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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: VCAN (spascer ID:1462)

Gene summary for VCAN

Gene summary

Gene information
	Species	Human
	Gene symbol	VCAN
	Gene ID	1462
	Gene name	versican
	Synonyms	CSPG2\|ERVR\|GHAP\|PG-M\|WGN\|WGN1
	Cytomap	5q14.2-q14.3
	Type of gene	protein-coding
	Description	versican core proteinchondroitin sulfate proteoglycan core protein 2glial hyaluronate-binding proteinlarge fibroblast proteoglycanversican proteoglycan
	Modification date	20220513
	UniProtAcc	P13611

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
VCAN	GO:0001501	skeletal system development	21873635	Process
VCAN	GO:0007417	central nervous system development	21873635	Process
VCAN	GO:0031012	extracellular matrix	21873635	Component

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Spatial pattern events for VCAN

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
VCAN	Human	Brain	rep_10	33558695	3.23e-15
VCAN	Human	Bladder	rep_1	34385456	1.74e-12
VCAN	Human	Bladder	rep_2	34385456	6.29e-15
VCAN	Human	Intestine	rep_colon1	34417225	1.95e-15
VCAN	Human	Intestine	rep_colon2	34417225	8.12e-16
VCAN	Human	Intestine	rep_colon3	34417225	1.01e-15
VCAN	Human	Liver	rep_liver1	34417225	1.08e-15
VCAN	Human	Liver	rep_liver2	34417225	6.98e-16
VCAN	Human	Liver	rep_liver4	34417225	7.71e-16
VCAN	Human	Intestine	A3	33406409	1.27e-13
VCAN	Human	Intestine	A4	33406409	7.35e-15
VCAN	Human	Intestine	A6	33406409	2.26e-10
VCAN	Human	Intestine	A7	33406409	7.10e-10
VCAN	Human	Intestine	A8	33406409	1.93e-12
VCAN	Human	Intestine	A9	33406409	1.96e-07
VCAN	Human	Uterus	rep_1	34857954	5.13e-15
VCAN	Human	Uterus	rep_2	34857954	2.55e-15
VCAN	Human	Uterus	rep_3	34857954	1.66e-15
VCAN	Human	Uterus	rep_4	34857954	1.82e-15
VCAN	Human	Breast	1142243F	34493872	2.30e-15
VCAN	Human	Breast	1160920F	34493872	1.48e-15
VCAN	Human	Breast	CID4290	34493872	4.68e-15
VCAN	Human	Breast	CID4465	34493872	4.85e-15
VCAN	Human	Breast	CID44971	34493872	1.76e-15
VCAN	Human	Breast	CID4535	34493872	6.37e-15
VCAN	Human	Heart	w6_s3	31835037	7.27e-05
VCAN	Human	Heart	w6_s5	31835037	8.11e-06
VCAN	Human	Heart	w6_s6	31835037	1.09e-08
VCAN	Human	Heart	w6_s7	31835037	1.76e-06
VCAN	Human	Heart	w6_s8	31835037	1.81e-07
VCAN	Human	Skin	P2_rep1	32946785	5.41e-15
VCAN	Human	Skin	P2_rep2	32946785	5.48e-15
VCAN	Human	Skin	P2_rep3	32946785	5.90e-15
VCAN	Human	Skin	mel1_rep1	30154148	8.54e-06
VCAN	Human	Lung	rep_1	35355018	1.37e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_10_H&E
Bladder_rep_1_H&E
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Intestine_A3_H&E
Intestine_A4_H&E
Intestine_A6_H&E
Intestine_A7_H&E
Intestine_A8_H&E
Intestine_A9_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Skin_P2_rep3_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has VCAN envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
VCAN	GOBP_Central_Nervous_System_Development	Human	Brain	rep_1	2.8e-23
VCAN	GOBP_Chondroitin_Sulfate_Proteoglycan_Metabolic_Process	Human	Bladder	rep_2	3.1e-05
VCAN	GOBP_External_Encapsulating_Structure_Organization	Human	Bladder	rep_2	8.7e-05
