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Spatial pattern gene: WDR4 (spascer ID:10785) |
Gene summary for WDR4 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | WDR4 | Gene ID | 10785 |
| Gene name | WD repeat domain 4 |
| Synonyms | GAMOS6|MIGSB|TRM82|TRMT82|Wuho|hWH |
| Cytomap | 21q22.3 |
| Type of gene | protein-coding |
| Description | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4TRM82 tRNA methyltransferase 82 homologWD repeat-containing protein 4protein Wuho homologtRNA (guanine-N(7)-)-methyltransferase subunit WDR4 |
| Modification date | 20220513 |
| UniProtAcc | P57081 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| WDR4 | GO:0005634 | nucleus | 21873635 | Component |
| WDR4 | GO:0005829 | cytosol | 21873635 | Component |
| WDR4 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity | 21873635 | Function |
| WDR4 | GO:0043527 | tRNA methyltransferase complex | 21873635 | Component |
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Spatial pattern events for WDR4 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| WDR4 | Human | Intestine | rep_colon1 | 34417225 | 2.69e-06 |
| WDR4 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Liver_rep_liver1_H&E  |  |
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Spatial pattern pathway has WDR4 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| WDR4 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Human | Intestine | A3 | 6.6e-16 |
| WDR4 | GOBP_Methylation | Human | Intestine | A3 | 5.9e-09 |
| WDR4 | GOBP_Ncrna_Metabolic_Process | Human | Intestine | A3 | 8.6e-07 |
| WDR4 | GOBP_Rna_Methylation | Human | Intestine | A3 | 2.7e-07 |
| WDR4 | GOBP_Rna_Modification | Human | Intestine | A3 | 4.5e-10 |
| WDR4 | GOBP_Rna_Processing | Human | Intestine | A3 | 3.9e-09 |
| WDR4 | GOBP_Trna_Metabolic_Process | Human | Intestine | A3 | 2.5e-12 |
| WDR4 | GOBP_Trna_Methylation | Human | Intestine | A3 | 1.7e-07 |
| WDR4 | GOBP_Trna_Processing | Human | Intestine | A3 | 1.6e-08 |
| WDR4 | GOBP_Ncrna_Processing | Human | Uterus | rep_1 | 4.5e-06 |
| WDR4 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Human | Uterus | rep_26 | 2.4e-07 |
| WDR4 | GOBP_Methylation | Human | Uterus | rep_26 | 1.9e-06 |
| WDR4 | GOBP_Rna_Methylation | Human | Uterus | rep_26 | 6.8e-13 |
| WDR4 | GOBP_Trna_Metabolic_Process | Human | Uterus | rep_26 | 9.4e-08 |
| WDR4 | GOBP_Trna_Methylation | Human | Uterus | rep_26 | 3.1e-10 |
| WDR4 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Human | Breast | rep_6 | 6.0e-06 |
| WDR4 | GOBP_Methylation | Human | Breast | rep_6 | 1.7e-06 |
| WDR4 | GOBP_Ncrna_Metabolic_Process | Human | Breast | rep_6 | 1.9e-04 |
| WDR4 | GOBP_Ncrna_Processing | Human | Breast | rep_6 | 1.3e-05 |
| WDR4 | GOBP_Rna_Methylation | Human | Breast | rep_6 | 3.8e-05 |
| WDR4 | GOBP_Rna_Modification | Human | Breast | rep_6 | 1.0e-04 |
| WDR4 | GOBP_Rna_Processing | Human | Breast | rep_6 | 3.5e-06 |
| WDR4 | GOBP_Trna_Metabolic_Process | Human | Breast | rep_6 | 3.9e-05 |
| WDR4 | GOBP_Trna_Processing | Human | Breast | rep_6 | 3.5e-08 |
| WDR4 | GOBP_Trna_Methylation | Human | Skin | P5_rep1 | 8.2e-13 |
| WDR4 | GOBP_Trna_Modification | Human | Skin | P5_rep1 | 4.1e-14 |
| WDR4 | GOBP_Rna_Guanine_N7_Methylation | Human | Skin | P10_rep2 | 2.0e-13 |
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WDR4 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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WDR4 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for WDR4 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for WDR4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for WDR4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| WDR4 | C0013336 | Dwarfism | 1 | GENOMICS_ENGLAND |
| WDR4 | C0265202 | Seckel syndrome | 1 | GENOMICS_ENGLAND |
| WDR4 | C0342573 | PITUITARY DWARFISM I | 1 | GENOMICS_ENGLAND |
| WDR4 | C0795949 | Galloway Mowat syndrome | 1 | ORPHANET |
| WDR4 | C1292778 | Chronic myeloproliferative disorder | 1 | GENOMICS_ENGLAND |
| WDR4 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
