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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: GADD45G (spascer ID:10912)

Gene summary for GADD45G

Gene summary

Gene information
	Species	Human
	Gene symbol	GADD45G
	Gene ID	10912
	Gene name	growth arrest and DNA damage inducible gamma
	Synonyms	CR6\|DDIT2\|GADD45gamma\|GRP17
	Cytomap	9q22.2
	Type of gene	protein-coding
	Description	growth arrest and DNA damage-inducible protein GADD45 gammaDDIT-2DNA damage-inducible transcript 2 proteinGADD45-gammacytokine-responsive protein CR6gadd-related protein, 17 kD
	Modification date	20220513
	UniProtAcc	O95257

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
GADD45G	GO:0005634	nucleus	21873635	Component
GADD45G	GO:0005737	cytoplasm	21873635	Component
GADD45G	GO:0051726	regulation of cell cycle	21873635	Process

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Spatial pattern events for GADD45G

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
GADD45G	Human	Bladder	rep_2	34385456	7.70e-10
GADD45G	Human	Intestine	rep_colon2	34417225	8.12e-16
GADD45G	Human	Intestine	rep_colon3	34417225	1.01e-15
GADD45G	Human	Liver	rep_liver1	34417225	1.08e-15
GADD45G	Human	Liver	rep_liver2	34417225	6.98e-16
GADD45G	Human	Liver	rep_liver3	34417225	3.51e-15
GADD45G	Human	Liver	rep_liver4	34417225	7.71e-16
GADD45G	Human	Uterus	rep_2	34857954	2.01e-06
GADD45G	Human	Uterus	rep_3	34857954	1.66e-15
GADD45G	Human	Breast	CID44971	34493872	3.29e-15
GADD45G	Human	Breast	CID4535	34493872	2.90e-06
GADD45G	Human	Lung	rep_1	35355018	1.37e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has GADD45G envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
GADD45G	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
GADD45G	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	3.1e-68
GADD45G	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
GADD45G	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Brain	rep_1	4.6e-05
GADD45G	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Brain	rep_1	2.8e-23
GADD45G	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
GADD45G	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Brain	rep_1	2.8e-23
GADD45G	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Brain	rep_1	2.8e-23
GADD45G	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
GADD45G	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
GADD45G	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Brain	rep_1	7.4e-34
GADD45G	GOBP_Regulation_Of_Protein_Modification_Process	Human	Brain	rep_1	7.4e-34
GADD45G	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Brain	rep_1	7.4e-34
GADD45G	GOBP_Regulation_Of_Response_To_Stress	Human	Brain	rep_1	4.6e-05
GADD45G	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
GADD45G	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
GADD45G	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
GADD45G	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Liver	rep_1	1.1e-67
GADD45G	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Liver	rep_1	1.0e-70
GADD45G	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
GADD45G	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Liver	rep_1	1.0e-70
GADD45G	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Liver	rep_1	1.0e-70
GADD45G	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
GADD45G	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
GADD45G	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Liver	rep_1	1.0e-70
GADD45G	GOBP_Regulation_Of_Protein_Modification_Process	Human	Liver	rep_1	1.0e-70
GADD45G	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Liver	rep_1	1.0e-70
GADD45G	GOBP_Regulation_Of_Response_To_Stress	Human	Liver	rep_1	5.3e-67
GADD45G	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
GADD45G	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	3.4e-10
GADD45G	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
GADD45G	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
GADD45G	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	rep_colon4	2.2e-52
GADD45G	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
GADD45G	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
GADD45G	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	rep_colon4	2.2e-52
