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Spatial pattern gene: PNPLA6 (spascer ID:10908) |
Gene summary for PNPLA6 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | PNPLA6 | Gene ID | 10908 |
| Gene name | patatin like phospholipase domain containing 6 |
| Synonyms | BNHS|LNMS|NTE|NTEMND|OMCS|SPG39|iPLA2delta|sws |
| Cytomap | 19p13.2 |
| Type of gene | protein-coding |
| Description | patatin-like phospholipase domain-containing protein 6neuropathy target esterase |
| Modification date | 20220513 |
| UniProtAcc | Q8IY17 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| PNPLA6 | GO:0004622 | lysophospholipase activity | 21873635 | Function |
| PNPLA6 | GO:0005783 | endoplasmic reticulum | 21873635 | Component |
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Spatial pattern events for PNPLA6 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| PNPLA6 | Human | Intestine | rep_colon1 | 34417225 | 2.80e-12 |
| PNPLA6 | Human | Intestine | rep_colon2 | 34417225 | 9.05e-10 |
| PNPLA6 | Human | Intestine | rep_colon3 | 34417225 | 1.01e-15 |
| PNPLA6 | Human | Intestine | rep_colon4 | 34417225 | 3.67e-13 |
| PNPLA6 | Human | Liver | rep_liver1 | 34417225 | 4.07e-07 |
| PNPLA6 | Human | Liver | rep_liver2 | 34417225 | 7.05e-07 |
| PNPLA6 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| PNPLA6 | Human | Breast | 1160920F | 34493872 | 5.66e-11 |
| PNPLA6 | Human | Breast | CID44971 | 34493872 | 4.51e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID44971_H&E  |  |
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Spatial pattern pathway has PNPLA6 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| PNPLA6 | GOBP_Lipid_Metabolic_Process | Human | Brain | rep_1 | 2.8e-23 |
| PNPLA6 | GOBP_Lipid_Metabolic_Process | Human | Liver | rep_1 | 1.0e-70 |
| PNPLA6 | GOBP_Glycerophospholipid_Metabolic_Process | Human | Intestine | A3 | 7.7e-12 |
| PNPLA6 | GOBP_Organophosphate_Catabolic_Process | Human | Intestine | A3 | 2.5e-07 |
| PNPLA6 | GOBP_Organophosphate_Metabolic_Process | Human | Intestine | A3 | 4.4e-13 |
| PNPLA6 | GOBP_Phospholipid_Metabolic_Process | Human | Intestine | A3 | 3.0e-11 |
| PNPLA6 | GOBP_Cellular_Lipid_Metabolic_Process | Human | Intestine | A8 | 3.8e-13 |
| PNPLA6 | GOBP_Glycerolipid_Metabolic_Process | Human | Intestine | A8 | 1.2e-09 |
| PNPLA6 | GOBP_Glycerophospholipid_Catabolic_Process | Human | Intestine | A8 | 9.5e-15 |
| PNPLA6 | GOBP_Lipid_Catabolic_Process | Human | Intestine | A8 | 3.2e-08 |
| PNPLA6 | GOBP_Lipid_Metabolic_Process | Human | Intestine | A8 | 1.1e-11 |
| PNPLA6 | GOBP_Phosphatidylcholine_Metabolic_Process | Human | Intestine | A8 | 7.1e-10 |
| PNPLA6 | GOBP_Phospholipid_Catabolic_Process | Human | Intestine | A8 | 1.0e-22 |
| PNPLA6 | GOBP_Phosphatidylcholine_Metabolic_Process | Human | Uterus | rep_1 | 2.5e-06 |
| PNPLA6 | GOBP_Cellular_Lipid_Catabolic_Process | Human | Uterus | rep_26 | 4.6e-06 |
| PNPLA6 | GOBP_Organophosphate_Catabolic_Process | Human | Uterus | rep_26 | 1.7e-07 |
| PNPLA6 | GOBP_Glycerolipid_Catabolic_Process | Human | Uterus | rep_29 | 1.7e-10 |
| PNPLA6 | GOBP_Glycerolipid_Metabolic_Process | Human | Uterus | rep_29 | 5.7e-07 |
| PNPLA6 | GOBP_Glycerophospholipid_Catabolic_Process | Human | Uterus | rep_29 | 2.0e-08 |
| PNPLA6 | GOBP_Phospholipid_Catabolic_Process | Human | Uterus | rep_29 | 9.3e-08 |
| PNPLA6 | GOBP_Glycerophospholipid_Catabolic_Process | Human | Breast | rep_1 | 7.2e-04 |
| PNPLA6 | GOBP_Phospholipid_Catabolic_Process | Human | Breast | rep_1 | 1.2e-36 |
| PNPLA6 | GOBP_Cellular_Lipid_Metabolic_Process | Human | Breast | rep_5 | 2.6e-07 |
