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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CST4 (spascer ID:1472)

Gene summary for CST4

Gene summary

Gene information
	Species	Human
	Gene symbol	CST4
	Gene ID	1472
	Gene name	cystatin S
	Synonyms	-
	Cytomap	20p11.21
	Type of gene	protein-coding
	Description	cystatin-Scystatin 4cystatin-SA-IIIsalivary acidic protein 1
	Modification date	20220513
	UniProtAcc	P01036

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CST4	GO:0005615	extracellular space	21873635	Component

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Spatial pattern events for CST4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CST4	Human	Liver	rep_liver2	34417225	6.98e-16
CST4	Human	Pancreas	PDAC-A-st1	31932730	1.60e-06
CST4	Human	Pancreas	PDAC-B-st1	31932730	8.45e-10
CST4	Human	Pancreas	PDAC-B-st3	31932730	2.96e-06
CST4	Human	Pancreas	PDAC-D-st1	31932730	6.89e-14
CST4	Human	Pancreas	PDAC-G-st1	31932730	8.96e-07
CST4	Human	Skin	mel2_rep2	30154148	5.74e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E

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Spatial pattern pathway has CST4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CST4	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Brain	rep_1	7.4e-34
CST4	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
CST4	GOBP_Negative_Regulation_Of_Proteolysis	Human	Brain	rep_1	2.8e-23
CST4	GOBP_Regulation_Of_Proteolysis	Human	Brain	rep_1	4.4e-07
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
CST4	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Brain	rep_4	4.1e-17
CST4	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Liver	rep_1	1.5e-73
CST4	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
CST4	GOBP_Negative_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.0e-70
CST4	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Liver	rep_1	6.0e-76
CST4	GOBP_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.1e-67
CST4	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	rep_colon4	1.9e-09
CST4	GOBP_Regulation_Of_Proteolysis	Human	Intestine	rep_colon4	1.2e-51
CST4	GOBP_Detection_Of_Chemical_Stimulus_Involved_In_Sensory_Perception_Of_Taste	Human	Intestine	A3	8.7e-08
CST4	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
CST4	GOBP_Multicellular_Organismal_Homeostasis	Human	Intestine	A3	8.8e-08
CST4	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	3.0e-12
CST4	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
CST4	GOBP_Nervous_System_Process	Human	Intestine	A3	9.7e-07
CST4	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Intestine	A3	9.8e-13
CST4	GOBP_Regulation_Of_Proteolysis	Human	Intestine	A3	9.5e-13
CST4	GOBP_Detection_Of_Stimulus	Human	Intestine	A8	2.4e-11
CST4	GOBP_Detection_Of_Stimulus_Involved_In_Sensory_Perception	Human	Intestine	A8	1.2e-14
CST4	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Intestine	A8	2.1e-14
CST4	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Intestine	A8	4.6e-12
CST4	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Intestine	A8	1.7e-19
CST4	GOBP_Negative_Regulation_Of_Proteolysis	Human	Intestine	A8	8.9e-12
CST4	GOBP_Sensory_Perception	Human	Intestine	A8	2.1e-09
CST4	GOBP_Sensory_Perception_Of_Taste	Human	Intestine	A8	3.2e-15
CST4	GOBP_Anatomical_Structure_Homeostasis	Human	Uterus	rep_1	8.8e-07
CST4	GOBP_Multicellular_Organismal_Homeostasis	Human	Uterus	rep_1	2.0e-06
CST4	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
CST4	GOBP_Nervous_System_Process	Human	Uterus	rep_26	2.3e-07
CST4	GOBP_Regulation_Of_Proteolysis	Human	Uterus	rep_26	2.1e-07
CST4	GOBP_Detection_Of_Chemical_Stimulus_Involved_In_Sensory_Perception_Of_Taste	Human	Uterus	rep_29	8.3e-13
CST4	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Uterus	rep_29	4.3e-12
CST4	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	2.9e-08
CST4	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Uterus	rep_29	1.6e-12
CST4	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	2.0e-13
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Uterus	rep_29	1.4e-10
CST4	GOBP_Sensory_Perception_Of_Bitter_Taste	Human	Uterus	rep_29	5.6e-07
CST4	GOBP_Detection_Of_Stimulus	Human	Breast	rep_1	1.8e-04
CST4	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
CST4	GOBP_Multicellular_Organismal_Homeostasis	Human	Breast	rep_1	1.5e-16
CST4	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Breast	rep_1	7.1e-11
CST4	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	7.8e-05
CST4	GOBP_Nervous_System_Process	Human	Breast	rep_1	1.2e-04
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Breast	rep_1	2.2e-33
CST4	GOBP_Regulation_Of_Proteolysis	Human	Breast	rep_1	6.4e-05
CST4	GOBP_Retina_Homeostasis	Human	Breast	rep_4	3.0e-05
CST4	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	3.6e-05
CST4	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
CST4	GOBP_Negative_Regulation_Of_Proteolysis	Human	Breast	rep_5	2.0e-06
CST4	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
CST4	GOBP_Detection_Of_Stimulus_Involved_In_Sensory_Perception	Human	Breast	rep_6	3.6e-05
CST4	GOBP_Sensory_Perception_Of_Taste	Human	Breast	rep_6	2.5e-06
CST4	GOBP_Detection_Of_Chemical_Stimulus_Involved_In_Sensory_Perception_Of_Taste	Human	Skin	P9_rep2	1.8e-14
CST4	GOBP_Sensory_Perception_Of_Bitter_Taste	Human	Skin	P9_rep2	2.0e-11
CST4	GOBP_Sensory_Perception_Of_Taste	Human	Skin	P9_rep2	9.9e-11
CST4	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Human	Skin	P10_rep2	6.5e-08
CST4	GOBP_Detection_Of_Chemical_Stimulus_Involved_In_Sensory_Perception_Of_Taste	Human	Lung	rep_1	2.4e-08
CST4	GOBP_Detection_Of_Stimulus_Involved_In_Sensory_Perception	Human	Lung	rep_1	6.6e-10
CST4	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Lung	rep_1	1.4e-08
CST4	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	5.7e-10
CST4	GOBP_Negative_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-10
CST4	GOBP_Negative_Regulation_Of_Proteolysis	Human	Lung	rep_1	5.7e-10
CST4	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
CST4	GOBP_Regulation_Of_Peptidase_Activity	Human	Lung	rep_1	4.6e-11
CST4	GOBP_Regulation_Of_Proteolysis	Human	Lung	rep_1	3.2e-08
CST4	GOBP_Sensory_Perception_Of_Bitter_Taste	Human	Lung	rep_1	5.9e-07
CST4	GOBP_Sensory_Perception_Of_Taste	Human	Lung	rep_1	2.1e-08

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CST4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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CST4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for CST4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for CST4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CST4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source