Intestine	A3	1.2e-13
CYLD	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
CYLD	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Human	Intestine	A3	3.4e-16
CYLD	GOBP_Inflammatory_Response	Human	Intestine	A3	2.9e-09
CYLD	GOBP_Intracellular_Receptor_Signaling_Pathway	Human	Intestine	A3	1.7e-24
CYLD	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Human	Intestine	A3	2.5e-16
CYLD	GOBP_Jnk_Cascade	Human	Intestine	A3	3.8e-08
CYLD	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
CYLD	GOBP_Mapk_Cascade	Human	Intestine	A3	1.1e-12
CYLD	GOBP_Microtubule_Based_Process	Human	Intestine	A3	3.4e-11
CYLD	GOBP_Microtubule_Cytoskeleton_Organization	Human	Intestine	A3	4.8e-11
CYLD	GOBP_Mitotic_Cell_Cycle	Human	Intestine	A3	1.8e-12
CYLD	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Intestine	A3	7.7e-11
CYLD	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Human	Intestine	A3	1.6e-07
CYLD	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
CYLD	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-18
CYLD	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	A3	6.2e-10
CYLD	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Intestine	A3	6.0e-11
CYLD	GOBP_Negative_Regulation_Of_Signaling	Human	Intestine	A3	4.9e-15
CYLD	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Human	Intestine	A3	1.2e-10
CYLD	GOBP_Nik_Nf_Kappab_Signaling	Human	Intestine	A3	2.0e-08
CYLD	GOBP_Nucleotide_Binding_Domain_Leucine_Rich_Repeat_Containing_Receptor_Signaling_Pathway	Human	Intestine	A3	2.4e-08
CYLD	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
CYLD	GOBP_Positive_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Intestine	A3	1.8e-07
CYLD	GOBP_Positive_Regulation_Of_Cell_Death	Human	Intestine	A3	4.5e-11
CYLD	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
CYLD	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
CYLD	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
CYLD	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
CYLD	GOBP_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Intestine	A3	1.3e-15
CYLD	GOBP_Regulation_Of_Cell_Cycle	Human	Intestine	A3	1.6e-08
CYLD	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
CYLD	GOBP_Regulation_Of_Cell_Projection_Assembly	Human	Intestine	A3	4.1e-07
CYLD	GOBP_Regulation_Of_Cell_Projection_Organization	Human	Intestine	A3	7.0e-08
CYLD	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	8.8e-12
CYLD	GOBP_Regulation_Of_Cellular_Response_To_Stress	Human	Intestine	A3	7.7e-17
CYLD	GOBP_Regulation_Of_Cilium_Assembly	Human	Intestine	A3	3.3e-09
CYLD	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	6.4e-13
CYLD	GOBP_Regulation_Of_Defense_Response	Human	Intestine	A3	1.6e-08
CYLD	GOBP_Regulation_Of_Dna_Binding_Transcription_Factor_Activity	Human	Intestine	A3	3.1e-19
CYLD	GOBP_Regulation_Of_Extrinsic_Apoptotic_Signaling_Pathway	Human	Intestine	A3	9.3e-12
CYLD	GOBP_Regulation_Of_Inflammatory_Response	Human	Intestine	A3	1.8e-11
CYLD	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
CYLD	GOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_Pathway	Human	Intestine	A3	1.3e-16
CYLD	GOBP_Regulation_Of_Microtubule_Based_Process	Human	Intestine	A3	1.2e-12
CYLD	GOBP_Regulation_Of_Microtubule_Cytoskeleton_Organization	Human	Intestine	A3	2.3e-15
CYLD	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Intestine	A3	1.5e-08
CYLD	GOBP_Regulation_Of_Necrotic_Cell_Death	Human	Intestine	A3	2.9e-07
CYLD	GOBP_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Intestine	A3	2.5e-08
CYLD	GOBP_Regulation_Of_Organelle_Assembly	Human	Intestine	A3	9.7e-21
CYLD	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
CYLD	GOBP_Regulation_Of_Response_To_Cytokine_Stimulus	Human	Intestine	A3	7.7e-20
