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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: ARAP1 (spascer ID:116985)

Gene summary for ARAP1

Gene summary

Gene information
	Species	Human
	Gene symbol	ARAP1
	Gene ID	116985
	Gene name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
	Synonyms	CENTD2\|cnt-d2
	Cytomap	11q13.4
	Type of gene	protein-coding
	Description	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1centaurin-delta-2
	Modification date	20220513
	UniProtAcc	Q96P48

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
ARAP1	GO:0005802	trans-Golgi network	21873635	Component
ARAP1	GO:0005886	plasma membrane	21873635	Component
ARAP1	GO:0031410	cytoplasmic vesicle	21873635	Component

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Spatial pattern events for ARAP1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
ARAP1	Human	Brain	rep_10	33558695	3.15e-09
ARAP1	Human	Intestine	rep_colon1	34417225	1.95e-15
ARAP1	Human	Intestine	rep_colon2	34417225	8.12e-16
ARAP1	Human	Intestine	rep_colon3	34417225	2.28e-11
ARAP1	Human	Intestine	rep_colon4	34417225	4.00e-09
ARAP1	Human	Liver	rep_liver1	34417225	1.70e-11
ARAP1	Human	Liver	rep_liver2	34417225	6.98e-16
ARAP1	Human	Liver	rep_liver4	34417225	3.92e-11
ARAP1	Human	Intestine	A2	33406409	1.34e-13
ARAP1	Human	Uterus	rep_1	34857954	6.22e-08
ARAP1	Human	Uterus	rep_3	34857954	1.66e-15
ARAP1	Human	Breast	1142243F	34493872	4.15e-15
ARAP1	Human	Breast	1160920F	34493872	1.48e-15
ARAP1	Human	Breast	CID44971	34493872	1.76e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_10_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Intestine_A2_H&E
Uterus_rep_1_H&E
Uterus_rep_3_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has ARAP1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
ARAP1	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Brain	rep_1	2.3e-68
ARAP1	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
ARAP1	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_1	8.7e-71
ARAP1	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
ARAP1	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
ARAP1	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Brain	rep_1	3.1e-68
ARAP1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
ARAP1	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Brain	rep_1	2.3e-68
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
ARAP1	GOBP_Cell_Morphogenesis	Human	Brain	rep_4	1.0e-14
ARAP1	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Brain	rep_4	4.1e-17
ARAP1	GOBP_Actin_Filament_Reorganization	Human	Bladder	rep_2	7.6e-15
ARAP1	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Bladder	rep_2	1.3e-05
ARAP1	GOBP_Cell_Morphogenesis	Human	Liver	rep_1	2.1e-52
ARAP1	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Liver	rep_1	8.8e-90
ARAP1	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
ARAP1	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	4.9e-46
ARAP1	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
ARAP1	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
ARAP1	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Liver	rep_1	1.0e-70
ARAP1	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Liver	rep_1	1.9e-71
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
ARAP1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
ARAP1	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Liver	rep_1	8.8e-90
ARAP1	GOBP_Cell_Morphogenesis	Human	Intestine	rep_colon2	1.5e-57
ARAP1	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Intestine	rep_colon2	5.0e-29
ARAP1	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
ARAP1	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon2	4.1e-22
ARAP1	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
ARAP1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
ARAP1	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Intestine	rep_colon2	5.0e-29
ARAP1	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
ARAP1	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Intestine	rep_colon4	9.0e-12
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
ARAP1	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Intestine	rep_liver2	1.0e-64
ARAP1	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
ARAP1	GOBP_Cell_Cycle_Process	Human	Intestine	A3	2.7e-14
ARAP1	GOBP_Cell_Morphogenesis	Human	Intestine	A3	9.7e-08
ARAP1	GOBP_Cell_Projection_Assembly	Human	Intestine	A3	4.9e-09
