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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: HCST (spascer ID:10870)

Gene summary for HCST

Gene summary

Gene information
	Species	Human
	Gene symbol	HCST
	Gene ID	10870
	Gene name	hematopoietic cell signal transducer
	Synonyms	DAP10\|KAP10\|PIK3AP
	Cytomap	19q13.12
	Type of gene	protein-coding
	Description	hematopoietic cell signal transducerDNAX-activation protein 10kinase assoc pro of ~10kDakinase assoc proteinmembrane protein DAP10phosphoinositide-3-kinase adaptor proteintransmembrane adapter protein KAP10
	Modification date	20220513
	UniProtAcc	Q9UBK5

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
HCST	GO:0005102	signaling receptor binding	21873635	Function
HCST	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	21873635	Process
HCST	GO:0043548	phosphatidylinositol 3-kinase binding	21873635	Function

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Spatial pattern events for HCST

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
HCST	Human	Intestine	rep_colon2	34417225	8.12e-16
HCST	Human	Intestine	rep_colon3	34417225	1.01e-15
HCST	Human	Liver	rep_liver1	34417225	1.08e-15
HCST	Human	Breast	1160920F	34493872	1.48e-15
HCST	Human	Breast	CID4465	34493872	4.85e-15
HCST	Human	Breast	CID44971	34493872	1.76e-15
HCST	Human	Breast	CID4535	34493872	6.37e-15
HCST	Human	Skin	mel1_rep1	30154148	1.57e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Breast_1160920F_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E

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Spatial pattern pathway has HCST envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
HCST	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	3.1e-68
HCST	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
HCST	GOBP_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
HCST	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
HCST	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
HCST	GOBP_Positive_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Bladder	rep_2	4.1e-07
HCST	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
HCST	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
HCST	GOBP_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
HCST	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
HCST	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
HCST	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	3.4e-10
HCST	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
HCST	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
HCST	GOBP_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
HCST	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
HCST	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-10
HCST	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
HCST	GOBP_Regulation_Of_Immune_Response	Human	Intestine	A3	1.6e-12
HCST	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
HCST	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
HCST	GOBP_Inositol_Lipid_Mediated_Signaling	Human	Intestine	A8	3.0e-18
HCST	GOBP_Phosphatidylinositol_3_Kinase_Signaling	Human	Intestine	A8	6.4e-12
HCST	GOBP_Positive_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Intestine	A8	7.1e-12
HCST	GOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Intestine	A8	1.7e-13
HCST	GOBP_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
HCST	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
HCST	GOBP_Positive_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Uterus	rep_26	9.6e-15
HCST	GOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Uterus	rep_26	9.3e-09
HCST	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_29	5.5e-06
HCST	GOBP_Positive_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Breast	rep_1	2.1e-71
HCST	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	5.3e-08
HCST	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
HCST	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
HCST	GOBP_Inositol_Lipid_Mediated_Signaling	Human	Breast	rep_6	1.7e-11
HCST	GOBP_Phosphatidylinositol_3_Kinase_Signaling	Human	Breast	rep_6	3.9e-10
HCST	GOBP_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Breast	rep_6	1.3e-08
HCST	GOBP_Positive_Regulation_Of_Phosphatidylinositol_3_Kinase_Signaling	Human	Lung	rep_1	7.5e-07
HCST	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07

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HCST function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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HCST function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for HCST envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for HCST

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HCST

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source