CYLD	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Intestine	A3	1.0e-09
CYLD	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	A3	1.1e-10
CYLD	GOBP_Response_To_Tumor_Necrosis_Factor	Human	Intestine	A3	2.5e-09
CYLD	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Intestine	A3	1.7e-07
CYLD	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
CYLD	GOBP_Necrotic_Cell_Death	Human	Intestine	A8	9.0e-13
CYLD	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Intestine	A8	6.2e-16
CYLD	GOBP_Negative_Regulation_Of_Jnk_Cascade	Human	Intestine	A8	1.5e-07
CYLD	GOBP_Negative_Regulation_Of_Mapk_Cascade	Human	Intestine	A8	1.2e-15
CYLD	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Intestine	A8	4.6e-12
CYLD	GOBP_Negative_Regulation_Of_Nf_Kappab_Transcription_Factor_Activity	Human	Intestine	A8	2.2e-12
CYLD	GOBP_Negative_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Intestine	A8	1.4e-10
CYLD	GOBP_Negative_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Intestine	A8	6.5e-23
CYLD	GOBP_Negative_Regulation_Of_Type_I_Interferon_Production	Human	Intestine	A8	1.3e-08
CYLD	GOBP_P38mapk_Cascade	Human	Intestine	A8	3.8e-20
CYLD	GOBP_Pattern_Recognition_Receptor_Signaling_Pathway	Human	Intestine	A8	1.4e-24
CYLD	GOBP_Positive_Regulation_Of_Extrinsic_Apoptotic_Signaling_Pathway	Human	Intestine	A8	9.1e-12
CYLD	GOBP_Programmed_Necrotic_Cell_Death	Human	Intestine	A8	2.5e-10
CYLD	GOBP_Protein_K63_Linked_Deubiquitination	Human	Intestine	A8	5.5e-14
CYLD	GOBP_Regulation_Of_Jnk_Cascade	Human	Intestine	A8	2.0e-08
CYLD	GOBP_Regulation_Of_Programmed_Necrotic_Cell_Death	Human	Intestine	A8	5.0e-14
CYLD	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Intestine	A8	4.3e-23
CYLD	GOBP_Regulation_Of_Tumor_Necrosis_Factor_Mediated_Signaling_Pathway	Human	Intestine	A8	1.1e-08
CYLD	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
CYLD	GOBP_Tumor_Necrosis_Factor_Mediated_Signaling_Pathway	Human	Intestine	A8	1.1e-17
CYLD	GOBP_Negative_Regulation_Of_Signaling	Human	Pancreas	PDAC-B-st1	1.7e-05
CYLD	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Human	Pancreas	PDAC-B-st1	4.2e-05
CYLD	GOBP_P38mapk_Cascade	Human	Pancreas	PDAC-B-st1	3.3e-06
CYLD	GOBP_Programmed_Necrotic_Cell_Death	Human	Pancreas	PDAC-B-st1	9.1e-05
CYLD	GOBP_Regulation_Of_Jnk_Cascade	Human	Pancreas	PDAC-B-st1	4.6e-05
CYLD	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Pancreas	PDAC-B-st1	1.6e-06
CYLD	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Pancreas	PDAC-B-st1	3.7e-05
CYLD	GOBP_Protein_Modification_By_Small_Protein_Removal	Human	Pancreas	PDAC-A-st2	1.0e-05
CYLD	GOBP_Regulation_Of_Cilium_Assembly	Human	Pancreas	PDAC-A-st2	2.2e-06
CYLD	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
CYLD	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
CYLD	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
CYLD	GOBP_Cytoplasmic_Pattern_Recognition_Receptor_Signaling_Pathway	Human	Uterus	rep_25	6.8e-10
CYLD	GOBP_Negative_Regulation_Of_Nf_Kappab_Transcription_Factor_Activity	Human	Uterus	rep_25	7.4e-07
CYLD	GOBP_Cell_Cell_Signaling_By_Wnt	Human	Uterus	rep_26	5.5e-06
CYLD	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Human	Uterus	rep_26	9.2e-08
CYLD	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
CYLD	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Uterus	rep_26	2.0e-10
CYLD	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Human	Uterus	rep_26	1.2e-09
CYLD	GOBP_Intracellular_Receptor_Signaling_Pathway	Human	Uterus	rep_26	7.9e-12
CYLD	GOBP_Jnk_Cascade	Human	Uterus	rep_26	2.0e-08
CYLD	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
CYLD	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	1.1e-07
CYLD	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Uterus	rep_26	6.8e-07
