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Spatial pattern gene: ARID5A (spascer ID:10865) |
Gene summary for ARID5A |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | ARID5A | Gene ID | 10865 |
| Gene name | AT-rich interaction domain 5A |
| Synonyms | MRF-1|MRF1|RP11-363D14 |
| Cytomap | 2q11.2 |
| Type of gene | protein-coding |
| Description | AT-rich interactive domain-containing protein 5AARID domain-containing protein 5AAT rich interactive domain 5A (MRF1-like)RFVG5814modulator recognition factor 1modulator recognition factor I |
| Modification date | 20220513 |
| UniProtAcc | Q03989 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| ARID5A | GO:0000976 | transcription cis-regulatory region binding | 21873635 | Function |
| ARID5A | GO:0005634 | nucleus | 21873635 | Component |
| ARID5A | GO:0006357 | regulation of transcription by RNA polymerase II | 21873635 | Process |
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Spatial pattern events for ARID5A |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| ARID5A | Human | Prostate | rep_9 | 29925878 | 5.92e-08 |
| ARID5A | Human | Bladder | rep_1 | 34385456 | 8.93e-15 |
| ARID5A | Human | Bladder | rep_4 | 34385456 | 8.91e-07 |
| ARID5A | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| ARID5A | Human | Intestine | rep_colon3 | 34417225 | 1.01e-15 |
| ARID5A | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| ARID5A | Human | Liver | rep_liver1 | 34417225 | 1.14e-09 |
| ARID5A | Human | Liver | rep_liver2 | 34417225 | 1.27e-15 |
| ARID5A | Human | Liver | rep_liver3 | 34417225 | 8.66e-07 |
| ARID5A | Human | Intestine | A1 | 33406409 | 3.49e-15 |
| ARID5A | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| ARID5A | Human | Uterus | rep_1 | 34857954 | 4.97e-07 |
| ARID5A | Human | Uterus | rep_2 | 34857954 | 6.29e-10 |
| ARID5A | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| ARID5A | Human | Breast | A1 | 34650042 | 4.50e-07 |
| ARID5A | Human | Breast | A4 | 34650042 | 4.27e-06 |
| ARID5A | Human | Breast | B1 | 34650042 | 1.07e-11 |
| ARID5A | Human | Breast | B2 | 34650042 | 2.43e-11 |
| ARID5A | Human | Breast | B3 | 34650042 | 1.40e-11 |
| ARID5A | Human | Breast | B4 | 34650042 | 2.72e-13 |
| ARID5A | Human | Breast | B5 | 34650042 | 1.08e-07 |
| ARID5A | Human | Breast | B6 | 34650042 | 9.25e-14 |
| ARID5A | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| ARID5A | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| ARID5A | Human | Breast | CID4535 | 34493872 | 6.37e-15 |
| ARID5A | Human | Skin | P2_rep1 | 32946785 | 8.43e-09 |
| ARID5A | Human | Skin | P2_rep2 | 32946785 | 1.65e-14 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_1_H&E  |  |
Bladder_rep_4_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver3_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_A1_H&E  |  |
Breast_A4_H&E  |  |
Breast_B1_H&E  |  |
Breast_B2_H&E  |  |
Breast_B3_H&E  |  |
Breast_B4_H&E  |  |
Breast_B5_H&E  |  |
Breast_B6_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID44971_H&E  |  |
Breast_CID4535_H&E  |  |
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Spatial pattern pathway has ARID5A envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| ARID5A | GOBP_Defense_Response | Human | Brain | rep_4 | 2.2e-20 |
| ARID5A | GOBP_Defense_Response_To_Other_Organism | Human | Brain | rep_4 | 1.2e-64 |
| ARID5A | GOBP_Innate_Immune_Response | Human | Brain | rep_4 | 1.2e-64 |
| ARID5A | GOBP_Response_To_Endogenous_Stimulus | Human | Brain | rep_10 | 2.8e-23 |
| ARID5A | GOBP_Response_To_Hormone | Human | Brain | rep_10 | 2.8e-23 |
| ARID5A | GOBP_Defense_Response | Human | Liver | rep_1 | 1.3e-59 |
| ARID5A | GOBP_Defense_Response_To_Other_Organism | Human | Liver | rep_1 | 4.3e-69 |
