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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: TRAF3IP2 (spascer ID:10758)

Gene summary for TRAF3IP2

Gene summary

Gene information
	Species	Human
	Gene symbol	TRAF3IP2
	Gene ID	10758
	Gene name	TRAF3 interacting protein 2
	Synonyms	ACT1\|C6orf2\|C6orf4\|C6orf5\|C6orf6\|CANDF8\|CIKS\|PSORS13
	Cytomap	6q21
	Type of gene	protein-coding
	Description	E3 ubiquitin ligase TRAF3IP2E3 ubiquitin-protein ligase CIKSNFkB-activating protein ACT1adapter protein CIKSconnection to IKK and SAPK/JNKnuclear factor NF-kappa-B activator 1symbol withdrawn, see C6orf4
	Modification date	20220513
	UniProtAcc	O43734

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
TRAF3IP2	GO:0006959	humoral immune response	21873635	Process
TRAF3IP2	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	21873635	Process

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Spatial pattern events for TRAF3IP2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
TRAF3IP2	Human	Liver	rep_liver2	34417225	6.98e-16
TRAF3IP2	Human	Uterus	rep_1	34857954	8.93e-15
TRAF3IP2	Human	Uterus	rep_3	34857954	1.66e-15
TRAF3IP2	Human	Breast	CID44971	34493872	5.35e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E
Uterus_rep_1_H&E
Uterus_rep_3_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has TRAF3IP2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
TRAF3IP2	GOBP_Humoral_Immune_Response	Human	Brain	rep_1	8.1e-16
TRAF3IP2	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
TRAF3IP2	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	3.1e-68
TRAF3IP2	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
TRAF3IP2	GOBP_Regulation_Of_Defense_Response	Human	Brain	rep_1	3.1e-41
TRAF3IP2	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
TRAF3IP2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
TRAF3IP2	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Brain	rep_1	4.6e-05
TRAF3IP2	GOBP_Regulation_Of_Response_To_Stress	Human	Brain	rep_1	4.6e-05
TRAF3IP2	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
TRAF3IP2	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
TRAF3IP2	GOBP_Inflammatory_Response	Human	Brain	rep_4	5.6e-28
TRAF3IP2	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
TRAF3IP2	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
TRAF3IP2	GOBP_Humoral_Immune_Response	Human	Liver	rep_1	9.0e-62
TRAF3IP2	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
TRAF3IP2	GOBP_Inflammatory_Response	Human	Liver	rep_1	1.1e-67
TRAF3IP2	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
TRAF3IP2	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
TRAF3IP2	GOBP_Regulation_Of_Defense_Response	Human	Liver	rep_1	3.7e-85
TRAF3IP2	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
TRAF3IP2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
TRAF3IP2	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Liver	rep_1	5.3e-67
TRAF3IP2	GOBP_Regulation_Of_Response_To_Stress	Human	Liver	rep_1	5.3e-67
TRAF3IP2	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	3.4e-10
TRAF3IP2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
TRAF3IP2	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
TRAF3IP2	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
TRAF3IP2	GOBP_Humoral_Immune_Response	Human	Intestine	rep_colon4	1.3e-27
TRAF3IP2	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
TRAF3IP2	GOBP_Inflammatory_Response	Human	Intestine	rep_colon4	3.1e-51
TRAF3IP2	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
TRAF3IP2	GOBP_Regulation_Of_Defense_Response	Human	Intestine	rep_colon4	5.8e-33
TRAF3IP2	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
TRAF3IP2	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Intestine	rep_colon4	2.2e-52
TRAF3IP2	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	rep_colon4	2.2e-52
TRAF3IP2	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Intestine	A3	2.6e-09
TRAF3IP2	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
TRAF3IP2	GOBP_Humoral_Immune_Response	Human	Intestine	A3	1.4e-08
TRAF3IP2	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
TRAF3IP2	GOBP_Inflammatory_Response	Human	Intestine	A3	2.9e-09
TRAF3IP2	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-10
TRAF3IP2	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
TRAF3IP2	GOBP_Protein_K63_Linked_Ubiquitination	Human	Intestine	A3	5.3e-12
TRAF3IP2	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
TRAF3IP2	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
TRAF3IP2	GOBP_Protein_Polyubiquitination	Human	Intestine	A3	2.1e-10
TRAF3IP2	GOBP_Regulation_Of_Defense_Response	Human	Intestine	A3	1.6e-08
TRAF3IP2	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
TRAF3IP2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
TRAF3IP2	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Intestine	A3	1.0e-09
TRAF3IP2	GOBP_Regulation_Of_Response_To_Stress	Human	Intestine	A3	1.1e-10