CYLD	GOBP_Negative_Regulation_Of_Dna_Binding_Transcription_Factor_Activity	Human	Uterus	rep_26	1.8e-07
CYLD	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_26	2.7e-06
CYLD	GOBP_Negative_Regulation_Of_Jnk_Cascade	Human	Uterus	rep_26	1.3e-11
CYLD	GOBP_Negative_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Uterus	rep_26	1.2e-11
CYLD	GOBP_Negative_Regulation_Of_P38mapk_Cascade	Human	Uterus	rep_26	5.0e-06
CYLD	GOBP_Negative_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Uterus	rep_26	2.6e-10
CYLD	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Human	Uterus	rep_26	1.4e-06
CYLD	GOBP_Nik_Nf_Kappab_Signaling	Human	Uterus	rep_26	1.7e-11
CYLD	GOBP_Nucleotide_Binding_Domain_Leucine_Rich_Repeat_Containing_Receptor_Signaling_Pathway	Human	Uterus	rep_26	1.2e-07
CYLD	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
CYLD	GOBP_P38mapk_Cascade	Human	Uterus	rep_26	4.8e-07
CYLD	GOBP_Positive_Regulation_Of_Extrinsic_Apoptotic_Signaling_Pathway	Human	Uterus	rep_26	2.8e-06
CYLD	GOBP_Programmed_Necrotic_Cell_Death	Human	Uterus	rep_26	4.5e-08
CYLD	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
CYLD	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
CYLD	GOBP_Protein_Modification_By_Small_Protein_Removal	Human	Uterus	rep_26	7.2e-09
CYLD	GOBP_Regulation_Of_Cilium_Assembly	Human	Uterus	rep_26	3.5e-10
CYLD	GOBP_Regulation_Of_Microtubule_Cytoskeleton_Organization	Human	Uterus	rep_26	1.4e-06
CYLD	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Uterus	rep_26	2.5e-07
CYLD	GOBP_Regulation_Of_Necrotic_Cell_Death	Human	Uterus	rep_26	1.5e-08
CYLD	GOBP_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Uterus	rep_26	8.5e-12
CYLD	GOBP_Regulation_Of_Organelle_Assembly	Human	Uterus	rep_26	2.0e-06
CYLD	GOBP_Regulation_Of_Programmed_Necrotic_Cell_Death	Human	Uterus	rep_26	1.4e-14
CYLD	GOBP_Regulation_Of_Response_To_Cytokine_Stimulus	Human	Uterus	rep_26	2.4e-10
CYLD	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Uterus	rep_26	7.8e-06
CYLD	GOBP_Regulation_Of_Tumor_Necrosis_Factor_Mediated_Signaling_Pathway	Human	Uterus	rep_26	1.8e-08
CYLD	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Human	Uterus	rep_26	9.9e-10
CYLD	GOBP_Response_To_Tumor_Necrosis_Factor	Human	Uterus	rep_26	1.5e-09
CYLD	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Uterus	rep_26	3.2e-09
CYLD	GOBP_Type_I_Interferon_Production	Human	Uterus	rep_26	7.8e-11
CYLD	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Uterus	rep_29	1.6e-12
CYLD	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Uterus	rep_29	1.2e-06
CYLD	GOBP_Negative_Regulation_Of_Signaling	Human	Uterus	rep_29	5.3e-06
CYLD	GOBP_Cell_Projection_Assembly	Human	Breast	rep_1	1.9e-26
CYLD	GOBP_Cell_Projection_Organization	Human	Breast	rep_1	1.8e-20
CYLD	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.5e-144
CYLD	GOBP_Cytokine_Production	Human	Breast	rep_1	6.5e-12
CYLD	GOBP_Cytoskeleton_Organization	Human	Breast	rep_1	1.3e-22
CYLD	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
CYLD	GOBP_Inflammatory_Response	Human	Breast	rep_1	3.7e-43
CYLD	GOBP_Necrotic_Cell_Death	Human	Breast	rep_1	1.3e-71
CYLD	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Breast	rep_1	1.3e-70
CYLD	GOBP_Negative_Regulation_Of_Dna_Binding_Transcription_Factor_Activity	Human	Breast	rep_1	1.1e-71
CYLD	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_1	3.6e-04
CYLD	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Breast	rep_1	7.1e-11
CYLD	GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process	Human	Breast	rep_1	8.3e-12
CYLD	GOBP_Negative_Regulation_Of_Nf_Kappab_Transcription_Factor_Activity	Human	Breast	rep_1	2.1e-20
CYLD	GOBP_Negative_Regulation_Of_P38mapk_Cascade	Human	Breast	rep_1	2.5e-16
CYLD	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Breast	rep_1	2.4e-07
