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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: HSPB6 (spascer ID:126393)

Gene summary for HSPB6

Gene summary

Gene information
	Species	Human
	Gene symbol	HSPB6
	Gene ID	126393
	Gene name	heat shock protein family B (small) member 6
	Synonyms	HEL55\|Hsp20\|PPP1R91
	Cytomap	19q13.12
	Type of gene	protein-coding
	Description	heat shock protein beta-6epididymis luminal protein 55epididymis secretory sperm binding proteinheat shock 20 kDa-like protein p20heat shock protein family B (small) member B6heat shock protein, alpha-crystallin-related, B6protein phosphatase 1, reg
	Modification date	20220513
	UniProtAcc	O14558

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
HSPB6	GO:0005634	nucleus	21873635	Component
HSPB6	GO:0005737	cytoplasm	21873635	Component
HSPB6	GO:0006457	protein folding	21873635	Process
HSPB6	GO:0043066	negative regulation of apoptotic process	21873635	Process
HSPB6	GO:0051082	unfolded protein binding	21873635	Function

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Spatial pattern events for HSPB6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
HSPB6	Human	Brain	rep_10	33558695	5.26e-07
HSPB6	Human	Prostate	rep_7	29925878	1.06e-14
HSPB6	Human	Prostate	rep_11	29925878	4.98e-07
HSPB6	Human	Bladder	rep_1	34385456	8.93e-15
HSPB6	Human	Intestine	rep_colon2	34417225	8.12e-16
HSPB6	Human	Intestine	rep_colon3	34417225	1.01e-15
HSPB6	Human	Liver	rep_liver1	34417225	1.08e-15
HSPB6	Human	Intestine	A1	33406409	2.09e-15
HSPB6	Human	Intestine	A2	33406409	2.47e-15
HSPB6	Human	Intestine	A4	33406409	5.90e-06
HSPB6	Human	Intestine	A6	33406409	1.25e-07
HSPB6	Human	Uterus	rep_1	34857954	3.12e-12
HSPB6	Human	Uterus	rep_2	34857954	2.55e-15
HSPB6	Human	Uterus	rep_3	34857954	1.66e-15
HSPB6	Human	Uterus	rep_4	34857954	1.82e-15
HSPB6	Human	Heart	w6_s4	31835037	1.91e-04
HSPB6	Human	Heart	w9_s1	31835037	5.93e-06
HSPB6	Human	Heart	w9_s2	31835037	8.02e-04
HSPB6	Human	Heart	w9_s5	31835037	4.96e-04
HSPB6	Human	Lung	rep_1	35355018	4.99e-15
HSPB6	Human	Lung	rep_2	35355018	2.37e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_10_H&E
Bladder_rep_1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Intestine_A4_H&E
Intestine_A6_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E