| PNPLA6 | GOBP_Lipid_Metabolic_Process | Human | Breast | rep_5 | 2.9e-06 |
| PNPLA6 | GOBP_Organophosphate_Catabolic_Process | Human | Breast | rep_5 | 5.9e-09 |
| PNPLA6 | GOBP_Cellular_Lipid_Catabolic_Process | Human | Breast | rep_6 | 3.6e-11 |
| PNPLA6 | GOBP_Glycerolipid_Catabolic_Process | Human | Breast | rep_6 | 1.2e-11 |
| PNPLA6 | GOBP_Glycerolipid_Metabolic_Process | Human | Breast | rep_6 | 9.2e-09 |
| PNPLA6 | GOBP_Glycerophospholipid_Metabolic_Process | Human | Breast | rep_6 | 3.2e-05 |
| PNPLA6 | GOBP_Lipid_Catabolic_Process | Human | Breast | rep_6 | 2.9e-05 |
| PNPLA6 | GOBP_Organophosphate_Metabolic_Process | Human | Breast | rep_6 | 1.0e-12 |
| PNPLA6 | GOBP_Phosphatidylcholine_Metabolic_Process | Human | Breast | rep_6 | 1.9e-10 |
| PNPLA6 | GOBP_Phospholipid_Metabolic_Process | Human | Breast | rep_6 | 4.1e-09 |
| PNPLA6 | GOBP_Glycerolipid_Catabolic_Process | Human | Lung | rep_2 | 8.6e-08 |
| PNPLA6 | GOBP_Glycerophospholipid_Catabolic_Process | Human | Lung | rep_2 | 3.5e-07 |
| PNPLA6 | GOBP_Lipid_Catabolic_Process | Human | Lung | rep_2 | 1.4e-09 |
| PNPLA6 | GOBP_Phospholipid_Catabolic_Process | Human | Lung | rep_2 | 4.4e-08 |
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PNPLA6 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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PNPLA6 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for PNPLA6 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for PNPLA6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PNPLA6 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| PNPLA6 | C2677586 | Spastic Paraplegia 39, Autosomal Recessive | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| PNPLA6 | C1859093 | Chorioretinal Dystrophy, Spinocerebellar Ataxia, and Hypogonadotropic Hypogonadism | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| PNPLA6 | C1848745 | Oliver-McFarlane syndrome | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| PNPLA6 | C0085084 | Motor Neuron Disease | 2 | CTD_human |
| PNPLA6 | C0154681 | Anterior Horn Cell Disease | 2 | CTD_human |
| PNPLA6 | C0154682 | Lateral Sclerosis | 2 | CTD_human |
| PNPLA6 | C0270763 | Familial Motor Neuron Disease | 2 | CTD_human |
| PNPLA6 | C0270764 | Motor Neuron Disease, Lower | 2 | CTD_human |
| PNPLA6 | C0521659 | Motor Neuron Disease, Upper | 2 | CTD_human |
| PNPLA6 | C0543858 | Motor Neuron Disease, Secondary | 2 | CTD_human |
| PNPLA6 | C0023138 | Laurence-Moon Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
| PNPLA6 | C0027765 | nervous system disorder | 1 | CTD_human |
| PNPLA6 | C0037050 | Sick Building Syndrome | 1 | CTD_human |
| PNPLA6 | C0037773 | Spastic Paraplegia, Hereditary | 1 | CTD_human |
| PNPLA6 | C0152025 | Polyneuropathy | 1 | CTD_human |
| PNPLA6 | C0271683 | Polyneuropathy, Motor | 1 | CTD_human |
| PNPLA6 | C0393851 | Polyneuropathy, Critical Illness | 1 | CTD_human |
| PNPLA6 | C0598589 | Inherited neuropathies | 1 | GENOMICS_ENGLAND |
| PNPLA6 | C0751448 | Polyneuropathy, Familial | 1 | CTD_human |
| PNPLA6 | C0751449 | Acquired Polyneuropathy | 1 | CTD_human |
| PNPLA6 | C0751602 | Hereditary Autosomal Dominant Spastic Paraplegia | 1 | CTD_human |
| PNPLA6 | C0751603 | Autosomal Recessive Hereditary Spastic Paraplegia | 1 | CTD_human |
| PNPLA6 | C0751604 | Hereditary X-Linked Recessive Spastic Paraplegia | 1 | CTD_human |
| PNPLA6 | C0751605 | X-Linked, Spastic Paraplegia, Hereditary | 1 | CTD_human |
| PNPLA6 | C1859305 | Cerebellar Ataxia and Hypogonadotropic Hypogonadism | 1 | ORPHANET |
| PNPLA6 | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human |
| PNPLA6 | C4721916 | HMSN Type V | 1 | CTD_human |