CYLD	GOBP_P38mapk_Cascade	Human	Breast	rep_1	5.5e-16
CYLD	GOBP_Positive_Regulation_Of_Cell_Death	Human	Breast	rep_1	2.2e-15
CYLD	GOBP_Positive_Regulation_Of_Extrinsic_Apoptotic_Signaling_Pathway	Human	Breast	rep_1	4.5e-10
CYLD	GOBP_Regulation_Of_Cell_Projection_Assembly	Human	Breast	rep_1	6.5e-29
CYLD	GOBP_Regulation_Of_Cell_Projection_Organization	Human	Breast	rep_1	3.8e-16
CYLD	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	4.6e-05
CYLD	GOBP_Regulation_Of_Cilium_Assembly	Human	Breast	rep_1	8.0e-07
CYLD	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	7.8e-76
CYLD	GOBP_Regulation_Of_Defense_Response	Human	Breast	rep_1	1.1e-15
CYLD	GOBP_Regulation_Of_Extrinsic_Apoptotic_Signaling_Pathway	Human	Breast	rep_1	1.4e-06
CYLD	GOBP_Regulation_Of_Inflammatory_Response	Human	Breast	rep_1	7.3e-22
CYLD	GOBP_Regulation_Of_Necrotic_Cell_Death	Human	Breast	rep_1	3.7e-53
CYLD	GOBP_Regulation_Of_Organelle_Assembly	Human	Breast	rep_1	1.0e-12
CYLD	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
CYLD	GOBP_Regulation_Of_Response_To_Cytokine_Stimulus	Human	Breast	rep_1	2.1e-159
CYLD	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Breast	rep_1	2.9e-17
CYLD	GOBP_Regulation_Of_Response_To_Stress	Human	Breast	rep_1	3.4e-19
CYLD	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
CYLD	GOBP_Response_To_Tumor_Necrosis_Factor	Human	Breast	rep_1	1.7e-52
CYLD	GOBP_Tumor_Necrosis_Factor_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.8e-64
CYLD	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
CYLD	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Human	Breast	rep_5	7.1e-11
CYLD	GOBP_Jnk_Cascade	Human	Breast	rep_5	4.2e-05
CYLD	GOBP_Mapk_Cascade	Human	Breast	rep_5	4.6e-17
CYLD	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
CYLD	GOBP_Negative_Regulation_Of_Signaling	Human	Breast	rep_5	8.6e-14
CYLD	GOBP_Negative_Regulation_Of_Type_I_Interferon_Production	Human	Breast	rep_5	6.4e-08
CYLD	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Human	Breast	rep_5	4.8e-05
CYLD	GOBP_Nik_Nf_Kappab_Signaling	Human	Breast	rep_5	1.3e-07
CYLD	GOBP_Pattern_Recognition_Receptor_Signaling_Pathway	Human	Breast	rep_5	9.3e-12
CYLD	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
CYLD	GOBP_Programmed_Necrotic_Cell_Death	Human	Breast	rep_5	2.5e-09
CYLD	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
CYLD	GOBP_Regulation_Of_Cell_Cycle	Human	Breast	rep_5	3.7e-04
CYLD	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
CYLD	GOBP_Regulation_Of_Cellular_Response_To_Stress	Human	Breast	rep_5	8.1e-10
CYLD	GOBP_Regulation_Of_Dna_Binding_Transcription_Factor_Activity	Human	Breast	rep_5	8.2e-07
CYLD	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
CYLD	GOBP_Regulation_Of_Jnk_Cascade	Human	Breast	rep_5	5.1e-06
CYLD	GOBP_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Breast	rep_5	2.7e-07
CYLD	GOBP_Regulation_Of_Programmed_Necrotic_Cell_Death	Human	Breast	rep_5	7.1e-17
CYLD	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Breast	rep_5	9.2e-08
CYLD	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Breast	rep_5	1.3e-07
CYLD	GOBP_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	4.8e-09
CYLD	GOBP_Canonical_Wnt_Signaling_Pathway	Human	Breast	rep_6	6.4e-04
CYLD	GOBP_Cell_Cell_Signaling	Human	Breast	rep_6	5.0e-05
CYLD	GOBP_Cell_Cell_Signaling_By_Wnt	Human	Breast	rep_6	4.2e-06
CYLD	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
CYLD	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Human	Breast	rep_6	1.5e-06
CYLD	GOBP_Cilium_Organization	Human	Breast	rep_6	3.8e-08
CYLD	GOBP_Cytoplasmic_Pattern_Recognition_Receptor_Signaling_Pathway	Human	Breast	rep_6	5.0e-06
CYLD	GOBP_Intracellular_Receptor_Signaling_Pathway	Human	Breast	rep_6	1.6e-06