TRAF3IP2	GOBP_Response_To_Virus	Human	Intestine	A3	2.4e-11
TRAF3IP2	GOBP_B_Cell_Apoptotic_Process	Human	Intestine	A8	1.0e-07
TRAF3IP2	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
TRAF3IP2	GOBP_Leukocyte_Apoptotic_Process	Human	Intestine	A8	6.1e-16
TRAF3IP2	GOBP_Lymphocyte_Apoptotic_Process	Human	Intestine	A8	1.5e-16
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Intestine	A8	3.3e-08
TRAF3IP2	GOBP_Regulation_Of_Immune_Effector_Process	Human	Intestine	A8	2.4e-12
TRAF3IP2	GOBP_Regulation_Of_Response_To_Biotic_Stimulus	Human	Intestine	A8	1.8e-07
TRAF3IP2	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
TRAF3IP2	GOBP_Response_To_Interleukin_17	Human	Intestine	A8	1.2e-22
TRAF3IP2	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
TRAF3IP2	GOBP_Humoral_Immune_Response	Human	Uterus	rep_4	2.0e-31
TRAF3IP2	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
TRAF3IP2	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
TRAF3IP2	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
TRAF3IP2	GOBP_Positive_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Uterus	rep_25	2.9e-07
TRAF3IP2	GOBP_Protein_K63_Linked_Ubiquitination	Human	Uterus	rep_25	4.3e-06
TRAF3IP2	GOBP_Protein_Polyubiquitination	Human	Uterus	rep_25	1.1e-17
TRAF3IP2	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Uterus	rep_26	2.0e-10
TRAF3IP2	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
TRAF3IP2	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus	Human	Uterus	rep_26	2.0e-09
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Uterus	rep_26	2.3e-06
TRAF3IP2	GOBP_Response_To_Interleukin_17	Human	Uterus	rep_26	2.6e-10
TRAF3IP2	GOBP_Response_To_Virus	Human	Uterus	rep_26	1.3e-09
TRAF3IP2	GOBP_Regulation_Of_Immune_Effector_Process	Human	Uterus	rep_28	5.1e-07
TRAF3IP2	GOBP_Regulation_Of_Response_To_Biotic_Stimulus	Human	Uterus	rep_28	8.0e-06
TRAF3IP2	GOBP_Leukocyte_Apoptotic_Process	Human	Uterus	rep_29	6.6e-08
TRAF3IP2	GOBP_Lymphocyte_Apoptotic_Process	Human	Uterus	rep_29	1.9e-11
TRAF3IP2	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_29	5.5e-06
TRAF3IP2	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.5e-144
TRAF3IP2	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
TRAF3IP2	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Breast	rep_1	1.2e-47
TRAF3IP2	GOBP_Inflammatory_Response	Human	Breast	rep_1	3.7e-43
TRAF3IP2	GOBP_Positive_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Breast	rep_1	8.4e-47
TRAF3IP2	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Breast	rep_1	2.0e-36
TRAF3IP2	GOBP_Regulation_Of_Defense_Response	Human	Breast	rep_1	1.1e-15
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus	Human	Breast	rep_1	1.8e-11
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Breast	rep_1	3.1e-81
TRAF3IP2	GOBP_Regulation_Of_Response_To_External_Stimulus	Human	Breast	rep_1	2.9e-17
TRAF3IP2	GOBP_Regulation_Of_Response_To_Stress	Human	Breast	rep_1	3.4e-19
TRAF3IP2	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
TRAF3IP2	GOBP_Response_To_Virus	Human	Breast	rep_1	7.9e-19
TRAF3IP2	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	5.3e-08
TRAF3IP2	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
TRAF3IP2	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
TRAF3IP2	GOBP_Response_To_Interleukin_17	Human	Breast	rep_5	2.0e-09
TRAF3IP2	GOBP_Protein_K63_Linked_Ubiquitination	Human	Breast	rep_6	4.0e-05
TRAF3IP2	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
TRAF3IP2	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
TRAF3IP2	GOBP_Protein_Polyubiquitination	Human	Breast	rep_6	6.3e-04
TRAF3IP2	GOBP_Lymphocyte_Apoptotic_Process	Human	Skin	P10_rep1	6.6e-09
TRAF3IP2	GOBP_Positive_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Skin	P10_rep1	1.0e-11
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus_By_Host	Human	Skin	P10_rep1	5.6e-12
TRAF3IP2	GOBP_Response_To_Interleukin_17	Human	Skin	P10_rep1	5.7e-10
TRAF3IP2	GOBP_Regulation_Of_Defense_Response_To_Virus	Human	Skin	P10_rep2	3.4e-24
TRAF3IP2	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
TRAF3IP2	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
TRAF3IP2	GOBP_Humoral_Immune_Response	Human	Lung	rep_1	1.7e-10
TRAF3IP2	GOBP_Inflammatory_Response	Human	Lung	rep_1	1.4e-10
TRAF3IP2	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07
TRAF3IP2	GOBP_Regulation_Of_Response_To_Biotic_Stimulus	Human	Lung	rep_1	4.1e-09
TRAF3IP2	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Lung	rep_2	6.0e-08
TRAF3IP2	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Lung	rep_2	2.5e-08

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TRAF3IP2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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TRAF3IP2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for TRAF3IP2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for TRAF3IP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TRAF3IP2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source