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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: NES (spascer ID:10763)

Gene summary for NES

Gene summary

Gene information
	Species	Human
	Gene symbol	NES
	Gene ID	10763
	Gene name	nestin
	Synonyms	Nbla00170
	Cytomap	1q23.1
	Type of gene	protein-coding
	Description	nestin
	Modification date	20220515
	UniProtAcc	P48681

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
NES	GO:0005882	intermediate filament	21873635	Component
NES	GO:0030844	positive regulation of intermediate filament depolymerization	21873635	Process
NES	GO:0031730	CCR5 chemokine receptor binding	21873635	Function

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Spatial pattern events for NES

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
NES	Human	Intestine	rep_colon1	34417225	1.95e-10
NES	Human	Intestine	rep_colon2	34417225	8.12e-16
NES	Human	Intestine	rep_colon3	34417225	8.65e-11
NES	Human	Liver	rep_liver1	34417225	1.08e-15
NES	Human	Liver	rep_liver2	34417225	6.98e-16
NES	Human	Uterus	rep_1	34857954	5.13e-15
NES	Human	Uterus	rep_2	34857954	2.55e-15
NES	Human	Uterus	rep_3	34857954	1.66e-15
NES	Human	Uterus	rep_4	34857954	1.82e-15
NES	Human	Breast	1142243F	34493872	5.19e-12
NES	Human	Breast	1160920F	34493872	1.48e-15
NES	Human	Breast	CID4465	34493872	4.85e-15
NES	Human	Breast	CID44971	34493872	3.18e-11
NES	Human	Breast	CID4535	34493872	1.14e-06
NES	Human	Heart	w6_s4	31835037	4.62e-05
NES	Human	Lung	rep_1	35355018	4.99e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has NES envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
NES	GOBP_Central_Nervous_System_Development	Human	Brain	rep_1	2.8e-23
NES	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Brain	rep_1	7.4e-34
NES	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Brain	rep_1	1.3e-60
NES	GOBP_Cell_Morphogenesis	Human	Brain	rep_4	1.0e-14
NES	GOBP_Cell_Morphogenesis	Human	Liver	rep_1	2.1e-52
NES	GOBP_Central_Nervous_System_Development	Human	Liver	rep_1	1.0e-70
NES	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Liver	rep_1	1.5e-73
NES	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Liver	rep_1	2.0e-49
NES	GOBP_Cell_Morphogenesis	Human	Intestine	rep_colon2	1.5e-57
NES	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Intestine	rep_colon2	2.9e-50
NES	GOBP_Camera_Type_Eye_Development	Human	Intestine	A3	9.7e-08
NES	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
NES	GOBP_Cell_Cycle_Phase_Transition	Human	Intestine	A3	3.5e-07
NES	GOBP_Cell_Cycle_Process	Human	Intestine	A3	2.7e-14
NES	GOBP_Cell_Morphogenesis	Human	Intestine	A3	9.7e-08
NES	GOBP_Cell_Part_Morphogenesis	Human	Intestine	A3	8.9e-08
NES	GOBP_Cell_Projection_Organization	Human	Intestine	A3	1.1e-09
NES	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
NES	GOBP_Central_Nervous_System_Development	Human	Intestine	A3	7.1e-11
NES	GOBP_Embryo_Development	Human	Intestine	A3	2.4e-07
NES	GOBP_Embryonic_Organ_Development	Human	Intestine	A3	1.4e-10
NES	GOBP_Head_Development	Human	Intestine	A3	3.8e-09
NES	GOBP_Mitotic_Cell_Cycle	Human	Intestine	A3	1.8e-12
NES	GOBP_Negative_Regulation_Of_Binding	Human	Intestine	A3	6.2e-10
NES	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	3.0e-12
NES	GOBP_Negative_Regulation_Of_Cell_Death	Human	Intestine	A3	5.8e-14
NES	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Human	Intestine	A3	2.9e-13
NES	GOBP_Negative_Regulation_Of_Neuron_Death	Human	Intestine	A3	9.1e-14
NES	GOBP_Negative_Regulation_Of_Protein_Binding	Human	Intestine	A3	7.7e-08
NES	GOBP_Neural_Precursor_Cell_Proliferation	Human	Intestine	A3	8.9e-11
NES	GOBP_Neuron_Apoptotic_Process	Human	Intestine	A3	7.8e-11
NES	GOBP_Neuron_Death	Human	Intestine	A3	2.4e-14