CYLD	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	2.7e-08
CYLD	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
CYLD	GOBP_Microtubule_Based_Process	Human	Breast	rep_6	1.8e-04
CYLD	GOBP_Microtubule_Cytoskeleton_Organization	Human	Breast	rep_6	1.9e-04
CYLD	GOBP_Mitotic_Cell_Cycle	Human	Breast	rep_6	3.2e-09
CYLD	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Breast	rep_6	2.2e-09
CYLD	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Human	Breast	rep_6	2.1e-06
CYLD	GOBP_Negative_Regulation_Of_Jnk_Cascade	Human	Breast	rep_6	6.8e-04
CYLD	GOBP_Negative_Regulation_Of_Mapk_Cascade	Human	Breast	rep_6	4.5e-09
CYLD	GOBP_Negative_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Breast	rep_6	7.7e-04
CYLD	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
CYLD	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
CYLD	GOBP_Positive_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	2.5e-08
CYLD	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
CYLD	GOBP_Protein_K63_Linked_Deubiquitination	Human	Breast	rep_6	5.6e-10
CYLD	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
CYLD	GOBP_Protein_Modification_By_Small_Protein_Removal	Human	Breast	rep_6	1.4e-06
CYLD	GOBP_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	1.6e-07
CYLD	GOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	3.3e-09
CYLD	GOBP_Regulation_Of_Microtubule_Based_Process	Human	Breast	rep_6	2.1e-05
CYLD	GOBP_Regulation_Of_Microtubule_Cytoskeleton_Organization	Human	Breast	rep_6	1.8e-05
CYLD	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Breast	rep_6	4.6e-09
CYLD	GOBP_Regulation_Of_Tumor_Necrosis_Factor_Mediated_Signaling_Pathway	Human	Breast	rep_6	1.0e-05
CYLD	GOBP_Type_I_Interferon_Production	Human	Breast	rep_6	3.7e-04
CYLD	GOBP_Protein_K63_Linked_Deubiquitination	Human	Skin	P2_rep2	1.7e-09
CYLD	GOBP_Negative_Regulation_Of_P38mapk_Cascade	Human	Skin	P5_rep3	1.6e-10
CYLD	GOBP_P38mapk_Cascade	Human	Skin	P5_rep3	9.4e-08
CYLD	GOBP_Cytoskeleton_Organization	Human	Skin	P9_rep3	3.1e-12
CYLD	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Human	Skin	P9_rep3	4.3e-09
CYLD	GOBP_Positive_Regulation_Of_Extrinsic_Apoptotic_Signaling_Pathway	Human	Skin	P10_rep1	7.4e-08
CYLD	GOBP_Type_I_Interferon_Production	Human	Skin	P10_rep1	8.1e-10
CYLD	GOBP_Programmed_Necrotic_Cell_Death	Human	Skin	P10_rep2	4.3e-17
CYLD	GOBP_Regulation_Of_Programmed_Necrotic_Cell_Death	Human	Skin	P10_rep2	3.0e-18
CYLD	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
CYLD	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
CYLD	GOBP_Inflammatory_Response	Human	Lung	rep_1	1.4e-10
CYLD	GOBP_Negative_Regulation_Of_Cytokine_Production	Human	Lung	rep_1	8.4e-07
CYLD	GOBP_Regulation_Of_Dna_Binding_Transcription_Factor_Activity	Human	Lung	rep_1	1.9e-10
CYLD	GOBP_Positive_Regulation_Of_Cell_Death	Human	Lung	rep_2	3.0e-07

Top

CYLD function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

CYLD function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for CYLD envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for CYLD

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CYLD

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
CYLD	C1857941	Brooke-Spiegler syndrome	13	CLINGEN;CTD_human;UNIPROT
CYLD	C1275122	Familial multiple trichoepitheliomata	5	CTD_human;ORPHANET;UNIPROT
CYLD	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
CYLD	C0007873	Uterine Cervical Neoplasm	1	CTD_human
CYLD	C0023860	Listeriosis	1	CTD_human
CYLD	C0040100	Thymoma	1	CTD_human
CYLD	C0205969	Thymic Carcinoma	1	CTD_human
CYLD	C1305968	Eccrine dermal cylindroma	1	CTD_human
CYLD	C1851526	Ancell-Spiegler cylindromas	1	ORPHANET
CYLD	C2239176	Liver carcinoma	1	CTD_human
CYLD	C4048328	cervical cancer	1	CTD_human