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Spatial pattern gene: POP4 (spascer ID:10775) |
Gene summary for POP4 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | POP4 | Gene ID | 10775 |
| Gene name | POP4 homolog, ribonuclease P/MRP subunit |
| Synonyms | RPP29 |
| Cytomap | 19q12 |
| Type of gene | protein-coding |
| Description | ribonuclease P protein subunit p29hPOP4 |
| Modification date | 20220513 |
| UniProtAcc | O95707 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| POP4 | GO:0000172 | ribonuclease MRP complex | 21873635 | Component |
| POP4 | GO:0006364 | rRNA processing | 21873635 | Process |
| POP4 | GO:0030677 | ribonuclease P complex | 21873635 | Component |
| POP4 | GO:0033204 | ribonuclease P RNA binding | 21873635 | Function |
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Spatial pattern events for POP4 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| POP4 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| POP4 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| POP4 | Human | Uterus | rep_3 | 34857954 | 3.77e-12 |
| POP4 | Human | Breast | E1 | 34650042 | 6.84e-08 |
| POP4 | Human | Breast | E2 | 34650042 | 2.12e-14 |
| POP4 | Human | Breast | E3 | 34650042 | 2.00e-13 |
| POP4 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_E1_H&E  |  |
Breast_E2_H&E  |  |
Breast_E3_H&E  |  |
Breast_1160920F_H&E  |  |
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Spatial pattern pathway has POP4 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| POP4 | GOBP_Ribosome_Biogenesis | Human | Intestine | A1 | 6.5e-08 |
| POP4 | GOBP_Ncrna_Metabolic_Process | Human | Intestine | A3 | 8.6e-07 |
| POP4 | GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis | Human | Intestine | A3 | 1.9e-08 |
| POP4 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Intestine | A3 | 2.3e-07 |
| POP4 | GOBP_Rna_Processing | Human | Intestine | A3 | 3.9e-09 |
| POP4 | GOBP_Trna_Metabolic_Process | Human | Intestine | A3 | 2.5e-12 |
| POP4 | GOBP_Trna_Processing | Human | Intestine | A3 | 1.6e-08 |
| POP4 | GOBP_Rna_5_End_Processing | Human | Intestine | A8 | 5.0e-12 |
| POP4 | GOBP_Trna_5_End_Processing | Human | Intestine | A8 | 3.5e-09 |
| POP4 | GOBP_Trna_5_Leader_Removal | Human | Intestine | A8 | 1.5e-07 |
| POP4 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Pancreas | PDAC-B-st1 | 3.3e-05 |
| POP4 | GOBP_Ncrna_Processing | Human | Uterus | rep_1 | 4.5e-06 |
| POP4 | GOBP_Ribosome_Biogenesis | Human | Uterus | rep_1 | 9.5e-06 |
| POP4 | GOBP_Rrna_Metabolic_Process | Human | Uterus | rep_1 | 2.4e-07 |
| POP4 | GOBP_Trna_5_Leader_Removal | Human | Uterus | rep_25 | 4.8e-06 |
| POP4 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Endonucleolytic | Human | Uterus | rep_26 | 3.6e-07 |
| POP4 | GOBP_Trna_Metabolic_Process | Human | Uterus | rep_26 | 9.4e-08 |
| POP4 | GOBP_Trna_5_End_Processing | Human | Breast | rep_1 | 6.1e-23 |
| POP4 | GOBP_Trna_5_Leader_Removal | Human | Breast | rep_1 | 3.1e-27 |
| POP4 | GOBP_Ncrna_Metabolic_Process | Human | Breast | rep_6 | 1.9e-04 |
| POP4 | GOBP_Ncrna_Processing | Human | Breast | rep_6 | 1.3e-05 |
| POP4 | GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis | Human | Breast | rep_6 | 2.6e-05 |
| POP4 | GOBP_Ribonucleoprotein_Complex_Biogenesis | Human | Breast | rep_6 | 1.3e-07 |
| POP4 | GOBP_Ribosome_Biogenesis | Human | Breast | rep_6 | 2.0e-06 |
| POP4 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Breast | rep_6 | 2.8e-06 |
| POP4 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Endonucleolytic | Human | Breast | rep_6 | 3.0e-08 |
| POP4 | GOBP_Rna_Processing | Human | Breast | rep_6 | 3.5e-06 |
| POP4 | GOBP_Rrna_Metabolic_Process | Human | Breast | rep_6 | 4.0e-06 |
| POP4 | GOBP_Trna_Metabolic_Process | Human | Breast | rep_6 | 3.9e-05 |
| POP4 | GOBP_Trna_Processing | Human | Breast | rep_6 | 3.5e-08 |
| POP4 | GOBP_Trna_5_End_Processing | Human | Skin | P10_rep1 | 4.4e-12 |
| POP4 | GOBP_Rna_5_End_Processing | Human | Skin | P10_rep2 | 1.5e-12 |
| POP4 | GOBP_Rna_Phosphodiester_Bond_Hydrolysis | Human | Lung | rep_1 | 8.8e-08 |
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POP4 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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POP4 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for POP4 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for POP4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for POP4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| POP4 | C0919267 | ovarian neoplasm | 1 | CTD_human |
| POP4 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
