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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: NEK6 (spascer ID:10783)

Gene summary for NEK6

Gene summary

Gene information
	Species	Human
	Gene symbol	NEK6
	Gene ID	10783
	Gene name	NIMA related kinase 6
	Synonyms	SID6-1512
	Cytomap	9q33.3
	Type of gene	protein-coding
	Description	serine/threonine-protein kinase Nek6NIMA (never in mitosis gene a)-related kinase 6never in mitosis A-related kinase 6nimA-related protein kinase 6protein kinase SID6-1512putative serine-threonine protein kinase
	Modification date	20220513
	UniProtAcc	Q9HC98

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for NEK6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
NEK6	Human	Intestine	rep_colon4	34417225	1.14e-15
NEK6	Human	Liver	rep_liver1	34417225	1.08e-15
NEK6	Human	Liver	rep_liver2	34417225	6.98e-16
NEK6	Human	Uterus	rep_2	34857954	4.65e-08
NEK6	Human	Uterus	rep_3	34857954	3.02e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E

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Spatial pattern pathway has NEK6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
NEK6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	3.1e-68
NEK6	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
NEK6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
NEK6	GOBP_Regulation_Of_Response_To_Stress	Human	Brain	rep_1	4.6e-05
NEK6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
NEK6	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
NEK6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
NEK6	GOBP_Regulation_Of_Response_To_Stress	Human	Liver	rep_1	5.3e-67
NEK6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	3.4e-10
NEK6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
NEK6	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
NEK6	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	rep_colon4	2.2e-52
NEK6	GOBP_Aging	Human	Intestine	A3	9.0e-18
NEK6	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
NEK6	GOBP_Cell_Cycle_Phase_Transition	Human	Intestine	A3	3.5e-07
NEK6	GOBP_Cell_Cycle_Process	Human	Intestine	A3	2.7e-14
NEK6	GOBP_Cell_Division	Human	Intestine	A3	2.7e-10
NEK6	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
NEK6	GOBP_Chromosome_Organization	Human	Intestine	A3	2.5e-13
NEK6	GOBP_Chromosome_Segregation	Human	Intestine	A3	4.7e-12
NEK6	GOBP_Chromosome_Separation	Human	Intestine	A3	2.3e-07
NEK6	GOBP_Endomembrane_System_Organization	Human	Intestine	A3	1.6e-16
NEK6	GOBP_Membrane_Organization	Human	Intestine	A3	2.7e-18
NEK6	GOBP_Microtubule_Based_Process	Human	Intestine	A3	3.4e-11
NEK6	GOBP_Microtubule_Cytoskeleton_Organization	Human	Intestine	A3	4.8e-11
NEK6	GOBP_Mitotic_Cell_Cycle	Human	Intestine	A3	1.8e-12
NEK6	GOBP_Mitotic_Nuclear_Division	Human	Intestine	A3	5.1e-12
NEK6	GOBP_Mitotic_Sister_Chromatid_Segregation	Human	Intestine	A3	6.7e-13
NEK6	GOBP_Nuclear_Chromosome_Segregation	Human	Intestine	A3	4.3e-09
NEK6	GOBP_Organelle_Fission	Human	Intestine	A3	3.4e-16
NEK6	GOBP_Peptidyl_Amino_Acid_Modification	Human	Intestine	A3	2.7e-09
NEK6	GOBP_Peptidyl_Serine_Modification	Human	Intestine	A3	9.8e-09
NEK6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-10
NEK6	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
NEK6	GOBP_Protein_Autophosphorylation	Human	Intestine	A3	8.1e-13
NEK6	GOBP_Regulation_Of_Cell_Cycle	Human	Intestine	A3	1.6e-08
NEK6	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Intestine	A3	2.6e-08
