Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CSF3R (spascer ID:1441)

Gene summary for CSF3R

Gene summary

Gene information
	Species	Human
	Gene symbol	CSF3R
	Gene ID	1441
	Gene name	colony stimulating factor 3 receptor
	Synonyms	CD114\|GCSFR\|SCN7
	Cytomap	1p34.3
	Type of gene	protein-coding
	Description	granulocyte colony-stimulating factor receptorCD114 antigenG-CSF receptorG-CSF-Rcolony stimulating factor 3 receptor (granulocyte)
	Modification date	20220515
	UniProtAcc	Q99062

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CSF3R	GO:0004896	cytokine receptor activity	21873635	Function
CSF3R	GO:0009897	external side of plasma membrane	21873635	Component
CSF3R	GO:0019221	cytokine-mediated signaling pathway	21873635	Process
CSF3R	GO:0019955	cytokine binding	21873635	Function
CSF3R	GO:0043235	receptor complex	21873635	Component
CSF3R	GO:0051916	granulocyte colony-stimulating factor binding	21873635	Function

Top

Spatial pattern events for CSF3R

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CSF3R	Human	Liver	rep_liver1	34417225	1.08e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E

Top

Spatial pattern pathway has CSF3R envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CSF3R	GOBP_Cell_Migration	Human	Brain	rep_1	3.1e-68
CSF3R	GOBP_Locomotion	Human	Brain	rep_1	3.1e-68
CSF3R	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
CSF3R	GOBP_Taxis	Human	Brain	rep_1	2.3e-68
CSF3R	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Brain	rep_4	4.1e-17
CSF3R	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Brain	rep_4	4.1e-17
CSF3R	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Liver	rep_1	6.0e-76
CSF3R	GOBP_Cell_Migration	Human	Liver	rep_1	1.9e-71
CSF3R	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
CSF3R	GOBP_Locomotion	Human	Liver	rep_1	1.9e-71
CSF3R	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Liver	rep_1	1.0e-70
CSF3R	GOBP_Taxis	Human	Liver	rep_1	8.8e-90
CSF3R	GOBP_Taxis	Human	Intestine	rep_colon2	5.0e-29
CSF3R	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
CSF3R	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
CSF3R	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Intestine	rep_colon4	9.0e-12
CSF3R	GOBP_Cell_Migration	Human	Intestine	rep_liver2	1.0e-64
CSF3R	GOBP_Locomotion	Human	Intestine	rep_liver2	1.0e-64
CSF3R	GOBP_Biological_Adhesion	Human	Intestine	A3	6.7e-11
CSF3R	GOBP_Cell_Migration	Human	Intestine	A3	1.6e-10
CSF3R	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Intestine	A3	2.6e-09
CSF3R	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
CSF3R	GOBP_Immune_System_Development	Human	Intestine	A3	4.3e-10
CSF3R	GOBP_Leukocyte_Migration	Human	Intestine	A3	1.5e-08
CSF3R	GOBP_Locomotion	Human	Intestine	A3	1.9e-08
CSF3R	GOBP_Myeloid_Leukocyte_Migration	Human	Intestine	A3	1.3e-07
CSF3R	GOBP_Odontogenesis_Of_Dentin_Containing_Tooth	Human	Intestine	A3	9.2e-11
CSF3R	GOBP_Regulation_Of_Cell_Differentiation	Human	Intestine	A3	1.7e-10
CSF3R	GOBP_Regulation_Of_Hemopoiesis	Human	Intestine	A3	3.4e-15
CSF3R	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Intestine	A3	1.8e-14
CSF3R	GOBP_Regulation_Of_Myeloid_Cell_Differentiation	Human	Intestine	A3	7.7e-14
CSF3R	GOBP_Taxis	Human	Intestine	A3	5.0e-08
CSF3R	GOBP_Amelogenesis	Human	Intestine	A8	5.8e-17
CSF3R	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	A8	3.3e-08
CSF3R	GOBP_Granulocyte_Chemotaxis	Human	Intestine	A8	8.1e-13
CSF3R	GOBP_Granulocyte_Migration	Human	Intestine	A8	1.6e-12
CSF3R	GOBP_Leukocyte_Chemotaxis	Human	Intestine	A8	3.7e-14
CSF3R	GOBP_Myeloid_Cell_Differentiation	Human	Intestine	A8	1.2e-21
CSF3R	GOBP_Neutrophil_Chemotaxis	Human	Intestine	A8	8.9e-16
CSF3R	GOBP_Neutrophil_Migration	Human	Intestine	A8	5.8e-10
CSF3R	GOBP_Odontogenesis	Human	Intestine	A8	5.2e-08
CSF3R	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
CSF3R	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
CSF3R	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
CSF3R	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Uterus	rep_26	2.0e-10
CSF3R	GOBP_Immune_System_Development	Human	Uterus	rep_26	1.0e-06
CSF3R	GOBP_Regulation_Of_Hemopoiesis	Human	Uterus	rep_26	4.0e-09
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Uterus	rep_26	7.3e-07
CSF3R	GOBP_Biological_Adhesion	Human	Uterus	rep_29	3.3e-06
CSF3R	GOBP_Leukocyte_Migration	Human	Uterus	rep_29	1.5e-07
CSF3R	GOBP_Myeloid_Cell_Differentiation	Human	Uterus	rep_29	2.6e-10
CSF3R	GOBP_Neutrophil_Migration	Human	Uterus	rep_29	1.3e-06
CSF3R	GOBP_Regulation_Of_Cell_Differentiation	Human	Uterus	rep_29	2.8e-06
CSF3R	GOBP_Regulation_Of_Myeloid_Cell_Differentiation	Human	Uterus	rep_29	1.8e-06
CSF3R	GOBP_Amelogenesis	Human	Breast	rep_1	1.3e-21
CSF3R	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Breast	rep_1	1.9e-98
CSF3R	GOBP_Animal_Organ_Morphogenesis	Human	Breast	rep_1	5.4e-25
CSF3R	GOBP_Biological_Adhesion	Human	Breast	rep_1	4.0e-110
CSF3R	GOBP_Cell_Migration	Human	Breast	rep_1	1.5e-45
CSF3R	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.5e-144
CSF3R	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
CSF3R	GOBP_Granulocyte_Chemotaxis	Human	Breast	rep_1	3.7e-93
CSF3R	GOBP_Granulocyte_Migration	Human	Breast	rep_1	3.5e-61
CSF3R	GOBP_Immune_System_Development	Human	Breast	rep_1	1.0e-31
CSF3R	GOBP_Locomotion	Human	Breast	rep_1	4.5e-54
CSF3R	GOBP_Myeloid_Cell_Differentiation	Human	Breast	rep_1	1.6e-14
CSF3R	GOBP_Neutrophil_Chemotaxis	Human	Breast	rep_1	4.8e-37
CSF3R	GOBP_Neutrophil_Migration	Human	Breast	rep_1	9.3e-15
CSF3R	GOBP_Odontogenesis	Human	Breast	rep_1	7.2e-134
CSF3R	GOBP_Odontogenesis_Of_Dentin_Containing_Tooth	Human	Breast	rep_1	1.1e-130
CSF3R	GOBP_Regulation_Of_Cell_Differentiation	Human	Breast	rep_1	2.5e-42
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Breast	rep_1	4.5e-113
CSF3R	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
CSF3R	GOBP_Cell_Chemotaxis	Human	Breast	rep_5	5.7e-10
CSF3R	GOBP_Leukocyte_Chemotaxis	Human	Breast	rep_5	5.0e-12
CSF3R	GOBP_Leukocyte_Migration	Human	Breast	rep_5	6.0e-14
CSF3R	GOBP_Myeloid_Leukocyte_Migration	Human	Breast	rep_5	2.3e-11
CSF3R	GOBP_Taxis	Human	Breast	rep_5	1.2e-12
CSF3R	GOBP_Amelogenesis	Human	Skin	P2_rep2	3.3e-09
CSF3R	GOBP_Taxis	Human	Skin	P2_rep2	1.2e-08
CSF3R	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
CSF3R	GOBP_Myeloid_Cell_Differentiation	Human	Lung	rep_1	8.1e-08
CSF3R	GOBP_Neutrophil_Migration	Human	Lung	rep_1	1.0e-07
CSF3R	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07
CSF3R	GOBP_Regulation_Of_Myeloid_Cell_Differentiation	Human	Lung	rep_1	6.3e-11
CSF3R	GOBP_Biological_Adhesion	Human	Lung	rep_2	6.6e-07
CSF3R	GOBP_Granulocyte_Chemotaxis	Human	Lung	rep_2	6.1e-07
CSF3R	GOBP_Granulocyte_Migration	Human	Lung	rep_2	2.1e-07
CSF3R	GOBP_Immune_System_Development	Human	Lung	rep_2	7.9e-07
CSF3R	GOBP_Regulation_Of_Hemopoiesis	Human	Lung	rep_2	1.5e-07
CSF3R	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Lung	rep_2	9.5e-07
CSF3R	GOBP_Taxis	Human	Lung	rep_2	4.0e-07

