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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CTSV (spascer ID:1515)

Gene summary for CTSV

Gene summary

Gene information
	Species	Human
	Gene symbol	CTSV
	Gene ID	1515
	Gene name	cathepsin V
	Synonyms	CATL2\|CTSL2\|CTSU
	Cytomap	9q22.33
	Type of gene	protein-coding
	Description	cathepsin L2cathepsin L2, preproproteincathepsin U
	Modification date	20220513
	UniProtAcc	O60911

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CTSV	GO:0004197	cysteine-type endopeptidase activity	21873635	Function
CTSV	GO:0005615	extracellular space	21873635	Component
CTSV	GO:0005764	lysosome	21873635	Component
CTSV	GO:0006955	immune response	21873635	Process
CTSV	GO:0051603	proteolysis involved in cellular protein catabolic process	21873635	Process

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Spatial pattern events for CTSV

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CTSV	Human	Bladder	rep_1	34385456	9.85e-11
CTSV	Human	Intestine	rep_colon1	34417225	6.48e-15
CTSV	Human	Liver	rep_liver1	34417225	1.08e-15
CTSV	Human	Intestine	A6	33406409	8.60e-14
CTSV	Human	Intestine	A7	33406409	5.31e-11
CTSV	Human	Skin	P2_rep3	32946785	6.56e-11
CTSV	Human	Skin	P10_rep2	32946785	6.19e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_1_H&E
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Intestine_A6_H&E
Intestine_A7_H&E
Skin_P2_rep3_H&E
Skin_P10_rep2_H&E

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Spatial pattern pathway has CTSV envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CTSV	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Brain	rep_4	4.1e-17
CTSV	GOBP_External_Encapsulating_Structure_Organization	Human	Bladder	rep_2	8.7e-05
CTSV	GOBP_Skin_Development	Human	Bladder	rep_2	4.8e-19
CTSV	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Liver	rep_1	1.0e-70
CTSV	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Intestine	rep_colon4	9.0e-12
CTSV	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
CTSV	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
CTSV	GOBP_Epidermis_Development	Human	Intestine	A3	2.4e-10
CTSV	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
CTSV	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
CTSV	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
CTSV	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
CTSV	GOBP_Regulation_Of_Cell_Differentiation	Human	Intestine	A3	1.7e-10
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Intestine	A3	1.8e-14
CTSV	GOBP_Antigen_Processing_And_Presentation	Human	Intestine	A8	1.7e-13
CTSV	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Human	Intestine	A8	8.9e-10
CTSV	GOBP_Epidermal_Cell_Differentiation	Human	Intestine	A8	2.8e-14
CTSV	GOBP_Epithelial_Cell_Differentiation	Human	Intestine	A8	6.8e-07
CTSV	GOBP_Extracellular_Matrix_Disassembly	Human	Intestine	A8	6.1e-14
CTSV	GOBP_Keratinocyte_Differentiation	Human	Intestine	A8	6.0e-13
CTSV	GOBP_Regulation_Of_Epidermis_Development	Human	Intestine	A8	4.2e-10
CTSV	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Human	Intestine	A8	2.6e-10
CTSV	GOBP_Regulation_Of_Keratinocyte_Differentiation	Human	Intestine	A8	6.4e-16
CTSV	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Human	Pancreas	PDAC-B-st1	7.1e-05
CTSV	GOBP_Extracellular_Matrix_Disassembly	Human	Pancreas	PDAC-B-st1	6.6e-05
CTSV	GOBP_Regulation_Of_Keratinocyte_Differentiation	Human	Pancreas	PDAC-A-st2	3.7e-08
CTSV	GOBP_Extracellular_Matrix_Disassembly	Human	Uterus	rep_1	2.1e-07
CTSV	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Human	Uterus	rep_26	7.6e-06
CTSV	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
CTSV	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
CTSV	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
CTSV	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
CTSV	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Uterus	rep_26	7.3e-07
CTSV	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Human	Uterus	rep_28	2.7e-08
CTSV	GOBP_Regulation_Of_Cell_Differentiation	Human	Uterus	rep_29	2.8e-06
CTSV	GOBP_Epidermal_Cell_Differentiation	Human	Breast	rep_1	6.0e-94
CTSV	GOBP_Epidermis_Development	Human	Breast	rep_1	1.4e-136
CTSV	GOBP_Epithelial_Cell_Differentiation	Human	Breast	rep_1	4.5e-30
CTSV	GOBP_Epithelium_Development	Human	Breast	rep_1	2.0e-22
CTSV	GOBP_External_Encapsulating_Structure_Organization	Human	Breast	rep_1	2.8e-108
CTSV	GOBP_Extracellular_Matrix_Disassembly	Human	Breast	rep_1	4.6e-83
CTSV	GOBP_Keratinocyte_Differentiation	Human	Breast	rep_1	6.5e-159
CTSV	GOBP_Regulation_Of_Cell_Differentiation	Human	Breast	rep_1	2.5e-42
CTSV	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Human	Breast	rep_1	5.9e-91
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Breast	rep_1	4.5e-113
CTSV	GOBP_Skin_Development	Human	Breast	rep_1	2.0e-70
CTSV	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
CTSV	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
CTSV	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
CTSV	GOBP_Regulation_Of_Epidermis_Development	Human	Breast	rep_5	9.2e-07
CTSV	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
CTSV	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
CTSV	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
CTSV	GOBP_Epidermis_Development	Human	Skin	P9_rep3	3.7e-09
CTSV	GOBP_Epithelium_Development	Human	Skin	P9_rep3	4.2e-08
CTSV	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Human	Lung	rep_2	1.2e-07
CTSV	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07
CTSV	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Lung	rep_2	9.5e-07

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CTSV function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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CTSV function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for CTSV envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for CTSV

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CTSV

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source