ARAP1	GOBP_Cell_Projection_Organization	Human	Intestine	A3	1.1e-09
ARAP1	GOBP_Erbb_Signaling_Pathway	Human	Intestine	A3	7.9e-08
ARAP1	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	9.1e-10
ARAP1	GOBP_Negative_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	4.5e-08
ARAP1	GOBP_Negative_Regulation_Of_Organelle_Organization	Human	Intestine	A3	3.5e-11
ARAP1	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
ARAP1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Human	Intestine	A3	1.2e-09
ARAP1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	1.9e-13
ARAP1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	3.8e-12
ARAP1	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.8e-12
ARAP1	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	2.8e-16
ARAP1	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
ARAP1	GOBP_Positive_Regulation_Of_Plasma_Membrane_Bounded_Cell_Projection_Assembly	Human	Intestine	A3	3.6e-08
ARAP1	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
ARAP1	GOBP_Receptor_Metabolic_Process	Human	Intestine	A3	1.2e-10
ARAP1	GOBP_Regulation_Of_Actin_Filament_Organization	Human	Intestine	A3	2.2e-08
ARAP1	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Intestine	A3	4.8e-12
ARAP1	GOBP_Regulation_Of_Cell_Morphogenesis	Human	Intestine	A3	5.8e-11
ARAP1	GOBP_Regulation_Of_Cell_Projection_Assembly	Human	Intestine	A3	4.1e-07
ARAP1	GOBP_Regulation_Of_Cell_Projection_Organization	Human	Intestine	A3	7.0e-08
ARAP1	GOBP_Regulation_Of_Cell_Shape	Human	Intestine	A3	3.3e-10
ARAP1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	8.8e-12
ARAP1	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Intestine	A3	1.1e-09
ARAP1	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	6.4e-13
ARAP1	GOBP_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.0e-12
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
ARAP1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
ARAP1	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
ARAP1	GOBP_Regulation_Of_Supramolecular_Fiber_Organization	Human	Intestine	A3	9.3e-07
ARAP1	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Intestine	A3	2.0e-11
ARAP1	GOBP_Actin_Filament_Reorganization	Human	Intestine	A8	1.8e-21
ARAP1	GOBP_Positive_Regulation_Of_Erbb_Signaling_Pathway	Human	Intestine	A8	3.7e-20
ARAP1	GOBP_Positive_Regulation_Of_Receptor_Recycling	Human	Intestine	A8	2.3e-14
ARAP1	GOBP_Receptor_Recycling	Human	Intestine	A8	2.9e-18
ARAP1	GOBP_Regulation_Of_Erbb_Signaling_Pathway	Human	Intestine	A8	2.4e-22
ARAP1	GOBP_Regulation_Of_Receptor_Recycling	Human	Intestine	A8	2.0e-21
ARAP1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Human	Intestine	A8	3.1e-07
ARAP1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Human	Intestine	A8	7.1e-10
ARAP1	GOBP_Negative_Regulation_Of_Organelle_Organization	Human	Pancreas	PDAC-B-st1	6.2e-05
ARAP1	GOBP_Receptor_Metabolic_Process	Human	Pancreas	PDAC-B-st1	6.8e-05
ARAP1	GOBP_Regulation_Of_Gtpase_Activity	Human	Pancreas	PDAC-B-st1	9.7e-05
ARAP1	GOBP_Negative_Regulation_Of_Actin_Filament_Bundle_Assembly	Human	Pancreas	PDAC-A-st2	5.0e-05
ARAP1	GOBP_Actin_Filament_Reorganization	Human	Uterus	rep_1	1.7e-09
ARAP1	GOBP_Positive_Regulation_Of_Receptor_Recycling	Human	Uterus	rep_25	6.1e-08
ARAP1	GOBP_Negative_Regulation_Of_Supramolecular_Fiber_Organization	Human	Uterus	rep_26	3.0e-08
ARAP1	GOBP_Receptor_Metabolic_Process	Human	Uterus	rep_26	3.6e-08
ARAP1	GOBP_Receptor_Recycling	Human	Uterus	rep_26	2.9e-11
ARAP1	GOBP_Regulation_Of_Receptor_Recycling	Human	Uterus	rep_26	1.4e-09
ARAP1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Human	Uterus	rep_26	9.8e-09
ARAP1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Human	Uterus	rep_26	4.7e-08
ARAP1	GOBP_Erbb_Signaling_Pathway	Human	Uterus	rep_29	2.5e-06
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
ARAP1	GOBP_Actin_Cytoskeleton_Reorganization	Human	Breast	rep_1	7.6e-89
ARAP1	GOBP_Actin_Filament_Based_Process	Human	Breast	rep_1	1.8e-86
ARAP1	GOBP_Actin_Filament_Bundle_Organization	Human	Breast	rep_1	4.8e-140
ARAP1	GOBP_Actin_Filament_Organization	Human	Breast	rep_1	4.0e-75
ARAP1	GOBP_Actin_Filament_Reorganization	Human	Breast	rep_1	5.8e-71
ARAP1	GOBP_Actomyosin_Structure_Organization	Human	Breast	rep_1	9.9e-158
ARAP1	GOBP_Cell_Morphogenesis	Human	Breast	rep_1	5.7e-26
ARAP1	GOBP_Cell_Projection_Assembly	Human	Breast	rep_1	1.9e-26