GADD45G	GOBP_Adaptive_Thermogenesis	Human	Intestine	A3	3.5e-11
GADD45G	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
GADD45G	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
GADD45G	GOBP_Jnk_Cascade	Human	Intestine	A3	3.8e-08
GADD45G	GOBP_Mapk_Cascade	Human	Intestine	A3	1.1e-12
GADD45G	GOBP_Multicellular_Organismal_Homeostasis	Human	Intestine	A3	8.8e-08
GADD45G	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
GADD45G	GOBP_Positive_Regulation_Of_Cell_Death	Human	Intestine	A3	4.5e-11
GADD45G	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-10
GADD45G	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Human	Intestine	A3	4.4e-09
GADD45G	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
GADD45G	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Intestine	A3	8.6e-17
GADD45G	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Intestine	A3	7.8e-15
GADD45G	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
GADD45G	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	9.1e-12
GADD45G	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Intestine	A3	2.0e-08
GADD45G	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Human	Intestine	A3	5.6e-07
GADD45G	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
GADD45G	GOBP_Positive_Regulation_Of_Transferase_Activity	Human	Intestine	A3	2.1e-11
GADD45G	GOBP_Regulation_Of_Cell_Cycle	Human	Intestine	A3	1.6e-08
GADD45G	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
GADD45G	GOBP_Regulation_Of_Cellular_Response_To_Stress	Human	Intestine	A3	7.7e-17
GADD45G	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
GADD45G	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Intestine	A3	1.5e-11
GADD45G	GOBP_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	1.1e-14
GADD45G	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Intestine	A3	8.8e-11
GADD45G	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	A3	1.1e-10
GADD45G	GOBP_Regulation_Of_Transferase_Activity	Human	Intestine	A3	3.9e-10
GADD45G	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Intestine	A3	1.7e-07
GADD45G	GOBP_Temperature_Homeostasis	Human	Intestine	A3	1.3e-08
GADD45G	GOBP_P38mapk_Cascade	Human	Intestine	A8	3.8e-20
GADD45G	GOBP_Positive_Regulation_Of_Cold_Induced_Thermogenesis	Human	Intestine	A8	5.3e-09
GADD45G	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Human	Intestine	A8	1.1e-12
GADD45G	GOBP_Regulation_Of_Jnk_Cascade	Human	Intestine	A8	2.0e-08
GADD45G	GOBP_Regulation_Of_Map_Kinase_Activity	Human	Intestine	A8	8.8e-11
GADD45G	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Intestine	A8	4.3e-23
GADD45G	GOBP_P38mapk_Cascade	Human	Pancreas	PDAC-B-st1	3.3e-06
GADD45G	GOBP_Positive_Regulation_Of_Jnk_Cascade	Human	Pancreas	PDAC-B-st1	3.6e-06
GADD45G	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Human	Pancreas	PDAC-B-st1	9.1e-07
GADD45G	GOBP_Positive_Regulation_Of_Mapk_Cascade	Human	Pancreas	PDAC-B-st1	1.1e-05
GADD45G	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Pancreas	PDAC-B-st1	8.9e-05
GADD45G	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Pancreas	PDAC-B-st1	4.7e-05
GADD45G	GOBP_Regulation_Of_Jnk_Cascade	Human	Pancreas	PDAC-B-st1	4.6e-05
GADD45G	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Pancreas	PDAC-B-st1	1.6e-06
GADD45G	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Pancreas	PDAC-B-st1	3.7e-05
GADD45G	GOBP_Temperature_Homeostasis	Human	Pancreas	PDAC-B-st1	7.9e-05
GADD45G	GOBP_Multicellular_Organismal_Homeostasis	Human	Uterus	rep_1	2.0e-06
GADD45G	GOBP_Positive_Regulation_Of_Jnk_Cascade	Human	Uterus	rep_1	1.1e-06
GADD45G	GOBP_Positive_Regulation_Of_Cold_Induced_Thermogenesis	Human	Uterus	rep_25	2.2e-07
GADD45G	GOBP_Activation_Of_Protein_Kinase_Activity	Human	Uterus	rep_26	2.8e-13
GADD45G	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
GADD45G	GOBP_Jnk_Cascade	Human	Uterus	rep_26	2.0e-08
GADD45G	GOBP_P38mapk_Cascade	Human	Uterus	rep_26	4.8e-07
GADD45G	GOBP_Positive_Regulation_Of_P38mapk_Cascade	Human	Uterus	rep_26	3.7e-10
GADD45G	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Uterus	rep_26	7.8e-06
GADD45G	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Uterus	rep_26	3.2e-09
GADD45G	GOBP_Temperature_Homeostasis	Human	Uterus	rep_26	1.9e-07
