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Spatial pattern gene: AGAP1 (spascer ID:116987) |
Gene summary for AGAP1 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | AGAP1 | Gene ID | 116987 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
| Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 |
| Cytomap | 2q37.2 |
| Type of gene | protein-coding |
| Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 |
| Modification date | 20220513 |
| UniProtAcc | Q9UPQ3 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| AGAP1 | GO:0005634 | nucleus | 21873635 | Component |
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Spatial pattern events for AGAP1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| AGAP1 | Human | Brain | rep_9 | 33558695 | 3.01e-15 |
| AGAP1 | Human | Brain | rep_10 | 33558695 | 5.75e-15 |
| AGAP1 | Human | Brain | rep_11 | 33558695 | 1.17e-11 |
| AGAP1 | Human | Brain | rep_12 | 33558695 | 2.93e-09 |
| AGAP1 | Human | Intestine | rep_colon1 | 34417225 | 6.96e-06 |
| AGAP1 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Brain_rep_11_H&E  |  |
Brain_rep_12_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Liver_rep_liver1_H&E  |  |
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Spatial pattern pathway has AGAP1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| AGAP1 | GOBP_Positive_Regulation_Of_Catalytic_Activity | Human | Brain | rep_1 | 8.7e-71 |
| AGAP1 | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Human | Brain | rep_1 | 8.7e-71 |
| AGAP1 | GOBP_Positive_Regulation_Of_Molecular_Function | Human | Brain | rep_1 | 8.7e-71 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Brain | rep_2 | 2.1e-15 |
| AGAP1 | GOBP_Positive_Regulation_Of_Catalytic_Activity | Human | Liver | rep_1 | 2.1e-52 |
| AGAP1 | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Human | Liver | rep_1 | 4.9e-46 |
| AGAP1 | GOBP_Positive_Regulation_Of_Molecular_Function | Human | Liver | rep_1 | 2.1e-52 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Liver | rep_1 | 6.0e-76 |
| AGAP1 | GOBP_Positive_Regulation_Of_Catalytic_Activity | Human | Intestine | rep_colon2 | 2.3e-37 |
| AGAP1 | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Human | Intestine | rep_colon2 | 4.1e-22 |
| AGAP1 | GOBP_Positive_Regulation_Of_Molecular_Function | Human | Intestine | rep_colon2 | 2.3e-37 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Intestine | rep_colon4 | 3.7e-11 |
| AGAP1 | GOBP_Establishment_Of_Protein_Localization | Human | Intestine | A3 | 5.0e-10 |
| AGAP1 | GOBP_Positive_Regulation_Of_Catalytic_Activity | Human | Intestine | A3 | 7.7e-16 |
| AGAP1 | GOBP_Positive_Regulation_Of_Gtpase_Activity | Human | Intestine | A3 | 1.8e-12 |
| AGAP1 | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Human | Intestine | A3 | 2.8e-16 |
| AGAP1 | GOBP_Positive_Regulation_Of_Molecular_Function | Human | Intestine | A3 | 2.1e-13 |
| AGAP1 | GOBP_Regulation_Of_Gtpase_Activity | Human | Intestine | A3 | 1.0e-12 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Intestine | A3 | 7.3e-16 |
| AGAP1 | GOBP_Regulation_Of_Gtpase_Activity | Human | Pancreas | PDAC-B-st1 | 9.7e-05 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Uterus | rep_29 | 6.6e-10 |
| AGAP1 | GOBP_Establishment_Of_Protein_Localization | Human | Breast | rep_1 | 7.2e-05 |
| AGAP1 | GOBP_Positive_Regulation_Of_Gtpase_Activity | Human | Breast | rep_1 | 1.4e-13 |
| AGAP1 | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Human | Breast | rep_1 | 7.8e-04 |
| AGAP1 | GOBP_Regulation_Of_Gtpase_Activity | Human | Breast | rep_1 | 9.6e-08 |
| AGAP1 | GOBP_Positive_Regulation_Of_Catalytic_Activity | Human | Breast | rep_5 | 1.9e-12 |
| AGAP1 | GOBP_Positive_Regulation_Of_Molecular_Function | Human | Breast | rep_5 | 7.4e-10 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Breast | rep_5 | 3.2e-13 |
| AGAP1 | GOBP_Regulation_Of_Hydrolase_Activity | Human | Lung | rep_1 | 4.1e-07 |
| AGAP1 | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Human | Lung | rep_2 | 7.9e-07 |
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AGAP1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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AGAP1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for AGAP1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for AGAP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AGAP1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| AGAP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