VCAN	GOBP_Mucopolysaccharide_Metabolic_Process	Human	Bladder	rep_2	1.6e-11
VCAN	GOBP_Ossification	Human	Bladder	rep_2	1.1e-10
VCAN	GOBP_Osteoblast_Differentiation	Human	Bladder	rep_2	3.8e-11
VCAN	GOBP_Proteoglycan_Metabolic_Process	Human	Bladder	rep_2	1.1e-15
VCAN	GOBP_Skeletal_System_Development	Human	Bladder	rep_2	2.5e-15
VCAN	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Bladder	rep_4	3.0e-06
VCAN	GOBP_Central_Nervous_System_Development	Human	Liver	rep_1	1.0e-70
VCAN	GOBP_Biological_Adhesion	Human	Intestine	A3	6.7e-11
VCAN	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Intestine	A3	1.8e-09
VCAN	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
VCAN	GOBP_Central_Nervous_System_Development	Human	Intestine	A3	7.1e-11
VCAN	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
VCAN	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
VCAN	GOBP_Osteoblast_Differentiation	Human	Intestine	A3	1.4e-08
VCAN	GOBP_Aminoglycan_Biosynthetic_Process	Human	Intestine	A8	6.2e-18
VCAN	GOBP_Aminoglycan_Catabolic_Process	Human	Intestine	A8	5.0e-10
VCAN	GOBP_Carbohydrate_Derivative_Catabolic_Process	Human	Intestine	A8	3.2e-10
VCAN	GOBP_Cell_Recognition	Human	Intestine	A8	4.6e-18
VCAN	GOBP_Chondroitin_Sulfate_Biosynthetic_Process	Human	Intestine	A8	3.1e-12
VCAN	GOBP_Chondroitin_Sulfate_Proteoglycan_Biosynthetic_Process	Human	Intestine	A8	1.2e-24
VCAN	GOBP_Dermatan_Sulfate_Metabolic_Process	Human	Intestine	A8	4.8e-14
VCAN	GOBP_Glycoprotein_Biosynthetic_Process	Human	Intestine	A8	1.4e-09
VCAN	GOBP_Glycoprotein_Metabolic_Process	Human	Intestine	A8	5.3e-08
VCAN	GOBP_Ossification	Human	Intestine	A8	3.0e-07
VCAN	GOBP_Proteoglycan_Biosynthetic_Process	Human	Intestine	A8	1.1e-09
VCAN	GOBP_Sulfur_Compound_Biosynthetic_Process	Human	Intestine	A8	4.5e-20
VCAN	GOBP_Sulfur_Compound_Catabolic_Process	Human	Intestine	A8	4.4e-08
VCAN	GOBP_Sulfur_Compound_Metabolic_Process	Human	Intestine	A8	2.5e-14
VCAN	GOBP_Osteoblast_Differentiation	Human	Pancreas	PDAC-B-st1	7.4e-05
VCAN	GOBP_Aminoglycan_Biosynthetic_Process	Human	Pancreas	PDAC-A-st2	8.4e-06
VCAN	GOBP_Chondroitin_Sulfate_Biosynthetic_Process	Human	Pancreas	PDAC-A-st2	2.4e-06
VCAN	GOBP_Chondroitin_Sulfate_Proteoglycan_Biosynthetic_Process	Human	Pancreas	PDAC-A-st2	1.8e-08
VCAN	GOBP_Chondroitin_Sulfate_Proteoglycan_Metabolic_Process	Human	Pancreas	PDAC-A-st2	4.9e-05
VCAN	GOBP_Proteoglycan_Biosynthetic_Process	Human	Pancreas	PDAC-A-st2	1.9e-07
VCAN	GOBP_Proteoglycan_Metabolic_Process	Human	Pancreas	PDAC-A-st2	7.3e-05
VCAN	GOBP_Chondroitin_Sulfate_Biosynthetic_Process	Human	Uterus	rep_1	3.3e-06
VCAN	GOBP_Dermatan_Sulfate_Proteoglycan_Metabolic_Process	Human	Uterus	rep_1	3.7e-14
VCAN	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Uterus	rep_26	3.5e-11
VCAN	GOBP_Carbohydrate_Derivative_Catabolic_Process	Human	Uterus	rep_26	5.1e-11
VCAN	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
VCAN	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
VCAN	GOBP_Sulfur_Compound_Metabolic_Process	Human	Uterus	rep_26	8.8e-08
VCAN	GOBP_Biological_Adhesion	Human	Uterus	rep_29	3.3e-06
VCAN	GOBP_Mucopolysaccharide_Metabolic_Process	Human	Uterus	rep_29	7.2e-06
