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Spatial pattern gene: ME3 (spascer ID:10873) |
Gene summary for ME3 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | ME3 | Gene ID | 10873 |
| Gene name | malic enzyme 3 |
| Synonyms | NADP-ME |
| Cytomap | 11q14.2 |
| Type of gene | protein-coding |
| Description | NADP-dependent malic enzyme, mitochondrialmalate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))malic enzyme 3, NADP(+)-dependent, mitochondrialmalic enzyme, NADP+-dependent, mitochondrialmitochondrial NADP(+)-dependent malic enzyme 3pyruvic-m |
| Modification date | 20220513 |
| UniProtAcc | Q16798 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| ME3 | GO:0004470 | malic enzyme activity | 21873635 | Function |
| ME3 | GO:0004473 | malate dehydrogenase (decarboxylating) (NADP+) activity | 21873635 | Function |
| ME3 | GO:0005739 | mitochondrion | 21873635 | Component |
| ME3 | GO:0006090 | pyruvate metabolic process | 21873635 | Process |
| ME3 | GO:0006108 | malate metabolic process | 21873635 | Process |
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Spatial pattern events for ME3 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| ME3 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| ME3 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
Uterus_rep_3_H&E  |  |
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Spatial pattern pathway has ME3 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| ME3 | GOBP_Malate_Metabolic_Process | Human | Bladder | rep_2 | 1.5e-06 |
| ME3 | GOBP_Aerobic_Respiration | Human | Bladder | rep_4 | 5.9e-17 |
| ME3 | GOBP_Cellular_Respiration | Human | Bladder | rep_4 | 2.0e-15 |
| ME3 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Bladder | rep_4 | 1.5e-12 |
| ME3 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Bladder | rep_4 | 3.4e-12 |
| ME3 | GOBP_Aerobic_Respiration | Human | Intestine | A3 | 1.5e-15 |
| ME3 | GOBP_Cellular_Respiration | Human | Intestine | A3 | 6.2e-15 |
| ME3 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Intestine | A3 | 2.5e-12 |
| ME3 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Intestine | A3 | 4.3e-14 |
| ME3 | GOBP_Dicarboxylic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.6e-15 |
| ME3 | GOBP_Malate_Metabolic_Process | Human | Intestine | A8 | 4.8e-12 |
| ME3 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Human | Intestine | A8 | 7.3e-16 |
| ME3 | GOBP_Organic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.5e-18 |
| ME3 | GOBP_Oxygen_Metabolic_Process | Human | Intestine | A8 | 5.2e-36 |
| ME3 | GOBP_Pyruvate_Metabolic_Process | Human | Intestine | A8 | 1.4e-20 |
| ME3 | GOBP_Small_Molecule_Metabolic_Process | Human | Intestine | A8 | 2.1e-15 |
| ME3 | GOBP_Tricarboxylic_Acid_Cycle | Human | Intestine | A8 | 5.7e-09 |
| ME3 | GOBP_Aerobic_Respiration | Human | Uterus | rep_26 | 3.1e-08 |
| ME3 | GOBP_Cellular_Respiration | Human | Uterus | rep_26 | 3.7e-07 |
| ME3 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Uterus | rep_26 | 7.2e-06 |
| ME3 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Uterus | rep_26 | 1.8e-06 |
| ME3 | GOBP_Organic_Acid_Metabolic_Process | Human | Uterus | rep_26 | 4.9e-06 |
| ME3 | GOBP_Pyruvate_Metabolic_Process | Human | Uterus | rep_26 | 1.3e-06 |
| ME3 | GOBP_Tricarboxylic_Acid_Cycle | Human | Uterus | rep_26 | 5.7e-11 |
| ME3 | GOBP_Oxygen_Metabolic_Process | Human | Breast | rep_1 | 7.6e-148 |
| ME3 | GOBP_Aerobic_Respiration | Human | Breast | rep_6 | 2.2e-06 |
| ME3 | GOBP_Cellular_Respiration | Human | Breast | rep_6 | 2.2e-06 |
| ME3 | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Breast | rep_6 | 5.2e-08 |
| ME3 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Breast | rep_6 | 7.1e-09 |
| ME3 | GOBP_Monocarboxylic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.1e-07 |
| ME3 | GOBP_Organic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.7e-05 |
| ME3 | GOBP_Pyruvate_Metabolic_Process | Human | Breast | rep_6 | 1.0e-04 |
| ME3 | GOBP_Small_Molecule_Metabolic_Process | Human | Breast | rep_6 | 5.5e-09 |
| ME3 | GOBP_Tricarboxylic_Acid_Cycle | Human | Breast | rep_6 | 8.0e-06 |
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ME3 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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ME3 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for ME3 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for ME3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ME3 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