| ARID5A | GOBP_Innate_Immune_Response | Human | Liver | rep_1 | 7.3e-68 |
| ARID5A | GOBP_Response_To_Endogenous_Stimulus | Human | Liver | rep_1 | 3.0e-55 |
| ARID5A | GOBP_Response_To_Hormone | Human | Liver | rep_1 | 3.0e-55 |
| ARID5A | GOBP_Defense_Response | Human | Intestine | rep_colon4 | 2.5e-86 |
| ARID5A | GOBP_Defense_Response_To_Other_Organism | Human | Intestine | rep_colon4 | 1.2e-82 |
| ARID5A | GOBP_Innate_Immune_Response | Human | Intestine | rep_colon4 | 3.4e-69 |
| ARID5A | GOBP_Response_To_Endogenous_Stimulus | Human | Intestine | rep_liver2 | 3.7e-39 |
| ARID5A | GOBP_Response_To_Hormone | Human | Intestine | rep_liver2 | 3.7e-39 |
| ARID5A | GOBP_Cellular_Response_To_Hormone_Stimulus | Human | Intestine | A3 | 8.7e-19 |
| ARID5A | GOBP_Defense_Response | Human | Intestine | A3 | 6.3e-13 |
| ARID5A | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Human | Intestine | A3 | 5.9e-17 |
| ARID5A | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Intestine | A3 | 7.7e-14 |
| ARID5A | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Intestine | A3 | 1.9e-15 |
| ARID5A | GOBP_Response_To_Endogenous_Stimulus | Human | Intestine | A3 | 5.2e-09 |
| ARID5A | GOBP_Response_To_Estrogen | Human | Intestine | A3 | 2.1e-09 |
| ARID5A | GOBP_Defense_Response_To_Other_Organism | Human | Intestine | A8 | 5.3e-08 |
| ARID5A | GOBP_Response_To_Hormone | Human | Intestine | A8 | 2.3e-13 |
| ARID5A | GOBP_Cellular_Response_To_Estrogen_Stimulus | Human | Pancreas | PDAC-A-st2 | 1.9e-06 |
| ARID5A | GOBP_Defense_Response_To_Other_Organism | Human | Uterus | rep_4 | 2.0e-31 |
| ARID5A | GOBP_Innate_Immune_Response | Human | Uterus | rep_4 | 6.1e-31 |
| ARID5A | GOBP_Cellular_Response_To_Estrogen_Stimulus | Human | Uterus | rep_1 | 1.7e-08 |
| ARID5A | GOBP_Defense_Response | Human | Uterus | rep_1 | 3.0e-06 |
| ARID5A | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Uterus | rep_26 | 2.1e-06 |
| ARID5A | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Uterus | rep_26 | 6.2e-13 |
| ARID5A | GOBP_Defense_Response | Human | Breast | rep_1 | 1.0e-09 |
| ARID5A | GOBP_Response_To_Estrogen | Human | Breast | rep_1 | 3.2e-73 |
| ARID5A | GOBP_Cellular_Response_To_Hormone_Stimulus | Human | Breast | rep_5 | 9.6e-12 |
| ARID5A | GOBP_Response_To_Endogenous_Stimulus | Human | Breast | rep_5 | 3.6e-09 |
| ARID5A | GOBP_Response_To_Hormone | Human | Breast | rep_5 | 2.9e-13 |
| ARID5A | GOBP_Cellular_Response_To_Estrogen_Stimulus | Human | Breast | rep_6 | 7.6e-06 |
| ARID5A | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Human | Breast | rep_6 | 2.6e-08 |
| ARID5A | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Breast | rep_6 | 3.5e-08 |
| ARID5A | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Breast | rep_6 | 8.2e-08 |
| ARID5A | GOBP_Cellular_Response_To_Estrogen_Stimulus | Human | Skin | P2_rep3 | 1.0e-17 |
| ARID5A | GOBP_Defense_Response | Human | Lung | rep_1 | 9.9e-12 |
| ARID5A | GOBP_Defense_Response_To_Other_Organism | Human | Lung | rep_1 | 1.5e-09 |
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ARID5A function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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ARID5A function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for ARID5A envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Arid5a | Kidney | LPS | Urothelium | Sparc,Flna,Pde3a, etc. | 0.254 |
| Arid5a | Kidney | LPS | TAL | Sparc,Flna,Pde3a, etc. | 0.27 |
| Arid5a | Kidney | LPS | VSM | Sparc,Flna,Pde3a, etc. | 0.284 |
| Arid5a | Kidney | LPS | Endothelial | Sparc,Flna,Pde3a, etc. | 0.376 |
| Motif information. |
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Related Drugs for ARID5A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARID5A |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