NES	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Intestine	A3	3.5e-07
NES	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	3.8e-12
NES	GOBP_Positive_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	3.4e-13
NES	GOBP_Positive_Regulation_Of_Neural_Precursor_Cell_Proliferation	Human	Intestine	A3	1.2e-11
NES	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.7e-13
NES	GOBP_Regulation_Of_Binding	Human	Intestine	A3	4.9e-11
NES	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
NES	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Intestine	A3	6.4e-13
NES	GOBP_Regulation_Of_Neural_Precursor_Cell_Proliferation	Human	Intestine	A3	2.0e-08
NES	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
NES	GOBP_Regulation_Of_Protein_Binding	Human	Intestine	A3	4.4e-10
NES	GOBP_Sensory_Organ_Development	Human	Intestine	A3	1.3e-12
NES	GOBP_Sensory_System_Development	Human	Intestine	A3	8.7e-09
NES	GOBP_Cell_Cycle_G2_M_Phase_Transition	Human	Intestine	A8	4.0e-09
NES	GOBP_Embryonic_Camera_Type_Eye_Development	Human	Intestine	A8	5.2e-09
NES	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Intestine	A8	4.6e-12
NES	GOBP_Positive_Regulation_Of_Protein_Containing_Complex_Disassembly	Human	Intestine	A8	2.3e-07
NES	GOBP_Stem_Cell_Proliferation	Human	Intestine	A8	2.8e-09
NES	GOBP_Camera_Type_Eye_Development	Human	Pancreas	PDAC-B-st1	5.7e-05
NES	GOBP_Head_Development	Human	Pancreas	PDAC-B-st1	2.0e-05
NES	GOBP_Stem_Cell_Proliferation	Human	Pancreas	PDAC-B-st1	7.2e-05
NES	GOBP_Positive_Regulation_Of_Protein_Containing_Complex_Disassembly	Human	Uterus	rep_1	4.0e-11
NES	GOBP_Cell_Cycle_Phase_Transition	Human	Uterus	rep_26	1.9e-06
NES	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
NES	GOBP_Embryonic_Camera_Type_Eye_Development	Human	Uterus	rep_26	1.3e-06
NES	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Human	Uterus	rep_26	6.4e-11
NES	GOBP_Negative_Regulation_Of_Neuron_Death	Human	Uterus	rep_26	3.7e-10
NES	GOBP_Neural_Precursor_Cell_Proliferation	Human	Uterus	rep_26	1.9e-08
NES	GOBP_Neuron_Apoptotic_Process	Human	Uterus	rep_26	4.5e-12
NES	GOBP_Neuron_Death	Human	Uterus	rep_26	4.0e-13
NES	GOBP_Positive_Regulation_Of_Neural_Precursor_Cell_Proliferation	Human	Uterus	rep_26	7.9e-17
NES	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Uterus	rep_26	1.2e-06
NES	GOBP_Positive_Regulation_Of_Protein_Depolymerization	Human	Uterus	rep_26	5.8e-08
NES	GOBP_Protein_Depolymerization	Human	Uterus	rep_26	1.7e-07
NES	GOBP_Negative_Regulation_Of_Binding	Human	Uterus	rep_29	3.5e-06
NES	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Uterus	rep_29	4.3e-12
NES	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Uterus	rep_29	1.6e-12
NES	GOBP_Negative_Regulation_Of_Protein_Binding	Human	Uterus	rep_29	1.6e-06
NES	GOBP_Cell_Morphogenesis	Human	Breast	rep_1	5.7e-26
NES	GOBP_Cell_Part_Morphogenesis	Human	Breast	rep_1	6.2e-28
NES	GOBP_Cell_Projection_Organization	Human	Breast	rep_1	1.8e-20
NES	GOBP_Cellular_Component_Morphogenesis	Human	Breast	rep_1	2.7e-58
NES	GOBP_Central_Nervous_System_Development	Human	Breast	rep_1	5.1e-04
NES	GOBP_Cytoskeleton_Organization	Human	Breast	rep_1	1.3e-22
NES	GOBP_Head_Development	Human	Breast	rep_1	1.0e-09
NES	GOBP_Intermediate_Filament_Based_Process	Human	Breast	rep_1	9.2e-49
NES	GOBP_Negative_Regulation_Of_Binding	Human	Breast	rep_1	3.4e-104
NES	GOBP_Negative_Regulation_Of_Molecular_Function	Human	Breast	rep_1	7.1e-11
NES	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Human	Breast	rep_1	1.2e-11
NES	GOBP_Negative_Regulation_Of_Protein_Binding	Human	Breast	rep_1	2.5e-112
NES	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Breast	rep_1	9.2e-11
NES	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	1.3e-17
