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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: IQGAP2 (spascer ID:10788)

Gene summary for IQGAP2

Gene summary

Gene information
	Species	Human
	Gene symbol	IQGAP2
	Gene ID	10788
	Gene name	IQ motif containing GTPase activating protein 2
	Synonyms	-
	Cytomap	5q13.3
	Type of gene	protein-coding
	Description	ras GTPase-activating-like protein IQGAP2
	Modification date	20220513
	UniProtAcc	Q13576

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
IQGAP2	GO:0005096	GTPase activator activity	21873635	Function
IQGAP2	GO:0005516	calmodulin binding	21873635	Function
IQGAP2	GO:0005737	cytoplasm	21873635	Component
IQGAP2	GO:0032956	regulation of actin cytoskeleton organization	21873635	Process
IQGAP2	GO:0051015	actin filament binding	21873635	Function

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Spatial pattern events for IQGAP2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
IQGAP2	Human	Intestine	rep_colon1	34417225	7.54e-11
IQGAP2	Human	Liver	rep_liver1	34417225	1.08e-15
IQGAP2	Human	Liver	rep_liver2	34417225	6.98e-16
IQGAP2	Human	Intestine	A1	33406409	2.37e-10
IQGAP2	Human	Intestine	A2	33406409	3.85e-15
IQGAP2	Human	Uterus	rep_3	34857954	9.31e-10
IQGAP2	Human	Breast	CID4290	34493872	8.08e-15
IQGAP2	Human	Breast	CID4535	34493872	2.08e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Uterus_rep_3_H&E
Breast_CID4290_H&E
Breast_CID4535_H&E