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Spatial pattern pathway has HSPB6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
HSPB6	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Brain	rep_1	4.6e-05
HSPB6	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Blood_Vessel_Morphogenesis	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Circulatory_System_Development	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Positive_Regulation_Of_Developmental_Process	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Positive_Regulation_Of_Vasculature_Development	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Regulation_Of_Vasculature_Development	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Tube_Development	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Tube_Morphogenesis	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Vasculature_Development	Human	Brain	rep_4	4.1e-17
HSPB6	GOBP_Blood_Vessel_Morphogenesis	Human	Bladder	rep_2	9.4e-07
HSPB6	GOBP_Circulatory_System_Development	Human	Bladder	rep_2	1.0e-16
HSPB6	GOBP_Positive_Regulation_Of_Vasculature_Development	Human	Bladder	rep_2	1.6e-04
HSPB6	GOBP_Regulation_Of_Vasculature_Development	Human	Bladder	rep_2	4.2e-09
HSPB6	GOBP_Vasculature_Development	Human	Bladder	rep_2	2.0e-14
HSPB6	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Blood_Vessel_Morphogenesis	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Circulatory_System_Development	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Positive_Regulation_Of_Developmental_Process	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Liver	rep_1	1.1e-67
HSPB6	GOBP_Positive_Regulation_Of_Vasculature_Development	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Liver	rep_1	1.0e-70
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Liver	rep_1	1.0e-70
HSPB6	GOBP_Regulation_Of_Vasculature_Development	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Tube_Development	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Tube_Morphogenesis	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Vasculature_Development	Human	Liver	rep_1	6.0e-76
HSPB6	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Blood_Vessel_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Circulatory_System_Development	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Positive_Regulation_Of_Developmental_Process	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	rep_colon4	2.2e-52
HSPB6	GOBP_Positive_Regulation_Of_Vasculature_Development	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Intestine	rep_colon4	9.0e-12
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Intestine	rep_colon4	9.0e-12
HSPB6	GOBP_Regulation_Of_Vasculature_Development	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Tube_Development	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Tube_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Vasculature_Development	Human	Intestine	rep_colon4	1.9e-09
HSPB6	GOBP_Blood_Vessel_Morphogenesis	Human	Intestine	A3	4.7e-07
HSPB6	GOBP_Chaperone_Mediated_Protein_Folding	Human	Intestine	A3	1.1e-14
HSPB6	GOBP_Circulatory_System_Development	Human	Intestine	A3	5.9e-08
HSPB6	GOBP_Muscle_Cell_Apoptotic_Process	Human	Intestine	A3	9.9e-09
HSPB6	GOBP_Negative_Regulation_Of_Cell_Death	Human	Intestine	A3	5.8e-14
HSPB6	GOBP_Negative_Regulation_Of_Muscle_Cell_Apoptotic_Process	Human	Intestine	A3	2.2e-13
HSPB6	GOBP_Negative_Regulation_Of_Striated_Muscle_Cell_Apoptotic_Process	Human	Intestine	A3	1.3e-07
HSPB6	GOBP_Positive_Regulation_Of_Developmental_Process	Human	Intestine	A3	1.5e-12
HSPB6	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	A3	8.6e-17
HSPB6	GOBP_Protein_Folding	Human	Intestine	A3	3.4e-14
HSPB6	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Intestine	A3	4.8e-12
HSPB6	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Intestine	A3	1.8e-14
HSPB6	GOBP_Striated_Muscle_Cell_Apoptotic_Process	Human	Intestine	A3	1.3e-08
HSPB6	GOBP_Tube_Development	Human	Intestine	A3	7.6e-08
HSPB6	GOBP_Tube_Morphogenesis	Human	Intestine	A3	9.4e-07
HSPB6	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	A8	3.3e-08
HSPB6	GOBP_Regulation_Of_Muscle_System_Process	Human	Intestine	A8	6.9e-07
HSPB6	GOBP_Vasculature_Development	Human	Intestine	A8	9.3e-07
HSPB6	GOBP_Muscle_Cell_Apoptotic_Process	Human	Pancreas	PDAC-B-st1	8.7e-07
HSPB6	GOBP_Negative_Regulation_Of_Muscle_Cell_Apoptotic_Process	Human	Pancreas	PDAC-B-st1	6.3e-05
HSPB6	GOBP_Protein_Folding	Human	Pancreas	PDAC-B-st1	1.2e-05
HSPB6	GOBP_Striated_Muscle_Cell_Apoptotic_Process	Human	Pancreas	PDAC-B-st1	1.3e-05
HSPB6	GOBP_Striated_Muscle_Cell_Apoptotic_Process	Human	Uterus	rep_1	1.9e-07
HSPB6	GOBP_Muscle_Cell_Apoptotic_Process	Human	Uterus	rep_25	5.4e-08
HSPB6	GOBP_Negative_Regulation_Of_Muscle_Cell_Apoptotic_Process	Human	Uterus	rep_25	6.0e-09
HSPB6	GOBP_Negative_Regulation_Of_Striated_Muscle_Cell_Apoptotic_Process	Human	Uterus	rep_25	4.3e-09
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Uterus	rep_26	7.3e-07
HSPB6	GOBP_Regulation_Of_Muscle_System_Process	Human	Uterus	rep_26	6.9e-08
HSPB6	GOBP_Regulation_Of_System_Process	Human	Uterus	rep_26	6.6e-10
HSPB6	GOBP_Positive_Regulation_Of_Developmental_Process	Human	Uterus	rep_29	8.8e-06
HSPB6	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Breast	rep_1	1.9e-98
HSPB6	GOBP_Blood_Vessel_Morphogenesis	Human	Breast	rep_1	1.5e-106
HSPB6	GOBP_Circulatory_System_Development	Human	Breast	rep_1	3.8e-70
HSPB6	GOBP_Muscle_Contraction	Human	Breast	rep_1	4.7e-70
HSPB6	GOBP_Muscle_System_Process	Human	Breast	rep_1	5.3e-20
HSPB6	GOBP_Negative_Regulation_Of_Striated_Muscle_Cell_Apoptotic_Process	Human	Breast	rep_1	1.4e-05
HSPB6	GOBP_Positive_Regulation_Of_Developmental_Process	Human	Breast	rep_1	1.4e-85
HSPB6	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Breast	rep_1	5.8e-20
HSPB6	GOBP_Positive_Regulation_Of_Vasculature_Development	Human	Breast	rep_1	4.6e-40
HSPB6	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Breast	rep_1	4.6e-22
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Breast	rep_1	4.5e-113
HSPB6	GOBP_Regulation_Of_Muscle_Contraction	Human	Breast	rep_1	1.7e-14
HSPB6	GOBP_Regulation_Of_Muscle_System_Process	Human	Breast	rep_1	5.5e-10
HSPB6	GOBP_Regulation_Of_System_Process	Human	Breast	rep_1	1.0e-09
HSPB6	GOBP_Regulation_Of_Vasculature_Development	Human	Breast	rep_1	1.9e-30
HSPB6	GOBP_Striated_Muscle_Cell_Apoptotic_Process	Human	Breast	rep_1	9.9e-13
HSPB6	GOBP_Tube_Development	Human	Breast	rep_1	3.8e-32
HSPB6	GOBP_Tube_Morphogenesis	Human	Breast	rep_1	2.7e-34
HSPB6	GOBP_Vasculature_Development	Human	Breast	rep_1	9.1e-95
HSPB6	GOBP_Chaperone_Mediated_Protein_Folding	Human	Breast	rep_5	2.9e-08
HSPB6	GOBP_Negative_Regulation_Of_Cell_Death	Human	Breast	rep_5	1.9e-07
HSPB6	GOBP_Protein_Folding	Human	Breast	rep_5	6.0e-09
HSPB6	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
HSPB6	GOBP_Negative_Regulation_Of_Muscle_Cell_Apoptotic_Process	Human	Breast	rep_6	5.0e-04
HSPB6	GOBP_Regulation_Of_Multicellular_Organismal_Development	Human	Lung	rep_2	9.5e-07

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HSPB6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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HSPB6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for HSPB6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for HSPB6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HSPB6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source