NEK6	GOBP_Regulation_Of_Cell_Cycle_Process	Human	Intestine	A3	1.1e-15
NEK6	GOBP_Regulation_Of_Cellular_Response_To_Stress	Human	Intestine	A3	7.7e-17
NEK6	GOBP_Regulation_Of_Chromosome_Organization	Human	Intestine	A3	3.2e-08
NEK6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
NEK6	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Intestine	A3	1.5e-08
NEK6	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
NEK6	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	A3	1.1e-10
NEK6	GOBP_Sister_Chromatid_Segregation	Human	Intestine	A3	1.0e-11
NEK6	GOBP_Spindle_Assembly	Human	Intestine	A3	6.2e-09
NEK6	GOBP_Spindle_Organization	Human	Intestine	A3	4.4e-08
NEK6	GOBP_Cellular_Senescence	Human	Intestine	A8	8.1e-11
NEK6	GOBP_Membrane_Disassembly	Human	Intestine	A8	1.1e-17
NEK6	GOBP_Metaphase_Anaphase_Transition_Of_Cell_Cycle	Human	Intestine	A8	1.0e-15
NEK6	GOBP_Regulation_Of_Chromosome_Segregation	Human	Intestine	A8	4.3e-08
NEK6	GOBP_Regulation_Of_Chromosome_Separation	Human	Intestine	A8	1.3e-16
NEK6	GOBP_Cell_Division	Human	Pancreas	PDAC-B-st1	5.8e-05
NEK6	GOBP_Chromosome_Segregation	Human	Pancreas	PDAC-B-st1	3.3e-05
NEK6	GOBP_Nuclear_Chromosome_Segregation	Human	Pancreas	PDAC-B-st1	3.3e-05
NEK6	GOBP_Organelle_Fission	Human	Pancreas	PDAC-B-st1	3.9e-05
NEK6	GOBP_Spindle_Organization	Human	Pancreas	PDAC-B-st1	3.4e-05
NEK6	GOBP_Membrane_Disassembly	Human	Uterus	rep_25	5.9e-10
NEK6	GOBP_Cell_Aging	Human	Uterus	rep_26	1.6e-06
NEK6	GOBP_Cell_Cycle_Phase_Transition	Human	Uterus	rep_26	1.9e-06
NEK6	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
NEK6	GOBP_Chromosome_Organization	Human	Uterus	rep_26	1.2e-09
NEK6	GOBP_Chromosome_Segregation	Human	Uterus	rep_26	5.6e-19
NEK6	GOBP_Chromosome_Separation	Human	Uterus	rep_26	1.2e-11
NEK6	GOBP_Metaphase_Anaphase_Transition_Of_Cell_Cycle	Human	Uterus	rep_26	1.9e-09
NEK6	GOBP_Mitotic_Nuclear_Division	Human	Uterus	rep_26	2.4e-07
NEK6	GOBP_Mitotic_Sister_Chromatid_Segregation	Human	Uterus	rep_26	4.0e-12
NEK6	GOBP_Nuclear_Chromosome_Segregation	Human	Uterus	rep_26	1.5e-12
NEK6	GOBP_Nuclear_Envelope_Organization	Human	Uterus	rep_26	1.3e-11
NEK6	GOBP_Nucleus_Organization	Human	Uterus	rep_26	1.3e-06
NEK6	GOBP_Organelle_Fission	Human	Uterus	rep_26	6.0e-11
NEK6	GOBP_Peptidyl_Serine_Modification	Human	Uterus	rep_26	1.9e-07
NEK6	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Uterus	rep_26	9.3e-07
NEK6	GOBP_Regulation_Of_Chromosome_Organization	Human	Uterus	rep_26	3.5e-08
NEK6	GOBP_Regulation_Of_Chromosome_Segregation	Human	Uterus	rep_26	3.3e-08
NEK6	GOBP_Regulation_Of_Chromosome_Separation	Human	Uterus	rep_26	3.6e-11
NEK6	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Uterus	rep_26	2.5e-07
NEK6	GOBP_Sister_Chromatid_Segregation	Human	Uterus	rep_26	3.3e-13
NEK6	GOBP_Spindle_Assembly	Human	Uterus	rep_26	8.1e-08
NEK6	GOBP_Spindle_Organization	Human	Uterus	rep_26	3.2e-06
NEK6	GOBP_Cellular_Senescence	Human	Uterus	rep_29	1.2e-07
NEK6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_29	5.5e-06
NEK6	GOBP_Regulation_Of_Cell_Aging	Human	Uterus	rep_29	3.9e-07
NEK6	GOBP_Aging	Human	Breast	rep_1	1.7e-60
NEK6	GOBP_Cytoskeleton_Organization	Human	Breast	rep_1	1.3e-22
NEK6	GOBP_Endomembrane_System_Organization	Human	Breast	rep_1	2.2e-04
NEK6	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Breast	rep_1	1.2e-47
NEK6	GOBP_Membrane_Disassembly	Human	Breast	rep_1	1.7e-15
NEK6	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Breast	rep_1	2.0e-36
