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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CS (spascer ID:1431)

Gene summary for CS

Gene summary

Gene information
	Species	Human
	Gene symbol	CS
	Gene ID	1431
	Gene name	citrate synthase
	Synonyms	-
	Cytomap	12q13.3
	Type of gene	protein-coding
	Description	citrate synthase, mitochondrialcitrate (Si)-synthase
	Modification date	20220513
	UniProtAcc	O75390

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CS	GO:0004108	citrate (Si)-synthase activity	21873635	Function
CS	GO:0005759	mitochondrial matrix	21873635	Component
CS	GO:0005975	carbohydrate metabolic process	21873635	Process
CS	GO:0006099	tricarboxylic acid cycle	21873635	Process

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Spatial pattern events for CS

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CS	Human	Intestine	rep_colon1	34417225	1.95e-15
CS	Human	Intestine	rep_colon2	34417225	1.98e-13
CS	Human	Intestine	rep_colon3	34417225	4.41e-13
CS	Human	Intestine	rep_colon4	34417225	5.37e-07
CS	Human	Liver	rep_liver1	34417225	1.08e-15
CS	Human	Liver	rep_liver2	34417225	6.98e-16
CS	Human	Liver	rep_liver4	34417225	7.71e-16
CS	Human	Uterus	rep_1	34857954	1.00e-06
CS	Human	Breast	CID44971	34493872	1.76e-15
CS	Human	Heart	w6_s2	31835037	5.90e-03
CS	Human	Heart	w9_s5	31835037	2.47e-09
CS	Human	Heart	w9_s6	31835037	1.47e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Uterus_rep_1_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has CS envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CS	GOBP_Aerobic_Respiration	Human	Bladder	rep_4	5.9e-17
CS	GOBP_Cellular_Respiration	Human	Bladder	rep_4	2.0e-15
CS	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Human	Bladder	rep_4	1.5e-12
CS	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Bladder	rep_4	3.4e-12
CS	GOBP_Aerobic_Respiration	Human	Intestine	A3	1.5e-15
CS	GOBP_Carbohydrate_Metabolic_Process	Human	Intestine	A3	4.1e-08
CS	GOBP_Cellular_Respiration	Human	Intestine	A3	6.2e-15
CS	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Human	Intestine	A3	2.5e-12
CS	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Intestine	A3	4.3e-14
CS	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
CS	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
CS	GOBP_Tricarboxylic_Acid_Cycle	Human	Intestine	A8	5.7e-09
CS	GOBP_Tricarboxylic_Acid_Metabolic_Process	Human	Intestine	A8	4.4e-10
CS	GOBP_Aerobic_Respiration	Human	Uterus	rep_26	3.1e-08
CS	GOBP_Cellular_Respiration	Human	Uterus	rep_26	3.7e-07
CS	GOBP_Citrate_Metabolic_Process	Human	Uterus	rep_26	1.0e-15
CS	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Human	Uterus	rep_26	7.2e-06
CS	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Uterus	rep_26	1.8e-06
CS	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
CS	GOBP_Tricarboxylic_Acid_Cycle	Human	Uterus	rep_26	5.7e-11
CS	GOBP_Carbohydrate_Metabolic_Process	Human	Breast	rep_5	3.5e-10
CS	GOBP_Aerobic_Respiration	Human	Breast	rep_6	2.2e-06
CS	GOBP_Cellular_Respiration	Human	Breast	rep_6	2.2e-06
CS	GOBP_Citrate_Metabolic_Process	Human	Breast	rep_6	3.4e-05
CS	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Human	Breast	rep_6	5.2e-08
CS	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Human	Breast	rep_6	7.1e-09
CS	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
CS	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
CS	GOBP_Tricarboxylic_Acid_Cycle	Human	Breast	rep_6	8.0e-06
CS	GOBP_Citrate_Metabolic_Process	Human	Skin	P10_rep2	4.1e-10

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CS function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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CS function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for CS envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for CS

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CS	O75390	DB04272	Citric acid	Citrate synthase, mitochondrial	SmallMoleculeDrug	approved\|nutraceutical\|vet_approved

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Related Diseases for CS

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
CS	C0003129	Anoxemia	1	CTD_human
CS	C0003130	Anoxia	1	CTD_human
CS	C0018801	Heart failure	1	CTD_human
CS	C0018802	Congestive heart failure	1	CTD_human
CS	C0023212	Left-Sided Heart Failure	1	CTD_human
CS	C0028754	Obesity	1	CTD_human
CS	C0033141	Cardiomyopathies, Primary	1	CTD_human
CS	C0036529	Myocardial Diseases, Secondary	1	CTD_human
CS	C0235527	Heart Failure, Right-Sided	1	CTD_human
CS	C0242184	Hypoxia	1	CTD_human
CS	C0700292	Hypoxemia	1	CTD_human
CS	C0878544	Cardiomyopathies	1	CTD_human
CS	C1959583	Myocardial Failure	1	CTD_human
CS	C1961112	Heart Decompensation	1	CTD_human