ARAP1	GOBP_Cell_Projection_Organization	Human	Breast	rep_1	1.8e-20
ARAP1	GOBP_Cytoskeleton_Organization	Human	Breast	rep_1	1.3e-22
ARAP1	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	7.3e-14
ARAP1	GOBP_Negative_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	3.9e-35
ARAP1	GOBP_Negative_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	2.9e-09
ARAP1	GOBP_Negative_Regulation_Of_Supramolecular_Fiber_Organization	Human	Breast	rep_1	1.7e-15
ARAP1	GOBP_Positive_Regulation_Of_Cell_Projection_Organization	Human	Breast	rep_1	1.6e-25
ARAP1	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	3.5e-04
ARAP1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	1.3e-17
ARAP1	GOBP_Positive_Regulation_Of_Erbb_Signaling_Pathway	Human	Breast	rep_1	2.3e-61
ARAP1	GOBP_Positive_Regulation_Of_Filopodium_Assembly	Human	Breast	rep_1	3.7e-11
ARAP1	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	1.4e-13
ARAP1	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_1	7.8e-04
ARAP1	GOBP_Positive_Regulation_Of_Receptor_Recycling	Human	Breast	rep_1	2.6e-161
ARAP1	GOBP_Receptor_Metabolic_Process	Human	Breast	rep_1	8.0e-42
ARAP1	GOBP_Receptor_Recycling	Human	Breast	rep_1	1.3e-114
ARAP1	GOBP_Regulation_Of_Actin_Filament_Based_Process	Human	Breast	rep_1	8.5e-105
ARAP1	GOBP_Regulation_Of_Actin_Filament_Bundle_Assembly	Human	Breast	rep_1	4.0e-96
ARAP1	GOBP_Regulation_Of_Actin_Filament_Organization	Human	Breast	rep_1	3.2e-110
ARAP1	GOBP_Regulation_Of_Actomyosin_Structure_Organization	Human	Breast	rep_1	1.2e-89
ARAP1	GOBP_Regulation_Of_Anatomical_Structure_Morphogenesis	Human	Breast	rep_1	4.6e-22
ARAP1	GOBP_Regulation_Of_Cell_Morphogenesis	Human	Breast	rep_1	5.0e-35
ARAP1	GOBP_Regulation_Of_Cell_Projection_Assembly	Human	Breast	rep_1	6.5e-29
ARAP1	GOBP_Regulation_Of_Cell_Projection_Organization	Human	Breast	rep_1	3.8e-16
ARAP1	GOBP_Regulation_Of_Cell_Shape	Human	Breast	rep_1	3.2e-94
ARAP1	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	4.6e-05
ARAP1	GOBP_Regulation_Of_Cellular_Component_Movement	Human	Breast	rep_1	5.5e-21
ARAP1	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	7.8e-76
ARAP1	GOBP_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	9.6e-08
ARAP1	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
ARAP1	GOBP_Regulation_Of_Receptor_Recycling	Human	Breast	rep_1	4.8e-161
ARAP1	GOBP_Regulation_Of_Supramolecular_Fiber_Organization	Human	Breast	rep_1	5.0e-50
ARAP1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Human	Breast	rep_1	3.4e-04
ARAP1	GOBP_Stress_Fiber_Assembly	Human	Breast	rep_1	3.3e-82
ARAP1	GOBP_Supramolecular_Fiber_Organization	Human	Breast	rep_1	2.8e-72
ARAP1	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Human	Breast	rep_1	1.4e-14
ARAP1	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Human	Breast	rep_5	4.6e-14
ARAP1	GOBP_Erbb_Signaling_Pathway	Human	Breast	rep_5	3.8e-06
ARAP1	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
ARAP1	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
ARAP1	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
ARAP1	GOBP_Regulation_Of_Erbb_Signaling_Pathway	Human	Breast	rep_5	2.2e-06
ARAP1	GOBP_Regulation_Of_Filopodium_Assembly	Human	Breast	rep_5	7.6e-12
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
ARAP1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
ARAP1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Human	Breast	rep_5	2.0e-07
ARAP1	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
ARAP1	GOBP_Cell_Cycle_Process	Human	Breast	rep_6	6.7e-09
ARAP1	GOBP_Actomyosin_Structure_Organization	Human	Skin	P5_rep1	7.8e-09
ARAP1	GOBP_Regulation_Of_Erbb_Signaling_Pathway	Human	Skin	P5_rep1	3.3e-08
ARAP1	GOBP_Cytoskeleton_Organization	Human	Skin	P9_rep3	3.1e-12
ARAP1	GOBP_Positive_Regulation_Of_Erbb_Signaling_Pathway	Human	Skin	P10_rep2	3.9e-16
ARAP1	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
ARAP1	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_2	7.9e-07
ARAP1	GOBP_Receptor_Metabolic_Process	Human	Lung	rep_2	1.1e-09

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ARAP1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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ARAP1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for ARAP1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for ARAP1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARAP1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source