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Spatial pattern pathway has IQGAP2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
IQGAP2	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Brain	rep_1	2.8e-23
IQGAP2	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
IQGAP2	GOBP_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
IQGAP2	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	2.8e-23
IQGAP2	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Brain	rep_1	7.4e-34
IQGAP2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
IQGAP2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_1	8.7e-71
IQGAP2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
IQGAP2	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Liver	rep_1	1.0e-70
IQGAP2	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
IQGAP2	GOBP_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	9.0e-62
IQGAP2	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	1.0e-70
IQGAP2	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Liver	rep_1	1.5e-73
IQGAP2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
IQGAP2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	4.9e-46
IQGAP2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
IQGAP2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
IQGAP2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon2	4.1e-22
IQGAP2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
IQGAP2	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
IQGAP2	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	rep_colon4	1.3e-27
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
IQGAP2	GOBP_Arp2_3_Complex_Mediated_Actin_Nucleation	Human	Intestine	A3	7.0e-09
IQGAP2	GOBP_Cell_Activation	Human	Intestine	A3	6.2e-08
IQGAP2	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Intestine	A3	4.0e-14
IQGAP2	GOBP_Exocytosis	Human	Intestine	A3	4.7e-10
IQGAP2	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
IQGAP2	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	A3	8.2e-10
IQGAP2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	3.0e-12
IQGAP2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
IQGAP2	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	1.9e-13
IQGAP2	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	3.8e-12
IQGAP2	GOBP_Positive_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	3.4e-13
IQGAP2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.8e-12
IQGAP2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	2.8e-16
IQGAP2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
IQGAP2	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.7e-13
IQGAP2	GOBP_Positive_Regulation_Of_Protein_Containing_Complex_Assembly	Human	Intestine	A3	2.7e-15
IQGAP2	GOBP_Positive_Regulation_Of_Protein_Polymerization	Human	Intestine	A3	1.6e-14
IQGAP2	GOBP_Protein_Polymerization	Human	Intestine	A3	2.3e-10
IQGAP2	GOBP_Regulation_Of_Actin_Filament_Organization	Human	Intestine	A3	2.2e-08
IQGAP2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	8.8e-12
IQGAP2	GOBP_Regulation_Of_Cellular_Component_Size	Human	Intestine	A3	3.0e-07
IQGAP2	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	6.4e-13
IQGAP2	GOBP_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.0e-12
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
IQGAP2	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
IQGAP2	GOBP_Regulation_Of_Protein_Containing_Complex_Assembly	Human	Intestine	A3	7.4e-11
IQGAP2	GOBP_Regulation_Of_Protein_Polymerization	Human	Intestine	A3	2.5e-10
IQGAP2	GOBP_Regulation_Of_Supramolecular_Fiber_Organization	Human	Intestine	A3	9.3e-07
IQGAP2	GOBP_Secretion	Human	Intestine	A3	1.8e-13
IQGAP2	GOBP_Actin_Nucleation	Human	Intestine	A8	2.0e-10
IQGAP2	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Intestine	A8	1.4e-14
IQGAP2	GOBP_Myeloid_Leukocyte_Activation	Human	Intestine	A8	3.8e-18
IQGAP2	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Intestine	A8	8.5e-11
IQGAP2	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Intestine	A8	2.1e-14
IQGAP2	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Intestine	A8	4.6e-12
IQGAP2	GOBP_Regulation_Of_Anatomical_Structure_Size	Human	Intestine	A8	3.3e-07
IQGAP2	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Pancreas	PDAC-B-st1	1.2e-05
IQGAP2	GOBP_Regulation_Of_Gtpase_Activity	Human	Pancreas	PDAC-B-st1	9.7e-05
IQGAP2	GOBP_Arp2_3_Complex_Mediated_Actin_Nucleation	Human	Pancreas	PDAC-A-st2	1.4e-07
IQGAP2	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
IQGAP2	GOBP_Leukocyte_Mediated_Immunity	Human	Uterus	rep_4	2.0e-31
IQGAP2	GOBP_Regulation_Of_Actin_Cytoskeleton_Reorganization	Human	Uterus	rep_1	6.7e-07
IQGAP2	GOBP_Actin_Nucleation	Human	Uterus	rep_26	3.4e-08
IQGAP2	GOBP_Arp2_3_Complex_Mediated_Actin_Nucleation	Human	Uterus	rep_26	1.1e-13
IQGAP2	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Uterus	rep_26	1.5e-11
IQGAP2	GOBP_Exocytosis	Human	Uterus	rep_26	5.1e-10
IQGAP2	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Uterus	rep_26	3.5e-06
IQGAP2	GOBP_Myeloid_Leukocyte_Activation	Human	Uterus	rep_26	1.4e-11
IQGAP2	GOBP_Negative_Regulation_Of_Gtpase_Activity	Human	Uterus	rep_26	7.4e-07
