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Spatial pattern gene: MTHFD2 (spascer ID:10797) |
Gene summary for MTHFD2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | MTHFD2 | Gene ID | 10797 |
| Gene name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| Synonyms | NMDMC |
| Cytomap | 2p13.1 |
| Type of gene | protein-coding |
| Description | bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialNAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase |
| Modification date | 20220513 |
| UniProtAcc | P13995 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| MTHFD2 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity | 21873635 | Function |
| MTHFD2 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity | 21873635 | Function |
| MTHFD2 | GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity | 21873635 | Function |
| MTHFD2 | GO:0005739 | mitochondrion | 21873635 | Component |
| MTHFD2 | GO:0035999 | tetrahydrofolate interconversion | 21873635 | Process |
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Spatial pattern events for MTHFD2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| MTHFD2 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| MTHFD2 | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| MTHFD2 | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| MTHFD2 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| MTHFD2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| MTHFD2 | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| MTHFD2 | Human | Intestine | A2 | 33406409 | 2.60e-10 |
| MTHFD2 | Human | Uterus | rep_2 | 34857954 | 2.55e-15 |
| MTHFD2 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| MTHFD2 | Human | Breast | 1142243F | 34493872 | 2.30e-15 |
| MTHFD2 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| MTHFD2 | Human | Lung | rep_1 | 35355018 | 4.35e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Lung_rep_1_H&E  |  |
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Spatial pattern pathway has MTHFD2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| MTHFD2 | GOBP_Cellular_Modified_Amino_Acid_Metabolic_Process | Human | Intestine | A8 | 5.4e-11 |
| MTHFD2 | GOBP_Dicarboxylic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.6e-15 |
| MTHFD2 | GOBP_Folic_Acid_Metabolic_Process | Human | Intestine | A8 | 6.2e-17 |
| MTHFD2 | GOBP_One_Carbon_Metabolic_Process | Human | Intestine | A8 | 4.4e-16 |
| MTHFD2 | GOBP_Organic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.5e-18 |
| MTHFD2 | GOBP_Pteridine_Containing_Compound_Metabolic_Process | Human | Intestine | A8 | 6.3e-16 |
| MTHFD2 | GOBP_Small_Molecule_Metabolic_Process | Human | Intestine | A8 | 2.1e-15 |
| MTHFD2 | GOBP_Vitamin_Metabolic_Process | Human | Intestine | A8 | 1.8e-09 |
| MTHFD2 | GOBP_Water_Soluble_Vitamin_Metabolic_Process | Human | Intestine | A8 | 5.2e-09 |
| MTHFD2 | GOBP_Tetrahydrofolate_Interconversion | Human | Pancreas | PDAC-B-st1 | 6.7e-06 |
| MTHFD2 | GOBP_Vitamin_Metabolic_Process | Human | Pancreas | PDAC-B-st1 | 2.8e-07 |
| MTHFD2 | GOBP_Tetrahydrofolate_Interconversion | Human | Uterus | rep_25 | 3.3e-18 |
| MTHFD2 | GOBP_Tetrahydrofolate_Metabolic_Process | Human | Uterus | rep_25 | 4.0e-10 |
| MTHFD2 | GOBP_Cellular_Modified_Amino_Acid_Metabolic_Process | Human | Uterus | rep_26 | 8.7e-10 |
| MTHFD2 | GOBP_Organic_Acid_Metabolic_Process | Human | Uterus | rep_26 | 4.9e-06 |
| MTHFD2 | GOBP_Vitamin_Metabolic_Process | Human | Uterus | rep_26 | 3.9e-06 |
| MTHFD2 | GOBP_Cellular_Modified_Amino_Acid_Metabolic_Process | Human | Breast | rep_1 | 2.3e-10 |
| MTHFD2 | GOBP_Vitamin_Metabolic_Process | Human | Breast | rep_1 | 3.1e-13 |
| MTHFD2 | GOBP_Water_Soluble_Vitamin_Metabolic_Process | Human | Breast | rep_1 | 2.6e-13 |
| MTHFD2 | GOBP_Cellular_Amide_Metabolic_Process | Human | Breast | rep_6 | 5.6e-05 |
| MTHFD2 | GOBP_Folic_Acid_Containing_Compound_Metabolic_Process | Human | Breast | rep_6 | 2.6e-12 |
| MTHFD2 | GOBP_Folic_Acid_Metabolic_Process | Human | Breast | rep_6 | 1.6e-05 |
| MTHFD2 | GOBP_One_Carbon_Metabolic_Process | Human | Breast | rep_6 | 7.1e-06 |
| MTHFD2 | GOBP_Organic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.7e-05 |
| MTHFD2 | GOBP_Pteridine_Containing_Compound_Metabolic_Process | Human | Breast | rep_6 | 1.9e-06 |
| MTHFD2 | GOBP_Small_Molecule_Metabolic_Process | Human | Breast | rep_6 | 5.5e-09 |
| MTHFD2 | GOBP_Tetrahydrofolate_Metabolic_Process | Human | Breast | rep_6 | 3.1e-04 |
| MTHFD2 | GOBP_Folic_Acid_Metabolic_Process | Human | Skin | P10_rep1 | 1.8e-17 |
| MTHFD2 | GOBP_Folic_Acid_Metabolic_Process | Human | Lung | rep_1 | 2.4e-12 |
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MTHFD2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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MTHFD2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for MTHFD2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for MTHFD2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| MTHFD2 | P13995 | DB00157 | NADH | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | SmallMoleculeDrug | approved|nutraceutical |
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Related Diseases for MTHFD2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| MTHFD2 | C0019829 | Hodgkin Disease | 1 | CTD_human |
| MTHFD2 | C0152266 | Mixed Cellularity Hodgkin Lymphoma | 1 | CTD_human |
| MTHFD2 | C0152267 | Hodgkin lymphoma, lymphocyte depletion | 1 | CTD_human |
| MTHFD2 | C0220597 | Adult Hodgkin Lymphoma | 1 | CTD_human |
| MTHFD2 | C1266194 | Lymphocyte Rich Classical Hodgkin Lymphoma | 1 | CTD_human |
| MTHFD2 | C1334968 | Nodular Lymphocyte Predominant Hodgkin Lymphoma | 1 | CTD_human |