Top

CSF3R function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

CSF3R function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for CSF3R envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for CSF3R

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CSF3R	Q99062	DB00019	Pegfilgrastim	Granulocyte colony-stimulating factor receptor	BiotechDrug	approved
CSF3R	Q99062	DB00099	Filgrastim	Granulocyte colony-stimulating factor receptor	BiotechDrug	approved
CSF3R	Q99062	DB13144	Lenograstim	Granulocyte colony-stimulating factor receptor	BiotechDrug	approved\|investigational
CSF3R	Q99062	DB13200	Lipegfilgrastim	Granulocyte colony-stimulating factor receptor	BiotechDrug	approved\|investigational

Top

Related Diseases for CSF3R

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
CSF3R	C4310764	NEUTROPENIA, SEVERE CONGENITAL, 7, AUTOSOMAL RECESSIVE	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
CSF3R	C0340970	Congenital neutropenia	2	GENOMICS_ENGLAND
CSF3R	C0023481	Chronic Neutrophilic Leukemia	1	CGI;ORPHANET
CSF3R	C0023518	Leukocytosis	1	CTD_human
CSF3R	C0151857	Pleocytosis	1	CTD_human
CSF3R	C0543669	Neutrophilia, Hereditary	1	ORPHANET;UNIPROT
CSF3R	C1292772	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	1	CGI;ORPHANET