|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
|
Spatial pattern gene: LYVE1 (spascer ID:10894) |
Gene summary for LYVE1 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | LYVE1 | Gene ID | 10894 |
| Gene name | lymphatic vessel endothelial hyaluronan receptor 1 |
| Synonyms | CRSBP-1|HAR|LYVE-1|XLKD1 |
| Cytomap | 11p15.4 |
| Type of gene | protein-coding |
| Description | lymphatic vessel endothelial hyaluronic acid receptor 1cell surface retention sequence binding protein-1extracellular link domain-containing 1extracellular link domain-containing protein 1hyaluronic acid receptor |
| Modification date | 20220513 |
| UniProtAcc | Q9Y5Y7 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| LYVE1 | GO:0004888 | transmembrane signaling receptor activity | 21873635 | Function |
| LYVE1 | GO:0005540 | hyaluronic acid binding | 21873635 | Function |
| LYVE1 | GO:0005886 | plasma membrane | 21873635 | Component |
Top |
Spatial pattern events for LYVE1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| LYVE1 | Human | Bladder | rep_1 | 34385456 | 6.03e-08 |
| LYVE1 | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| LYVE1 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| LYVE1 | Human | Liver | rep_liver3 | 34417225 | 1.15e-14 |
| LYVE1 | Human | Intestine | A3 | 33406409 | 1.38e-14 |
| LYVE1 | Human | Intestine | A8 | 33406409 | 6.11e-12 |
| LYVE1 | Human | Lung | rep_1 | 35355018 | 1.70e-11 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver3_H&E  |  |
Intestine_A3_H&E  |  |
Intestine_A8_H&E  |  |
Lung_rep_1_H&E  |  |
Top |
Spatial pattern pathway has LYVE1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| LYVE1 | GOBP_Response_To_Wounding | Human | Brain | rep_1 | 6.9e-125 |
| LYVE1 | GOBP_Cell_Substrate_Adhesion | Human | Bladder | rep_2 | 4.6e-09 |
| LYVE1 | GOBP_Mucopolysaccharide_Metabolic_Process | Human | Bladder | rep_2 | 1.6e-11 |
| LYVE1 | GOBP_Response_To_Wounding | Human | Liver | rep_1 | 3.1e-62 |
| LYVE1 | GOBP_Response_To_Wounding | Human | Intestine | rep_colon2 | 3.9e-21 |
| LYVE1 | GOBP_Biological_Adhesion | Human | Intestine | A3 | 6.7e-11 |
| LYVE1 | GOBP_Carbohydrate_Derivative_Metabolic_Process | Human | Intestine | A3 | 3.3e-11 |
| LYVE1 | GOBP_Macromolecule_Catabolic_Process | Human | Intestine | A3 | 2.2e-16 |
| LYVE1 | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Intestine | A3 | 4.5e-13 |
| LYVE1 | GOBP_Aminoglycan_Catabolic_Process | Human | Intestine | A8 | 5.0e-10 |
| LYVE1 | GOBP_Carbohydrate_Derivative_Catabolic_Process | Human | Intestine | A8 | 3.2e-10 |
| LYVE1 | GOBP_Hyaluronan_Catabolic_Process | Human | Intestine | A8 | 3.7e-28 |
| LYVE1 | GOBP_Hyaluronan_Metabolic_Process | Human | Intestine | A8 | 3.9e-21 |
| LYVE1 | GOBP_Carbohydrate_Derivative_Catabolic_Process | Human | Uterus | rep_26 | 5.1e-11 |
| LYVE1 | GOBP_Macromolecule_Catabolic_Process | Human | Uterus | rep_26 | 5.0e-08 |
| LYVE1 | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Uterus | rep_26 | 1.0e-08 |
| LYVE1 | GOBP_Biological_Adhesion | Human | Uterus | rep_29 | 3.3e-06 |
| LYVE1 | GOBP_Mucopolysaccharide_Metabolic_Process | Human | Uterus | rep_29 | 7.2e-06 |
| LYVE1 | GOBP_Aminoglycan_Metabolic_Process | Human | Breast | rep_1 | 2.4e-24 |
| LYVE1 | GOBP_Biological_Adhesion | Human | Breast | rep_1 | 4.0e-110 |
| LYVE1 | GOBP_Cell_Matrix_Adhesion | Human | Breast | rep_1 | 3.3e-132 |
| LYVE1 | GOBP_Cell_Substrate_Adhesion | Human | Breast | rep_1 | 9.7e-103 |
| LYVE1 | GOBP_Mucopolysaccharide_Metabolic_Process | Human | Breast | rep_1 | 7.8e-52 |
| LYVE1 | GOBP_Response_To_Wounding | Human | Breast | rep_1 | 4.7e-165 |
| LYVE1 | GOBP_Carbohydrate_Derivative_Catabolic_Process | Human | Breast | rep_5 | 1.1e-09 |
| LYVE1 | GOBP_Hyaluronan_Metabolic_Process | Human | Breast | rep_5 | 1.4e-06 |
| LYVE1 | GOBP_Carbohydrate_Derivative_Metabolic_Process | Human | Breast | rep_6 | 6.1e-07 |
| LYVE1 | GOBP_Macromolecule_Catabolic_Process | Human | Breast | rep_6 | 1.3e-05 |
| LYVE1 | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Breast | rep_6 | 9.5e-06 |
| LYVE1 | GOBP_Hyaluronan_Catabolic_Process | Human | Skin | P10_rep1 | 7.0e-08 |
| LYVE1 | GOBP_Hyaluronan_Metabolic_Process | Human | Skin | P10_rep1 | 3.5e-09 |
| LYVE1 | GOBP_Biological_Adhesion | Human | Lung | rep_2 | 6.6e-07 |
Top |
LYVE1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
Top |
LYVE1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication | ||
| VEGFC | LYVE1 | VEGFC_LYVE1 | Intestine | rep_colon2 | ||
| VEGFC | LYVE1 | VEGFC_LYVE1 | Liver | rep_liver1 |
Top |
Transcription factor for LYVE1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
Top |
Related Drugs for LYVE1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for LYVE1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| LYVE1 | C2239176 | Liver carcinoma | 1 | CTD_human |