VCAN	GOBP_Osteoblast_Differentiation	Human	Uterus	rep_29	6.4e-07
VCAN	GOBP_Aminoglycan_Biosynthetic_Process	Human	Breast	rep_1	1.4e-24
VCAN	GOBP_Aminoglycan_Metabolic_Process	Human	Breast	rep_1	2.4e-24
VCAN	GOBP_Biological_Adhesion	Human	Breast	rep_1	4.0e-110
VCAN	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Breast	rep_1	2.1e-06
VCAN	GOBP_Central_Nervous_System_Development	Human	Breast	rep_1	5.1e-04
VCAN	GOBP_Chondroitin_Sulfate_Biosynthetic_Process	Human	Breast	rep_1	4.2e-163
VCAN	GOBP_Chondroitin_Sulfate_Proteoglycan_Biosynthetic_Process	Human	Breast	rep_1	9.6e-172
VCAN	GOBP_Chondroitin_Sulfate_Proteoglycan_Metabolic_Process	Human	Breast	rep_1	1.7e-63
VCAN	GOBP_Dermatan_Sulfate_Metabolic_Process	Human	Breast	rep_1	3.4e-77
VCAN	GOBP_Dermatan_Sulfate_Proteoglycan_Metabolic_Process	Human	Breast	rep_1	7.4e-173
VCAN	GOBP_External_Encapsulating_Structure_Organization	Human	Breast	rep_1	2.8e-108
VCAN	GOBP_Mucopolysaccharide_Metabolic_Process	Human	Breast	rep_1	7.8e-52
VCAN	GOBP_Proteoglycan_Metabolic_Process	Human	Breast	rep_1	8.4e-40
VCAN	GOBP_Carbohydrate_Derivative_Catabolic_Process	Human	Breast	rep_5	1.1e-09
VCAN	GOBP_Glycoprotein_Metabolic_Process	Human	Breast	rep_5	1.5e-14
VCAN	GOBP_Osteoblast_Differentiation	Human	Breast	rep_5	1.2e-07
VCAN	GOBP_Post_Translational_Protein_Modification	Human	Breast	rep_5	9.8e-05
VCAN	GOBP_Proteoglycan_Biosynthetic_Process	Human	Breast	rep_5	3.2e-06
VCAN	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
VCAN	GOBP_Glycoprotein_Biosynthetic_Process	Human	Breast	rep_6	4.8e-07
VCAN	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
VCAN	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
VCAN	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
VCAN	GOBP_Ossification	Human	Breast	rep_6	8.4e-04
VCAN	GOBP_Sulfur_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
VCAN	GOBP_Sulfur_Compound_Catabolic_Process	Human	Breast	rep_6	4.7e-11
VCAN	GOBP_Sulfur_Compound_Metabolic_Process	Human	Breast	rep_6	3.0e-10
VCAN	GOBP_Sulfur_Compound_Biosynthetic_Process	Human	Skin	P5_rep1	6.9e-17
VCAN	GOBP_Dermatan_Sulfate_Proteoglycan_Metabolic_Process	Human	Skin	P10_rep1	2.3e-17
VCAN	GOBP_Ossification	Human	Lung	rep_1	8.0e-09
VCAN	GOBP_Biological_Adhesion	Human	Lung	rep_2	6.6e-07

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VCAN function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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VCAN function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for VCAN envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for VCAN

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
VCAN	P13611	DB08818	Hyaluronic acid	Versican core protein	SmallMoleculeDrug	approved\|vet_approved

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Related Diseases for VCAN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
VCAN	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
VCAN	C0014175	Endometriosis	1	CTD_human
VCAN	C0036095	Salivary Gland Neoplasms	1	CTD_human
VCAN	C0220636	Malignant neoplasm of salivary gland	1	CTD_human
VCAN	C0269102	Endometrioma	1	CTD_human