GADD45G	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_29	5.5e-06
GADD45G	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Uterus	rep_29	2.8e-06
GADD45G	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
GADD45G	GOBP_Multicellular_Organismal_Homeostasis	Human	Breast	rep_1	1.5e-16
GADD45G	GOBP_P38mapk_Cascade	Human	Breast	rep_1	5.5e-16
GADD45G	GOBP_Positive_Regulation_Of_Cell_Death	Human	Breast	rep_1	2.2e-15
GADD45G	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Human	Breast	rep_1	5.8e-20
GADD45G	GOBP_Regulation_Of_Response_To_Stress	Human	Breast	rep_1	3.4e-19
GADD45G	GOBP_Jnk_Cascade	Human	Breast	rep_5	4.2e-05
GADD45G	GOBP_Mapk_Cascade	Human	Breast	rep_5	4.6e-17
GADD45G	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
GADD45G	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	5.3e-08
GADD45G	GOBP_Positive_Regulation_Of_Jnk_Cascade	Human	Breast	rep_5	4.6e-11
GADD45G	GOBP_Positive_Regulation_Of_Mapk_Cascade	Human	Breast	rep_5	1.9e-16
GADD45G	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
GADD45G	GOBP_Positive_Regulation_Of_P38mapk_Cascade	Human	Breast	rep_5	1.4e-10
GADD45G	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Breast	rep_5	5.9e-12
GADD45G	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
GADD45G	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_5	3.0e-10
GADD45G	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Breast	rep_5	1.0e-15
GADD45G	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
GADD45G	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Breast	rep_5	3.2e-11
GADD45G	GOBP_Regulation_Of_Cell_Cycle	Human	Breast	rep_5	3.7e-04
GADD45G	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
GADD45G	GOBP_Regulation_Of_Cellular_Response_To_Stress	Human	Breast	rep_5	8.1e-10
GADD45G	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
GADD45G	GOBP_Regulation_Of_Jnk_Cascade	Human	Breast	rep_5	5.1e-06
GADD45G	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Breast	rep_5	2.5e-06
GADD45G	GOBP_Regulation_Of_Protein_Kinase_Activity	Human	Breast	rep_5	1.4e-06
GADD45G	GOBP_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_5	9.1e-07
GADD45G	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Breast	rep_5	5.8e-14
GADD45G	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Human	Breast	rep_5	1.7e-10
GADD45G	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Breast	rep_5	9.2e-08
GADD45G	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Human	Breast	rep_5	1.3e-07
GADD45G	GOBP_Activation_Of_Protein_Kinase_Activity	Human	Breast	rep_6	1.8e-04
GADD45G	GOBP_Adaptive_Thermogenesis	Human	Breast	rep_6	1.1e-10
GADD45G	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
GADD45G	GOBP_Positive_Regulation_Of_Cold_Induced_Thermogenesis	Human	Breast	rep_6	8.2e-10
GADD45G	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Human	Breast	rep_6	1.9e-05
GADD45G	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Human	Breast	rep_6	1.5e-05
GADD45G	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Human	Breast	rep_6	5.3e-05
GADD45G	GOBP_Positive_Regulation_Of_Transferase_Activity	Human	Breast	rep_6	3.2e-05
GADD45G	GOBP_Regulation_Of_Transferase_Activity	Human	Breast	rep_6	4.6e-05
GADD45G	GOBP_Temperature_Homeostasis	Human	Breast	rep_6	5.4e-12
GADD45G	GOBP_Temperature_Homeostasis	Human	Skin	P2_rep2	3.4e-09
GADD45G	GOBP_P38mapk_Cascade	Human	Skin	P5_rep3	9.4e-08
GADD45G	GOBP_Positive_Regulation_Of_P38mapk_Cascade	Human	Lung	rep_1	5.1e-07
GADD45G	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Human	Lung	rep_1	7.4e-09
GADD45G	GOBP_Regulation_Of_Protein_Kinase_Activity	Human	Lung	rep_1	3.2e-09
GADD45G	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Human	Lung	rep_1	9.4e-09
GADD45G	GOBP_Positive_Regulation_Of_Cell_Death	Human	Lung	rep_2	3.0e-07

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GADD45G function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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GADD45G function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for GADD45G envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for GADD45G

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GADD45G

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source