NES	GOBP_Positive_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	7.1e-32
NES	GOBP_Positive_Regulation_Of_Neural_Precursor_Cell_Proliferation	Human	Breast	rep_1	4.0e-05
NES	GOBP_Positive_Regulation_Of_Protein_Depolymerization	Human	Breast	rep_1	4.2e-22
NES	GOBP_Regulation_Of_Binding	Human	Breast	rep_1	6.1e-11
NES	GOBP_Regulation_Of_Cytoskeleton_Organization	Human	Breast	rep_1	7.8e-76
NES	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
NES	GOBP_Regulation_Of_Protein_Binding	Human	Breast	rep_1	1.6e-99
NES	GOBP_Regulation_Of_Protein_Containing_Complex_Disassembly	Human	Breast	rep_1	1.1e-29
NES	GOBP_Regulation_Of_Protein_Depolymerization	Human	Breast	rep_1	1.8e-45
NES	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
NES	GOBP_Embryo_Development	Human	Breast	rep_5	5.5e-08
NES	GOBP_Embryonic_Organ_Development	Human	Breast	rep_5	3.3e-05
NES	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	3.6e-05
NES	GOBP_Negative_Regulation_Of_Cell_Death	Human	Breast	rep_5	1.9e-07
NES	GOBP_Negative_Regulation_Of_Neuron_Death	Human	Breast	rep_5	9.9e-10
NES	GOBP_Neuron_Death	Human	Breast	rep_5	6.5e-07
NES	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
NES	GOBP_Camera_Type_Eye_Development	Human	Breast	rep_6	9.2e-06
NES	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
NES	GOBP_Cell_Cycle_G2_M_Phase_Transition	Human	Breast	rep_6	3.0e-12
NES	GOBP_Cell_Cycle_Phase_Transition	Human	Breast	rep_6	4.9e-09
NES	GOBP_Cell_Cycle_Process	Human	Breast	rep_6	6.7e-09
NES	GOBP_Embryonic_Camera_Type_Eye_Development	Human	Breast	rep_6	5.8e-08
NES	GOBP_Mitotic_Cell_Cycle	Human	Breast	rep_6	3.2e-09
NES	GOBP_Neural_Precursor_Cell_Proliferation	Human	Breast	rep_6	2.0e-05
NES	GOBP_Neuron_Apoptotic_Process	Human	Breast	rep_6	1.3e-06
NES	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Breast	rep_6	7.3e-09
NES	GOBP_Positive_Regulation_Of_Protein_Containing_Complex_Disassembly	Human	Breast	rep_6	1.1e-09
NES	GOBP_Protein_Containing_Complex_Disassembly	Human	Breast	rep_6	1.0e-13
NES	GOBP_Protein_Depolymerization	Human	Breast	rep_6	1.1e-04
NES	GOBP_Sensory_Organ_Development	Human	Breast	rep_6	1.3e-09
NES	GOBP_Sensory_System_Development	Human	Breast	rep_6	8.2e-06
NES	GOBP_Stem_Cell_Proliferation	Human	Breast	rep_6	1.2e-07
NES	GOBP_Embryonic_Camera_Type_Eye_Development	Human	Skin	P5_rep3	6.9e-23
NES	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Skin	P5_rep3	4.1e-08
NES	GOBP_Cytoskeleton_Organization	Human	Skin	P9_rep3	3.1e-12
NES	GOBP_Positive_Regulation_Of_Neural_Precursor_Cell_Proliferation	Human	Skin	P10_rep2	5.4e-15
NES	GOBP_Negative_Regulation_Of_Catalytic_Activity	Human	Lung	rep_1	1.4e-08
NES	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Lung	rep_1	7.3e-07
NES	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07
NES	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Human	Lung	rep_2	7.1e-08
NES	GOBP_Negative_Regulation_Of_Neuron_Death	Human	Lung	rep_2	8.1e-08
NES	GOBP_Neuron_Apoptotic_Process	Human	Lung	rep_2	7.1e-08
NES	GOBP_Neuron_Death	Human	Lung	rep_2	3.5e-08

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NES function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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NES function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for NES envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for NES

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NES

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
NES	C0014549	Tonic-Clonic Epilepsy	1	CTD_human
NES	C0027720	Nephrosis	1	CTD_human
NES	C0751117	Cryptogenic Tonic-Clonic Epilepsy	1	CTD_human
NES	C0751118	Epilepsy, Tonic-Clonic, Familial	1	CTD_human
NES	C0751119	Epilepsy, Tonic-Clonic, Symptomatic	1	CTD_human