IQGAP2	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Uterus	rep_26	1.2e-06
IQGAP2	GOBP_Regulation_Of_Protein_Containing_Complex_Assembly	Human	Uterus	rep_26	9.2e-07
IQGAP2	GOBP_Cell_Activation	Human	Uterus	rep_28	2.5e-06
IQGAP2	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Uterus	rep_28	8.7e-06
IQGAP2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Uterus	rep_29	4.3e-12
IQGAP2	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	2.9e-08
IQGAP2	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Uterus	rep_29	1.6e-12
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
IQGAP2	GOBP_Actin_Cytoskeleton_Reorganization	Human	Breast	rep_1	7.6e-89
IQGAP2	GOBP_Actin_Filament_Based_Process	Human	Breast	rep_1	1.8e-86
IQGAP2	GOBP_Actin_Filament_Organization	Human	Breast	rep_1	4.0e-75
IQGAP2	GOBP_Actin_Nucleation	Human	Breast	rep_1	5.2e-23
IQGAP2	GOBP_Actin_Polymerization_Or_Depolymerization	Human	Breast	rep_1	6.2e-53
IQGAP2	GOBP_Arp2_3_Complex_Mediated_Actin_Nucleation	Human	Breast	rep_1	5.7e-20
IQGAP2	GOBP_Cytoskeleton_Organization	Human	Breast	rep_1	1.3e-22
IQGAP2	GOBP_Exocytosis	Human	Breast	rep_1	2.8e-29
IQGAP2	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Breast	rep_1	3.6e-09
IQGAP2	GOBP_Myeloid_Leukocyte_Activation	Human	Breast	rep_1	2.2e-37
IQGAP2	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Breast	rep_1	7.1e-11
IQGAP2	GOBP_Positive_Regulation_Of_Actin_Filament_Polymerization	Human	Breast	rep_1	2.9e-68
IQGAP2	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	3.5e-04
IQGAP2	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	1.3e-17
IQGAP2	GOBP_Positive_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	7.1e-32
IQGAP2	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	1.4e-13
IQGAP2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_1	7.8e-04
IQGAP2	GOBP_Protein_Polymerization	Human	Breast	rep_1	6.4e-28
IQGAP2	GOBP_Regulation_Of_Actin_Cytoskeleton_Reorganization	Human	Breast	rep_1	4.3e-13
IQGAP2	GOBP_Regulation_Of_Actin_Filament_Based_Process	Human	Breast	rep_1	8.5e-105
IQGAP2	GOBP_Regulation_Of_Actin_Filament_Length	Human	Breast	rep_1	1.2e-62
IQGAP2	GOBP_Regulation_Of_Actin_Filament_Organization	Human	Breast	rep_1	3.2e-110
IQGAP2	GOBP_Regulation_Of_Anatomical_Structure_Size	Human	Breast	rep_1	1.1e-84
IQGAP2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	4.6e-05
IQGAP2	GOBP_Regulation_Of_Cellular_Component_Size	Human	Breast	rep_1	8.6e-78
IQGAP2	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	7.8e-76
IQGAP2	GOBP_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	9.6e-08
IQGAP2	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
IQGAP2	GOBP_Regulation_Of_Protein_Polymerization	Human	Breast	rep_1	3.1e-31
IQGAP2	GOBP_Regulation_Of_Supramolecular_Fiber_Organization	Human	Breast	rep_1	5.0e-50
IQGAP2	GOBP_Secretion	Human	Breast	rep_1	9.7e-57
IQGAP2	GOBP_Supramolecular_Fiber_Organization	Human	Breast	rep_1	2.8e-72
IQGAP2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	3.6e-05
IQGAP2	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
IQGAP2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
IQGAP2	GOBP_Negative_Regulation_Of_Gtpase_Activity	Human	Breast	rep_6	9.6e-12
IQGAP2	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Breast	rep_6	7.3e-09
IQGAP2	GOBP_Positive_Regulation_Of_Protein_Containing_Complex_Assembly	Human	Breast	rep_6	3.1e-06
IQGAP2	GOBP_Positive_Regulation_Of_Protein_Polymerization	Human	Breast	rep_6	3.7e-05
IQGAP2	GOBP_Negative_Regulation_Of_Gtpase_Activity	Human	Skin	P5_rep1	2.6e-11
IQGAP2	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Skin	P5_rep3	4.1e-08
IQGAP2	GOBP_Cytoskeleton_Organization	Human	Skin	P9_rep3	3.1e-12
IQGAP2	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Human	Skin	P10_rep2	1.1e-22
IQGAP2	GOBP_Cell_Activation	Human	Lung	rep_1	2.1e-08
IQGAP2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Lung	rep_1	1.4e-08
IQGAP2	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	5.7e-10
IQGAP2	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
IQGAP2	GOBP_Cell_Activation_Involved_In_Immune_Response	Human	Lung	rep_2	8.0e-10
IQGAP2	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Lung	rep_2	4.8e-08
IQGAP2	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_2	7.9e-07

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IQGAP2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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IQGAP2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for IQGAP2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for IQGAP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IQGAP2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
IQGAP2	C0006118	Brain Neoplasms	1	CTD_human
IQGAP2	C0153633	Malignant neoplasm of brain	1	CTD_human
IQGAP2	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
IQGAP2	C0750974	Brain Tumor, Primary	1	CTD_human
IQGAP2	C0750977	Recurrent Brain Neoplasm	1	CTD_human
IQGAP2	C0750979	Primary malignant neoplasm of brain	1	CTD_human
IQGAP2	C1527390	Neoplasms, Intracranial	1	CTD_human
IQGAP2	C2239176	Liver carcinoma	1	CTD_human