NEK6	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
NEK6	GOBP_Regulation_Of_Response_To_Stress	Human	Breast	rep_1	3.4e-19
NEK6	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
NEK6	GOBP_Peptidyl_Serine_Modification	Human	Breast	rep_5	1.3e-04
NEK6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	5.3e-08
NEK6	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
NEK6	GOBP_Protein_Autophosphorylation	Human	Breast	rep_5	2.3e-14
NEK6	GOBP_Regulation_Of_Cell_Cycle	Human	Breast	rep_5	3.7e-04
NEK6	GOBP_Regulation_Of_Cellular_Response_To_Stress	Human	Breast	rep_5	8.1e-10
NEK6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
NEK6	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
NEK6	GOBP_Cell_Cycle_Phase_Transition	Human	Breast	rep_6	4.9e-09
NEK6	GOBP_Cell_Cycle_Process	Human	Breast	rep_6	6.7e-09
NEK6	GOBP_Cell_Division	Human	Breast	rep_6	8.2e-07
NEK6	GOBP_Chromosome_Organization	Human	Breast	rep_6	1.1e-06
NEK6	GOBP_Chromosome_Segregation	Human	Breast	rep_6	1.9e-05
NEK6	GOBP_Chromosome_Separation	Human	Breast	rep_6	4.1e-08
NEK6	GOBP_Microtubule_Based_Process	Human	Breast	rep_6	1.8e-04
NEK6	GOBP_Microtubule_Cytoskeleton_Organization	Human	Breast	rep_6	1.9e-04
NEK6	GOBP_Mitotic_Cell_Cycle	Human	Breast	rep_6	3.2e-09
NEK6	GOBP_Mitotic_Nuclear_Division	Human	Breast	rep_6	2.5e-08
NEK6	GOBP_Mitotic_Sister_Chromatid_Segregation	Human	Breast	rep_6	4.0e-04
NEK6	GOBP_Nuclear_Chromosome_Segregation	Human	Breast	rep_6	4.6e-06
NEK6	GOBP_Nuclear_Envelope_Organization	Human	Breast	rep_6	1.0e-04
NEK6	GOBP_Nucleus_Organization	Human	Breast	rep_6	8.5e-06
NEK6	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
NEK6	GOBP_Organelle_Fission	Human	Breast	rep_6	3.0e-05
NEK6	GOBP_Peptidyl_Amino_Acid_Modification	Human	Breast	rep_6	3.8e-05
NEK6	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Breast	rep_6	2.7e-07
NEK6	GOBP_Regulation_Of_Cell_Cycle_Process	Human	Breast	rep_6	6.1e-08
NEK6	GOBP_Regulation_Of_Chromosome_Organization	Human	Breast	rep_6	3.0e-04
NEK6	GOBP_Regulation_Of_Chromosome_Segregation	Human	Breast	rep_6	2.6e-07
NEK6	GOBP_Regulation_Of_Chromosome_Separation	Human	Breast	rep_6	3.3e-05
NEK6	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Breast	rep_6	4.6e-09
NEK6	GOBP_Sister_Chromatid_Segregation	Human	Breast	rep_6	5.3e-04
NEK6	GOBP_Spindle_Assembly	Human	Breast	rep_6	2.6e-07
NEK6	GOBP_Spindle_Organization	Human	Breast	rep_6	2.9e-05
NEK6	GOBP_Nuclear_Chromosome_Segregation	Human	Skin	P5_rep1	7.9e-09
NEK6	GOBP_Nuclear_Envelope_Organization	Human	Skin	P5_rep1	2.1e-08
NEK6	GOBP_Organelle_Fission	Human	Skin	P5_rep3	1.0e-09
NEK6	GOBP_Cytoskeleton_Organization	Human	Skin	P9_rep3	3.1e-12
NEK6	GOBP_Cell_Aging	Human	Skin	P10_rep1	5.6e-10
NEK6	GOBP_Cellular_Senescence	Human	Skin	P10_rep1	7.6e-16
NEK6	GOBP_Regulation_Of_Cell_Aging	Human	Skin	P10_rep2	4.5e-08
NEK6	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07
NEK6	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Lung	rep_2	6.0e-08
NEK6	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Lung	rep_2	2.5e-08

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NEK6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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NEK6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for NEK6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for NEK6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NEK6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
NEK6	C0023893	Liver Cirrhosis, Experimental	1	CTD_human